ES2058081T3 - Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. - Google Patents

Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.

Info

Publication number
ES2058081T3
ES2058081T3 ES87112279T ES87112279T ES2058081T3 ES 2058081 T3 ES2058081 T3 ES 2058081T3 ES 87112279 T ES87112279 T ES 87112279T ES 87112279 T ES87112279 T ES 87112279T ES 2058081 T3 ES2058081 T3 ES 2058081T3
Authority
ES
Spain
Prior art keywords
alkylene oxide
medicines
administration
systems
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112279T
Other languages
English (en)
Inventor
Donald James Casey
Louis Rosati
Peter Kendrick Jarrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/903,801 external-priority patent/US4882168A/en
Priority claimed from US06/903,797 external-priority patent/US4716203A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2058081T3 publication Critical patent/ES2058081T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

LA INVENCION ES UN BLOQUE COPLIMERO ABA O AB ASI COMO UN SISTEMA DE LIBERACION DE FARMACOS DE LENTA LIBERACION QUE COMPRENDE UN FARMACO Y EL BLOQUE COPOLIMERO ABA O AB EN DONDE UN BLOQUE (B) EN UN POLI(ALQUILENE OXIDO) Y LOS OTROS BLOQUES (A) CONSTAN DE COPOLIMEROS DEGRADABLES AL AZAR DEL (1) ESTER CICLICO DE UN ACIDO ALFA-HIDROXI Y (2) UN SEGUNDO MONOMERO DE ESTER CICLICO CON LA CONDICION DE QUE EL SEGUNDO MONOMERO DE ESTER CICLICO NO SEA EL MISMO QUE EN EL PRIMER ESTER CICLICO.
ES87112279T 1986-09-05 1987-08-25 Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. Expired - Lifetime ES2058081T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/903,801 US4882168A (en) 1986-09-05 1986-09-05 Polyesters containing alkylene oxide blocks as drug delivery systems
US06/903,797 US4716203A (en) 1986-09-05 1986-09-05 Diblock and triblock copolymers

Publications (1)

Publication Number Publication Date
ES2058081T3 true ES2058081T3 (es) 1994-11-01

Family

ID=27129378

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87112279T Expired - Lifetime ES2058081T3 (es) 1986-09-05 1987-08-25 Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.

Country Status (13)

Country Link
EP (1) EP0258780B1 (es)
KR (1) KR880003985A (es)
AU (1) AU605172B2 (es)
BR (1) BR8704648A (es)
CA (1) CA1283988C (es)
DE (1) DE3786309T2 (es)
DK (1) DK462287A (es)
ES (1) ES2058081T3 (es)
FI (1) FI873840A (es)
GR (1) GR3008526T3 (es)
HU (1) HU205711B (es)
IL (1) IL83764A (es)
NZ (1) NZ221647A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9401703A (nl) * 1994-10-14 1996-05-01 Rijksuniversiteit Kauwgom.
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
CN1195788C (zh) * 1997-10-03 2005-04-06 麦克罗梅德公司 具有可逆热胶凝性质的可生物降解低分子量三嵌段聚(丙交酯－共聚－乙交酯)聚乙二醇共聚物
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
AU2002246028B2 (en) * 2001-03-23 2006-02-16 Gumlink A/S Degradable resin substitute for chewing gum
JP4354700B2 (ja) 2001-03-23 2009-10-28 ガムリンク エー／エス 改良された保存寿命を有する被覆された分解性チューインガムおよびその調製方法
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
DE60320224T2 (de) * 2002-02-15 2009-05-14 Nektar Therapeutics Al, Corp., Huntsville Hydrolytisch abbaubare polyalkylenoxid-polymere
CA2483778A1 (en) 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
CN1290893C (zh) * 2002-05-03 2006-12-20 詹森药业有限公司 聚合物微乳状液
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
KR101476067B1 (ko) 2002-09-06 2014-12-23 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
MXPA05002961A (es) 2002-09-24 2005-06-03 Gumlink As Goma de mascar que comprende al menos dos diferentes polimeros biodegradables.
AU2002342578B2 (en) 2002-09-24 2008-05-15 Gumlink A/S Biodegradable chewing gum comprising at least one high molecular weight biodegradable polymer
DE60323055D1 (de) 2003-05-06 2008-10-02 Gumlinck As Methode zur Herstellung von Kaugummigranulat und komprimierten Kaugummiprodukten, sowie ein Kaugummigranuliersystem
EP1474995B1 (en) 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
US8465537B2 (en) 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US8153591B2 (en) 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
AU2004296851A1 (en) 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
WO2009086483A2 (en) 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
WO2010057177A2 (en) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
MX366955B (es) 2009-09-15 2019-07-31 Bluelink Pharmaceuticals Inc Crlx101 para usarse en el tratamiento de cáncer.
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20230285576A1 (en) 2020-08-05 2023-09-14 Ellipses Pharma Ltd Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US4047533A (en) * 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4429080A (en) * 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same

Also Published As

Publication number Publication date
KR880003985A (ko) 1988-05-31
FI873840A0 (fi) 1987-09-04
HU205711B (en) 1992-06-29
HUT52945A (en) 1990-09-28
DE3786309T2 (de) 1994-02-10
GR3008526T3 (es) 1993-10-29
DE3786309D1 (de) 1993-07-29
EP0258780A3 (en) 1988-05-18
EP0258780B1 (en) 1993-06-23
BR8704648A (pt) 1988-04-26
EP0258780A2 (en) 1988-03-09
AU7797087A (en) 1988-03-10
DK462287A (da) 1988-03-06
FI873840A (fi) 1988-03-06
NZ221647A (en) 1990-09-26
DK462287D0 (da) 1987-09-04
IL83764A (en) 1991-05-12
IL83764A0 (en) 1988-02-29
AU605172B2 (en) 1991-01-10
CA1283988C (en) 1991-05-07

Similar Documents

Publication Publication Date Title
ES2058081T3 (es) Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.
ES2188787T3 (es) Compuesto medicamentoso de micela copolimera y metodo para su preparacion.
DK0644771T3 (da) Lægemiddelsystem til levering af erythropoietin
ES2039450T3 (es) Una composicion de recubrimiento en polvo termoendurecible.
ES2054750T3 (es) Estabilizantes de uv unidos a polimeros.
GB1415686A (en) Voided films
DE69123795T3 (de) Pharmazeutische Zusammensetzung zur rektalen Verabreichung von Wirkstoffen mit topischer medizinischer Wirkung im Dickdarmniveau
EP0232877A3 (en) Buccal drug dosage form
AR000320A1 (es) Proceso para la producción de copolímeros de poliéster que contienen unidades de tereftalato y naftalato
KR880009639A (ko) 서방성 매트릭스 제형
ES2065461T3 (es) Unidades de administracion de un farmaco de liberacion constante.
ES2093961T3 (es) Procedimiento para la obtencion de copolimeros a partir de monomeros monoetilenicamente insaturados, que contienen grupos acidos, y de n-vinil-lactamas.
DE3781827D1 (de) Glas/poly(karbonsaeure)-zement.
DE69931188D1 (de) Bioabbaubare polyhydroxyalkanoat (pha) copolymere
ES2056820T3 (es) Composiciones adhesivas modificadas por acido.
PL310072A1 (en) Small-diameter microcapsules, method of making them and their applications
DK0770384T3 (da) Faste, vandfrie farmaceutiske sammensætninger til vaginal anvendelse
DE3776119D1 (de) Sequenziert aufgebaute copolymere auf der basis von cyclischen carbonaten und estern.
ATE318152T1 (de) Polyhydroxyalkanoat-copolymere enthaltende abbaubare kunststoffartikel
FI942826A0 (fi) Laktonin ja karbonaatin kopolymeeri sekä menetelmä tällaisen kopolymeerin valmistamiseksi
JPS5215588A (en) Process for polymerizing liquid olefin polymers
ES2079598T3 (es) Procedimiento para el revestimiento de principios activos con un polimero sensible al ph.
AR241459A1 (es) Pelicula sellable por calor.
AR005569A1 (es) Un metodo para inducir la muerte de celulas neoplasicas mediante derivados de la piperazina
JPS5215587A (en) Process for polymerizing liquid olefin polymers

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 258780

Country of ref document: ES