NO2009009I2 - Tocilizumab - Google Patents
TocilizumabInfo
- Publication number
- NO2009009I2 NO2009009I2 NO2009009C NO2009009C NO2009009I2 NO 2009009 I2 NO2009009 I2 NO 2009009I2 NO 2009009 C NO2009009 C NO 2009009C NO 2009009 C NO2009009 C NO 2009009C NO 2009009 I2 NO2009009 I2 NO 2009009I2
- Authority
- NO
- Norway
- Prior art keywords
- cell growth
- growth inhibitor
- synovial cell
- antibody
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24403594 | 1994-10-07 | ||
PCT/JP1995/001144 WO1996011020A1 (fr) | 1994-10-07 | 1995-06-07 | Medicament contre la polyarthrite rhumatoide contenant un antagoniste d'interleukine 6 comme principe actif |
Publications (2)
Publication Number | Publication Date |
---|---|
NO2009009I1 NO2009009I1 (no) | 2009-05-11 |
NO2009009I2 true NO2009009I2 (no) | 2013-03-18 |
Family
ID=17112746
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19971546A NO321089B1 (no) | 1994-10-07 | 1997-04-04 | Anvendelse av et interleukin-6 antistoff eller interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandling av unormal synovialcelle-vekst. |
NO20055446A NO20055446L (no) | 1994-10-07 | 2005-11-17 | Anvendelse av et interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandlingav kronisk reumatoid artritt |
NO2009009C NO2009009I2 (no) | 1994-10-07 | 2009-05-04 | Tocilizumab |
NO2018017C NO2018017I1 (no) | 1994-10-07 | 2018-05-23 | Interleukin-6 (IL-6) reseptor antistoff (Krav 1 i NO321089). Forlenget SPC |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19971546A NO321089B1 (no) | 1994-10-07 | 1997-04-04 | Anvendelse av et interleukin-6 antistoff eller interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandling av unormal synovialcelle-vekst. |
NO20055446A NO20055446L (no) | 1994-10-07 | 2005-11-17 | Anvendelse av et interleukin-6 reseptorantistoff for fremstilling av en farmasoytisk blanding for behandlingav kronisk reumatoid artritt |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2018017C NO2018017I1 (no) | 1994-10-07 | 2018-05-23 | Interleukin-6 (IL-6) reseptor antistoff (Krav 1 i NO321089). Forlenget SPC |
Country Status (19)
Country | Link |
---|---|
EP (3) | EP2107070A1 (no) |
JP (1) | JP3067987B2 (no) |
KR (1) | KR100306517B1 (no) |
CN (2) | CN101361972B (no) |
AT (1) | ATE552012T1 (no) |
AU (1) | AU700819B2 (no) |
CA (1) | CA2201781C (no) |
CZ (1) | CZ296919B6 (no) |
DK (1) | DK0783893T3 (no) |
ES (1) | ES2384222T3 (no) |
FI (1) | FI120721B (no) |
HK (1) | HK1127497A1 (no) |
HU (1) | HU223602B1 (no) |
LU (1) | LU92048I2 (no) |
NO (4) | NO321089B1 (no) |
PL (1) | PL186506B1 (no) |
PT (1) | PT783893E (no) |
RU (1) | RU2147443C1 (no) |
WO (1) | WO1996011020A1 (no) |
Families Citing this family (79)
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JPH10324639A (ja) * | 1997-03-21 | 1998-12-08 | Chugai Pharmaceut Co Ltd | Il−6アンタゴニストを有効成分として含有する感作t細胞関与疾患の予防・治療剤 |
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US20050074434A1 (en) * | 2001-02-23 | 2005-04-07 | Tomoaki Hoshino | Remedies for metabolic bone diseases |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
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GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
JP2007104901A (ja) * | 2004-01-16 | 2007-04-26 | Astellas Pharma Inc | 関節リウマチ治療薬のスクリーニング法 |
ATE464908T1 (de) * | 2004-02-11 | 2010-05-15 | Warner Lambert Co | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
PE20061324A1 (es) * | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
CA2625773C (en) | 2005-10-14 | 2015-05-12 | Fukuoka University | Inhibition of interleukin-6 (il-6) receptor promotes pancreatic islet transplantation |
JP5191235B2 (ja) | 2005-10-21 | 2013-05-08 | 中外製薬株式会社 | 心疾患治療剤 |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
AR059213A1 (es) | 2006-01-27 | 2008-03-19 | Univ Keio | Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
CN101495146B (zh) | 2006-04-07 | 2012-10-17 | 国立大学法人大阪大学 | 肌肉再生促进剂 |
US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
RS52643B (en) | 2006-06-02 | 2013-06-28 | Regeneron Pharmaceuticals Inc. | HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR |
WO2008019061A2 (en) | 2006-08-03 | 2008-02-14 | Vaccinex, Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
MX2009007830A (es) | 2007-01-23 | 2009-10-07 | Univ Shinshu | Inhibidor de rechazo cronico. |
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CN101939425B (zh) | 2007-09-26 | 2014-05-14 | 中外制药株式会社 | 抗il-6受体抗体 |
RU2531521C2 (ru) | 2007-12-05 | 2014-10-20 | Чугаи Сейяку Кабусики Кайся | Антитело против nr10 и его применение |
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EP2297202B1 (en) | 2008-05-13 | 2016-01-13 | NovImmune SA | Anti-il-6/il-6r antibodies and methods of use thereof |
CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
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JP6049455B2 (ja) * | 2009-05-18 | 2016-12-21 | ザ ユニバーシティ オブ ホンコンThe University of Hong Kong | 炎症性関節炎を治療するための組成物および方法 |
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US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
SG11201607165YA (en) | 2014-12-19 | 2016-09-29 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
TWI808330B (zh) | 2014-12-19 | 2023-07-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
TW202248212A (zh) | 2015-02-05 | 2022-12-16 | 日商中外製藥股份有限公司 | 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途 |
TW202339800A (zh) | 2015-02-27 | 2023-10-16 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
EP3279216A4 (en) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER |
US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
JP7128460B2 (ja) | 2015-06-04 | 2022-08-31 | 国立研究開発法人国立精神・神経医療研究センター | Il-6阻害剤を有効成分とする精神疾患治療剤 |
JP7272794B2 (ja) | 2015-11-03 | 2023-05-12 | サノフィ・バイオテクノロジー | ブドウ膜炎および黄斑浮腫の処置のためのil6r抗体を含む組成物およびそれを使用する方法 |
EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
AU2017233658B2 (en) | 2016-03-14 | 2023-09-21 | Chugai Seiyaku Kabushiki Kaisha | Cell injury inducing therapeutic drug for use in cancer therapy |
EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATING TO IL-8 |
CN108339118A (zh) * | 2017-01-23 | 2018-07-31 | 瑞阳(苏州)生物科技有限公司 | 治疗或预防阻塞性睡眠呼吸暂停的药物组合物 |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
EP3683234A1 (en) | 2017-09-13 | 2020-07-22 | Jiangsu Hengrui Medicine Co., Ltd. | Il-6r antibody and antigen binding fragment thereof and medical use |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
MA53481A (fr) | 2018-08-29 | 2021-07-07 | Regeneron Pharma | Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde |
CN109517064B (zh) * | 2018-10-10 | 2020-05-08 | 北京汇智和源生物技术有限公司 | 白介素-6的人源化单克隆抗体、其编码基因及应用 |
JP2022519828A (ja) | 2019-01-31 | 2022-03-25 | サノフィ・バイオテクノロジー | 若年性特発性関節炎を治療するための抗il-6受容体抗体 |
WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
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WO1992019759A1 (en) * | 1991-04-25 | 1992-11-12 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
JPH05300338A (ja) | 1992-04-17 | 1993-11-12 | Ricoh Co Ltd | 複合機 |
JPH05304986A (ja) * | 1992-04-28 | 1993-11-19 | Tosoh Corp | gp130蛋白質に対するモノクロ−ナル抗体 |
FR2694767B1 (fr) * | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
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JP3525221B2 (ja) * | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
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1995
- 1995-06-07 WO PCT/JP1995/001144 patent/WO1996011020A1/ja active IP Right Grant
- 1995-06-07 CN CN2008102100070A patent/CN101361972B/zh not_active Expired - Lifetime
- 1995-06-07 ES ES95921130T patent/ES2384222T3/es not_active Expired - Lifetime
- 1995-06-07 HU HU9701906A patent/HU223602B1/hu active Protection Beyond IP Right Term
- 1995-06-07 EP EP09009350A patent/EP2107070A1/en not_active Withdrawn
- 1995-06-07 CZ CZ0103497A patent/CZ296919B6/cs not_active IP Right Cessation
- 1995-06-07 AU AU26303/95A patent/AU700819B2/en not_active Expired
- 1995-06-07 AT AT95921130T patent/ATE552012T1/de active
- 1995-06-07 KR KR1019970702209A patent/KR100306517B1/ko not_active IP Right Cessation
- 1995-06-07 RU RU97108276A patent/RU2147443C1/ru active Protection Beyond IP Right Term
- 1995-06-07 CN CNA2009101322726A patent/CN101601861A/zh active Pending
- 1995-06-07 CA CA002201781A patent/CA2201781C/en not_active Expired - Lifetime
- 1995-06-07 EP EP95921130A patent/EP0783893B1/en not_active Expired - Lifetime
- 1995-06-07 DK DK95921130.1T patent/DK0783893T3/da active
- 1995-06-07 EP EP09000787A patent/EP2077120A3/en not_active Withdrawn
- 1995-06-07 PL PL95319574A patent/PL186506B1/pl unknown
- 1995-06-07 PT PT95921130T patent/PT783893E/pt unknown
- 1995-10-06 JP JP7284364A patent/JP3067987B2/ja not_active Expired - Lifetime
-
1997
- 1997-04-04 NO NO19971546A patent/NO321089B1/no not_active IP Right Cessation
- 1997-04-04 FI FI971404A patent/FI120721B/fi not_active IP Right Cessation
-
2005
- 2005-11-17 NO NO20055446A patent/NO20055446L/no not_active Application Discontinuation
-
2009
- 2009-05-04 NO NO2009009C patent/NO2009009I2/no unknown
- 2009-06-10 HK HK09105189.1A patent/HK1127497A1/xx not_active IP Right Cessation
-
2012
- 2012-07-20 LU LU92048C patent/LU92048I2/fr unknown
-
2018
- 2018-05-23 NO NO2018017C patent/NO2018017I1/no unknown
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