EA030777B9 - Анти-альфа-синуклеинсвязывающие молекулы - Google Patents

Анти-альфа-синуклеинсвязывающие молекулы

Info

Publication number
EA030777B9
EA030777B9 EA201391761A EA201391761A EA030777B9 EA 030777 B9 EA030777 B9 EA 030777B9 EA 201391761 A EA201391761 A EA 201391761A EA 201391761 A EA201391761 A EA 201391761A EA 030777 B9 EA030777 B9 EA 030777B9
Authority
EA
Eurasian Patent Office
Prior art keywords
binding molecules
synuclein
alpha synuclein
synuclein binding
human immunoglobulin
Prior art date
Application number
EA201391761A
Other languages
English (en)
Other versions
EA201391761A1 (ru
EA030777B1 (ru
Inventor
Андреас Вайхофен
Ян Гримм
Кристоф Хок
Рогер Нитш
Лихэ Су
Пол Вейнреб
Original Assignee
Байоджен Интернэшнл Нейросайенз Гмбх
Юниверсити Оф Цюрих
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен Интернэшнл Нейросайенз Гмбх, Юниверсити Оф Цюрих filed Critical Байоджен Интернэшнл Нейросайенз Гмбх
Publication of EA201391761A1 publication Critical patent/EA201391761A1/ru
Publication of EA030777B1 publication Critical patent/EA030777B1/ru
Publication of EA030777B9 publication Critical patent/EA030777B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Abstract

Описывается получение молекул, специфически связывающих α-синуклеин - против имуноглобулинов человека, например антитела или их антигенсвязывающие фрагменты, варианты или производные этого, а также способы, имеющие отношение к этому. Дополнительно описывается получение молекул, связывающих α-синуклеин - против иммуноглобулинов человека, которые связываются со специфическими N-концевым и C-концевым эпитопами α-синуклеина человеческого организма. Описанные в этой заявке связывающие молекулы могут использоваться в фармацевтических и диагностических композициях для анти-α-синуклеиновой иммунотерапии и диагностики соответственно.
EA201391761A 2011-06-23 2012-06-22 Анти-альфа-синуклеинсвязывающие молекулы EA030777B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161500580P 2011-06-23 2011-06-23
PCT/US2012/043701 WO2012177972A1 (en) 2011-06-23 2012-06-22 Anti-alpha synuclein binding molecules

Publications (3)

Publication Number Publication Date
EA201391761A1 EA201391761A1 (ru) 2014-09-30
EA030777B1 EA030777B1 (ru) 2018-09-28
EA030777B9 true EA030777B9 (ru) 2019-02-28

Family

ID=47422964

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391761A EA030777B9 (ru) 2011-06-23 2012-06-22 Анти-альфа-синуклеинсвязывающие молекулы

Country Status (23)

Country Link
US (3) US9580493B2 (ru)
EP (1) EP2723379B1 (ru)
JP (2) JP2014528695A (ru)
KR (1) KR101976887B1 (ru)
CN (1) CN103796679B (ru)
AU (1) AU2012272790B2 (ru)
BR (1) BR112013033258B1 (ru)
CA (1) CA2839563C (ru)
CY (1) CY1121392T1 (ru)
DK (1) DK2723379T3 (ru)
EA (1) EA030777B9 (ru)
ES (1) ES2699801T3 (ru)
HR (1) HRP20181553T1 (ru)
HU (1) HUE041391T2 (ru)
IL (1) IL230028B (ru)
LT (1) LT2723379T (ru)
MX (1) MX357193B (ru)
PL (1) PL2723379T3 (ru)
PT (1) PT2723379T (ru)
SI (1) SI2723379T1 (ru)
TR (1) TR201815563T4 (ru)
WO (1) WO2012177972A1 (ru)
ZA (1) ZA201309623B (ru)

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