MX9201016A - Anticuerpos monoclonales humanizados y quimericos - Google Patents

Anticuerpos monoclonales humanizados y quimericos

Info

Publication number
MX9201016A
MX9201016A MX9201016A MX9201016A MX9201016A MX 9201016 A MX9201016 A MX 9201016A MX 9201016 A MX9201016 A MX 9201016A MX 9201016 A MX9201016 A MX 9201016A MX 9201016 A MX9201016 A MX 9201016A
Authority
MX
Mexico
Prior art keywords
monoclonal antibodies
humanized monoclonal
chemical
relates
humanized
Prior art date
Application number
MX9201016A
Other languages
English (en)
Inventor
Klaus Irmscher
Siegfried Neumann
Mary Bendig
Catherine A Kettleborough
Original Assignee
Merck Patent Gmbh
Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Haftung filed Critical Merck Patent Gmbh
Publication of MX9201016A publication Critical patent/MX9201016A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

Abstract

Se describe la invención de nuevos anticuerpos monoclonales humanizados, que comprenden una secuencia consecutiva modificada, artificial, al menos de las regiones estructurales (FRs) de la cadena pesada de la región variable de una inmunoglobulina humana. La invención se refiere además, a los correspondientes anticuerpos monoclonales humanizados quiméricos, los cuales se unen epítopes del factor en crecimiento en piel ( Epipdérmico ), en donde las regiones hipervariables responsables tienen las siguientes secuencia de aminoácidos: cadena ligera; CDR-1 -Ser-Ala-Ser-Ser-Ser-Val-Tre-Tir-Met-Tir-;CDR-2 -Asp-Tre-Ser-Asn-Leu-Ala-Ser-; CDR-3 -Gln-Gln-Trp-Ser-Ser-His-Ile-Fen-Tre-; cadena pesada; CDR-1 -Ser-His-Trp-Met-His-; CDR-2 -Glu-Fen-Asn-Pro-Ser-Asn-Gli-Arg-Tre-Asn-Glu-Lis-F en-Lis-Ser-; CDR-3 -Arg-Asp-Tir-Asp-Tir-Asp-Gli-Arg-Tir-Fen-Asp-Tir-. Los anticuerpos se pueden usar para fines terapéuticos y de diagnóstico.
MX9201016A 1991-03-06 1992-03-06 Anticuerpos monoclonales humanizados y quimericos MX9201016A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91103389 1991-03-06

Publications (1)

Publication Number Publication Date
MX9201016A true MX9201016A (es) 1993-08-01

Family

ID=8206486

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9201016A MX9201016A (es) 1991-03-06 1992-03-06 Anticuerpos monoclonales humanizados y quimericos

Country Status (19)

Country Link
US (1) US5558864A (es)
EP (2) EP1362868A3 (es)
JP (1) JP3854306B2 (es)
KR (1) KR100240308B1 (es)
AT (1) ATE247168T1 (es)
AU (1) AU658396B2 (es)
CA (1) CA2082160C (es)
CZ (2) CZ282603B6 (es)
DE (1) DE69233153T2 (es)
DK (1) DK0531472T3 (es)
ES (1) ES2204890T3 (es)
HU (1) HU219537B (es)
IE (1) IE920705A1 (es)
MX (1) MX9201016A (es)
PT (1) PT100195B (es)
SK (2) SK281143B6 (es)
TW (1) TW222279B (es)
WO (1) WO1992015683A1 (es)
ZA (1) ZA921661B (es)

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