BR0209815A - Processo para preparação de ribavirina - Google Patents

Processo para preparação de ribavirina

Info

Publication number
BR0209815A
BR0209815A BR0209815-6A BR0209815A BR0209815A BR 0209815 A BR0209815 A BR 0209815A BR 0209815 A BR0209815 A BR 0209815A BR 0209815 A BR0209815 A BR 0209815A
Authority
BR
Brazil
Prior art keywords
formula
ribavirin
preparation process
group
ribavirin preparation
Prior art date
Application number
BR0209815-6A
Other languages
English (en)
Inventor
Aldo Banfi
Bruno Dall Oro
Marco Frigerio
Alfredo Mancini
Original Assignee
Clariant Lsm Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Lsm Italia Spa filed Critical Clariant Lsm Italia Spa
Publication of BR0209815A publication Critical patent/BR0209815A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE RIBAVIRINA". A invenção refere-se a um processo para preparação de ribavirina em uma escala industrial, que compreende a reação de glicosilação de triazóis 3-substituídos em presença de um ácido de Lewis. O dito processo compreende: a) reação de um triazol da fórmula: com uma ribofuranose protegida da fórmula: b) a remoção dos grupos Pg e, opcionalmente, a conversão, em um grupo carboxiamida, do grupo R~ 2~ do composto obtido da fórmula:
BR0209815-6A 2001-07-30 2002-07-29 Processo para preparação de ribavirina BR0209815A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01830510A EP1281715B1 (en) 2001-07-30 2001-07-30 Process for the preparation of ribavirin
PCT/IB2002/002950 WO2003011884A1 (en) 2001-07-30 2002-07-29 Process for the preparation of ribavirin

Publications (1)

Publication Number Publication Date
BR0209815A true BR0209815A (pt) 2004-06-01

Family

ID=8184638

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0210278-1A BR0210278A (pt) 2001-07-30 2002-07-25 Processo para a preparação de l-ribavirina
BR0209815-6A BR0209815A (pt) 2001-07-30 2002-07-29 Processo para preparação de ribavirina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0210278-1A BR0210278A (pt) 2001-07-30 2002-07-25 Processo para a preparação de l-ribavirina

Country Status (13)

Country Link
US (2) US7285660B2 (pt)
EP (2) EP1281715B1 (pt)
JP (2) JP2004538317A (pt)
KR (2) KR20040031784A (pt)
CN (2) CN1255420C (pt)
AT (2) ATE252594T1 (pt)
AU (1) AU2002328974A1 (pt)
BR (2) BR0210278A (pt)
DE (2) DE60101056T2 (pt)
ES (2) ES2208540T3 (pt)
HU (2) HUP0401615A2 (pt)
MX (2) MXPA04000382A (pt)
WO (2) WO2003011883A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005539032A (ja) * 2002-08-12 2005-12-22 エフ．ホフマン−ラ　ロシュ　アーゲー リボフラノースの製造方法
WO2007007183A2 (en) * 2005-07-08 2007-01-18 Aurobindo Pharma Limited Compositions of antiviral compound
JP2008222630A (ja) * 2007-03-12 2008-09-25 Permachem Asia Ltd １−β−Ｄ−リボフラノシルー１，２，４−トリアゾール−３−カルボキサミドのＲ−ＩＩ型結晶の製造法
CN101891786B (zh) * 2010-08-04 2012-09-05 王明 一种利巴韦林化合物及其制法
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
CN102127134B (zh) * 2010-12-02 2012-11-14 海南美兰史克制药有限公司 一种利巴韦林化合物及其方法
CN102532226B (zh) * 2010-12-15 2014-05-07 上海迪赛诺医药发展有限公司 利巴韦林晶型及其制备方法
CN109134565A (zh) * 2017-08-15 2019-01-04 李双喜 一种1/10水利巴韦林化合物及其药物组合物
CN109134566A (zh) * 2017-08-18 2019-01-04 樊艳芳 一种1/20水利巴韦林化合物
CN108484691A (zh) * 2018-06-28 2018-09-04 牡丹江师范学院 一种利巴韦林缩合物的化学合成方法
CN111647033A (zh) * 2020-06-08 2020-09-11 济南明鑫制药股份有限公司 一锅法制备利巴韦林的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
JPS55160793A (en) * 1979-05-29 1980-12-13 Microbial Chem Res Found Preparation of virazole
JPS5931797A (ja) * 1982-08-18 1984-02-20 Sumitomo Chem Co Ltd 新規１−置換イミダゾ−ルヌクレオシドおよびその製造法
JPS60252493A (ja) * 1984-05-25 1985-12-13 Takeda Chem Ind Ltd シチジン誘導体の製造法
KR880011146A (ko) * 1987-03-25 1988-10-26 엠.피.젝슨 3'-아지도-3'-디옥시티미딘의 신규 제조방법 및 이러한 공정에 유용한 중간체
CN1049435C (zh) * 1994-11-09 2000-02-16 中国科学院上海药物研究所 含苯基和杂环基的青蒿素衍生物及其制备方法
EP1254911A1 (en) * 1996-10-16 2002-11-06 ICN Pharmaceuticals, Inc. Monocyclic L-nucleosides, analogs and uses thereof
SK284054B6 (sk) * 1996-10-16 2004-08-03 Icn Pharmaceuticals, Inc. Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie

Also Published As

Publication number Publication date
KR20040021670A (ko) 2004-03-10
DE60101056D1 (de) 2003-11-27
WO2003011883A2 (en) 2003-02-13
ES2208540T3 (es) 2004-06-16
AU2002328974A1 (en) 2003-02-17
EP1414836B1 (en) 2004-12-29
CN1255421C (zh) 2006-05-10
WO2003011883A3 (en) 2003-04-17
DE60101056T2 (de) 2004-05-19
CN1535277A (zh) 2004-10-06
DE60202483D1 (de) 2005-02-03
CN1535278A (zh) 2004-10-06
US7285660B2 (en) 2007-10-23
HUP0401899A2 (hu) 2004-12-28
KR100953031B1 (ko) 2010-04-14
HUP0401615A2 (hu) 2004-11-29
EP1414836A2 (en) 2004-05-06
US20040192904A1 (en) 2004-09-30
EP1281715A1 (en) 2003-02-05
ES2233857T3 (es) 2005-06-16
JP2004538318A (ja) 2004-12-24
DE60202483T2 (de) 2005-12-29
EP1281715B1 (en) 2003-10-22
US20040176587A1 (en) 2004-09-09
ATE252594T1 (de) 2003-11-15
MXPA04000382A (es) 2004-07-23
ATE286062T1 (de) 2005-01-15
MXPA03010251A (es) 2004-03-16
WO2003011884A1 (en) 2003-02-13
BR0210278A (pt) 2004-07-20
CN1255420C (zh) 2006-05-10
KR20040031784A (ko) 2004-04-13
JP2004538317A (ja) 2004-12-24
US7285659B2 (en) 2007-10-23

Similar Documents

Publication Publication Date Title
BR0209815A (pt) Processo para preparação de ribavirina
BR0210424A (pt) Derivados de ácidos dicarboxìlicos aromáticos
EP1666092A3 (en) Drug combination comprising a fatty acid and a uridine compound.
PT1914237E (pt) Compostos antivíricos de éster fosfonato
TR200000009T2 (tr) Triazol bileşikleri ve bunların dopamin-D3-ligandları olarak kullanımları.
HUP0401101A3 (en) Topical leave-on compositions containing selected pantothenic acid derivatives
WO1999015540A3 (de) Verfahren zur herstellung eines pentopyranosyl-nucleosids
AU2002226475A1 (en) Polyamide compositions containing (hypo)phosphorous acid
BR9807349A (pt) Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a.
MXPA03001536A (es) (aminoalcoxibenzoil) benzofuranos o benzotiofenos, metodo para preparar los mismo y composiciones que los contienen.
AU1160800A (en) Bifunctional photoinitiators suitable for photopolymerization and photopolymerizable systems containing the same
MXPA01008346A (es) Compuestos quimicos.
BR0007982A (pt) Processo para a preparação de um composto, e,composto
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
AU2003300385A8 (en) Anticancer compounds
HK1041696A1 (zh) 取代的(氨基亞氨基甲基或氨基甲基)苯並雜芳基化合物
WO2003008489A3 (en) Composition and process for inhibiting corrosion of metallic substrates
WO1999038857A3 (de) Verfahren zur herstellung von 5-alkoxy (bzw. 5-aroxy)-2,3-dihydrofuran-2-onen
BR0013799A (pt) Processo para a preparação de um composto, e, composto
ES2164454T3 (es) Nuevos compuestos derivados de acido alquilendiamina di o tri-acetico, su procedimiento de preparacion, su utilizacion en composiciones cosmeticas y farmaceuticas y composiciones que los contienen.
WO2002016338A8 (fr) Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
BR9909756A (pt) Processo para a preparação de um composto
BR9902525A (pt) Processo para compostos de ácido pirrolidinil-hidroxâmico
ES2170377T3 (es) Composicion que contiene quitosana.
IT1309601B1 (it) Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2317 DE 02-06-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.