ATE308522T1 - Opioidrezeptorantagonisten - Google Patents
OpioidrezeptorantagonistenInfo
- Publication number
- ATE308522T1 ATE308522T1 AT03733973T AT03733973T ATE308522T1 AT E308522 T1 ATE308522 T1 AT E308522T1 AT 03733973 T AT03733973 T AT 03733973T AT 03733973 T AT03733973 T AT 03733973T AT E308522 T1 ATE308522 T1 AT E308522T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- opioid receptor
- racemate
- diastereomers
- enantiomer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38460302P | 2002-05-30 | 2002-05-30 | |
PCT/US2003/014540 WO2003101963A1 (en) | 2002-05-30 | 2003-05-22 | Opioid receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE308522T1 true ATE308522T1 (de) | 2005-11-15 |
Family
ID=29712067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03733973T ATE308522T1 (de) | 2002-05-30 | 2003-05-22 | Opioidrezeptorantagonisten |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050222204A1 (de) |
EP (1) | EP1513813B1 (de) |
AT (1) | ATE308522T1 (de) |
AU (1) | AU2003239389A1 (de) |
DE (1) | DE60302157T2 (de) |
ES (1) | ES2249722T3 (de) |
WO (1) | WO2003101963A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1353909B1 (de) | 2000-10-31 | 2005-04-06 | Rensselaer Polytechnic Institute | 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien |
SI1440059T1 (sl) | 2001-10-22 | 2008-08-31 | Pfizer Prod Inc | Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja |
US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
ATE420858T1 (de) * | 2004-03-15 | 2009-01-15 | Lilly Co Eli | 4-(5-(aminomethyl)-indol-1- ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit |
US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
AU2012200919B2 (en) * | 2005-10-27 | 2015-05-28 | Merck Sharp & Dohme Llc | Novel opioid antagonists |
ATE516021T1 (de) | 2006-04-21 | 2011-07-15 | Dsm Ip Assets Bv | Verwendung von opioid-rezeptor-antagonisten |
EP2064199A1 (de) | 2006-09-08 | 2009-06-03 | Pfizer Products Inc. | Diaryletherderivate und anwendungen davon |
WO2008142454A1 (en) | 2007-05-22 | 2008-11-27 | Prosidion Limited | Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders |
US8063247B2 (en) | 2007-09-07 | 2011-11-22 | Prosidion Limited | Bicyclic aryl and heteroaryl receptor modulators |
WO2010067233A1 (en) | 2008-12-08 | 2010-06-17 | Pfizer Inc. | 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir) |
US20100311782A1 (en) * | 2009-06-08 | 2010-12-09 | Adolor Corporation | Substituted piperidinylpropanoic acid compounds and methods of their use |
NZ600379A (en) | 2009-12-04 | 2014-05-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
JP5964809B2 (ja) | 2010-03-22 | 2016-08-03 | レンセラール ポリテクニック インスティチュート | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
CA2807965C (en) | 2010-08-23 | 2016-03-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
LT2725908T (lt) | 2011-06-29 | 2017-09-11 | Alkermes, Inc. | Periferinio poveikio opioidų junginiai |
KR101996108B1 (ko) | 2011-12-15 | 2019-10-01 | 엘커메스 파마 아일랜드 리미티드 | 부프레놀핀 및 뮤-오피오이드 수용체 길항물질의 조성물 |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
CA2911231C (en) | 2013-05-24 | 2021-12-07 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
EP4243768A1 (de) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Mehrschichttablette mit sofortiger freisetzung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
-
2003
- 2003-05-22 WO PCT/US2003/014540 patent/WO2003101963A1/en not_active Application Discontinuation
- 2003-05-22 ES ES03733973T patent/ES2249722T3/es not_active Expired - Lifetime
- 2003-05-22 AU AU2003239389A patent/AU2003239389A1/en not_active Abandoned
- 2003-05-22 DE DE60302157T patent/DE60302157T2/de not_active Expired - Fee Related
- 2003-05-22 AT AT03733973T patent/ATE308522T1/de not_active IP Right Cessation
- 2003-05-22 EP EP03733973A patent/EP1513813B1/de not_active Expired - Lifetime
- 2003-05-22 US US10/510,272 patent/US20050222204A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60302157D1 (de) | 2005-12-08 |
DE60302157T2 (de) | 2006-07-27 |
WO2003101963A1 (en) | 2003-12-11 |
AU2003239389A1 (en) | 2003-12-19 |
US20050222204A1 (en) | 2005-10-06 |
EP1513813B1 (de) | 2005-11-02 |
ES2249722T3 (es) | 2006-04-01 |
EP1513813A1 (de) | 2005-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE308522T1 (de) | Opioidrezeptorantagonisten | |
ATE406360T1 (de) | Antagonisten der opioidrezeptoren | |
ATE377589T1 (de) | 6-substituierte nikotinamidderivate als opioidrezeptorantagonisten | |
ATE324371T1 (de) | N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten | |
MY130803A (en) | New quinuclidine amide derivatives | |
NO20041504L (no) | Lactamderivater som antagonister for humane 11CBY reseptorer. | |
DE602004024375D1 (de) | Carboxamidderivate | |
MXPA05009985A (es) | Ligandos de receptores de canabinoides. | |
ATE397605T1 (de) | Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol | |
WO2004000808A3 (en) | N-substituted piperidine derivatives as serotonin receptor agents | |
ATE399770T1 (de) | Tachykininrezeptorantagonisten | |
RS53428B (en) | COMPOSITIONS AND ANTI-VIRUS ACTIVITY OF SUBSTITUTED AZAINDOLOXOSCETER PIPERAZINE DERIVATIVES | |
MXPA05007609A (es) | Antagonista de un receptor sensible al calcio. | |
WO2004082623A3 (en) | Substituted piperidine compounds | |
IL172542A0 (en) | 2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | |
DK1440059T3 (da) | 3-azabicyclo(3.1.0)hexanderivater som opioidreceptorantagonister | |
MXPA05013474A (es) | Derivados de quinolilamida como antagonistas de ccr-5. | |
NO20014855L (no) | N-(2-fenyl-4-aminobutyl)-1-naftamider som neurokinin-1- reseptorantagonister | |
DE60225694D1 (de) | Fexofenadine hydrochlorid polymorph | |
MXPA05011476A (es) | Imidazolin-2-il-aminofenil-amidas como antagonistas de prostaglandina i2. | |
WO2004048381A3 (en) | Pyrazoloazepine compounds as pharmaceutical agents | |
WO2004103305A3 (en) | Spiropyrazole compound | |
ITVR20020030A0 (it) | Miscela per polvere di saldatura, nonche procedimento per l'impiego di detta miscela. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |