MX2014006087A - Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico. - Google Patents
Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico.Info
- Publication number
- MX2014006087A MX2014006087A MX2014006087A MX2014006087A MX2014006087A MX 2014006087 A MX2014006087 A MX 2014006087A MX 2014006087 A MX2014006087 A MX 2014006087A MX 2014006087 A MX2014006087 A MX 2014006087A MX 2014006087 A MX2014006087 A MX 2014006087A
- Authority
- MX
- Mexico
- Prior art keywords
- egfr
- resistant
- tumors
- treatment
- cytotoxic agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Abstract
La presente invención se refiere a la identificación de que los inmunoconjugados de anticuerpos dirigidos contra EGFR son eficaces para inhibir el crecimiento de células tumorales que han desarrollado mecanismos de resistencia a EGFR y/o ALK. Se describen también los métodos para administrar inmunoconjugados de anticuerpos dirigidos contra EGFR a pacientes que tienen células tumorales resistentes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161562157P | 2011-11-21 | 2011-11-21 | |
US201261639452P | 2012-04-27 | 2012-04-27 | |
PCT/US2012/066205 WO2013078271A1 (en) | 2011-11-21 | 2012-11-21 | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014006087A true MX2014006087A (es) | 2014-08-01 |
Family
ID=48470279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006087A MX2014006087A (es) | 2011-11-21 | 2012-11-21 | Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico. |
Country Status (16)
Country | Link |
---|---|
US (1) | US9233171B2 (es) |
EP (1) | EP2794010A4 (es) |
JP (1) | JP2014533954A (es) |
KR (1) | KR20140105765A (es) |
CN (1) | CN104066481A (es) |
AU (1) | AU2012340686A1 (es) |
BR (1) | BR112014012155A2 (es) |
CA (1) | CA2856411A1 (es) |
CL (1) | CL2014001282A1 (es) |
HK (1) | HK1201772A1 (es) |
IL (1) | IL232666A0 (es) |
MX (1) | MX2014006087A (es) |
PH (1) | PH12014501119A1 (es) |
RU (1) | RU2014121820A (es) |
SG (1) | SG11201402343SA (es) |
WO (1) | WO2013078271A1 (es) |
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AU2011320318B9 (en) | 2010-10-29 | 2015-11-19 | Immunogen, Inc. | Non-antagonistic EGFR-binding molecules and immunoconjugates thereof |
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CA2856411A1 (en) | 2011-11-21 | 2013-05-30 | Immunogen, Inc. | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
CN105473616B (zh) * | 2013-07-05 | 2020-08-04 | 形成生物产品有限公司 | Egfr抗体缀合物 |
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AR099812A1 (es) * | 2014-03-21 | 2016-08-17 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr |
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CA2965362A1 (en) * | 2014-10-31 | 2016-05-06 | Formation Biologics Inc. | Egfr antibody-based combination therapy |
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US11576873B2 (en) * | 2017-03-31 | 2023-02-14 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
CN107496933B (zh) * | 2017-08-21 | 2019-12-24 | 山东新华制药股份有限公司 | 一种用于治疗胰腺癌的抗体药物偶联物及其制备方法 |
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2012
- 2012-11-21 CA CA2856411A patent/CA2856411A1/en not_active Abandoned
- 2012-11-21 JP JP2014542584A patent/JP2014533954A/ja active Pending
- 2012-11-21 BR BR112014012155A patent/BR112014012155A2/pt not_active IP Right Cessation
- 2012-11-21 AU AU2012340686A patent/AU2012340686A1/en not_active Abandoned
- 2012-11-21 KR KR1020147016745A patent/KR20140105765A/ko not_active Application Discontinuation
- 2012-11-21 US US13/682,948 patent/US9233171B2/en not_active Expired - Fee Related
- 2012-11-21 MX MX2014006087A patent/MX2014006087A/es not_active Application Discontinuation
- 2012-11-21 WO PCT/US2012/066205 patent/WO2013078271A1/en active Application Filing
- 2012-11-21 SG SG11201402343SA patent/SG11201402343SA/en unknown
- 2012-11-21 RU RU2014121820/15A patent/RU2014121820A/ru not_active Application Discontinuation
- 2012-11-21 CN CN201280056769.4A patent/CN104066481A/zh active Pending
- 2012-11-21 EP EP12850911.4A patent/EP2794010A4/en not_active Withdrawn
-
2014
- 2014-05-15 CL CL2014001282A patent/CL2014001282A1/es unknown
- 2014-05-18 IL IL232666A patent/IL232666A0/en unknown
- 2014-05-19 PH PH12014501119A patent/PH12014501119A1/en unknown
-
2015
- 2015-03-10 HK HK15102403.0A patent/HK1201772A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201402343SA (en) | 2014-06-27 |
CN104066481A (zh) | 2014-09-24 |
JP2014533954A (ja) | 2014-12-18 |
US20130156796A1 (en) | 2013-06-20 |
AU2012340686A1 (en) | 2014-06-19 |
PH12014501119A1 (en) | 2014-08-04 |
CA2856411A1 (en) | 2013-05-30 |
EP2794010A1 (en) | 2014-10-29 |
RU2014121820A (ru) | 2015-12-27 |
US9233171B2 (en) | 2016-01-12 |
HK1201772A1 (en) | 2015-09-11 |
IL232666A0 (en) | 2014-07-31 |
BR112014012155A2 (pt) | 2017-05-30 |
KR20140105765A (ko) | 2014-09-02 |
CL2014001282A1 (es) | 2014-11-14 |
EP2794010A4 (en) | 2015-10-21 |
WO2013078271A1 (en) | 2013-05-30 |
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