PT1420780E - Análogos ciclopropilados e ciclobutilados da epotilona - Google Patents
Análogos ciclopropilados e ciclobutilados da epotilona Download PDFInfo
- Publication number
- PT1420780E PT1420780E PT02767418T PT02767418T PT1420780E PT 1420780 E PT1420780 E PT 1420780E PT 02767418 T PT02767418 T PT 02767418T PT 02767418 T PT02767418 T PT 02767418T PT 1420780 E PT1420780 E PT 1420780E
- Authority
- PT
- Portugal
- Prior art keywords
- cyclopropyl
- cyclobutyl
- epothilone analogs
- compounds
- cyclobutyl epothilone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31469801P | 2001-08-23 | 2001-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1420780E true PT1420780E (pt) | 2008-12-29 |
Family
ID=23221047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02767418T PT1420780E (pt) | 2001-08-23 | 2002-08-22 | Análogos ciclopropilados e ciclobutilados da epotilona |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7358266B2 (pt) |
| EP (2) | EP2070534A3 (pt) |
| JP (2) | JP4176015B2 (pt) |
| CN (1) | CN100536841C (pt) |
| AT (1) | ATE409473T1 (pt) |
| AU (1) | AU2002331171A1 (pt) |
| BR (1) | BR0212107A (pt) |
| CA (1) | CA2456280A1 (pt) |
| DE (1) | DE60229143D1 (pt) |
| ES (1) | ES2315399T3 (pt) |
| HK (1) | HK1066464A1 (pt) |
| PT (1) | PT1420780E (pt) |
| WO (1) | WO2003018002A2 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| PT1420780E (pt) * | 2001-08-23 | 2008-12-29 | Novartis Ag | Análogos ciclopropilados e ciclobutilados da epotilona |
| ES2297189T3 (es) * | 2002-08-02 | 2008-05-01 | Novartis Ag | Derivados de epotilona. |
| JP4791183B2 (ja) * | 2002-08-23 | 2011-10-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体、類似体の合成およびその使用 |
| US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7384964B2 (en) * | 2002-08-23 | 2008-06-10 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20050171167A1 (en) | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| GB0405898D0 (en) * | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| CN101535492A (zh) | 2005-02-11 | 2009-09-16 | 南加州大学 | 表达含有二硫键的蛋白质的方法 |
| CN101360494A (zh) * | 2005-11-22 | 2009-02-04 | 斯克里普斯研究学院 | 高效埃博霉素的化学合成 |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| JP5115729B2 (ja) * | 2008-06-20 | 2013-01-09 | 信越化学工業株式会社 | トリアルキルシリル基で保護されたアセト酢酸エステル基含有有機ケイ素化合物及びその製造方法 |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| AU2011255647A1 (en) | 2010-05-18 | 2012-11-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| CN115850224A (zh) * | 2022-07-22 | 2023-03-28 | 北京先通国际医药科技股份有限公司 | 一种修饰长链脂肪酸型pet试剂前体的合成方法及其用途 |
| CN115141087B (zh) * | 2022-09-06 | 2023-03-24 | 北京先通国际医药科技股份有限公司 | Pet前体关键中间体的异构体的合成方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380395B1 (en) * | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
| DE19848306A1 (de) * | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
| SK11452001A3 (sk) * | 1999-02-11 | 2002-04-04 | Schering Aktiengesellschaft | Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie |
| PT1420780E (pt) * | 2001-08-23 | 2008-12-29 | Novartis Ag | Análogos ciclopropilados e ciclobutilados da epotilona |
-
2002
- 2002-08-22 PT PT02767418T patent/PT1420780E/pt unknown
- 2002-08-22 CA CA002456280A patent/CA2456280A1/en not_active Abandoned
- 2002-08-22 AT AT02767418T patent/ATE409473T1/de not_active IP Right Cessation
- 2002-08-22 ES ES02767418T patent/ES2315399T3/es not_active Expired - Lifetime
- 2002-08-22 DE DE60229143T patent/DE60229143D1/de not_active Expired - Fee Related
- 2002-08-22 EP EP08165542A patent/EP2070534A3/en not_active Withdrawn
- 2002-08-22 BR BR0212107-7A patent/BR0212107A/pt not_active IP Right Cessation
- 2002-08-22 WO PCT/EP2002/009407 patent/WO2003018002A2/en active IP Right Grant
- 2002-08-22 CN CNB028164415A patent/CN100536841C/zh not_active Expired - Fee Related
- 2002-08-22 EP EP02767418A patent/EP1420780B1/en not_active Expired - Lifetime
- 2002-08-22 JP JP2003522522A patent/JP4176015B2/ja not_active Expired - Fee Related
- 2002-08-22 AU AU2002331171A patent/AU2002331171A1/en not_active Abandoned
- 2002-08-23 US US10/227,073 patent/US7358266B2/en not_active Expired - Fee Related
-
2004
- 2004-11-25 HK HK04109321.7A patent/HK1066464A1/xx not_active IP Right Cessation
-
2008
- 2008-07-15 JP JP2008183765A patent/JP2009007367A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003018002A3 (en) | 2003-09-04 |
| US20040039026A1 (en) | 2004-02-26 |
| EP2070534A2 (en) | 2009-06-17 |
| US7358266B2 (en) | 2008-04-15 |
| JP2005501107A (ja) | 2005-01-13 |
| ATE409473T1 (de) | 2008-10-15 |
| CN1545411A (zh) | 2004-11-10 |
| ES2315399T3 (es) | 2009-04-01 |
| CA2456280A1 (en) | 2003-03-06 |
| HK1066464A1 (en) | 2005-03-24 |
| WO2003018002A2 (en) | 2003-03-06 |
| CN100536841C (zh) | 2009-09-09 |
| DE60229143D1 (en) | 2008-11-13 |
| EP1420780A2 (en) | 2004-05-26 |
| AU2002331171A1 (en) | 2003-03-10 |
| JP2009007367A (ja) | 2009-01-15 |
| EP2070534A3 (en) | 2009-08-26 |
| JP4176015B2 (ja) | 2008-11-05 |
| BR0212107A (pt) | 2004-08-24 |
| EP1420780B1 (en) | 2008-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1066464A1 (en) | Cyclopropyl and cyclobutyl epothilone analogs | |
| MXPA04000756A (es) | Nuevos compuestos. | |
| EP1256588A4 (en) | NEW PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THEIR SALTS AND INTERMEDIATES FOR BOTH PRODUCTION | |
| IL148384A0 (en) | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | |
| MY129422A (en) | Medicinal compounds | |
| WO2004026863A8 (en) | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors | |
| NO20051209L (no) | Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk anvendelse derav samt intermediater for samme | |
| ZA200604719B (en) | DPP-IV inhibitors | |
| MXPA04005099A (es) | Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento. | |
| HUT54357A (en) | Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients | |
| BG105137A (en) | Antiparasitic artemisinin derivatives (endoperoxides) | |
| DE60330407D1 (de) | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung | |
| MXPA04004548A (es) | Acidos heteroarilalalcanoicos substituidos y su uso como inhibidores de aldosa reductasa. | |
| GB0114004D0 (en) | Chemical compounds | |
| IL172290A0 (en) | Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain | |
| DK0826681T3 (da) | Epoxyravsyrederivater | |
| AU4811396A (en) | Substituted benzothienylpiperazines their use as medicaments, and processes for their preparation | |
| GB9912417D0 (en) | Compounds useful in therapy | |
| WO2004074249A3 (en) | Synthesis of peloruside a and analogs thereof for use as antitumor agents | |
| WO2005056000A3 (fr) | Substance neuroactive et utilisations d'une telle substance | |
| TH68162A (th) | อิมิดาโซควิโนลีนซึ่งถูกแทนที่ด้วยซัลโฟนามิโดอีเทอร์ |