MX360856B - 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas. - Google Patents

3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.

Info

Publication number
MX360856B
MX360856B MX2014001598A MX2014001598A MX360856B MX 360856 B MX360856 B MX 360856B MX 2014001598 A MX2014001598 A MX 2014001598A MX 2014001598 A MX2014001598 A MX 2014001598A MX 360856 B MX360856 B MX 360856B
Authority
MX
Mexico
Prior art keywords
naphthyridinones
dihydro
antibacterial
compounds
homopiperidinyl substituted
Prior art date
Application number
MX2014001598A
Other languages
English (en)
Other versions
MX2014001598A (es
Inventor
Jerôme Emile Georges Guillemont
Anil Koul
David Francis Alain Lançois
Magali Madeleine Simone Motte
Wendy Mia Albert Balemans
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2014001598A publication Critical patent/MX2014001598A/es
Publication of MX360856B publication Critical patent/MX360856B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) novedosos que inhiben la actividad de la enzima FabI, los cuales son por lo tanto útiles en el tratamiento de infecciones bacterianas; también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a procesos químicos para la preparación de estos compuestos. (ver Fórmula).
MX2014001598A 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas. MX360856B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11177115 2011-08-10
PCT/EP2012/065729 WO2013021051A1 (en) 2011-08-10 2012-08-10 Antibacterial homopiperidinyl substituted 3,4 dihydro 1h [1,8]naphthyridinones

Publications (2)

Publication Number Publication Date
MX2014001598A MX2014001598A (es) 2014-04-25
MX360856B true MX360856B (es) 2018-11-20

Family

ID=46639542

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001598A MX360856B (es) 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.

Country Status (13)

Country Link
US (1) US9394295B2 (es)
EP (1) EP2742044B1 (es)
JP (2) JP6521631B2 (es)
KR (1) KR101996866B1 (es)
CN (2) CN108003155A (es)
AU (1) AU2012293618B2 (es)
BR (1) BR112014003146B1 (es)
CA (1) CA2842526C (es)
EA (1) EA038317B1 (es)
ES (1) ES2776145T3 (es)
HK (2) HK1200445A1 (es)
MX (1) MX360856B (es)
WO (1) WO2013021051A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX360856B (es) * 2011-08-10 2018-11-20 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.
JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
EP2785715A1 (en) 2011-12-02 2014-10-08 Aurigene Discovery Technologies Limited Substituted pyridine derivatives as fabi inhibitors
US9062075B2 (en) 2011-12-02 2015-06-23 Aurigene Discovery Technologies Limited Tetrahydropyridine derivatives as FabI inhibitors
WO2014072930A2 (en) * 2012-11-09 2014-05-15 Aurigene Discovery Technologies Limited Fused pyridine derivatives as antibacterial agents
EP3004099B1 (en) 2013-06-04 2023-04-19 Aurigene Oncology Limited Tetrahydropyridine derivatives as fabi inhibitors
WO2015071780A1 (en) * 2013-11-12 2015-05-21 Aurigene Discovery Technologies Limited Alkylidine substituted heterocyclyl derivatives as anti-bacterial agents
EP3941905A1 (en) * 2019-03-19 2022-01-26 Suvalent Therapeutics, Inc. Sumo inhibitor compounds and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215123A (en) 1979-05-07 1980-07-29 American Home Products Corporation Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
JP4803935B2 (ja) 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
AU7866300A (en) 1999-10-08 2001-04-23 Smithkline Beecham Corporation Fab i inhibitors
WO2001026654A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
DE60230934D1 (de) 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
PT1828167E (pt) * 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
BR112012011793A2 (pt) 2009-11-18 2019-09-24 Fab Pharma Sas "acrilamidas heterocíclicas e seu uso como farmacêuticos"
MX360856B (es) * 2011-08-10 2018-11-20 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.

Also Published As

Publication number Publication date
EA038317B1 (ru) 2021-08-09
BR112014003146B1 (pt) 2022-03-15
JP6521631B2 (ja) 2019-05-29
US20140171418A1 (en) 2014-06-19
ES2776145T3 (es) 2020-07-29
KR101996866B1 (ko) 2019-07-05
AU2012293618A1 (en) 2014-02-06
CA2842526A1 (en) 2013-02-14
JP2017222646A (ja) 2017-12-21
CN104039782A (zh) 2014-09-10
CN108003155A (zh) 2018-05-08
KR20140072025A (ko) 2014-06-12
US9394295B2 (en) 2016-07-19
JP2014531403A (ja) 2014-11-27
MX2014001598A (es) 2014-04-25
EA201490436A1 (ru) 2014-07-30
BR112014003146A2 (pt) 2021-01-26
EP2742044B1 (en) 2019-12-04
AU2012293618B2 (en) 2017-04-20
WO2013021051A1 (en) 2013-02-14
EP2742044A1 (en) 2014-06-18
CA2842526C (en) 2019-07-23
HK1200445A1 (en) 2015-08-07
HK1254403A1 (zh) 2019-07-19

Similar Documents

Publication Publication Date Title
MX360856B (es) 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.
JO3611B1 (ar) سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
MX363478B (es) 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con piperidinilo antibacterianas.
NZ708928A (en) Mannose derivatives for treating bacterial infections
WO2013122888A3 (en) Methods of treating bacterial infections
PH12014501671A1 (en) Amidine substituted beta-lactam compounds, their preparation and use as antibacterial agents
MX2014000354A (es) Quinazolinas sustituidas, su preparacion y su uso en composiciones farmaceuticas.
MY188960A (en) Cyclic boronic acid ester derivatives and therapeutic uses thereof
MX336189B (es) Compuesto de dihidroazol antiparasiticos y composiciones qe¡ue comprenden los mismos.
WO2011117145A3 (en) Pyrrolopyrazine kinase inhibitors
GEP20156285B (en) Compounds and compositions as trk inhibitors
MX349827B (es) Compuestos que contienen nitrogeno y su uso.
MX2013008162A (es) Inhibidores de pirimidina y topoisomerasa iv.
MX2011008043A (es) Derivados de actagardina.
NZ596628A (en) Ketolide compounds having antimicrobial activity
MX2015001834A (es) Nuevos compuestos antibacterianos.
MX2011013869A (es) Agentes antihelminticos y su uso.
WO2012017434A3 (en) Guanine nucleotide derivatives for treating bacterial infections
MX2015001835A (es) Nuevos compuestos antibacterianos.
WO2009116044A3 (en) Guanine nucleotide derivatives for treating bacterial infections
WO2013166282A3 (en) Methods and compositions for treating bacterial infection
MX357352B (es) Uso de derivados poliaminoisoprenilo en un tratamiento antibiotico o antiseptico.
WO2012018662A3 (en) Fused-imidazoyl compounds useful as antimicrobial agents
MY182136A (en) Pharmaceutical compositions

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: JANSSEN SCIENCES IRELAND UC

FG Grant or registration