US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
US4433059A
(en)
|
1981-09-08 |
1984-02-21 |
Ortho Diagnostic Systems Inc. |
Double antibody conjugate
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
US4496654A
(en)
|
1983-04-08 |
1985-01-29 |
Quidel |
Detection of HCG with solid phase support having avidin coating
|
DE3474511D1
(en)
|
1983-11-01 |
1988-11-17 |
Terumo Corp |
Pharmaceutical composition containing urokinase
|
EP0173552B1
(en)
|
1984-08-24 |
1991-10-09 |
The Upjohn Company |
Recombinant dna compounds and the expression of polypeptides such as tpa
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
US5869620A
(en)
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
US5026773A
(en)
|
1987-03-11 |
1991-06-25 |
Samuel Steel |
Apparatus for a solid phase synthesis of peptide analogs
|
JPH021556A
(en)
|
1988-06-09 |
1990-01-05 |
Snow Brand Milk Prod Co Ltd |
Hybrid antibody and production thereof
|
DE68927933T2
(en)
|
1988-09-02 |
1997-08-14 |
Dyax Corp |
PRODUCTION AND SELECTION OF RECOMBINANT PROTEINS WITH DIFFERENT BINDING POINTS
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
US6291159B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for producing polymers having a preselected activity
|
DE3920358A1
(en)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
|
US5071909A
(en)
|
1989-07-26 |
1991-12-10 |
Millipore Corporation |
Immobilization of proteins and peptides on insoluble supports
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
DE59109273D1
(en)
|
1990-02-01 |
2010-01-07 |
Siemens Healthcare Diagnostics |
Production and Use of Genebanks of Human Antibodies ("Human Antibody Libraries")
|
CZ280777B6
(en)
|
1990-02-02 |
1996-04-17 |
Ústav Organické Chemie A Biochemie Avčr |
Process of multistep synthesis of peptides on planar carriers and apparatus for making the same
|
US5273743A
(en)
|
1990-03-09 |
1993-12-28 |
Hybritech Incorporated |
Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
|
GB9012995D0
(en)
|
1990-06-11 |
1990-08-01 |
Celltech Ltd |
Multivalent antigen-binding proteins
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
KR0185215B1
(en)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
A controlled-release pharmaceutical preparation for intra-ocular implant
|
US5582996A
(en)
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
WO1992018619A1
(en)
|
1991-04-10 |
1992-10-29 |
The Scripps Research Institute |
Heterodimeric receptor libraries using phagemids
|
DE4118120A1
(en)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
TETRAVALENT BISPECIFIC RECEPTORS, THEIR PRODUCTION AND USE
|
US6511663B1
(en)
|
1991-06-11 |
2003-01-28 |
Celltech R&D Limited |
Tri- and tetra-valent monospecific antigen-binding proteins
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
NL9101953A
(en)
|
1991-11-21 |
1993-06-16 |
Seed Capital Investments |
TESTING DEVICE CONTAINING A PLATE WITH A MULTIPLE OF WELLS WITH AN ASSOCIATED DOSING DEVICE, AND A KIT INCLUDING THESE DEVICES AND USE OF THE DEVICES.
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
PT1696031E
(en)
|
1991-12-02 |
2010-06-25 |
Medical Res Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
DE69334255D1
(en)
|
1992-02-06 |
2009-02-12 |
Novartis Vaccines & Diagnostic |
Marker for cancer and biosynthetic binding protein for it
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
CA2135408A1
(en)
|
1992-05-08 |
1993-11-25 |
Peter C. Keck |
Chimeric multivalent protein analogues and methods of use thereof
|
US5287082A
(en)
|
1992-07-02 |
1994-02-15 |
Cornell Research Foundation, Inc. |
Submicron isolated, released resistor structure
|
DK1087013T3
(en)
|
1992-08-21 |
2009-05-11 |
Univ Bruxelles |
Immunoglobulins without light chains
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
WO1994007921A1
(en)
|
1992-09-25 |
1994-04-14 |
Commonwealth Scientific And Industrial Research Organisation |
Target binding polypeptide
|
GB9221657D0
(en)
|
1992-10-15 |
1992-11-25 |
Scotgen Ltd |
Recombinant bispecific antibodies
|
US5837821A
(en)
|
1992-11-04 |
1998-11-17 |
City Of Hope |
Antibody construct
|
GB9323648D0
(en)
|
1992-11-23 |
1994-01-05 |
Zeneca Ltd |
Proteins
|
US5837242A
(en)
|
1992-12-04 |
1998-11-17 |
Medical Research Council |
Multivalent and multispecific binding proteins, their manufacture and use
|
US6838254B1
(en)
|
1993-04-29 |
2005-01-04 |
Conopco, Inc. |
Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
|
US6476198B1
(en)
|
1993-07-13 |
2002-11-05 |
The Scripps Research Institute |
Multispecific and multivalent antigen-binding polypeptide molecules
|
US5635602A
(en)
|
1993-08-13 |
1997-06-03 |
The Regents Of The University Of California |
Design and synthesis of bispecific DNA-antibody conjugates
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
JPH09506262A
(en)
|
1993-12-08 |
1997-06-24 |
ジェンザイム・コーポレイション |
Method for producing specific antibody
|
DE69534347T2
(en)
|
1994-01-31 |
2006-05-24 |
Trustees Of Boston University, Boston |
Libraries of polyclonal antibodies
|
WO1996013583A2
(en)
|
1994-10-20 |
1996-05-09 |
Morphosys Gesellschaft Für Proteinoptimierung Mbh |
Targeted hetero-association of recombinant proteins to multi-functional complexes
|
US5556752A
(en)
|
1994-10-24 |
1996-09-17 |
Affymetrix, Inc. |
Surface-bound, unimolecular, double-stranded DNA
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
EP0827544B1
(en)
|
1995-05-23 |
2004-08-18 |
MorphoSys AG |
Multimeric proteins
|
ATE219517T1
(en)
|
1995-08-18 |
2002-07-15 |
Morphosys Ag |
PROTEIN/(POLY)PEPTIDE LIBRARIES
|
CN1173878A
(en)
|
1995-10-16 |
1998-02-18 |
尤尼利弗公司 |
Bifunctional or bivalent antibody fragment analogue
|
WO1997038102A1
(en)
|
1996-04-04 |
1997-10-16 |
Unilever Plc |
Multivalent and multispecific antigen-binding protein
|
US6001329A
(en)
|
1996-05-06 |
1999-12-14 |
Uab Research Foundation |
Radiolabeled fusion toxins for cancer therapy
|
US6323322B1
(en)
|
1997-04-30 |
2001-11-27 |
Enzon, Inc. |
Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
PT1012280E
(en)
|
1997-06-11 |
2005-02-28 |
Borean Pharma As |
TRIMMING MODULE
|
WO1999023221A2
(en)
|
1997-10-27 |
1999-05-14 |
Unilever Plc |
Multivalent antigen-binding proteins
|
WO1999037791A1
(en)
|
1998-01-23 |
1999-07-29 |
Vlaams Interuniversitair Instituut Voor Biotechnologie |
Multipurpose antibody derivatives
|
CZ121599A3
(en)
|
1998-04-09 |
1999-10-13 |
Aventis Pharma Deutschland Gmbh |
Single-chain molecule binding several antigens, process of its preparation and medicament in which the molecule is comprised
|
DE19819846B4
(en)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalent antibody constructs
|
GB9812545D0
(en)
|
1998-06-10 |
1998-08-05 |
Celltech Therapeutics Ltd |
Biological products
|
US6333396B1
(en)
|
1998-10-20 |
2001-12-25 |
Enzon, Inc. |
Method for targeted delivery of nucleic acids
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
PT1176195E
(en)
|
1999-04-09 |
2013-07-18 |
Kyowa Hakko Kirin Co Ltd |
Method for controlling the activity of immunologically functional molecule
|
US7534866B2
(en)
|
2005-10-19 |
2009-05-19 |
Ibc Pharmaceuticals, Inc. |
Methods and compositions for generating bioactive assemblies of increased complexity and uses
|
US7527787B2
(en)
|
2005-10-19 |
2009-05-05 |
Ibc Pharmaceuticals, Inc. |
Multivalent immunoglobulin-based bioactive assemblies
|
DE60033293D1
(en)
|
1999-08-23 |
2007-03-22 |
Dana Farber Cancer Inst Inc |
NEW B7-4 MOLECULES AND THEIR USES
|
CA3016482A1
(en)
|
1999-11-30 |
2001-06-07 |
Mayo Foundation For Medical Education And Research |
B7-h1, a novel immunoregulatory molecule
|
DK2857516T3
(en)
|
2000-04-11 |
2017-08-07 |
Genentech Inc |
Multivalent antibodies and uses thereof
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
US20020103345A1
(en)
|
2000-05-24 |
2002-08-01 |
Zhenping Zhu |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
WO2002002781A1
(en)
|
2000-06-30 |
2002-01-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Heterodimeric fusion proteins
|
CN1461344A
(en)
|
2000-07-25 |
2003-12-10 |
免疫医疗公司 |
Multivalent target binding protein
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
EP1197755A1
(en)
|
2000-10-11 |
2002-04-17 |
Pepscan Systems B.V. |
Identification of protein binding sites
|
US20040242847A1
(en)
|
2000-10-20 |
2004-12-02 |
Naoshi Fukushima |
Degraded agonist antibody
|
ATE498718T1
(en)
|
2000-12-18 |
2011-03-15 |
Dyax Corp |
DIRECTED LIBRARIES THAT ARE GENETICALLY PACKAGED
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
AU2002247826A1
(en)
|
2001-03-13 |
2002-09-24 |
University College London |
Specific binding members
|
DK1399484T3
(en)
|
2001-06-28 |
2010-11-08 |
Domantis Ltd |
Double-specific ligand and its use
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
DE60124912T2
(en)
|
2001-09-14 |
2007-06-14 |
Affimed Therapeutics Ag |
Multimeric, single chain, tandem Fv antibodies
|
US20030211078A1
(en)
|
2001-12-07 |
2003-11-13 |
Heavner George A. |
Pseudo-antibody constructs
|
JP4968498B2
(en)
|
2002-01-23 |
2012-07-04 |
ユニバーシティ オブ ユタ リサーチ ファウンデーション |
Targeted chromosomal mutagenesis using zinc finger nuclease
|
EP1487879B1
(en)
|
2002-03-01 |
2012-12-26 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
US20030232410A1
(en)
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
JP4386741B2
(en)
|
2002-04-15 |
2009-12-16 |
中外製薬株式会社 |
How to create scDb library
|
WO2003104415A2
(en)
|
2002-06-05 |
2003-12-18 |
Sopherion Therapeutics, Inc. |
Method to screen ligands using eukaryotic cell display
|
PT2206517T
(en)
|
2002-07-03 |
2023-11-07 |
Tasuku Honjo |
Immunopotentiating compositions comprising anti-pd-l1 antibodies
|
AU2003298574B2
(en)
|
2002-09-05 |
2008-04-24 |
California Institute Of Technology |
Use of chimeric nucleases to stimulate gene targeting
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
GB0305702D0
(en)
|
2003-03-12 |
2003-04-16 |
Univ Birmingham |
Bispecific antibodies
|
EP1618181B1
(en)
|
2003-04-22 |
2014-10-15 |
IBC Pharmaceuticals |
Polyvalent protein complex
|
WO2005000898A2
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
AU2004255216B2
(en)
|
2003-07-01 |
2010-08-19 |
Immunomedics, Inc. |
Multivalent carriers of bi-specific antibodies
|
US7696322B2
(en)
|
2003-07-28 |
2010-04-13 |
Catalent Pharma Solutions, Inc. |
Fusion antibodies
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
WO2005035586A1
(en)
|
2003-10-08 |
2005-04-21 |
Kyowa Hakko Kogyo Co., Ltd. |
Fused protein composition
|
US20050136051A1
(en)
|
2003-12-22 |
2005-06-23 |
Bernard Scallon |
Methods for generating multimeric molecules
|
GB0329825D0
(en)
|
2003-12-23 |
2004-01-28 |
Celltech R&D Ltd |
Biological products
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
US7557197B2
(en)
|
2004-01-28 |
2009-07-07 |
Oregon Health & Science University |
Human soluble neuropilin-1 primary polyadenylation signal and uses thereof
|
US8383575B2
(en)
|
2004-01-30 |
2013-02-26 |
Paul Scherrer Institut |
(DI)barnase-barstar complexes
|
US8685435B2
(en)
|
2004-04-30 |
2014-04-01 |
Allergan, Inc. |
Extended release biodegradable ocular implants
|
EP1751181B1
(en)
|
2004-06-02 |
2012-08-15 |
AdAlta Pty Ltd |
BINDING MOIETIES BASED ON SHARK IgNAR DOMAINS
|
EP1786918A4
(en)
|
2004-07-17 |
2009-02-11 |
Imclone Systems Inc |
Novel tetravalent bispecific antibody
|
US20060040354A1
(en)
|
2004-07-20 |
2006-02-23 |
O'keefe Theresa L |
Novel polyadenylation signal for use in expression vectors
|
JP2008511337A
(en)
|
2004-09-02 |
2008-04-17 |
ジェネンテック・インコーポレーテッド |
Heteromultimeric molecule
|
EP1848672A4
(en)
|
2005-02-01 |
2009-11-04 |
Morphosys Ag |
Libraries and methods for isolating antibodies
|
ES2592271T3
(en)
|
2005-03-31 |
2016-11-29 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide production methods by regulating the association of polypeptides
|
JP5011277B2
(en)
|
2005-04-06 |
2012-08-29 |
アイビーシー・ファーマシューティカルズ・インコーポレーテッド |
Methods and uses for generating stably linked complexes consisting of homodimers, homotetramers or dimeric dimers
|
WO2006113665A2
(en)
|
2005-04-15 |
2006-10-26 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US20060263367A1
(en)
|
2005-05-23 |
2006-11-23 |
Fey Georg H |
Bispecific antibody devoid of Fc region and method of treatment using same
|
MX2007015942A
(en)
|
2005-07-01 |
2008-03-07 |
Medarex Inc |
Human monoclonal antibodies to programmed death ligand 1 (pd-l1).
|
EP1913149A4
(en)
|
2005-07-26 |
2009-08-05 |
Sangamo Biosciences Inc |
Targeted integration and expression of exogenous nucleic acid sequences
|
BRPI0615026A8
(en)
|
2005-08-19 |
2018-03-06 |
Abbott Lab |
double variable domain immunoglobulin and its uses
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
DE602005018477D1
(en)
|
2005-08-26 |
2010-02-04 |
Pls Design Gmbh |
Bivalent IgY antibody constructs for diagnostic and therapeutic applications
|
WO2007044887A2
(en)
|
2005-10-11 |
2007-04-19 |
Transtarget, Inc. |
Method for producing a population of homogenous tetravalent bispecific antibodies
|
CA2625619A1
(en)
|
2005-10-14 |
2007-04-26 |
Medimmune, Inc. |
Cell display of antibody libraries
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
WO2007062466A1
(en)
|
2005-11-29 |
2007-06-07 |
The University Of Sydney |
Demibodies: dimerisation-activated therapeutic agents
|
AU2007215013A1
(en)
|
2006-02-15 |
2007-08-23 |
Imclone Systems Incorporated |
Functional antibodies
|
JP5374359B2
(en)
|
2006-03-17 |
2013-12-25 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
Stabilized polypeptide compounds
|
US9315578B2
(en)
|
2006-03-23 |
2016-04-19 |
Tohoku Univeristy |
High functional bispecific antibody
|
US8946391B2
(en)
|
2006-03-24 |
2015-02-03 |
The Regents Of The University Of California |
Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition
|
AR060070A1
(en)
|
2006-03-24 |
2008-05-21 |
Merck Patent Gmbh |
HETERODYMERIC PROTEIN DOMAINS OBTAINED BY ENGINEERING
|
EP4218801A3
(en)
|
2006-03-31 |
2023-08-23 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
EP2799449A1
(en)
|
2006-05-25 |
2014-11-05 |
Bayer Intellectual Property GmbH |
Dimeric molecular complexes
|
US20070274985A1
(en)
|
2006-05-26 |
2007-11-29 |
Stefan Dubel |
Antibody
|
CA3149553C
(en)
|
2006-06-12 |
2023-11-21 |
Aptevo Research And Development Llc |
Single-chain multivalent binding proteins with effector function
|
US8759297B2
(en)
|
2006-08-18 |
2014-06-24 |
Armagen Technologies, Inc. |
Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
|
EP2471816A1
(en)
|
2006-08-30 |
2012-07-04 |
Genentech, Inc. |
Multispecific antibodies
|
EP2078040B1
(en)
|
2006-11-02 |
2017-06-28 |
Daniel J. Capon |
Methods of producing hybrid polypeptides with moving parts
|
WO2008119353A1
(en)
|
2007-03-29 |
2008-10-09 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
US20080260738A1
(en)
|
2007-04-18 |
2008-10-23 |
Moore Margaret D |
Single chain fc, methods of making and methods of treatment
|
US20090155275A1
(en)
|
2007-07-31 |
2009-06-18 |
Medimmune, Llc |
Multispecific epitope binding proteins and uses thereof
|
US9624309B2
(en)
|
2007-08-15 |
2017-04-18 |
Bayer Intellectual Property Gmbh |
Monospecific and multispecific antibodies and method of use
|
CA2964398C
(en)
|
2007-09-14 |
2023-03-07 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
US7947495B2
(en)
|
2007-11-01 |
2011-05-24 |
Abbott Biotherapeutics Corp. |
Immunoglobulin display vectors
|
US20110189203A1
(en)
|
2007-11-27 |
2011-08-04 |
Ablynx N.V. |
Immunoglobulin constructs
|
ES2614284T3
(en)
|
2007-11-30 |
2017-05-30 |
Glaxo Group Limited |
Antigen binding constructs
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
EP2235064B1
(en)
|
2008-01-07 |
2015-11-25 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
WO2009089295A2
(en)
|
2008-01-07 |
2009-07-16 |
Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Anti-hiv domain antibodies and method of making and using same
|
DE102008010362A1
(en)
|
2008-02-18 |
2009-08-20 |
Florian Prof. Dr. Lang |
Sgk1 as a therapeutic and diagnostic target for viral diseases
|
WO2009132287A2
(en)
|
2008-04-24 |
2009-10-29 |
Dyax Corp. |
Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
|
US8735331B2
(en)
|
2008-09-10 |
2014-05-27 |
Philochem Ag |
Display library for antibody selection
|
PL2342226T3
(en)
*
|
2008-09-26 |
2017-01-31 |
Dana-Farber Cancer Institute, Inc. |
Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses thereof
|
EP2424567B1
(en)
|
2009-04-27 |
2018-11-21 |
OncoMed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
CN102625848A
(en)
|
2009-07-17 |
2012-08-01 |
生物蛋白有限公司 |
Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
|
WO2011034605A2
(en)
|
2009-09-16 |
2011-03-24 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
KR101930964B1
(en)
|
2010-04-20 |
2018-12-19 |
젠맵 에이/에스 |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
DK3336225T3
(en)
|
2010-07-16 |
2020-03-30 |
Adimab Llc |
ANTIBODY LIBRARIES
|
CN102760801B
(en)
|
2011-04-29 |
2015-04-01 |
清华大学 |
Preparation method of light-emitting diode
|
EP3939613A1
(en)
|
2011-08-11 |
2022-01-19 |
ONO Pharmaceutical Co., Ltd. |
Therapeutic agent for autoimmune diseases comprising pd-1 agonist
|
EP3674320A3
(en)
|
2011-10-27 |
2020-08-12 |
Genmab A/S |
Production of heterodimeric proteins
|
EP2890715B1
(en)
|
2012-08-03 |
2020-12-16 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-pd-l1 and pd-l2 dual binding antibodies and methods of use
|
KR102229873B1
(en)
*
|
2012-10-12 |
2021-03-19 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
Enhancement of the immune response
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
MX2015011095A
(en)
|
2013-02-26 |
2016-03-11 |
Sloan Kettering Inst Cancer |
Compositions and methods for immunotherapy.
|
RS60826B1
(en)
|
2013-07-16 |
2020-10-30 |
Hoffmann La Roche |
Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
|
BR112016015140A2
(en)
|
2013-12-30 |
2018-01-23 |
Epimab Biotherapeutics Inc. |
tandem-fab immunoglobulin and its uses
|
WO2015103602A1
(en)
|
2014-01-06 |
2015-07-09 |
The Trustees Of The University Of Pennsylvania |
Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
|
US10927154B2
(en)
|
2014-01-13 |
2021-02-23 |
Pieris Pharmaceuticals Gmbh |
Multi-specific polypeptide useful for localized tumor immunomodulation
|
TWI681969B
(en)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
Human antibodies to pd-1
|
ES2783026T3
(en)
|
2014-02-04 |
2020-09-16 |
Pfizer |
Combination of a PD-1 antagonist and a 4-1BB agonist for the treatment of cancer
|
US9300829B2
(en)
|
2014-04-04 |
2016-03-29 |
Canon Kabushiki Kaisha |
Image reading apparatus and correction method thereof
|
DK3149042T3
(en)
|
2014-05-29 |
2019-11-04 |
Spring Bioscience Corp |
PD-L1 antibodies and uses thereof
|
CN110964108B
(en)
|
2014-08-05 |
2023-07-07 |
中美冠科生物技术(太仓)有限公司 |
anti-PD-L1 antibodies
|
JP6586454B2
(en)
|
2014-08-14 |
2019-10-02 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Combination therapy of an antibody that activates human CD40 and an antibody against human PD-L1
|
WO2016029073A2
(en)
|
2014-08-22 |
2016-02-25 |
Bristol-Myers Squibb Company |
Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
|
WO2016030455A1
(en)
|
2014-08-28 |
2016-03-03 |
Medimmune Limited |
Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer
|
UY36351A
(en)
*
|
2014-10-14 |
2016-06-01 |
Novartis Ag |
ANTIBODY MOLECULES THAT JOIN PD-L1 AND USES OF THE SAME
|
BR112017015136A2
(en)
|
2015-01-14 |
2018-01-30 |
Compass Therapeutics Llc |
multispecific immunomodulator antigen binding construct polypeptide, multispecific immunomodulator antigen binding construct, conjugate, pharmaceutical composition, method for treating an individual with cancer, method for inhibiting or reducing cancer growth, composition, cell, method of making a polypeptide of multispecific immunomodulatory antigen binding construct, vector or vector set and kit
|
SG11201708223QA
(en)
|
2015-04-17 |
2017-11-29 |
Bristol Myers Squibb Co |
Compositions comprising a combination of an anti-pd-1 antibody and another antibody
|
US9861621B2
(en)
|
2015-06-29 |
2018-01-09 |
Biomed Valley Discoveries, Inc. |
LPT-723 and immune checkpoint inhibitor combinations and methods of treatment
|
CA2998589A1
(en)
|
2015-09-14 |
2017-03-23 |
Compass Therapeutics Llc |
Compositions and methods for treating cancer via antagonism of the cd155/tigit pathway and tgf-.beta.
|
PE20181349A1
(en)
|
2015-10-07 |
2018-08-22 |
Hoffmann La Roche |
BIESPECIFIC ANTIBODIES WITH TETRAVALENCE FOR A CO-STIMULATING FNT RECEIVER
|
JP2019503349A
(en)
*
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Antibody molecules against PD-1 and uses thereof
|
AU2017207480A1
(en)
|
2016-01-13 |
2018-08-02 |
Compass Therapeutics Llc |
Multispecific immunomodulatory antigen-binding constructs
|
MX2018009581A
(en)
|
2016-02-06 |
2019-05-06 |
Epimab Biotherapeutics Inc |
Fabs-in-tandem immunoglobulin and uses thereof.
|
CN109072191B
(en)
|
2016-04-04 |
2024-03-22 |
苏黎世联邦理工学院 |
Mammalian cell lines for protein production and library generation
|
AR108377A1
(en)
|
2016-05-06 |
2018-08-15 |
Medimmune Llc |
BISPECIFIC UNION PROTEINS AND ITS USES
|
PE20190510A1
(en)
|
2016-06-13 |
2019-04-10 |
I Mab |
ANTI-PD-L1 ANTIBODIES AND USES OF THE SAME
|
KR102629905B1
(en)
*
|
2017-04-01 |
2024-01-30 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
Anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof
|
CN111094347A
(en)
*
|
2017-07-06 |
2020-05-01 |
美勒斯公司 |
Binding molecules that modulate biological activity expressed by cells
|
WO2020006605A1
(en)
|
2018-07-04 |
2020-01-09 |
Honeycomb Media Pty Ltd |
Method and system for providing incentives to users
|