DK2488867T3 - Fremgangsmåder til affinitetsmodning af antistoffer - Google Patents

Fremgangsmåder til affinitetsmodning af antistoffer Download PDF

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Publication number
DK2488867T3
DK2488867T3 DK10824085.4T DK10824085T DK2488867T3 DK 2488867 T3 DK2488867 T3 DK 2488867T3 DK 10824085 T DK10824085 T DK 10824085T DK 2488867 T3 DK2488867 T3 DK 2488867T3
Authority
DK
Denmark
Prior art keywords
antibodies
procedures
affinity mature
mature
affinity
Prior art date
Application number
DK10824085.4T
Other languages
English (en)
Inventor
Johan Fransson
Gopalan Raghunathan
Juan-Carlos Almagro
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Application granted granted Critical
Publication of DK2488867T3 publication Critical patent/DK2488867T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK10824085.4T 2009-10-14 2010-10-14 Fremgangsmåder til affinitetsmodning af antistoffer DK2488867T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25144509P 2009-10-14 2009-10-14
PCT/US2010/052660 WO2011047146A2 (en) 2009-10-14 2010-10-14 Methods of affinity maturing antibodies

Publications (1)

Publication Number Publication Date
DK2488867T3 true DK2488867T3 (da) 2020-11-09

Family

ID=43876863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10824085.4T DK2488867T3 (da) 2009-10-14 2010-10-14 Fremgangsmåder til affinitetsmodning af antistoffer

Country Status (6)

Country Link
US (1) US8580714B2 (da)
EP (1) EP2488867B1 (da)
JP (1) JP2013508287A (da)
DK (1) DK2488867T3 (da)
ES (1) ES2826883T3 (da)
WO (1) WO2011047146A2 (da)

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JP6895380B2 (ja) * 2015-02-06 2021-06-30 ナショナル ユニバーシティ オブ シンガポール 治療免疫細胞の有効性を改良するための方法
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CN109996544A (zh) 2016-06-27 2019-07-09 加利福尼亚大学董事会 癌症治疗组合
GB201614627D0 (en) * 2016-08-30 2016-10-12 Glaxosmithkline Ip Dev Ltd Antigen binding proteins
SG10201912387PA (en) 2016-11-22 2020-02-27 Nat Univ Singapore Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
JOP20180021A1 (ar) 2017-03-16 2019-01-30 Janssen Biotech Inc الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
US20190038733A1 (en) 2017-08-10 2019-02-07 National University Of Singapore T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
WO2019099454A2 (en) 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
JP7471224B2 (ja) * 2018-01-15 2024-04-19 シュティッヒティング・サンコン・ブロードフォールジーニング Ｈ因子増強抗体及びその使用
US20210002358A1 (en) 2018-03-05 2021-01-07 Linda Barone Anti-phf-tau antibodies and uses thereof
CN108840932B (zh) * 2018-04-28 2022-03-29 中国科学院微生物研究所 一种pd-1特异性抗体及其抗肿瘤应用
CN113272322A (zh) * 2018-10-08 2021-08-17 Uab 研究基金会 神经内分泌癌靶向治疗
KR20220057530A (ko) 2019-07-17 2022-05-09 제미니 테라퓨틱스 서브, 인코포레이티드 인자 h 강화 항체 및 이의 용도
US20230265212A1 (en) * 2019-12-19 2023-08-24 Kevin S. EISENFRATS Compositions and methods for oocyte-specific contraception
IL298111A (en) 2020-06-02 2023-01-01 Arcus Biosciences Inc Antibodies to tigit
WO2022003693A1 (en) * 2020-07-02 2022-01-06 Biolojic Design Ltd. Anti-tumor necrosis factor receptor (tnfr2) antibodies and uses thereof
CN112920267B (zh) * 2021-03-09 2021-08-13 北京康乐卫士生物技术股份有限公司 一种抗人***瘤病毒31型的单克隆中和抗体及其应用
CN116217724B (zh) * 2021-12-02 2023-10-27 北京东方百泰生物科技股份有限公司 一种抗tslp的单克隆抗体、其抗原结合片段及其应用
CN117659201A (zh) * 2022-08-23 2024-03-08 东莞市朋志生物科技有限公司 抗***抗体或其功能性片段、检测***的试剂和试剂盒
CN116731184B (zh) * 2022-11-25 2024-06-14 厦门康基生物科技有限公司 一种特异性结合Taq酶的单克隆抗体F6H12及其应用
CN116003619B (zh) * 2022-12-12 2023-08-04 三门峡市眼科医院 人源化抗Ang-2和VEGF双功能抗体及其医药用途

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Also Published As

Publication number Publication date
US8580714B2 (en) 2013-11-12
EP2488867A4 (en) 2014-05-07
JP2013508287A (ja) 2013-03-07
US20110092372A1 (en) 2011-04-21
WO2011047146A3 (en) 2011-06-16
ES2826883T3 (es) 2021-05-19
WO2011047146A2 (en) 2011-04-21
EP2488867A2 (en) 2012-08-22
EP2488867B1 (en) 2020-09-30

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