RU2011113823A - Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний - Google Patents
Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний Download PDFInfo
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Abstract
1. Фармацевтическая композиция, включающая ! агонист GPR119 в комбинации с ! ингибитором ДПП-4 формулы (I) ! ! или формулы (II) ! , ! или формулы (III) ! , ! или формулы (IV) ! , ! где R1 обозначает ([1,5]нафтиридин-2-ил)метил, (хиназолин-2-ил)метил, (хиноксалин-6-ил)метил, (4-метилхиназолин-2-ил)метил, 2-цианобензил, (3-цианохинолин-2-ил)метил, (3-цианопиридин-2-ил)метил, (4-метилпиримидин-2-ил)метил, или (4,6-диметилпиримидин-2-ил)метил и R2 обозначает 3-(R)- аминопиперидин-1-ил, (2-амино-2-метилпропил)метиламино или (2-(S)-аминопропил)метиламино, или его фармацевтически приемлемую соль. ! 2. Фармацевтическая композиция по п.1, где указанный ингибитор ДПП-4 выбран из группы, включающей: ! 1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-(3-(R)-аминопиперидин-1-ил)ксантин, ! 1-[([1,5]нафтиридин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, ! 1-[(хиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, ! 2-((R)-3-аминопиперидин-1-ил)-3-(бут-2-инил)-5-(4-метилхиназолин-2-илметил)-3,5-дигидроимидазо[4,5-d]пиридазин-4-он, ! 1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-[(2-амино-2-метилпропил)метиламино]ксантин, ! 1-[(3-цианохинолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, ! 1-(2-цианобензил)-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, ! 1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-[(S)-(2-аминопропил)метиламино]ксантин, ! 1-[(3-цианопиридин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, !1-[(4-метилпиримидин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин, ! 1-[(4,6-диметилпиримидин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин и ! 1-[(хиноксалин-6-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-(
Claims (19)
1. Фармацевтическая композиция, включающая
агонист GPR119 в комбинации с
ингибитором ДПП-4 формулы (I)
или формулы (II)
или формулы (III)
или формулы (IV)
где R1 обозначает ([1,5]нафтиридин-2-ил)метил, (хиназолин-2-ил)метил, (хиноксалин-6-ил)метил, (4-метилхиназолин-2-ил)метил, 2-цианобензил, (3-цианохинолин-2-ил)метил, (3-цианопиридин-2-ил)метил, (4-метилпиримидин-2-ил)метил, или (4,6-диметилпиримидин-2-ил)метил и R2 обозначает 3-(R)- аминопиперидин-1-ил, (2-амино-2-метилпропил)метиламино или (2-(S)-аминопропил)метиламино, или его фармацевтически приемлемую соль.
2. Фармацевтическая композиция по п.1, где указанный ингибитор ДПП-4 выбран из группы, включающей:
1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-(3-(R)-аминопиперидин-1-ил)ксантин,
1-[([1,5]нафтиридин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
1-[(хиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
2-((R)-3-аминопиперидин-1-ил)-3-(бут-2-инил)-5-(4-метилхиназолин-2-илметил)-3,5-дигидроимидазо[4,5-d]пиридазин-4-он,
1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-[(2-амино-2-метилпропил)метиламино]ксантин,
1-[(3-цианохинолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
1-(2-цианобензил)-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-[(S)-(2-аминопропил)метиламино]ксантин,
1-[(3-цианопиридин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
1-[(4-метилпиримидин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
1-[(4,6-диметилпиримидин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин и
1-[(хиноксалин-6-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-((R)-3-аминопиперидин-1-ил)ксантин,
или их фармацевтически приемлемую соль.
3. Фармацевтическая композиция по п.1, где указанным ингибитором ДПП-4 является 1-[(4-метилхиназолин-2-ил)метил]-3-метил-7-(2-бутин-1-ил)-8-(3-(R)-аминопиперидин-1-ил)ксантин.
4. Фармацевтическая композиция по п.3, где указанный агонист GPR119 выбран из таблицы, представленной ниже:
или их фармацевтически приемлемой соли.
5. Фармацевтическая композиция по любому из предшествующих пунктов, предназначенная
- для профилактики, снижения прогрессирования, замедления развития или лечения метаболического нарушения,
- для улучшения гликемического контроля и/или снижения уровня глюкозы в плазме крови натощак, постпрандиальной глюкозы в плазме и/или гликозилированного гемоглобина HbA1c,
- для профилактики, снижения, замедления или обращения вспять прогрессии нарушенной толерантности к глюкозе, резистентности к инсулину и/или состояний от метаболического синдрома до сахарного диабета типа 2,
- для профилактики, снижения прогрессирования, замедления развития или лечения состояния или нарушения, выбранного из группы, включающей осложнения при сахарном диабете,
- для уменьшения массы тела или профилактики увеличения массы тела или ускорения снижения массы тела,
- для профилактики или лечения дегенерации бета-клеток поджелудочной железы и/или улучшения, и/или восстановления функции бета-клеток поджелудочной железы, и/или восстановления функции секреции инсулина поджелудочной железой, и/или
- поддержание и/или улучшение чувствительности к инсулину и/или лечение или профилактика гиперинсулинемии и/или резистентности к инсулину.
6. Фармацевтическая композиция по любому из пп.1-4 для применения при снижении уровня глюкозы в крови пациентов, страдающих от диабета.
7. Фармацевтическая композиция по любому из пп.1-4 для применения при улучшении гликемического контроля у пациентов, страдающих от диабета.
8. Фармацевтическая композиция по любому из пп.1-4 для применения при улучшении гликемического контроля у пациентов, страдающих от диабета в состоянии натощак и/или после еды.
9. Фармацевтическая композиция по любому из пп.1-4 для применения при повышении уровня ГЛП-1 в плазме крови пациентов, страдающих от диабета.
10. Фармацевтическая композиция по любому из пп.1-4 для применения при лечении и/или профилактике заболевания, нарушения или состояния, чувствительного к повышению уровня ГЛП-1 в плазме крови.
11. Фармацевтическая композиция по любому из пп.1-4 для терапевтического применения, например для улучшения гликемического контроля у диабетических пациентов с высокой резистентностью к инсулину.
12. Фармацевтическая композиция по любому из пп.1-4 для применения при лечении и/или профилактике диабета типа 1, диабета типа 2, нарушенной толерантности к глюкозе, резистентности к инсулину, гипергликемии, гиперлипидемии, гиперхолестеринемии, дислипидемии, синдрома X, метаболического синдрома, ожирения, гипертензии, хронического системного воспаления, ретинопатии, нейропатии, нефропатии, атеросклероза, дисфункции эндотелия и остеопороза.
13. Фармацевтическая композиция по любому из пп.1-4 для применения при снижении массы тела или лечении ожирения.
14. Фармацевтическая композиция по любому из пп.1-4 для применения при лечении дислипидемии, гиперлипидемии или гиперхолестеринемии.
15. Фармацевтическая композиция по любому из пп.1-4 для применения при лечении метаболического синдрома (синдрома X).
16. Фармацевтическая композиция по одному из пп.1-4, где композиция является пригодной для одновременного, последовательного или отдельного применения агониста GPR119 и ингибитора ДПП-4.
17. Фармацевтическая композиция по одному из пп.1-4, где агонист GPR119 и ингибитор ДПП-4 присутствуют в одной лекарственной форме.
18. Фармацевтическая композиция по одному из пп.1-4, где агонист GPR119 и ингибитор ДПП-4 каждый присутствует в отдельной лекарственной форме.
19. Ингибитор ДПП-4 по любому из пп.1-3 для применения в комбинации с агонистом GPR119 по п.1 или 4.
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EP08105293.8 | 2008-09-10 | ||
EP08105293 | 2008-09-10 |
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US (2) | US8513264B2 (ru) |
EP (1) | EP2344195A2 (ru) |
JP (1) | JP2012502081A (ru) |
KR (1) | KR20110067096A (ru) |
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-
2009
- 2009-09-08 AU AU2009290911A patent/AU2009290911A1/en not_active Abandoned
- 2009-09-08 BR BRPI0919288A patent/BRPI0919288A2/pt not_active IP Right Cessation
- 2009-09-08 MX MX2011002558A patent/MX2011002558A/es unknown
- 2009-09-08 WO PCT/EP2009/061659 patent/WO2010029089A2/en active Application Filing
- 2009-09-08 KR KR1020117005582A patent/KR20110067096A/ko not_active Application Discontinuation
- 2009-09-08 RU RU2011113823/15A patent/RU2011113823A/ru not_active Application Discontinuation
- 2009-09-08 JP JP2011526480A patent/JP2012502081A/ja active Pending
- 2009-09-08 CA CA2736421A patent/CA2736421A1/en not_active Abandoned
- 2009-09-08 CN CN2009801352522A patent/CN102149407A/zh active Pending
- 2009-09-08 US US13/062,777 patent/US8513264B2/en active Active
- 2009-09-08 EP EP09782792A patent/EP2344195A2/en not_active Withdrawn
- 2009-09-09 AR ARP090103458A patent/AR073563A1/es unknown
- 2009-09-09 TW TW098130408A patent/TW201014861A/zh unknown
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2011
- 2011-01-25 IL IL210856A patent/IL210856A0/en unknown
- 2011-03-08 CL CL2011000501A patent/CL2011000501A1/es unknown
-
2013
- 2013-07-24 US US13/949,579 patent/US20130310398A1/en not_active Abandoned
Also Published As
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CL2011000501A1 (es) | 2011-07-15 |
CA2736421A1 (en) | 2010-03-18 |
IL210856A0 (en) | 2011-04-28 |
EP2344195A2 (en) | 2011-07-20 |
BRPI0919288A2 (pt) | 2015-12-15 |
US20110263617A1 (en) | 2011-10-27 |
MX2011002558A (es) | 2011-04-26 |
CN102149407A (zh) | 2011-08-10 |
WO2010029089A2 (en) | 2010-03-18 |
AR073563A1 (es) | 2010-11-17 |
US8513264B2 (en) | 2013-08-20 |
AU2009290911A1 (en) | 2010-03-18 |
TW201014861A (en) | 2010-04-16 |
US20130310398A1 (en) | 2013-11-21 |
WO2010029089A3 (en) | 2010-05-06 |
KR20110067096A (ko) | 2011-06-21 |
JP2012502081A (ja) | 2012-01-26 |
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