MX2021006269A - Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos. - Google Patents

Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.

Info

Publication number
MX2021006269A
MX2021006269A MX2021006269A MX2021006269A MX2021006269A MX 2021006269 A MX2021006269 A MX 2021006269A MX 2021006269 A MX2021006269 A MX 2021006269A MX 2021006269 A MX2021006269 A MX 2021006269A MX 2021006269 A MX2021006269 A MX 2021006269A
Authority
MX
Mexico
Prior art keywords
libraries
antibody libraries
synthetic antibody
rationally designed
uses therefor
Prior art date
Application number
MX2021006269A
Other languages
English (en)
Inventor
Michael Feldhaus
Tillman U Gerngross
K Dane Wittrup
Maximiliano Vasquez
Original Assignee
Adimab Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adimab Llc filed Critical Adimab Llc
Publication of MX2021006269A publication Critical patent/MX2021006269A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención supera lo inadecuado inherente en los métodos conocidos para generar bancos de polinucleótidos que codifican anticuerpos por el diseño específico de bancos con diversidad de secuencia y longitud dirigida. Los bancos se diseñan para reflejar el repertorio preinmune creado naturalmente por el sistema inmune humano y se basan en el diseño racional informado por examen de bases de datos disponibles públicamente de secuencias de anticuerpos humanos.
MX2021006269A 2007-09-14 2010-03-09 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos. MX2021006269A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99378507P 2007-09-14 2007-09-14

Publications (1)

Publication Number Publication Date
MX2021006269A true MX2021006269A (es) 2022-06-29

Family

ID=40350153

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2010002661A MX2010002661A (es) 2007-09-14 2008-09-12 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.
MX2013010158A MX344415B (es) 2007-09-14 2008-09-12 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.
MX2021006269A MX2021006269A (es) 2007-09-14 2010-03-09 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2010002661A MX2010002661A (es) 2007-09-14 2008-09-12 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.
MX2013010158A MX344415B (es) 2007-09-14 2008-09-12 Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.

Country Status (11)

Country Link
US (4) US8691730B2 (es)
EP (3) EP3753947A1 (es)
JP (6) JP5933894B2 (es)
CN (1) CN101855242B (es)
AU (1) AU2008298603B2 (es)
BR (1) BRPI0816785A2 (es)
CA (3) CA2964398C (es)
DK (1) DK3124497T3 (es)
HK (1) HK1147271A1 (es)
MX (3) MX2010002661A (es)
WO (1) WO2009036379A2 (es)

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