NO331653B1 - Oralt tolagspreparat med langvarig frigivelse - Google Patents
Oralt tolagspreparat med langvarig frigivelse Download PDFInfo
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- NO331653B1 NO331653B1 NO20006503A NO20006503A NO331653B1 NO 331653 B1 NO331653 B1 NO 331653B1 NO 20006503 A NO20006503 A NO 20006503A NO 20006503 A NO20006503 A NO 20006503A NO 331653 B1 NO331653 B1 NO 331653B1
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- Norway
- Prior art keywords
- layer
- desloratadine
- pharmaceutically acceptable
- weight
- preparation according
- Prior art date
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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NO20006503A NO331653B1 (no) | 1999-12-20 | 2000-12-20 | Oralt tolagspreparat med langvarig frigivelse |
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US (3) | US6709676B2 (ja) |
EP (3) | EP1110543B1 (ja) |
JP (2) | JP5158919B2 (ja) |
KR (2) | KR20010062543A (ja) |
CN (3) | CN101134038B (ja) |
AR (1) | AR027034A1 (ja) |
AT (2) | ATE329584T1 (ja) |
AU (2) | AU2276801A (ja) |
BR (1) | BR0005938A (ja) |
CA (1) | CA2329172C (ja) |
CO (1) | CO5251421A1 (ja) |
CY (3) | CY1105231T1 (ja) |
CZ (1) | CZ302471B6 (ja) |
DE (3) | DE60028710T2 (ja) |
DK (2) | DK1674084T3 (ja) |
EC (1) | ECSP003835A (ja) |
ES (2) | ES2261158T3 (ja) |
FR (1) | FR08C0004I2 (ja) |
HK (2) | HK1034452A1 (ja) |
HU (1) | HU227538B1 (ja) |
IL (1) | IL140451A (ja) |
LU (1) | LU91403I2 (ja) |
MX (1) | MXPA00012957A (ja) |
MY (1) | MY128658A (ja) |
NL (1) | NL300328I2 (ja) |
NO (1) | NO331653B1 (ja) |
NZ (1) | NZ509034A (ja) |
PE (1) | PE20010952A1 (ja) |
PL (1) | PL209401B1 (ja) |
PT (2) | PT1110543E (ja) |
RU (1) | RU2284182C9 (ja) |
SA (2) | SA06270068B1 (ja) |
SG (2) | SG183573A1 (ja) |
SI (2) | SI1674084T1 (ja) |
SK (1) | SK287105B6 (ja) |
TR (1) | TR200003788A3 (ja) |
TW (1) | TWI222885B (ja) |
WO (1) | WO2001045676A2 (ja) |
ZA (1) | ZA200007714B (ja) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2276801A (en) * | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
WO2001045668A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
JP4318899B2 (ja) * | 2001-08-27 | 2009-08-26 | 第一三共ヘルスケア株式会社 | 抗感冒剤 |
JP2009132734A (ja) * | 2001-08-27 | 2009-06-18 | Daiichi Sankyo Healthcare Co Ltd | 抗感冒剤 |
JP4320217B2 (ja) * | 2002-07-10 | 2009-08-26 | 剤盛堂薬品株式会社 | 鼻炎用経口製剤 |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
US20040253311A1 (en) * | 2002-12-18 | 2004-12-16 | Roger Berlin | Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines |
CL2003002653A1 (es) * | 2002-12-18 | 2005-04-22 | Wyeth Corp | Composicion farmaceutica que comprende (a) un antiinflamatorio no esteroidal (nsaid), preferentemente ibuprofeno, (b) un descongestionante, preferentemente pseudoefedrina y (c) un antihistaminico, preferentemente clorfeniramina; metodo para su prepar |
EP1507774A1 (en) * | 2003-03-12 | 2005-02-23 | Biogal Gyogyszergyar Rt. | Processes for preparation of polymorphic forms of desloratadine |
WO2005046650A1 (en) * | 2003-11-12 | 2005-05-26 | Glenmark Pharmaceuticals Limited | Pharmaceutical formulation containing muscle relaxant and cox-ii inhibitor |
EP1696881A2 (en) | 2003-12-23 | 2006-09-06 | Sun Pharmaceutical Industries Limited | Stable oral composition |
JP5369435B2 (ja) * | 2005-03-10 | 2013-12-18 | 大正製薬株式会社 | 糖衣剤 |
US20110081415A1 (en) * | 2005-03-10 | 2011-04-07 | Taisho Pharmaceutical Co., Ltd | Coating apparatus |
US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
CA2547274A1 (en) * | 2005-05-20 | 2006-11-20 | Dr. Reddy's Laboratories Limited | Stable desloratadine compositions |
US20070004671A1 (en) * | 2005-05-20 | 2007-01-04 | Agarwal Sudeep K | Stable desloratadine compositions |
US20070014855A1 (en) * | 2005-07-12 | 2007-01-18 | Rahul Gawande S | Stable desloratadine compositions |
ES2389666T3 (es) | 2005-09-09 | 2012-10-30 | Angelini Labopharm, Llc | Composición de trazodona para una administración de una vez al día |
US8340944B2 (en) * | 2005-11-30 | 2012-12-25 | The Invention Science Fund I, Llc | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
US8000981B2 (en) | 2005-11-30 | 2011-08-16 | The Invention Science Fund I, Llc | Methods and systems related to receiving nutraceutical associated information |
US20070174128A1 (en) * | 2005-11-30 | 2007-07-26 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging |
US20070289258A1 (en) * | 2006-06-14 | 2007-12-20 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Individualized pharmaceutical selection and packaging |
US8297028B2 (en) | 2006-06-14 | 2012-10-30 | The Invention Science Fund I, Llc | Individualized pharmaceutical selection and packaging |
US20080103746A1 (en) * | 2005-11-30 | 2008-05-01 | Searete Llc, A Limited Liability Corporation | Systems and methods for pathogen detection and response |
US20080114577A1 (en) * | 2005-11-30 | 2008-05-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems associated with nutraceutical related assays |
US20070136092A1 (en) * | 2005-11-30 | 2007-06-14 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging |
US20080004905A1 (en) * | 2006-06-28 | 2008-01-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for analysis of nutraceutical associated components |
US20070124176A1 (en) * | 2005-11-30 | 2007-05-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational and/or control systems and methods related to nutraceutical agent selection and dosing |
US20070124219A1 (en) * | 2005-11-30 | 2007-05-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational and/or control systems related to individualized nutraceutical selection and packaging |
US7827042B2 (en) * | 2005-11-30 | 2010-11-02 | The Invention Science Fund I, Inc | Methods and systems related to transmission of nutraceutical associated information |
US7974856B2 (en) | 2005-11-30 | 2011-07-05 | The Invention Science Fund I, Llc | Computational systems and methods related to nutraceuticals |
US7927787B2 (en) * | 2006-06-28 | 2011-04-19 | The Invention Science Fund I, Llc | Methods and systems for analysis of nutraceutical associated components |
US10296720B2 (en) * | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
US20080033763A1 (en) * | 2005-11-30 | 2008-02-07 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems related to receiving nutraceutical associated information |
US20080052114A1 (en) * | 2005-11-30 | 2008-02-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational systems and methods related to nutraceuticals |
US20110145009A1 (en) * | 2005-11-30 | 2011-06-16 | Jung Edward K Y | Methods and systems related to transmission of nutraceutical associatd information |
WO2007096733A2 (en) * | 2006-02-22 | 2007-08-30 | Orchid Chemicals & Pharmaceuticals Limited | Desloratadine-containing formulation stabilized with cyclodextrin |
CA2541045A1 (en) * | 2006-03-24 | 2007-09-24 | Pharmascience Inc. | A descarbonylethoxyloratadine containing pharmaceutical composition |
CA2653953C (en) | 2006-06-01 | 2015-12-08 | Schering-Plough Healthcare Products, Inc. | Phenylephrine pharmaceutical formulations and compositions for colonic absorption |
NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
SG172660A1 (en) * | 2006-06-01 | 2011-07-28 | Schering Corp | Pharmaceutical compositions for sustained release of phenylephrine |
AU2007254819A1 (en) * | 2006-06-01 | 2007-12-13 | Schering Corporation | Phenylphrine pulsed release formulations and pharmaceutical compositions |
US7718649B1 (en) * | 2006-11-10 | 2010-05-18 | Pisgah Labs, Inc. | Physical states of a pharmaceutical drug substance |
CN101848706A (zh) * | 2007-06-01 | 2010-09-29 | 先灵-普劳健康护理产品公司 | 包含底物和含活性成分和聚乙烯醇的包衣的药用组合物 |
TWI400042B (zh) * | 2007-06-08 | 2013-07-01 | Tci Co Ltd | 食品錠劑 |
MX336494B (es) | 2007-10-16 | 2016-01-21 | Paladin Labs Inc | Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol. |
PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
KR20100121463A (ko) | 2007-12-17 | 2010-11-17 | 라보팜 인코포레이트 | 오용 예방적 방출 제어형 제제 |
ES2509497T3 (es) | 2008-12-16 | 2014-10-17 | Paladin Labs Inc. | Formulación de liberación controlada para evitar un uso indebido |
EP2705181B1 (en) | 2011-05-04 | 2016-12-21 | Intellikine, LLC | Combination pharmaceutical compositions and uses thereof |
BR102012030828A2 (pt) | 2012-12-03 | 2014-09-16 | Ems Sa | Composição farmacêutica compreendendo desloratadina e prednisolona e seu uso |
WO2018058009A1 (en) | 2016-09-26 | 2018-03-29 | The Procter & Gamble Company | Extended relief dosage form |
US10463656B2 (en) | 2017-01-05 | 2019-11-05 | Iowa State University Research Foundation, Inc. | Methods and compositions for prevention of feedlot bovine respiratory disease |
CN109966254B (zh) * | 2017-12-28 | 2021-06-01 | 广州医药研究总院有限公司 | 复方地氯伪麻缓释小丸及其制备方法 |
CN108578406A (zh) * | 2018-04-18 | 2018-09-28 | 曹建华 | 一种用于过敏性鼻炎治疗的组合物 |
WO2021168133A1 (en) * | 2020-02-19 | 2021-08-26 | Nevakar Inc. | Isoproterenol compositions and methods |
CN113230235B (zh) * | 2021-04-15 | 2022-11-11 | 海南普利制药股份有限公司 | 含地氯雷他定的复方缓释胶囊及其制备方法 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US3940485A (en) | 1973-12-12 | 1976-02-24 | Levinson Harold N | Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds |
US4008796A (en) | 1974-03-26 | 1977-02-22 | General Concrete Of Canada Limited | Control method for feeding items on a conveyor |
GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
US4282233B1 (en) | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
WO1985003707A1 (en) | 1984-02-15 | 1985-08-29 | Schering Corporation | 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
US4783465A (en) | 1984-04-09 | 1988-11-08 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4552899A (en) | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
SE8404467D0 (sv) | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
US4731447A (en) | 1985-05-13 | 1988-03-15 | Schering Corporation | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof |
US4804666A (en) | 1985-08-14 | 1989-02-14 | Schering Corporation | Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines |
JPS6396126A (ja) | 1986-10-13 | 1988-04-27 | Taisho Pharmaceut Co Ltd | 安定化組成物 |
US5089496A (en) | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
US4777170A (en) | 1987-02-03 | 1988-10-11 | Heinrich William A | Method to prevent and treat the signs and symptoms of motion sickness |
GB8707421D0 (en) | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
US4863931A (en) | 1988-09-15 | 1989-09-05 | Schering Corporation | Antihistaminic fluoro substituted benzocycloheptapyridines |
US5019591A (en) | 1989-02-17 | 1991-05-28 | Pennsylvania Research Corporation | Method for treating retinopathy and other small vessel disorders associated with diabetes |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
IL98572A (en) | 1990-06-22 | 1995-07-31 | Schering Corp | Bite-benzo or benzopyrido compounds Cyclohepta piperidine, piperidylidene and piperazine, preparations and methods of use. |
AU665341B2 (en) | 1990-12-18 | 1996-01-04 | Wellcome Foundation Limited, The | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
PT100502A (pt) | 1991-05-20 | 1993-08-31 | Alza Corp | Composicoes farmaceuticas para aumentar a capacidade de permeacao na pele utilizando monolinoleato de glicerol |
YU48263B (sh) | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
ES2042421B1 (es) | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
US5314697A (en) | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
IT1264517B1 (it) | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
JP2646972B2 (ja) | 1993-11-01 | 1997-08-27 | 日本電気株式会社 | 多ビットメモリ |
DE4442999A1 (de) | 1994-12-02 | 1996-06-05 | Hexal Pharma Gmbh | Pharmazeutische Zusammensetzung mit einem aktiven Loratidin-Metaboliten |
US7214683B1 (en) | 1994-12-30 | 2007-05-08 | Sepracor Inc. | Compositions of descarboethoxyloratadine |
US7211582B1 (en) | 1994-12-30 | 2007-05-01 | Sepracor Inc. | Methods for treating urticaria using descarboethoxyloratadine |
US5595997A (en) | 1994-12-30 | 1997-01-21 | Sepracor Inc. | Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine |
CN1235545A (zh) * | 1996-10-31 | 1999-11-17 | 先灵公司 | 含有氯雷他定和减充血剂的用于治疗哮喘的组合物 |
PE71699A1 (es) | 1997-02-07 | 1999-08-03 | Sepracor Inc | Composicion farmaceutica de descarboetoxiloratadina sin lactosa, no higroscopica y anhidra |
US5900421A (en) | 1997-02-11 | 1999-05-04 | Sepracor Inc. | Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine |
US5939426A (en) | 1997-02-28 | 1999-08-17 | Sepracor Inc. | Methods for treating urinary incontinence using descarboethoxyloratadine |
US6506767B1 (en) | 1997-07-02 | 2003-01-14 | Schering Corporation | 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine |
AU725811B2 (en) * | 1997-08-26 | 2000-10-19 | Aventisub Llc | Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
US6270796B1 (en) | 1997-10-29 | 2001-08-07 | Robert E. Weinstein | Antihistamine/decongestant regimens for treating rhinitis |
US6132758A (en) * | 1998-06-01 | 2000-10-17 | Schering Corporation | Stabilized antihistamine syrup |
DE69940932D1 (de) * | 1998-07-10 | 2009-07-09 | Schering Corp | Orale Zusammensetzungen mit 8-chloro-6,11-dihydro-11-(4-piperidylene)-5H-benzoÄ5,6Ü-cyclo-heptaÄ1,2-bÜpyridin |
US6423721B1 (en) * | 1998-09-10 | 2002-07-23 | Schering Corporation | Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines |
US6051585A (en) | 1998-12-07 | 2000-04-18 | Weinstein; Robert E. | Single-dose antihistamine/decongestant formulations for treating rhinitis |
US6521254B2 (en) | 1998-12-07 | 2003-02-18 | J-Med Pharmaceuticals, Inc. | Single-dose antihistamine/decongestant formulations for treating rhinitis |
US6100274A (en) | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
US6114346A (en) | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
WO2001045668A2 (en) | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
AU2276801A (en) * | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
WO2001056571A1 (en) | 2000-02-03 | 2001-08-09 | Schering Corporation | Treating allergic and inflammatory conditions |
ES2222370T3 (es) * | 2000-05-19 | 2005-02-01 | Alcon Inc. | Derivados de disulfuro de anilina para tratar enfermedades alergicas. |
US6599913B1 (en) | 2001-06-29 | 2003-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
US6679463B1 (en) * | 2003-06-11 | 2004-01-20 | Kye Systems Corp. | Support with multi-stage clamping mechanism |
EP1696881A2 (en) * | 2003-12-23 | 2006-09-06 | Sun Pharmaceutical Industries Limited | Stable oral composition |
BRPI0513417A (pt) * | 2004-07-16 | 2008-05-06 | Cipla Ltd | composição farmacêutica estável, usos de um poliol, e de uma composição, processo para preparar uma composição farmacêutica, e, método para tratar uma condição responsiva à administração de uma anti-histamina |
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