DK1098909T3 - Hybride menneske/gnaver igg-antistoffer mod cd3 og fremgangsmåder til fremstilling deraf - Google Patents

Hybride menneske/gnaver igg-antistoffer mod cd3 og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1098909T3
DK1098909T3 DK99934931.9T DK99934931T DK1098909T3 DK 1098909 T3 DK1098909 T3 DK 1098909T3 DK 99934931 T DK99934931 T DK 99934931T DK 1098909 T3 DK1098909 T3 DK 1098909T3
Authority
DK
Denmark
Prior art keywords
ser
asp
pro
rodent
phe
Prior art date
Application number
DK99934931.9T
Other languages
English (en)
Inventor
Herman Waldmann
Mark Frewin
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Application granted granted Critical
Publication of DK1098909T3 publication Critical patent/DK1098909T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK99934931.9T 1998-07-21 1999-07-21 Hybride menneske/gnaver igg-antistoffer mod cd3 og fremgangsmåder til fremstilling deraf DK1098909T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815909.8A GB9815909D0 (en) 1998-07-21 1998-07-21 Antibody preparation
PCT/GB1999/002380 WO2000005268A1 (en) 1998-07-21 1999-07-21 Hybrid human/rodent igg antibody to cd3, and methods of its construction

Publications (1)

Publication Number Publication Date
DK1098909T3 true DK1098909T3 (da) 2012-06-25

Family

ID=10835937

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99934931.9T DK1098909T3 (da) 1998-07-21 1999-07-21 Hybride menneske/gnaver igg-antistoffer mod cd3 og fremgangsmåder til fremstilling deraf

Country Status (16)

Country Link
US (4) US20020131968A1 (da)
EP (2) EP2388275A3 (da)
JP (1) JP4629228B2 (da)
KR (1) KR100629017B1 (da)
AT (1) ATE551366T1 (da)
AU (1) AU766486B2 (da)
CA (1) CA2334047C (da)
CY (1) CY1113296T1 (da)
DK (1) DK1098909T3 (da)
ES (1) ES2384319T3 (da)
GB (1) GB9815909D0 (da)
NZ (1) NZ509074A (da)
PT (1) PT1098909E (da)
RU (1) RU2244720C2 (da)
WO (1) WO2000005268A1 (da)
ZA (1) ZA200100478B (da)

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Also Published As

Publication number Publication date
US7993641B2 (en) 2011-08-09
EP2388275A2 (en) 2011-11-23
CY1113296T1 (el) 2016-04-13
NZ509074A (en) 2003-09-26
GB9815909D0 (en) 1998-09-16
AU5055299A (en) 2000-02-14
KR20010082010A (ko) 2001-08-29
KR100629017B1 (ko) 2006-09-26
RU2244720C2 (ru) 2005-01-20
US20110282037A1 (en) 2011-11-17
CA2334047A1 (en) 2000-02-03
JP4629228B2 (ja) 2011-02-09
US20040006216A1 (en) 2004-01-08
US20070092516A1 (en) 2007-04-26
ZA200100478B (en) 2001-07-30
EP2388275A3 (en) 2013-04-03
US20020131968A1 (en) 2002-09-19
JP2002521022A (ja) 2002-07-16
WO2000005268A1 (en) 2000-02-03
EP1098909B1 (en) 2012-03-28
EP1098909A1 (en) 2001-05-16
AU766486B2 (en) 2003-10-16
US7994289B2 (en) 2011-08-09
ATE551366T1 (de) 2012-04-15
ES2384319T3 (es) 2012-07-03
PT1098909E (pt) 2012-06-25
CA2334047C (en) 2015-11-24

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