MXPA03010251A - Proceso para la preparacion de ribavirina. - Google Patents

Proceso para la preparacion de ribavirina.

Info

Publication number
MXPA03010251A
MXPA03010251A MXPA03010251A MXPA03010251A MXPA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A MX PA03010251 A MXPA03010251 A MX PA03010251A
Authority
MX
Mexico
Prior art keywords
formula
paper copy
ribavirin
preparation
reaction
Prior art date
Application number
MXPA03010251A
Other languages
English (en)
Inventor
Aldo Banfi
Original Assignee
Clariant Lsm Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Lsm Italia Spa filed Critical Clariant Lsm Italia Spa
Publication of MXPA03010251A publication Critical patent/MXPA03010251A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Se describe un proceso para la preparacion de ribavirina en una escala industrial, el cual comprende la reaccion de glicosilacion de triazoles 3-substituidos en la presencia de un acido de Lewis. El proceso comprende a) la reaccion de un triazol de la formula (I) con una ribofuranosa protegida de la formula (II) b) la remocion de los grupos Pg y, opcionalmente, la conversion en un grupo carboxiamida del grupo Rz del compuesto obtenido de la formula (III). (Ver Formula I. II. III).
MXPA03010251A 2001-07-30 2002-07-29 Proceso para la preparacion de ribavirina. MXPA03010251A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01830510A EP1281715B1 (en) 2001-07-30 2001-07-30 Process for the preparation of ribavirin
PCT/IB2002/002950 WO2003011884A1 (en) 2001-07-30 2002-07-29 Process for the preparation of ribavirin

Publications (1)

Publication Number Publication Date
MXPA03010251A true MXPA03010251A (es) 2004-03-16

Family

ID=8184638

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA04000382A MXPA04000382A (es) 2001-07-30 2002-07-25 Proceso para preparacion de l-ribavirina.
MXPA03010251A MXPA03010251A (es) 2001-07-30 2002-07-29 Proceso para la preparacion de ribavirina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA04000382A MXPA04000382A (es) 2001-07-30 2002-07-25 Proceso para preparacion de l-ribavirina.

Country Status (13)

Country Link
US (2) US7285660B2 (es)
EP (2) EP1281715B1 (es)
JP (2) JP2004538317A (es)
KR (2) KR20040031784A (es)
CN (2) CN1255420C (es)
AT (2) ATE252594T1 (es)
AU (1) AU2002328974A1 (es)
BR (2) BR0210278A (es)
DE (2) DE60101056T2 (es)
ES (2) ES2208540T3 (es)
HU (2) HUP0401615A2 (es)
MX (2) MXPA04000382A (es)
WO (2) WO2003011883A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005539032A (ja) * 2002-08-12 2005-12-22 エフ．ホフマン−ラ　ロシュ　アーゲー リボフラノースの製造方法
WO2007007183A2 (en) * 2005-07-08 2007-01-18 Aurobindo Pharma Limited Compositions of antiviral compound
JP2008222630A (ja) * 2007-03-12 2008-09-25 Permachem Asia Ltd １−β−Ｄ−リボフラノシルー１，２，４−トリアゾール−３−カルボキサミドのＲ−ＩＩ型結晶の製造法
CN101891786B (zh) * 2010-08-04 2012-09-05 王明 一种利巴韦林化合物及其制法
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
CN102127134B (zh) * 2010-12-02 2012-11-14 海南美兰史克制药有限公司 一种利巴韦林化合物及其方法
CN102532226B (zh) * 2010-12-15 2014-05-07 上海迪赛诺医药发展有限公司 利巴韦林晶型及其制备方法
CN109134565A (zh) * 2017-08-15 2019-01-04 李双喜 一种1/10水利巴韦林化合物及其药物组合物
CN109134566A (zh) * 2017-08-18 2019-01-04 樊艳芳 一种1/20水利巴韦林化合物
CN108484691A (zh) * 2018-06-28 2018-09-04 牡丹江师范学院 一种利巴韦林缩合物的化学合成方法
CN111647033A (zh) * 2020-06-08 2020-09-11 济南明鑫制药股份有限公司 一锅法制备利巴韦林的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
JPS55160793A (en) * 1979-05-29 1980-12-13 Microbial Chem Res Found Preparation of virazole
JPS5931797A (ja) * 1982-08-18 1984-02-20 Sumitomo Chem Co Ltd 新規１−置換イミダゾ−ルヌクレオシドおよびその製造法
JPS60252493A (ja) * 1984-05-25 1985-12-13 Takeda Chem Ind Ltd シチジン誘導体の製造法
KR880011146A (ko) * 1987-03-25 1988-10-26 엠.피.젝슨 3'-아지도-3'-디옥시티미딘의 신규 제조방법 및 이러한 공정에 유용한 중간체
CN1049435C (zh) * 1994-11-09 2000-02-16 中国科学院上海药物研究所 含苯基和杂环基的青蒿素衍生物及其制备方法
EP1254911A1 (en) * 1996-10-16 2002-11-06 ICN Pharmaceuticals, Inc. Monocyclic L-nucleosides, analogs and uses thereof
SK284054B6 (sk) * 1996-10-16 2004-08-03 Icn Pharmaceuticals, Inc. Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie

Also Published As

Publication number Publication date
KR20040021670A (ko) 2004-03-10
DE60101056D1 (de) 2003-11-27
WO2003011883A2 (en) 2003-02-13
ES2208540T3 (es) 2004-06-16
AU2002328974A1 (en) 2003-02-17
EP1414836B1 (en) 2004-12-29
CN1255421C (zh) 2006-05-10
WO2003011883A3 (en) 2003-04-17
DE60101056T2 (de) 2004-05-19
CN1535277A (zh) 2004-10-06
DE60202483D1 (de) 2005-02-03
CN1535278A (zh) 2004-10-06
BR0209815A (pt) 2004-06-01
US7285660B2 (en) 2007-10-23
HUP0401899A2 (hu) 2004-12-28
KR100953031B1 (ko) 2010-04-14
HUP0401615A2 (hu) 2004-11-29
EP1414836A2 (en) 2004-05-06
US20040192904A1 (en) 2004-09-30
EP1281715A1 (en) 2003-02-05
ES2233857T3 (es) 2005-06-16
JP2004538318A (ja) 2004-12-24
DE60202483T2 (de) 2005-12-29
EP1281715B1 (en) 2003-10-22
US20040176587A1 (en) 2004-09-09
ATE252594T1 (de) 2003-11-15
MXPA04000382A (es) 2004-07-23
ATE286062T1 (de) 2005-01-15
WO2003011884A1 (en) 2003-02-13
BR0210278A (pt) 2004-07-20
CN1255420C (zh) 2006-05-10
KR20040031784A (ko) 2004-04-13
JP2004538317A (ja) 2004-12-24
US7285659B2 (en) 2007-10-23

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