FR2888239B1 - Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk - Google Patents

Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk

Info

Publication number
FR2888239B1
FR2888239B1 FR0507370A FR0507370A FR2888239B1 FR 2888239 B1 FR2888239 B1 FR 2888239B1 FR 0507370 A FR0507370 A FR 0507370A FR 0507370 A FR0507370 A FR 0507370A FR 2888239 B1 FR2888239 B1 FR 2888239B1
Authority
FR
France
Prior art keywords
ikk
medicaments
inhibitors
novel
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0507370A
Other languages
English (en)
Other versions
FR2888239A1 (fr
Inventor
Michael Bosch
Monsif Bouaboula
Pierre Casellas
Samir Jegham
Jean Flaubert Nguefack
Jean Wagnon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0507370A priority Critical patent/FR2888239B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to CNA200680029511XA priority patent/CN101243071A/zh
Priority to JP2008520910A priority patent/JP2009501711A/ja
Priority to BRPI0613452-1A priority patent/BRPI0613452A2/pt
Priority to PCT/FR2006/001619 priority patent/WO2007006926A2/fr
Priority to EA200800285A priority patent/EA200800285A1/ru
Priority to CA002614597A priority patent/CA2614597A1/fr
Priority to KR1020087000779A priority patent/KR20080027832A/ko
Priority to EP06778795A priority patent/EP1904479A2/fr
Priority to AU2006268531A priority patent/AU2006268531A1/en
Priority to NZ564872A priority patent/NZ564872A/en
Priority to MX2008000574A priority patent/MX2008000574A/es
Publication of FR2888239A1 publication Critical patent/FR2888239A1/fr
Priority to TNP2007000471A priority patent/TNSN07471A1/en
Priority to CR9602A priority patent/CR9602A/es
Priority to EC2007008064A priority patent/ECSP078064A/es
Priority to IL188494A priority patent/IL188494A0/en
Priority to US11/971,389 priority patent/US20080269170A1/en
Priority to NO20080456A priority patent/NO20080456L/no
Priority to MA30603A priority patent/MA29649B1/fr
Publication of FR2888239B1 publication Critical patent/FR2888239B1/fr
Application granted granted Critical
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
FR0507370A 2005-07-11 2005-07-11 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk Expired - Fee Related FR2888239B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR0507370A FR2888239B1 (fr) 2005-07-11 2005-07-11 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
EP06778795A EP1904479A2 (fr) 2005-07-11 2006-07-06 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
MX2008000574A MX2008000574A (es) 2005-07-11 2006-07-06 Nuevos derivados de 2,4-dianilinopirimidinas, la preparacion de los mismos, su uso como medicamentos, composiciones farmaceuticas y, en particular, como inhibidores ikk.
PCT/FR2006/001619 WO2007006926A2 (fr) 2005-07-11 2006-07-06 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
EA200800285A EA200800285A1 (ru) 2005-07-11 2006-07-06 Новые производные 2,4-дианилинопиримидинов, их получение, лекарственные средства, фармацевтические композиции, содержащие указанные производные, и их применение, в частности, в качестве ингибиторов ikk
CA002614597A CA2614597A1 (fr) 2005-07-11 2006-07-06 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
KR1020087000779A KR20080027832A (ko) 2005-07-11 2006-07-06 신규의 2,4-디아닐리노피리미딘 유도체, 그의 제법, 및의약으로서, 제약 조성물로서, 특히 ｉｋｋ 억제제로서의그의 용도
JP2008520910A JP2009501711A (ja) 2005-07-11 2006-07-06 新規２，４−ジアニリノピリミジン誘導体、その調製、医薬、医薬組成物としての、特に、ｉｋｋ阻害剤としてのそれらの使用
AU2006268531A AU2006268531A1 (en) 2005-07-11 2006-07-06 Novel 2,4-dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and, in particular, as IKK inhibitors
NZ564872A NZ564872A (en) 2005-07-11 2006-07-06 Novel 2,4-dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and, in particular, as ikk inhibitors
CNA200680029511XA CN101243071A (zh) 2005-07-11 2006-07-06 2,4-二苯胺嘧啶衍生物，其制备，它们作为药物，药物组合物和特别是作为ikk抑制剂的应用
BRPI0613452-1A BRPI0613452A2 (pt) 2005-07-11 2006-07-06 derivados de 2,4-dianilino pirimidinas, o respectivo preparo, a tìtulo de medicamentos, composições farmacêuticas e notadamente como inibidores de ikk
TNP2007000471A TNSN07471A1 (en) 2005-07-11 2007-12-14 Novel 2,4 - dianilinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and, in particular, as ikk inhibitors
CR9602A CR9602A (es) 2005-07-11 2007-12-18 Nuevos derivados de 2,4-dianilinpirimidinas, su preparacion, como medicamentos, composiciones farmaceuticas y particularmente como inhibidores de ikk
EC2007008064A ECSP078064A (es) 2005-07-11 2007-12-28 NUEVOS DERIVADOS de 2,4-DIANILINOPIRIMIDINAS, SU PREPARACIÓN, COMO MEDICAMENTOS, COMPOSICIONES FARMACÉUTICAS Y PRINCIPALMENTE COMO INHIBIDORES DE IKK
IL188494A IL188494A0 (en) 2005-07-11 2007-12-30 Novel 2,4-dianlinopyrimidine derivatives, the preparation thereof, their use as medicaments, pharmaceutical compositions and, in particular, as ikk inhibitors
US11/971,389 US20080269170A1 (en) 2005-07-11 2008-01-09 Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors
NO20080456A NO20080456L (no) 2005-07-11 2008-01-24 Nye 2,4-dianilinopyrimidinderivater, fremstilling derav og deres anvendelse som medikamenter, farmasoytiske sammensetninger og, spesielt, som IKK inhibitorer
MA30603A MA29649B1 (fr) 2005-07-11 2008-01-28 Nouveaux derives de 2,4- dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0507370A FR2888239B1 (fr) 2005-07-11 2005-07-11 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk

Publications (2)

Publication Number Publication Date
FR2888239A1 FR2888239A1 (fr) 2007-01-12
FR2888239B1 true FR2888239B1 (fr) 2008-05-09

Family

ID=35883489

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0507370A Expired - Fee Related FR2888239B1 (fr) 2005-07-11 2005-07-11 Nouveaux derives de 2,4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk

Country Status (2)

Country Link
CN (1) CN101243071A (fr)
FR (1) FR2888239B1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104262322B (zh) * 2014-09-12 2016-09-07 福州大学 一种制备ml264关键中间体的方法
CN109438365B (zh) * 2018-12-06 2022-04-05 华南师范大学 N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物
CN115028661A (zh) * 2022-05-19 2022-09-09 上海应用技术大学 一种4-氨基哌啶-1-甲基磷酸酯及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0004888D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
US6939874B2 (en) * 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
CA2476281A1 (fr) * 2002-02-08 2003-08-14 Smithkline Beecham Corporation Composes de pyrimidine
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
DE602004032446D1 (de) * 2003-08-07 2011-06-09 Rigel Pharmaceuticals Inc 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel
US20070105839A1 (en) * 2003-09-18 2007-05-10 Patricia Imbach 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders

Also Published As

Publication number Publication date
FR2888239A1 (fr) 2007-01-12
CN101243071A (zh) 2008-08-13

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Legal Events

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ST Notification of lapse

Effective date: 20120330