MX366629B - Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. - Google Patents

Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.

Info

Publication number
MX366629B
MX366629B MX2014000354A MX2014000354A MX366629B MX 366629 B MX366629 B MX 366629B MX 2014000354 A MX2014000354 A MX 2014000354A MX 2014000354 A MX2014000354 A MX 2014000354A MX 366629 B MX366629 B MX 366629B
Authority
MX
Mexico
Prior art keywords
preparation
pharmaceutical compositions
substituted quinazolines
quinazolines
substituted
Prior art date
Application number
MX2014000354A
Other languages
English (en)
Other versions
MX2014000354A (es
Inventor
Klein Thomas
Frank Markus
Pfrengle Waldemar
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46506460&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX366629(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2014000354A publication Critical patent/MX2014000354A/es
Publication of MX366629B publication Critical patent/MX366629B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a quinazolinas sustituidas de la fórmula (I) en donde X e Y se definen como en la reivindicación 1, sus tautómeros, estereoisómeros, mezclas y sales, que tienen valiosas propiedades farmacológicas, en particular, un efecto inhibidor sobre la actividad de la enzima dipeptidilpeptidasa-IV (DPP-IV).
MX2014000354A 2011-07-15 2012-07-13 Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. MX366629B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11174266 2011-07-15
EP12170055 2012-05-30
PCT/EP2012/063852 WO2013010964A1 (en) 2011-07-15 2012-07-13 Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions

Publications (2)

Publication Number Publication Date
MX2014000354A MX2014000354A (es) 2014-05-01
MX366629B true MX366629B (es) 2019-07-17

Family

ID=46506460

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000354A MX366629B (es) 2011-07-15 2012-07-13 Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas.

Country Status (17)

Country Link
US (3) US8883800B2 (es)
EP (2) EP3517539B1 (es)
JP (1) JP5876150B2 (es)
KR (2) KR20190062621A (es)
CN (1) CN103781788B (es)
AU (1) AU2012285904C1 (es)
BR (1) BR112014000938A2 (es)
CA (1) CA2841552C (es)
CL (1) CL2014000076A1 (es)
DK (2) DK2731947T3 (es)
EA (1) EA030121B1 (es)
ES (2) ES2713566T3 (es)
HU (2) HUE061596T2 (es)
MX (1) MX366629B (es)
NZ (1) NZ618698A (es)
PL (2) PL3517539T3 (es)
WO (1) WO2013010964A1 (es)

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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
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PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
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JP6034781B2 (ja) 2010-05-05 2016-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
EP3725325B1 (en) 2010-06-24 2023-05-31 Boehringer Ingelheim International GmbH Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
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US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
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CN106389435B (zh) * 2016-09-05 2019-07-05 深圳海王医药科技研究院有限公司 一种含萘普替尼或其盐的药物组合物及其杂质控制方法
WO2018049145A1 (en) 2016-09-09 2018-03-15 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3558998A4 (en) 2016-12-22 2020-06-10 Calithera Biosciences, Inc. ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE
SG11202012001YA (en) * 2018-06-21 2021-01-28 Calithera Biosciences Inc Ectonucleotidase inhibitors and methods of use thereof
CN110894198B (zh) * 2018-09-13 2022-12-02 齐鲁制药有限公司 一种黄嘌呤类化合物及其制备方法和用途

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EP3517539B1 (en) 2022-12-14
CL2014000076A1 (es) 2014-09-05
JP5876150B2 (ja) 2016-03-02
US8962636B2 (en) 2015-02-24
ES2934843T3 (es) 2023-02-27
BR112014000938A2 (pt) 2017-01-10
MX2014000354A (es) 2014-05-01
CA2841552A1 (en) 2013-01-24
US9199998B2 (en) 2015-12-01
AU2012285904B2 (en) 2016-10-13
KR20140037225A (ko) 2014-03-26
CA2841552C (en) 2020-06-23
AU2012285904A1 (en) 2014-01-09
EA030121B1 (ru) 2018-06-29
DK3517539T3 (en) 2023-01-16
NZ618698A (en) 2015-08-28
KR101985384B1 (ko) 2019-06-03
US20140228283A1 (en) 2014-08-14
KR20190062621A (ko) 2019-06-05
HUE043540T2 (hu) 2019-08-28
JP2014518287A (ja) 2014-07-28
AU2012285904C1 (en) 2017-08-31
EP2731947A1 (en) 2014-05-21
CN103781788A (zh) 2014-05-07
ES2713566T3 (es) 2019-05-22
PL2731947T3 (pl) 2019-07-31
EP3517539A1 (en) 2019-07-31

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