NO322359B1 - 1-(syklisk amino)-alkylsykloheksanforbindelser, farmasoytiske preparater derav og deres anvendelse som antikonvulsive midler - Google Patents

1-(syklisk amino)-alkylsykloheksanforbindelser, farmasoytiske preparater derav og deres anvendelse som antikonvulsive midler Download PDF

Info

Publication number: NO322359B1
Authority: NO; Norway
Prior art keywords: compound; cyclic amino; compounds; alkylcyclohexane; amino
Prior art date: 1999-11-01

Application number

NO20022044A

Other languages

English (en)

Norwegian (no)

Other versions

NO20022044D0 (no

NO20022044L (no

Inventor

Wojciech Danysz

Markus Gold

Ivars Kalvinsh

Christopher Graham Rap Parsons

Valerjans Kauss

Aigars Jirgensons

Original Assignee

Merz Pharma Gmbh & Co Kgaa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-01

Filing date

2002-04-30

Publication date

2006-09-18

2002-04-30 Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa

2002-04-30 Publication of NO20022044D0 publication Critical patent/NO20022044D0/no

2002-04-30 Publication of NO20022044L publication Critical patent/NO20022044L/no

2006-09-18 Publication of NO322359B1 publication Critical patent/NO322359B1/no

Links

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150000003839 salts Chemical class 0.000 claims abstract description 21
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 14
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
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Chemical Kinetics & Catalysis (AREA)
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Biomedical Technology (AREA)
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NO20022044A 1999-11-01 2002-04-30 1-(syklisk amino)-alkylsykloheksanforbindelser, farmasoytiske preparater derav og deres anvendelse som antikonvulsive midler NO322359B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP1999/008317 WO2001032640A1 (en)	1999-11-01	1999-11-01	1-cyclic amino-alkylcyclohexane compounds, pharmaceutical compositions thereof, and their use as anticonvulsants

Publications (3)

Publication Number	Publication Date
NO20022044D0 NO20022044D0 (no)	2002-04-30
NO20022044L NO20022044L (no)	2002-04-30
NO322359B1 true NO322359B1 (no)	2006-09-18

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Application Number	Title	Priority Date	Filing Date
NO20022044A NO322359B1 (no)	1999-11-01	2002-04-30	1-(syklisk amino)-alkylsykloheksanforbindelser, farmasoytiske preparater derav og deres anvendelse som antikonvulsive midler

Country Status (24)

Country	Link
EP (1)	EP1228052B1 (ja)
JP (1)	JP4043236B2 (ja)
KR (1)	KR100548600B1 (ja)
CN (1)	CN1264827C (ja)
AT (1)	ATE361284T1 (ja)
AU (1)	AU782760B2 (ja)
CA (1)	CA2389325C (ja)
CY (1)	CY1106672T1 (ja)
CZ (1)	CZ20021533A3 (ja)
DE (1)	DE69936004T2 (ja)
DK (1)	DK1228052T3 (ja)
EA (1)	EA005684B1 (ja)
ES (1)	ES2285870T3 (ja)
HK (1)	HK1049160B (ja)
HU (1)	HUP0203275A3 (ja)
IL (2)	IL149401A0 (ja)
MX (1)	MXPA02004368A (ja)
NO (1)	NO322359B1 (ja)
PL (1)	PL199587B1 (ja)
PT (1)	PT1228052E (ja)
SI (1)	SI1228052T1 (ja)
TW (1)	TWI242547B (ja)
UA (1)	UA72558C2 (ja)
WO (1)	WO2001032640A1 (ja)

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US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2008055945A1 (en)	2006-11-09	2008-05-15	Probiodrug Ag	3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (sl)	2006-11-30	2012-07-31	Probiodrug Ag	Novi inhibitorji glutaminil ciklaze
ZA200905537B (en)	2007-03-01	2010-10-27	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
ES2548913T3 (es)	2009-09-11	2015-10-21	Probiodrug Ag	Derivados heterocíclicos como inhibidores de glutaminil ciclasa
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
JP5688745B2 (ja)	2010-03-10	2015-03-25	プロビオドルグエージー	グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
CN104211663B (zh) *	2014-08-11	2017-01-11	杭州偶联医药科技有限公司	一种(s)-n-甲氧基-甲基-2-(四氢吡咯基)丙酰胺及其制备方法和应用
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase
RU2714135C1 (ru) *	2019-11-22	2020-02-12	Федеральное государственное бюджетное учреждение науки "Институт токсикологии Федерального медико-биологического агентства"	Гидрохлорид (1-метилпиперидин-4-ил)-2-пропилпентаноата, обладающий холинолитической и противосудорожной активностью

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097207A (en) *	1958-03-06	1963-07-09	Parke Davis & Co	1-halophenyl and 1-alkoxyphenyl cyclohexylamines
EA002254B1 (ru) *	1997-06-30	2002-02-28	Мерц + Ко. Гмбх Унд Ко.	1-аминоалкилциклогексановые антагонисты рецепторов nmda

1999
- 1999-01-11 UA UA2002054475A patent/UA72558C2/uk unknown
- 1999-11-01 DE DE69936004T patent/DE69936004T2/de not_active Expired - Fee Related
- 1999-11-01 AU AU11585/00A patent/AU782760B2/en not_active Ceased
- 1999-11-01 HU HU0203275A patent/HUP0203275A3/hu unknown
- 1999-11-01 CA CA002389325A patent/CA2389325C/en not_active Expired - Fee Related
- 1999-11-01 CN CNB998169900A patent/CN1264827C/zh not_active Expired - Fee Related
- 1999-11-01 IL IL14940199A patent/IL149401A0/xx active IP Right Grant
- 1999-11-01 DK DK99974146T patent/DK1228052T3/da active
- 1999-11-01 PL PL354519A patent/PL199587B1/pl not_active IP Right Cessation
- 1999-11-01 MX MXPA02004368A patent/MXPA02004368A/es not_active IP Right Cessation
- 1999-11-01 KR KR1020027005621A patent/KR100548600B1/ko not_active IP Right Cessation
- 1999-11-01 WO PCT/EP1999/008317 patent/WO2001032640A1/en active IP Right Grant
- 1999-11-01 EA EA200200522A patent/EA005684B1/ru not_active IP Right Cessation
- 1999-11-01 EP EP99974146A patent/EP1228052B1/en not_active Expired - Lifetime
- 1999-11-01 AT AT99974146T patent/ATE361284T1/de not_active IP Right Cessation
- 1999-11-01 ES ES99974146T patent/ES2285870T3/es not_active Expired - Lifetime
- 1999-11-01 JP JP2001534791A patent/JP4043236B2/ja not_active Expired - Fee Related
- 1999-11-01 PT PT99974146T patent/PT1228052E/pt unknown
- 1999-11-01 SI SI9930972T patent/SI1228052T1/sl unknown
- 1999-11-01 CZ CZ20021533A patent/CZ20021533A3/cs unknown
- 1999-11-15 TW TW088119884A patent/TWI242547B/zh not_active IP Right Cessation
2002
- 2002-04-29 IL IL149401A patent/IL149401A/en not_active IP Right Cessation
- 2002-04-30 NO NO20022044A patent/NO322359B1/no not_active IP Right Cessation
2003
- 2003-02-18 HK HK03101158.3A patent/HK1049160B/zh not_active IP Right Cessation
2007
- 2007-06-21 CY CY20071100831T patent/CY1106672T1/el unknown

Also Published As

Publication number	Publication date
CA2389325A1 (en)	2001-05-10
UA72558C2 (uk)	2005-03-15
EA005684B1 (ru)	2005-04-28
PL199587B1 (pl)	2008-10-31
CN1264827C (zh)	2006-07-19
KR100548600B1 (ko)	2006-02-01
EA200200522A1 (ru)	2002-10-31
CN1374956A (zh)	2002-10-16
HK1049160A1 (en)	2003-05-02
HUP0203275A2 (hu)	2003-01-28
DE69936004D1 (de)	2007-06-14
EP1228052A1 (en)	2002-08-07
AU1158500A (en)	2001-05-14
CZ20021533A3 (cs)	2002-08-14
PT1228052E (pt)	2007-05-31
PL354519A1 (en)	2004-01-26
HUP0203275A3 (en)	2003-11-28
DK1228052T3 (da)	2007-06-18
ATE361284T1 (de)	2007-05-15
DE69936004T2 (de)	2008-01-10
JP2003513083A (ja)	2003-04-08
WO2001032640A1 (en)	2001-05-10
MXPA02004368A (es)	2002-11-14
IL149401A (en)	2008-03-20
IL149401A0 (en)	2002-11-10
ES2285870T3 (es)	2007-11-16
HK1049160B (zh)	2006-11-17
NO20022044D0 (no)	2002-04-30
SI1228052T1 (sl)	2007-10-31
KR20020063172A (ko)	2002-08-01
NO20022044L (no)	2002-04-30
JP4043236B2 (ja)	2008-02-06
TWI242547B (en)	2005-11-01
EP1228052B1 (en)	2007-05-02
CY1106672T1 (el)	2012-05-23
CA2389325C (en)	2007-01-09
AU782760B2 (en)	2005-08-25

Legal Events

Date	Code	Title	Description
2010-06-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO322359B1 (no)	2006-09-18	1-(syklisk amino)-alkylsykloheksanforbindelser, farmasoytiske preparater derav og deres anvendelse som antikonvulsive midler
NO321130B1 (no)	2006-03-20	Aminocycloheksyleterforbindelser og anvendelser derav
TW200848411A (en)	2008-12-16	Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
IL172334A (en)	2013-08-29	Benzazepine Derivatives, Pharmaceutical Preparation, Method of Manufacturing Pharmaceutical Preparation, Use of Pharmaceutical Manufacture Derivatives
WO1997027169A1 (en)	1997-07-31	(2-dimethylphenoxy-1-methylethyl) ethylamine
NO744397L (ja)	1975-06-30
CA1161853A (en)	1984-02-07	N-lower-alkyl 3-phenoxy-1-azetidine-carboxamides
KR20230003503A (ko)	2023-01-06	신경학적 및 정신의학적 장애의 치료를 위한 (S)-(4,5-디히드로-7H-티에노[2,3-c]피란-7-일)-N-메틸메탄아민
AU2004265243A1 (en)	2005-02-24	N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c receptor associated diseases
KR100570374B1 (ko)	2006-04-24	5-ｈｔ3 및 신경세포의 니코틴작용성 수용체 길항물질로서의 1-아미노-알킬시클로헥산 화합물을 이용한 치료방법 및 이 화합물을 함유하는 약학적 조성물
AU2001281861A1 (en)	2002-03-21	1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinicreceptor antagonists
US4173646A (en)	1979-11-06	Tricyclicdicarboximides
US4006233A (en)	1977-02-01	N-(pyrimidinyl)-tricyclo[3(or 4).2.2.02,4(or 5) ]-non (or dec)ene-dicarboximides
AU649302B2 (en)	1994-05-19	Tricyclic pyridone derivative
DE2227842C3 (de)	1975-11-27	Diphenylcyclopentane und diese enthaltende Arzneimittel
AT376659B (de)	1984-12-27	Verfahren zur herstellung von neuen substituierten 2-benzylpyrrolidinen
NO890519L (no)	1989-08-11	Fremgangsmaate for fremstilling av terapeutisk aktive propanon-derivater.
WO2010115124A2 (en)	2010-10-07	Compositions of cholinesterase inhibitors
JPH05502659A (ja)	1993-05-13	２，３，３ａ，４，５，６―ヘキサヒドロ―８―シクロヘキシル―１Ｈ―ピラジノ（３，２，１―ｊ，ｋ）カルバゾール塩酸塩、その化合物の調製方法及びそれに基づく抗うつ性医薬製剤