ATE377602T1 - Morphinanderivate und ihre medizinische anwendung - Google Patents

Morphinanderivate und ihre medizinische anwendung

Info

Publication number
ATE377602T1
ATE377602T1 AT98911044T AT98911044T ATE377602T1 AT E377602 T1 ATE377602 T1 AT E377602T1 AT 98911044 T AT98911044 T AT 98911044T AT 98911044 T AT98911044 T AT 98911044T AT E377602 T1 ATE377602 T1 AT E377602T1
Authority
AT
Austria
Prior art keywords
morphinan derivatives
medical applications
morphinan
derivatives
opioid
Prior art date
Application number
AT98911044T
Other languages
English (en)
Inventor
Hiroshi Nagase
Hideaki Fujii
Takashi Endoh
Koji Kawai
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE377602T1 publication Critical patent/ATE377602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
AT98911044T 1997-03-27 1998-03-27 Morphinanderivate und ihre medizinische anwendung ATE377602T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7634097 1997-03-27

Publications (1)

Publication Number Publication Date
ATE377602T1 true ATE377602T1 (de) 2007-11-15

Family

ID=13602637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911044T ATE377602T1 (de) 1997-03-27 1998-03-27 Morphinanderivate und ihre medizinische anwendung

Country Status (12)

Country Link
US (1) US6187782B1 (de)
EP (1) EP0915094B1 (de)
KR (1) KR20000016052A (de)
CN (1) CN1150196C (de)
AT (1) ATE377602T1 (de)
AU (1) AU743929B2 (de)
CA (1) CA2256897C (de)
DE (1) DE69838662T2 (de)
ES (1) ES2297882T3 (de)
NO (1) NO985518L (de)
NZ (1) NZ333101A (de)
WO (1) WO1998043978A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001014383A1 (fr) * 1999-08-24 2001-03-01 Toray Industries, Inc. Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2007313103C1 (en) * 2006-10-17 2014-01-30 Penick Corporation Process for preparing oxymorphone
ES2401892T3 (es) * 2007-05-01 2013-04-25 Concert Pharmaceuticals Inc. Compuestos morfinanos
CA2945581C (en) 2007-05-01 2021-11-16 Concert Pharmaceuticals Inc. Evaluating metabolic stability of a deuterated morphinan compound
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
EP2303897A4 (de) 2008-06-05 2012-02-22 Harvard College Hochvalente palladiumfluoridkomplexe und anwendungen davon
TR201802379T4 (tr) * 2008-10-24 2018-03-21 Toray Industries 4,5-epoksimorfinan türevi içeren stabil tablet.
US9024093B2 (en) 2008-11-20 2015-05-05 President And Fellows Of Harvard College Fluorination of organic compounds
KR20110104097A (ko) * 2009-01-09 2011-09-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 불소 함유 화합물 및 이의 사용방법
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
EP2697204B1 (de) 2011-04-12 2017-03-08 President and Fellows of Harvard College Fluorierung organischer verbindungen
CA2861150C (en) * 2011-09-09 2019-07-30 The Kitasato Institute Morphinan derivative
WO2014021273A1 (ja) * 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
WO2014052622A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
MX2015008624A (es) 2012-12-31 2016-12-08 Rhodes Tech PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS.
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
JP6814470B2 (ja) * 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
JPWO2019045006A1 (ja) * 2017-08-31 2020-10-01 国立大学法人 筑波大学 モルヒナン誘導体
WO2019168025A1 (ja) * 2018-02-28 2019-09-06 日本ケミファ株式会社 モルヒナン誘導体の製造方法
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2229770A1 (de) * 1972-06-19 1974-01-10 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
ZA855058B (en) * 1984-07-05 1987-03-25 Du Pont Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung

Also Published As

Publication number Publication date
CA2256897C (en) 2006-10-03
US6187782B1 (en) 2001-02-13
EP0915094A1 (de) 1999-05-12
NO985518L (no) 1999-01-21
NO985518D0 (no) 1998-11-26
AU743929B2 (en) 2002-02-07
WO1998043978A1 (fr) 1998-10-08
CN1220667A (zh) 1999-06-23
CN1150196C (zh) 2004-05-19
DE69838662D1 (de) 2007-12-20
ES2297882T3 (es) 2008-05-01
EP0915094B1 (de) 2007-11-07
EP0915094A4 (de) 2004-09-22
CA2256897A1 (en) 1998-10-08
KR20000016052A (ko) 2000-03-25
DE69838662T2 (de) 2008-08-28
AU6518998A (en) 1998-10-22
NZ333101A (en) 2000-05-26

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