NO325241B1 - Pyrimidinderivat, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk sammensetning - Google Patents

Pyrimidinderivat, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk sammensetning Download PDF

Info

Publication number: NO325241B1
Authority: NO; Norway
Prior art keywords: formula; pharmaceutically acceptable; 4alkyl; alkyl; acceptable salt
Prior art date: 2000-03-01

Application number

NO20024154A

Other languages

English (en)

Norwegian (no)

Other versions

NO20024154D0 (no

NO20024154L (no

Inventor

Elizabeth Janet Pease

Jeffrey James Morris

Gloria Anne Breault

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-01

Filing date

2002-08-30

Publication date

2008-03-03

2002-08-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-08-30 Publication of NO20024154D0 publication Critical patent/NO20024154D0/no

2002-10-28 Publication of NO20024154L publication Critical patent/NO20024154L/no

2008-03-03 Publication of NO325241B1 publication Critical patent/NO325241B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 66
150000003230 pyrimidines Chemical class 0.000 title claims abstract description 44
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
230000008569 process Effects 0.000 title claims abstract description 5
238000002360 preparation method Methods 0.000 title claims description 8
-1 sulphamoyl Chemical group 0.000 claims abstract description 107
150000003839 salts Chemical class 0.000 claims abstract description 43
125000000217 alkyl group Chemical group 0.000 claims abstract description 42
125000001424 substituent group Chemical group 0.000 claims abstract description 26
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 25
229910052799 carbon Inorganic materials 0.000 claims abstract description 20
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 18
238000004519 manufacturing process Methods 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 78
238000006243 chemical reaction Methods 0.000 claims description 26
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 23
229910052736 halogen Inorganic materials 0.000 claims description 23
150000002367 halogens Chemical class 0.000 claims description 23
125000000623 heterocyclic group Chemical group 0.000 claims description 23
238000011282 treatment Methods 0.000 claims description 20
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 18
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 17
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
230000000694 effects Effects 0.000 claims description 15
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150000001412 amines Chemical class 0.000 claims description 13
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230000002401 inhibitory effect Effects 0.000 claims description 13
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241000282414 Homo sapiens Species 0.000 claims description 8
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CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 7
125000005236 alkanoylamino group Chemical group 0.000 claims description 7
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 7
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
230000001093 anti-cancer Effects 0.000 claims description 6
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20024154A 2000-03-01 2002-08-30 Pyrimidinderivat, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk sammensetning NO325241B1 (no)

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NO2015020C NO2015020I1 (no)	2000-03-01	2015-09-10	Ceritinib, 5-klor-N-5-metyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oksy]fenyl-N-[2-(propan-2-sulfonyl)fenyl]pyrimidine-2,4-diamin, eller et farmasøytisk akseptabelt salt derav

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CN (1)	CN100445270C (ja)
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2000
- 2000-03-01 GB GBGB0004888.4A patent/GB0004888D0/en not_active Ceased
2001
- 2001-02-26 ES ES01905990T patent/ES2284617T3/es not_active Expired - Lifetime
- 2001-02-26 CA CA2399196A patent/CA2399196C/en not_active Expired - Lifetime
- 2001-02-26 PT PT01905990T patent/PT1272477E/pt unknown
- 2001-02-26 KR KR1020027011407A patent/KR100790414B1/ko active IP Right Grant
- 2001-02-26 EP EP01905990A patent/EP1272477B1/en not_active Expired - Lifetime
- 2001-02-26 NZ NZ520394A patent/NZ520394A/en not_active IP Right Cessation
- 2001-02-26 DE DE60128343T patent/DE60128343T2/de not_active Expired - Lifetime
- 2001-02-26 AT AT01905990T patent/ATE361916T1/de active
- 2001-02-26 DK DK01905990T patent/DK1272477T3/da active
- 2001-02-26 BR BRPI0108841A patent/BRPI0108841B8/pt not_active IP Right Cessation
- 2001-02-26 US US10/220,139 patent/US7153964B2/en not_active Expired - Lifetime
- 2001-02-26 IL IL15088301A patent/IL150883A0/xx active IP Right Grant
- 2001-02-26 AU AU33953/01A patent/AU765151B2/en active Active
- 2001-02-26 CN CNB018058450A patent/CN100445270C/zh not_active Expired - Lifetime
- 2001-02-26 WO PCT/GB2001/000782 patent/WO2001064654A1/en active IP Right Grant
- 2001-02-26 MX MXPA02008370A patent/MXPA02008370A/es active IP Right Grant
- 2001-02-26 JP JP2001563496A patent/JP4913305B2/ja not_active Expired - Lifetime
2002
- 2002-07-23 IL IL150883A patent/IL150883A/en unknown
- 2002-08-02 ZA ZA200206191A patent/ZA200206191B/xx unknown
- 2002-08-30 NO NO20024154A patent/NO325241B1/no not_active IP Right Cessation
2007
- 2007-07-11 CY CY20071100918T patent/CY1108019T1/el unknown
2015
- 2015-09-07 CY CY2015035C patent/CY2015035I1/el unknown
- 2015-09-10 LU LU92824C patent/LU92824I2/xx unknown
- 2015-09-10 NO NO2015020C patent/NO2015020I1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2399196C (en)	2010-05-04
CN100445270C (zh)	2008-12-24
JP2003525277A (ja)	2003-08-26
NO2015020I1 (no)	2015-09-21
NO20024154D0 (no)	2002-08-30
WO2001064654A1 (en)	2001-09-07
AU765151B2 (en)	2003-09-11
GB0004888D0 (en)	2000-04-19
EP1272477B1 (en)	2007-05-09
US7153964B2 (en)	2006-12-26
LU92824I2 (fr)	2015-11-24
CN1406231A (zh)	2003-03-26
ZA200206191B (en)	2003-11-03
IL150883A0 (en)	2003-02-12
EP1272477A1 (en)	2003-01-08
BR0108841A (pt)	2003-05-06
DE60128343T2 (de)	2008-01-17
BRPI0108841B1 (pt)	2016-08-02
NO20024154L (no)	2002-10-28
ATE361916T1 (de)	2007-06-15
PT1272477E (pt)	2007-07-16
US20030149064A1 (en)	2003-08-07
DK1272477T3 (da)	2007-09-03
CA2399196A1 (en)	2001-09-07
JP4913305B2 (ja)	2012-04-11
CY2015035I2 (el)	2016-04-13
AU3395301A (en)	2001-09-12
BRPI0108841B8 (pt)	2021-05-25
KR20020075462A (ko)	2002-10-04
CY1108019T1 (el)	2013-09-04
NZ520394A (en)	2004-04-30
ES2284617T3 (es)	2007-11-16
IL150883A (en)	2008-08-07
KR100790414B1 (ko)	2008-01-02
DE60128343D1 (de)	2007-06-21
NO2015020I2 (no)	2015-09-10
CY2015035I1 (el)	2016-04-13
MXPA02008370A (es)	2002-12-13

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Publication	Publication Date	Title
NO325241B1 (no)	2008-03-03	Pyrimidinderivat, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk sammensetning
US6670368B1 (en)	2003-12-30	Pyrimidine compounds with pharmaceutical activity
DE69920509T2 (de)	2006-03-09	Pyrimidine verbindungen
KR100683512B1 (ko)	2007-02-16	피리미딘 화합물
EP1268444B1 (en)	2007-01-17	2,4-di(hetero-)arylamino(-oxy)-5-substituted pyrmidines as antineoplastic agents
KR100762190B1 (ko)	2007-10-04	피리미딘 화합물
AU2001233979B2 (en)	2004-11-11	2,4,di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
NO325280B1 (no)	2008-03-17	Pyrimidin-derivater, fremgangsmate for fremstilling av slike, farmasoytisk preparat inneholdende slike, slike forbindelser for anvendelse som medikament samt anvendelse av slike forbindelser for fremstilling av medikament for behandling av sykdommer
MXPA01006575A (en)	2002-03-26	Pyrimidine compounds