ATE464908T1 - Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern - Google Patents
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpernInfo
- Publication number
- ATE464908T1 ATE464908T1 AT05702390T AT05702390T ATE464908T1 AT E464908 T1 ATE464908 T1 AT E464908T1 AT 05702390 T AT05702390 T AT 05702390T AT 05702390 T AT05702390 T AT 05702390T AT E464908 T1 ATE464908 T1 AT E464908T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- treating osteoarthritis
- osteoarthritis
- treating
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54381404P | 2004-02-11 | 2004-02-11 | |
PCT/IB2005/000240 WO2005080429A2 (en) | 2004-02-11 | 2005-01-31 | Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464908T1 true ATE464908T1 (de) | 2010-05-15 |
Family
ID=34885980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05702390T ATE464908T1 (de) | 2004-02-11 | 2005-01-31 | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
Country Status (9)
Country | Link |
---|---|
US (2) | US20080145367A1 (de) |
EP (1) | EP1715891B2 (de) |
JP (1) | JP2008505054A (de) |
AT (1) | ATE464908T1 (de) |
BR (1) | BRPI0506679A (de) |
CA (1) | CA2555688C (de) |
DE (1) | DE602005020743D1 (de) |
ES (1) | ES2341461T5 (de) |
WO (1) | WO2005080429A2 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007114319A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 抗体の血中動態を制御する方法 |
CA2652976C (en) * | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
CN101563365B (zh) | 2006-08-03 | 2012-10-31 | 瓦西尼斯公司 | 抗-il-6单克隆抗体及其用途 |
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
WO2009010539A2 (de) * | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) form macaca fascicularis |
RU2510400C9 (ru) | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
TWI464262B (zh) | 2007-09-26 | 2014-12-11 | 中外製藥股份有限公司 | 抗體固定區的變異 |
JP2009092508A (ja) * | 2007-10-09 | 2009-04-30 | Norihiro Nishimoto | リウマチ治療剤の効果の予測方法 |
CN102056946A (zh) | 2008-04-11 | 2011-05-11 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
DK2376121T4 (da) | 2008-12-22 | 2021-08-16 | Univ Melbourne | Slidgigtbehandling |
JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
AU2010225951B2 (en) * | 2009-03-19 | 2014-03-13 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical formulation containing improved antibody molecules |
EP3674317A1 (de) | 2009-03-19 | 2020-07-01 | Chugai Seiyaku Kabushiki Kaisha | Variante einer konstanten antikörperregion |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
JP5918275B2 (ja) * | 2011-02-08 | 2016-05-18 | アッヴィ・インコーポレイテッド | 変形性関節症及び疼痛の治療 |
SG10201609665PA (en) | 2011-02-25 | 2017-01-27 | Chugai Pharmaceutical Co Ltd | FcɣRIIb-SPECIFIC Fc ANTIBODY |
AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
US20150056182A1 (en) | 2011-11-30 | 2015-02-26 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
US20170266168A1 (en) * | 2014-09-18 | 2017-09-21 | Rush University Medical Center | Methods for preventing or treating osteoarthritis |
TWI779010B (zh) | 2014-12-19 | 2022-10-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
PT3233921T (pt) | 2014-12-19 | 2021-12-09 | Chugai Pharmaceutical Co Ltd | Anticorpos anti-c5 e processos para a sua utilização |
MX2017008978A (es) | 2015-02-05 | 2017-10-25 | Chugai Pharmaceutical Co Ltd | Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos. |
KR101892883B1 (ko) | 2015-02-27 | 2018-10-05 | 추가이 세이야쿠 가부시키가이샤 | Il-6 관련 질환 치료용 조성물 |
JP6875683B2 (ja) | 2015-05-19 | 2021-05-26 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症(ms)患者の新規治療適用判断方法 |
CN113117074A (zh) | 2015-07-31 | 2021-07-16 | 米迪缪尼有限公司 | 用于治疗海帕西啶介导的病症的方法 |
CN107922507B (zh) | 2015-08-18 | 2022-04-05 | 瑞泽恩制药公司 | 抗pcsk9抑制性抗体用来治疗接受脂蛋白单采的高脂血症患者 |
EP3394098A4 (de) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper und verfahren zur verwendung |
AU2017305073B2 (en) | 2016-08-05 | 2024-02-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for prevention or treatment of IL-8 related diseases |
WO2018139623A1 (en) | 2017-01-30 | 2018-08-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-sclerostin antibodies and methods of use |
JP2020506190A (ja) | 2017-02-01 | 2020-02-27 | イェール ユニバーシティーYale University | 利尿薬耐性の治療 |
WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
KR20200116089A (ko) | 2018-01-05 | 2020-10-08 | 코비디아 테라퓨틱스, 인크. | 면역억제 없이 il-6 매개 염증을 치료하기 위한 방법 |
US11498969B2 (en) | 2019-01-31 | 2022-11-15 | Sanofi Biotechnology | Compositions and methods for treating juvenile idiopathic arthritis |
WO2021067749A2 (en) * | 2019-10-02 | 2021-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for the treatment of osteoarthritis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT52962A (en) * | 1988-03-04 | 1990-09-28 | Sandoz Ag | Process for production of medical compositions eliminating bone-absorption and promoting forming of bones |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JP3370324B2 (ja) * | 1991-04-25 | 2003-01-27 | 中外製薬株式会社 | ヒトインターロイキン−6受容体に対する再構成ヒト抗体 |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
DK0783893T3 (da) * | 1994-10-07 | 2012-05-29 | Chugai Pharmaceutical Co Ltd | Inhibering af unormal vækst af synovial-celler under anvendelse af il-6-antagonist som aktiv bestanddel |
US5617790A (en) * | 1995-05-31 | 1997-04-08 | P.R. Graphics Limited | Apparatus for producing flexographic printing plates |
US20030202977A1 (en) * | 1998-11-16 | 2003-10-30 | New York University | Treatment of osteoarthritis |
AR035642A1 (es) * | 2000-05-26 | 2004-06-23 | Pharmacia Corp | Uso de una composicion de celecoxib para el alivio rapido del dolor |
MXPA04004671A (es) * | 2001-11-14 | 2005-08-25 | Johnson & Johnson | Anticuerpos anti-interleucina-6, composiciones, metodos y usos. |
-
2005
- 2005-01-31 ES ES05702390.5T patent/ES2341461T5/es active Active
- 2005-01-31 AT AT05702390T patent/ATE464908T1/de not_active IP Right Cessation
- 2005-01-31 CA CA2555688A patent/CA2555688C/en not_active Expired - Fee Related
- 2005-01-31 EP EP05702390.5A patent/EP1715891B2/de not_active Not-in-force
- 2005-01-31 US US10/588,911 patent/US20080145367A1/en not_active Abandoned
- 2005-01-31 WO PCT/IB2005/000240 patent/WO2005080429A2/en active Search and Examination
- 2005-01-31 DE DE602005020743T patent/DE602005020743D1/de active Active
- 2005-01-31 JP JP2006552709A patent/JP2008505054A/ja active Pending
- 2005-01-31 BR BRPI0506679-4A patent/BRPI0506679A/pt not_active IP Right Cessation
-
2010
- 2010-03-16 US US12/724,920 patent/US20100215654A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2341461T3 (es) | 2010-06-21 |
CA2555688C (en) | 2011-11-08 |
US20080145367A1 (en) | 2008-06-19 |
DE602005020743D1 (de) | 2010-06-02 |
EP1715891B2 (de) | 2014-08-13 |
EP1715891A2 (de) | 2006-11-02 |
WO2005080429A3 (en) | 2006-02-23 |
ES2341461T5 (es) | 2014-10-29 |
JP2008505054A (ja) | 2008-02-21 |
EP1715891B1 (de) | 2010-04-21 |
BRPI0506679A (pt) | 2007-05-15 |
CA2555688A1 (en) | 2005-09-01 |
WO2005080429A2 (en) | 2005-09-01 |
US20100215654A1 (en) | 2010-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE464908T1 (de) | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern | |
DE502004009142D1 (de) | Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen | |
ATE435209T1 (de) | Verfahren zur herstellung von montelukast-natrium | |
DE602004021790D1 (de) | Verfahren zur behandlung von parkinson-krankheit | |
ATE550353T1 (de) | Die bindung von mit il-6ralpha komplexiertem il-6 an gp130 verhindernde anti-il-6-antikörper | |
DE602004032160D1 (de) | Verfahren zur Zubereitung von Getränken | |
ATE482966T1 (de) | Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide | |
ATE469908T1 (de) | Verfahren zur herstellung von pimecrolimus | |
DK1784426T3 (da) | Humaniserede anti-beta7-antagonister og anvendelser deraf | |
EA200802168A1 (ru) | Гуманизированное антитело к с-kit | |
DE602006021324D1 (de) | Verfahren zur herstellung stabiler b-lymphozyten | |
DE602005011656D1 (de) | Verfahren zur behandlung von dickdarmkrebs mit botulinum neurotoxin | |
DE502005002345D1 (de) | Verfahren zur einstellung von sitzkomponenten | |
DE602006018354D1 (de) | Verfahren zur behandlung von abnormalem zellwachstum | |
ATE529409T1 (de) | Verfahren zur herstellung von kristallinen aripiprazolformen | |
DE602007001103D1 (de) | Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2 | |
DE502005000987D1 (de) | Verfahren zur kontinuierlichen herstellung von siilicon emulsionen | |
DE602004000313D1 (de) | Verfahren zur Verfügungstellung von ozonenthaltendem Wasser | |
EA202191656A1 (ru) | Анти-il-36 антитела и способы их применения | |
DE60223688D1 (de) | Verfahren zur behandlung von multiplem myelom | |
ATE516290T1 (de) | Verfahren zur herstellung von buprenorphin und derivaten von buprenorphin | |
DE602005021766D1 (de) | Verfahren zur behandlung von atherosklerose | |
DE602006002371D1 (de) | Verfahren zur herstellung von brillengläsern | |
ATE546524T1 (de) | Verfahren zur herstellung aktiver scfv-antikörper und bibliotheken dafür | |
DE602004018249D1 (de) | Verfahren zur Dearomatisierung von Molkeprotein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |