MX2019000225A - Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. - Google Patents
Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.Info
- Publication number
- MX2019000225A MX2019000225A MX2019000225A MX2019000225A MX2019000225A MX 2019000225 A MX2019000225 A MX 2019000225A MX 2019000225 A MX2019000225 A MX 2019000225A MX 2019000225 A MX2019000225 A MX 2019000225A MX 2019000225 A MX2019000225 A MX 2019000225A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- treatment
- disease
- autoimmune
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se proporcionan métodos que se relación con el uso conjugados de CDP-agente terapéutico para el tratamiento de la enfermedad autoinmune, enfermedad inflamatoria, o cáncer. Se proporcionan, además, conjugados de CDP-agente terapéutico, partículas que comprenden los conjugados de CDP-agente terapéutico, y composiciones que comprenden los conjugados de CDP-agente terapéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34564110P | 2010-05-18 | 2010-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019000225A true MX2019000225A (es) | 2019-05-15 |
Family
ID=44992046
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013100A MX2012013100A (es) | 2010-05-18 | 2011-05-18 | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
MX2019000225A MX2019000225A (es) | 2010-05-18 | 2012-11-09 | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013100A MX2012013100A (es) | 2010-05-18 | 2011-05-18 | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20110300150A1 (es) |
EP (2) | EP3566719A1 (es) |
JP (2) | JP5881254B2 (es) |
CN (2) | CN103037903A (es) |
AU (2) | AU2011255647A1 (es) |
CA (2) | CA2799202C (es) |
EA (1) | EA035193B1 (es) |
IL (2) | IL222800A0 (es) |
MX (2) | MX2012013100A (es) |
WO (1) | WO2011146638A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120104412A (ko) | 2002-09-06 | 2012-09-20 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
US20120064107A1 (en) * | 2010-05-18 | 2012-03-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other disease |
JP2015505557A (ja) * | 2012-01-31 | 2015-02-23 | セルリアン・ファーマ・インコーポレイテッド | 治療的送達のためのシクロデキストリンに基づく重合体 |
JP2015505559A (ja) * | 2012-01-31 | 2015-02-23 | セルリアン・ファーマ・インコーポレイテッド | 治療剤送達のためのシクロデキストリン系ポリマー |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
NZ746440A (en) | 2012-10-11 | 2019-11-29 | Daiichi Sankyo Co Ltd | Glycinamide derivatives and production methods thereof |
WO2014061277A1 (ja) | 2012-10-19 | 2014-04-24 | 第一三共株式会社 | 親水性構造を含むリンカーで結合させた抗体-薬物コンジュゲート |
CN103012672B (zh) * | 2012-12-27 | 2014-08-06 | 西北师范大学 | 具有抗肿瘤活性的五氟尿嘧啶共聚物及其制备方法 |
WO2014161072A1 (en) * | 2013-04-02 | 2014-10-09 | The Governing Council Of The University Of Toronto | Α-boryl isocyanides, boropeptides and boron heterocycles |
SG11201509026VA (en) * | 2013-05-02 | 2015-12-30 | Hoffmann La Roche | Combination therapy of an afucosylated cd20 antibody with a cd22 antibody-drug conjugate |
US9572832B2 (en) * | 2013-08-29 | 2017-02-21 | Holy Stone Healthcare Co., Ltd. | Compound of glycosaminoglycan and its fabrication method as well as application |
WO2015095784A1 (en) * | 2013-12-19 | 2015-06-25 | Luminus Biosciences, Inc. | Solid nanoparticle formulation of microtubule inhibitors with reduced ostwald ripening for oral administration |
AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
EP3973995A1 (en) | 2014-01-31 | 2022-03-30 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
JP6612738B2 (ja) | 2014-04-10 | 2019-11-27 | 第一三共株式会社 | 抗her2抗体−薬物コンジュゲート |
NZ722668A (en) | 2014-04-10 | 2024-02-23 | Daiichi Sankyo Europe Gmbh | Anti-her3 antibody-drug conjugate |
KR20180021723A (ko) | 2015-06-29 | 2018-03-05 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 선택적 제조 방법 |
MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
WO2018110515A1 (ja) | 2016-12-12 | 2018-06-21 | 第一三共株式会社 | 抗体-薬物コンジュゲートと免疫チェックポイント阻害剤の組み合わせ |
MX2019008059A (es) | 2017-01-17 | 2019-12-11 | Daiichi Sankyo Co Ltd | Anticuerpo anti-gpr20 y conjugado de anticuerpo-medicamento anti-gpr20. |
TWI794230B (zh) | 2017-05-15 | 2023-03-01 | 日商第一三共股份有限公司 | 抗cdh6抗體及抗cdh6抗體-藥物結合物、以及其製造方法 |
US11318212B2 (en) | 2017-08-31 | 2022-05-03 | Daiichi Sankyo Company, Limited | Method for producing antibody-drug conjugate |
CN111051330A (zh) | 2017-08-31 | 2020-04-21 | 第一三共株式会社 | 抗体-药物缀合物的改进制备方法 |
CN111417410B (zh) | 2017-12-01 | 2023-06-23 | 艾伯维公司 | 糖皮质激素受体激动剂及其免疫缀合物 |
EP3794041B1 (en) | 2018-05-18 | 2023-07-12 | Glycotope GmbH | Anti-muc1 antibody |
CN115109258A (zh) * | 2021-03-19 | 2022-09-27 | 江西中医药大学 | 7-乙基-10-羟基喜树碱聚合物、制备方法及其应用 |
Family Cites Families (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE37983T1 (de) | 1982-04-22 | 1988-11-15 | Ici Plc | Mittel mit verzoegerter freigabe. |
US4438253A (en) | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
ES2058081T3 (es) | 1986-09-05 | 1994-11-01 | American Cyanamid Co | Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. |
JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
IE910713A1 (en) | 1990-03-05 | 1991-09-11 | Cephalon Inc | Chymotrypsin-like proteases |
FR2665169A1 (fr) | 1990-07-30 | 1992-01-31 | Rhone Poulenc Chimie | Composes d'inclusion de cyclodextrines enfermant des antioxydants phenoliques et leur utilisation dans les polymeres. |
US5330768A (en) | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
EP1808183A3 (en) * | 1993-09-08 | 2009-07-01 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
JP3699141B2 (ja) * | 1994-09-24 | 2005-09-28 | 伸彦 由井 | 超分子構造の生体内分解性医薬高分子集合体及びその調製方法 |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
ES2206607T3 (es) | 1995-11-17 | 2004-05-16 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Derivados de epotilones, preparacion y utilizacion. |
US5969145A (en) | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
CA2264908C (en) | 1996-09-06 | 2006-04-25 | Obducat Ab | Method for anisotropic etching of structures in conducting materials |
DE59712968D1 (de) | 1996-11-18 | 2008-10-30 | Biotechnolog Forschung Gmbh | Epothilone E und F |
AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6320045B1 (en) | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
US6280999B1 (en) | 1998-01-23 | 2001-08-28 | Kosan Bioscience | Sorangium polyketide synthases and encoding DNA therefor |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US6302838B1 (en) | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
US6380395B1 (en) | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6121029A (en) | 1998-06-18 | 2000-09-19 | Novartis Ag | Genes for the biosynthesis of epothilones |
US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
US7091192B1 (en) | 1998-07-01 | 2006-08-15 | California Institute Of Technology | Linear cyclodextrin copolymers |
DE19848306A1 (de) | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
KR100716272B1 (ko) | 1998-11-20 | 2007-05-09 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
PT1140944E (pt) | 1998-12-22 | 2004-01-30 | Novartis Pharma Gmbh | Derivados de epotilona e sua utilizacao como agentes antitumorais |
US6780620B1 (en) | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
SK11452001A3 (sk) | 1999-02-11 | 2002-04-04 | Schering Aktiengesellschaft | Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie |
GEP20033067B (en) | 1999-02-22 | 2003-09-25 | Bristol Myers Squibb Co | C-21 Modified Epothilones |
CA2368658A1 (en) | 1999-03-29 | 2000-10-05 | Soong-Hoon Kim | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
US6291684B1 (en) | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
PE20010116A1 (es) | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
WO2001007439A2 (en) | 1999-07-22 | 2001-02-01 | Schering Aktiengesellschaft | Process for the production of epothiolone b and derivatives as well as intermediate products for this process |
GB9918429D0 (en) | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
AU7662600A (en) | 1999-10-08 | 2001-04-23 | Novartis Ag | 13-alkyl epothilone derivatives |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
WO2001074382A1 (en) | 2000-03-31 | 2001-10-11 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
US8618085B2 (en) | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
US6489314B1 (en) | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
US6589968B2 (en) | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
WO2001092255A2 (en) | 2000-05-26 | 2001-12-06 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
AU7902501A (en) | 2000-07-25 | 2002-02-05 | Kosan Biosciences Inc | Fermentation process for epothilones |
AU2001283275A1 (en) | 2000-08-09 | 2002-02-18 | Kosan Biosciences, Inc. | Bio-intermediates for use in the chemical synthesis of polyketides |
DE10134172A1 (de) | 2001-07-13 | 2003-01-23 | Morphochem Ag | Epothilone-Synthesebausteine IV:Unsymmetrisch substituierte Acyloine und Acyloinderivate und Verfahren zu deren Herstellung |
DE10051136A1 (de) | 2000-10-16 | 2002-04-18 | Ludger A Wessjohann | Epothilone-Synthesebausteine III und Verfahren zur Herstellung von Epothilon B, D und Epothilonderivaten |
WO2002042432A2 (en) | 2000-11-22 | 2002-05-30 | Novartis Ag | Epothilone resistant cell lines |
GB0029895D0 (en) | 2000-12-07 | 2001-01-24 | Novartis Ag | Organic compounds |
SK288098B6 (sk) | 2001-01-25 | 2013-07-02 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
EP3078667B1 (en) | 2001-01-25 | 2018-11-21 | The United States of America, represented by the Secretary, Department of Health and Human Services | Formulation of boronic acid compounds |
KR20030071853A (ko) | 2001-01-25 | 2003-09-06 | 브리스톨-마이어스스퀴브컴파니 | 에포틸론 유사체를 함유한 비경구용 제제 |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
EE200300397A (et) | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaadid refraktaarsete kasvajate raviks |
RU2003128311A (ru) | 2001-02-20 | 2005-03-10 | Бристол-Маерс Сквибб Компани (Us) | Способ лечения резистентных опухолей с применением аналогов эпотилона |
WO2002067941A2 (en) | 2001-02-27 | 2002-09-06 | Novartis Ag | Combination comprising a signal transduction inhibitor and an epothilone derivative |
WO2002072085A1 (en) | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
WO2002074042A2 (en) | 2001-03-19 | 2002-09-26 | Novartis Ag | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative |
TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
PT1420780E (pt) | 2001-08-23 | 2008-12-29 | Novartis Ag | Análogos ciclopropilados e ciclobutilados da epotilona |
WO2003042217A2 (en) | 2001-11-15 | 2003-05-22 | Kosan Biosciences, Inc. | Method for making epothilone compounds by bioconversion with microorganisms |
WO2003045324A2 (en) | 2001-11-26 | 2003-06-05 | Kosan Biosciences, Inc. | 14-methyl-epothilones |
TWI287986B (en) | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
IL162595A0 (en) | 2002-01-14 | 2005-11-20 | Novartis Ag | Combinations comprising epothilones and antimetabolites |
AU2003239121A1 (en) | 2002-02-22 | 2003-09-09 | Insert Therapeutics, Inc. | Carbohydrate-modified polymers, compositions and uses related thereto |
ATE380861T1 (de) | 2002-02-25 | 2007-12-15 | Kosan Biosciences Inc | Modulation der verteilung artverwandter sekundärer metaboliten |
CN1939299A (zh) | 2002-03-08 | 2007-04-04 | 诺瓦提斯公司 | 包含埃坡霉素衍生物和烷化剂的组合 |
US6719540B2 (en) | 2002-03-12 | 2004-04-13 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
WO2003077903A1 (en) | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
TW200403994A (en) | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
EP1503756B1 (en) | 2002-05-01 | 2009-08-12 | Novartis AG | Epothilone derivative for the treatment of hepatoma and other cancer diseases |
TW200400191A (en) | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
JP2006514681A (ja) | 2002-05-20 | 2006-05-11 | コーザン バイオサイエンシス インコーポレイテッド | エポチロンdの投与方法 |
US7119071B2 (en) | 2002-05-21 | 2006-10-10 | University Of Medicine And Dentistry Of New Jersey | Amino terminal substance P compositions and methods for using the same |
CN101816792A (zh) | 2002-06-10 | 2010-09-01 | 诺瓦提斯公司 | 包含埃坡霉素的组合及其药学用途 |
DE10232094A1 (de) | 2002-07-15 | 2004-02-05 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | 5-Thiaepothilone und 15-disubstituierte Epothilone |
PT1546152E (pt) | 2002-08-02 | 2008-03-12 | Scripps Research Inst | Derivados de epotilona |
EP1562627A4 (en) * | 2002-08-23 | 2006-11-02 | Mclean Hospital Corp | CORTICOSTEROID CONJUGATES AND ITS USES |
CA2892003A1 (en) * | 2002-09-06 | 2004-03-18 | Cerulean Pharma Inc. | Modified cyclodextrin ring compounds having exactly two hydroxyl moieties substituted with an amino acid for therapeutics delivery |
US20040047835A1 (en) * | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
KR20120104412A (ko) * | 2002-09-06 | 2012-09-20 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
GB0221312D0 (en) | 2002-09-13 | 2002-10-23 | Novartis Ag | Organic compounds |
US7091193B2 (en) | 2002-10-09 | 2006-08-15 | Kosan Biosciences Incorporated | Therapeutic formulations |
EP1549269A4 (en) * | 2002-10-09 | 2010-10-06 | Cerulean Pharma Inc | CYCLODEXTRIN BASED MATERIALS, COMPOSITIONS AND ITS USE |
MXPA05003706A (es) | 2002-10-09 | 2005-07-01 | Kosan Biosciences Inc | Epo d+5-fu/gemcitabina. |
GB0230024D0 (en) | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
AU2003219947A1 (en) | 2003-02-26 | 2004-09-28 | Bristol-Myers Squibb Company | Compositions and methods for hydroxylating epothilones |
GB0305928D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
US7691838B2 (en) | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
MXPA06003835A (es) | 2003-10-09 | 2006-06-14 | Kosan Biosciences Inc | Formulaciones terapeuticas. |
US20050203174A1 (en) | 2004-03-09 | 2005-09-15 | Kosan Biosciences, Inc. | Combination therapies using leptomycin B |
US20050215604A1 (en) | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
DK3385267T3 (da) | 2004-03-30 | 2021-11-01 | Millennium Pharm Inc | Syntese af boronestere og syreforbindelser |
US20090004277A1 (en) | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
CN1988904A (zh) | 2004-07-26 | 2007-06-27 | 诺瓦提斯公司 | 埃坡霉素组合 |
ATE411053T1 (de) * | 2004-08-09 | 2008-10-15 | Deutsches Krebsforsch | Albuminkonjugate, die eine glucuron-verknüpfung enthalten |
JO2596B1 (en) | 2004-11-30 | 2011-02-27 | نوفارتيس ايه جي | Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses |
EP2325236A1 (en) | 2005-04-20 | 2011-05-25 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
KR20090005310A (ko) | 2006-04-05 | 2009-01-13 | 노파르티스 아게 | 암을 치료하기 위한 치료제의 조합물 |
PE20080316A1 (es) | 2006-05-25 | 2008-04-10 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
KR20090038902A (ko) | 2006-08-16 | 2009-04-21 | 노파르티스 아게 | 에포틸론 b의 결정 형태 및 제약 조성물에서의 용도 |
EP1930004A1 (en) | 2006-12-08 | 2008-06-11 | Bayer Schering Pharma Aktiengesellschaft | Use of epothilones in the treatment of osteoporosis and related diseases |
TWI528976B (zh) * | 2006-12-13 | 2016-04-11 | 斯茹林製藥公司 | 用於醫物傳遞之以環糊精為基之聚合物 |
KR20090082486A (ko) | 2006-12-14 | 2009-07-30 | 노파르티스 아게 | 항암성 약물로서 c12-c13 위치에서 개질된 에포틸론 유사체 |
JP2010516625A (ja) * | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
US8030503B2 (en) | 2007-05-11 | 2011-10-04 | Kosan Biosciences Incorporated | Process for the preparation of epothilones |
EP2009114A1 (en) | 2007-06-29 | 2008-12-31 | Bayer Schering Pharma Aktiengesellschaft | Methods, kits, and compounds for determining responsiveness to treatment of a pathological disorder by epothilones |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
US7838673B2 (en) | 2007-10-16 | 2010-11-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
US8410305B2 (en) | 2007-11-12 | 2013-04-02 | Kosan Biosciences Incorporated | Intermediates and methods for the preparation of epothilones |
DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
US20110152512A1 (en) * | 2009-09-09 | 2011-06-23 | John Ryan | Cyclodextrin-based polymers for therapeutics delivery |
CN102781237A (zh) * | 2009-11-23 | 2012-11-14 | 天蓝制药公司 | 用于传递治疗剂的基于环糊精的聚合物 |
-
2011
- 2011-05-18 CA CA2799202A patent/CA2799202C/en not_active Expired - Fee Related
- 2011-05-18 US US13/110,606 patent/US20110300150A1/en not_active Abandoned
- 2011-05-18 EA EA201201400A patent/EA035193B1/ru not_active IP Right Cessation
- 2011-05-18 MX MX2012013100A patent/MX2012013100A/es unknown
- 2011-05-18 CN CN2011800231439A patent/CN103037903A/zh active Pending
- 2011-05-18 AU AU2011255647A patent/AU2011255647A1/en not_active Abandoned
- 2011-05-18 JP JP2013510367A patent/JP5881254B2/ja not_active Expired - Fee Related
- 2011-05-18 EP EP19165905.1A patent/EP3566719A1/en not_active Withdrawn
- 2011-05-18 EP EP11784186.6A patent/EP2571525A4/en not_active Withdrawn
- 2011-05-18 CN CN201610243765.7A patent/CN105797168A/zh active Pending
- 2011-05-18 CA CA2927832A patent/CA2927832C/en not_active Expired - Fee Related
- 2011-05-18 WO PCT/US2011/037025 patent/WO2011146638A1/en active Application Filing
-
2012
- 2012-11-01 IL IL222800A patent/IL222800A0/en unknown
- 2012-11-09 MX MX2019000225A patent/MX2019000225A/es unknown
-
2014
- 2014-07-18 JP JP2014147399A patent/JP2014196359A/ja active Pending
-
2015
- 2015-02-17 AU AU2015200791A patent/AU2015200791A1/en not_active Abandoned
-
2019
- 2019-05-30 IL IL267014A patent/IL267014A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2571525A4 (en) | 2016-04-27 |
AU2015200791A1 (en) | 2015-03-12 |
EP3566719A1 (en) | 2019-11-13 |
CA2799202A1 (en) | 2011-11-24 |
JP5881254B2 (ja) | 2016-03-09 |
IL222800A0 (en) | 2012-12-31 |
CA2927832C (en) | 2021-03-23 |
CA2927832A1 (en) | 2011-11-24 |
EP2571525A1 (en) | 2013-03-27 |
CA2799202C (en) | 2016-07-05 |
WO2011146638A1 (en) | 2011-11-24 |
IL267014A (en) | 2019-07-31 |
CN105797168A (zh) | 2016-07-27 |
JP2013526549A (ja) | 2013-06-24 |
CN103037903A (zh) | 2013-04-10 |
JP2014196359A (ja) | 2014-10-16 |
MX2012013100A (es) | 2013-01-22 |
US20110300150A1 (en) | 2011-12-08 |
EA035193B1 (ru) | 2020-05-14 |
AU2011255647A1 (en) | 2012-11-15 |
EA201201400A1 (ru) | 2013-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019000225A (es) | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. | |
UA109464C2 (uk) | Спірооксіндольні антагоністи mdm2 | |
TN2012000161A1 (en) | Spiro-oxindole mdm2 antagonists | |
PH12014501815A1 (en) | Purinone compounds as kinase inhibitors | |
IN2012MN02591A (es) | ||
WO2012088266A3 (en) | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 | |
MX2020012426A (es) | Anticuerpos anti-cd38. | |
MX2016008448A (es) | Conjugados de var2csa-farmaco. | |
MX350200B (es) | Anticuerpos humanos y conjugados de anticuerpo-farmaco contra cd74. | |
TN2012000414A1 (en) | Forms of rifaximin and uses thereof | |
EP2569330A4 (en) | CHLOROTOXINE VARIANTS, CONJUGATES, AND METHODS OF USE THEREOF | |
MX366804B (es) | Translocaciones de la r-espondina y sus metodos de uso. | |
MX359639B (es) | Metodos y composiciones para uso en tratamientos celulares. | |
TN2012000611A1 (en) | Formulations of rifaximin and uses thereof | |
MX2012010434A (es) | Compuestos y composiciones novedosas para atacar a las celulas madre del cancer. | |
MX347734B (es) | Anticuerpos anti-s100a4 y usos aplicaciones terapéuticas. | |
MX2011014019A (es) | Derivados de diazahomoadamantano y sus metodos de uso. | |
WO2012061390A3 (en) | Therapeutic compositions and methods | |
MX357166B (es) | Anticuerpos que se unen a notum pectinacetilesterasa. | |
IN2015MN00001A (es) | ||
EP2576575A4 (en) | PROSTAGLANDIN-BISPHOSPHONATE CONJUGATE COMPOUNDS, THEIR METHODS OF MANUFACTURE AND USES THEREOF | |
MX363385B (es) | Métodos para el tratamiento de enfermedad de células falciformes y otras condiciones inflamatorias. | |
WO2011130697A3 (en) | Tissue targeting | |
MX342239B (es) | Composiciones y metodos para el diagnostico y tratamiento de tumores. | |
MX2013003859A (es) | Polimorfos de picropodofilina b o c para su uso en la terapia del cancer. |