MX2018003537A - Variantes optimizadas de anticuerpos anti-vegf. - Google Patents
Variantes optimizadas de anticuerpos anti-vegf.Info
- Publication number
- MX2018003537A MX2018003537A MX2018003537A MX2018003537A MX2018003537A MX 2018003537 A MX2018003537 A MX 2018003537A MX 2018003537 A MX2018003537 A MX 2018003537A MX 2018003537 A MX2018003537 A MX 2018003537A MX 2018003537 A MX2018003537 A MX 2018003537A
- Authority
- MX
- Mexico
- Prior art keywords
- vegf antibodies
- optimized variants
- present
- variants
- formuiations
- Prior art date
Links
- 208000034038 Pathologic Neovascularization Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- C07K—PEPTIDES
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- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Abstract
La presente invención proporciona anticuerpos anti- VEGF y composiciones que incluyen anticuerpos anti-VEGF (por ejemplo, conjugados de anticuerpos, proteínas de fusión, y formulaciones poliméricas), y usos de los mismos, por ejemplo para el tratamiento de trastornos asociados con la angiogénesis patológica. La presente invención también proporciona métodos para la identificación de variantes de anticuerpos con propiedades mejoradas, por ejemplo, afinidad de unión incrementada, estabilidad, farmacocinética, y/o expresión.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562222698P | 2015-09-23 | 2015-09-23 | |
US201562271913P | 2015-12-28 | 2015-12-28 | |
PCT/US2016/053454 WO2017053807A2 (en) | 2015-09-23 | 2016-09-23 | Optimized variants of anti-vegf antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018003537A true MX2018003537A (es) | 2018-08-01 |
Family
ID=57043061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003537A MX2018003537A (es) | 2015-09-23 | 2016-09-23 | Variantes optimizadas de anticuerpos anti-vegf. |
Country Status (24)
Country | Link |
---|---|
US (4) | US10072075B2 (es) |
EP (1) | EP3353203A2 (es) |
JP (2) | JP6959912B2 (es) |
KR (1) | KR20180053315A (es) |
CN (2) | CN116987187A (es) |
AU (1) | AU2016326666B2 (es) |
BR (1) | BR112018005737A2 (es) |
CA (1) | CA2992602A1 (es) |
CL (2) | CL2018000732A1 (es) |
CO (1) | CO2018003863A2 (es) |
CR (1) | CR20180221A (es) |
HK (1) | HK1254198A1 (es) |
IL (1) | IL257565B1 (es) |
MA (1) | MA42924A (es) |
MX (1) | MX2018003537A (es) |
MY (1) | MY191756A (es) |
PE (1) | PE20181363A1 (es) |
PH (1) | PH12018500657A1 (es) |
RU (1) | RU2763916C2 (es) |
SG (1) | SG10201911226QA (es) |
TW (1) | TWI748962B (es) |
UA (1) | UA125432C2 (es) |
WO (1) | WO2017053807A2 (es) |
ZA (1) | ZA201800770B (es) |
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SMP200800060B (it) | 2006-04-07 | 2009-07-14 | Procter & Gamble | Anticorpi che legano la proteina umana tirosina fosfatasi beta (hptbeta) e loro usi |
AU2009228217A1 (en) | 2008-03-28 | 2009-10-01 | The Regents Of The University Of California | Polypeptide-polymer conjugates and methods of use thereof |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
WO2017053807A2 (en) | 2015-09-23 | 2017-03-30 | Genentech, Inc. | Optimized variants of anti-vegf antibodies |
US10975131B2 (en) * | 2015-10-27 | 2021-04-13 | University Of Massachusetts | Factor H-Fc immunotheraphy |
CN113546178A (zh) | 2015-12-09 | 2021-10-26 | 加利福尼亚大学董事会 | 治疗眼部疾病或病症的方法 |
RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
AU2017299581A1 (en) | 2016-07-20 | 2019-01-17 | EyePoint Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target ve-ptp (hptp-β) |
MX2019011141A (es) | 2017-03-22 | 2019-11-05 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares. |
SG10202107829YA (en) | 2017-03-22 | 2021-08-30 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
KR20200004366A (ko) * | 2017-05-06 | 2020-01-13 | 리제너론 파아마슈티컬스, 인크. | Aplnr 길항제 및 vegf 저해제를 이용한, 안 장애의 치료 방법 |
AU2018272023A1 (en) | 2017-05-26 | 2019-11-21 | Cloudbreak Therapeutics Llc | A topical composition for treating rosacea and a method for treating rosacea with the same |
AU2018279278A1 (en) * | 2017-06-05 | 2019-12-19 | Janssen Biotech, Inc. | Methods of engineering surface charge for bispecific antibody production |
WO2019094387A1 (en) * | 2017-11-08 | 2019-05-16 | The Regents Of The University Of Colorado, A Body Corporate | Hydrogel drug delivery systems for the treatment of pediatric growth plate injuries |
MX2020005166A (es) | 2017-11-30 | 2020-09-03 | Regeneron Pharma | Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos. |
CN111479588A (zh) * | 2017-12-29 | 2020-07-31 | 豪夫迈·罗氏有限公司 | 用于改善抗vegf抗体的vegf受体阻断选择性的方法 |
JP6938796B2 (ja) * | 2018-03-16 | 2021-09-22 | ノバルティス アーゲー | 眼疾患を治療するための方法 |
JP7339325B2 (ja) * | 2018-03-20 | 2023-09-05 | ナショナル ヘルス リサーチ インスティテューツ | 単離抗体、医薬組成物、単離抗体結合体、ダイマー化阻害方法、シグナル伝達阻害方法、管新生阻害方法、治療方法、および断片検出方法 |
CN108752473B (zh) * | 2018-05-03 | 2021-08-31 | 陕西师范大学 | 一种抗c5全人源单链抗体c5b3及其应用 |
JP7235770B2 (ja) | 2018-05-10 | 2023-03-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 高濃度vegf受容体融合タンパク質を含む製剤 |
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