WO2011128699A3 - Novel process for the preparation of sunitinib - Google Patents

Novel process for the preparation of sunitinib Download PDF

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Publication number
WO2011128699A3
WO2011128699A3 PCT/GB2011/050752 GB2011050752W WO2011128699A3 WO 2011128699 A3 WO2011128699 A3 WO 2011128699A3 GB 2011050752 W GB2011050752 W GB 2011050752W WO 2011128699 A3 WO2011128699 A3 WO 2011128699A3
Authority
WO
WIPO (PCT)
Prior art keywords
sunitinib
preparation
novel process
salts
relates
Prior art date
Application number
PCT/GB2011/050752
Other languages
French (fr)
Other versions
WO2011128699A2 (en
Inventor
Vinayak Govind Gore
Laxmikant Narahari Patkar
Bharati Pandit Choudhari
Mahesh Gorakhnath Hublikar
Kiran Shivaji Pokharkar
Prakash Vishnu Bansode
Original Assignee
Generics [Uk] Limited
Mylan India Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics [Uk] Limited, Mylan India Private Limited filed Critical Generics [Uk] Limited
Publication of WO2011128699A2 publication Critical patent/WO2011128699A2/en
Publication of WO2011128699A3 publication Critical patent/WO2011128699A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention relates to novel processes tor the preparation of sunitinib and salts thereof, in particular sunitinib (2S)-2-hvdroxybutanedioate. The invention further relates to novel intermediates, their use in the preparation of sunitinib or salts thereof and to processes for the preparation of said intermediates. The invention also relates to compositions comprising sunitinib or its pharmaceutically acceptable salts.Formula (IV).
PCT/GB2011/050752 2010-04-16 2011-04-15 Novel process WO2011128699A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1260MU2010 2010-04-16
IN1260/MUM/2010 2010-04-16

Publications (2)

Publication Number Publication Date
WO2011128699A2 WO2011128699A2 (en) 2011-10-20
WO2011128699A3 true WO2011128699A3 (en) 2012-03-08

Family

ID=44022027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/050752 WO2011128699A2 (en) 2010-04-16 2011-04-15 Novel process

Country Status (1)

Country Link
WO (1) WO2011128699A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103319392B (en) * 2013-07-10 2015-10-28 张家港市华昌药业有限公司 A kind of preparation method of sutent intermediate
PT3039424T (en) 2013-08-28 2020-09-03 Crown Bioscience Inc Taicang Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2003070725A2 (en) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
WO2009150523A1 (en) * 2008-06-13 2009-12-17 Medichem, S.A. Process for preparing a 3-pyrrole substituted 2-indolinone malate salt

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA006445B9 (en) 2001-08-15 2017-02-28 Фармация Энд Апджон Компани Crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene) methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
US20060009510A1 (en) 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
AU2009265360A1 (en) 2008-07-02 2010-01-07 Generics [Uk] Limited Preparation of 3-pyrrole substituted 2-indolinone derivatives
WO2010023473A2 (en) 2008-08-25 2010-03-04 Generics [Uk] Limited Novel crystalline form and processes for its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156292A1 (en) * 2000-02-15 2002-10-24 Tang Peng Cho Pyrrole substituted 2-indolinone protein kinase inhibitors
WO2003070725A2 (en) * 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
WO2009150523A1 (en) * 2008-06-13 2009-12-17 Medichem, S.A. Process for preparing a 3-pyrrole substituted 2-indolinone malate salt

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JERAD M MANLEY ET AL: "Early Amidation Approach to 3-[(4-Amido)pyrrol-2-yl]-2-indolinones", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 68, no. 16, 7 November 2003 (2003-11-07), pages 6447 - 6450, XP007905198, ISSN: 0022-3263, DOI: DOI:10.1021/JO034304Q *

Also Published As

Publication number Publication date
WO2011128699A2 (en) 2011-10-20

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