CN103204933B - 一种稳定性高的人源抗vegf抗体及其应用 - Google Patents
一种稳定性高的人源抗vegf抗体及其应用 Download PDFInfo
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- CN103204933B CN103204933B CN201310075262.XA CN201310075262A CN103204933B CN 103204933 B CN103204933 B CN 103204933B CN 201310075262 A CN201310075262 A CN 201310075262A CN 103204933 B CN103204933 B CN 103204933B
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突变位点 | 亲和力变化 | 热稳定性 | 突变位点 | 亲和力变化 | 热稳定性 |
A23T | 1 | ↑ | D62P | 3 | ↑ |
T28P | 0.5 | — | S63P | 1 | ↓ |
T28D | 1.5 | ↑ | T69K | 1 | ↓ |
S31D | 1.5 | ↑ | N77K | 1.5 | ↓ |
S35L | 0.5 | ↓ | N77G | 1.5 | ↓ |
T52S | 1.5 | - | Y80S | 0.7 | ↓ |
G53P | 1 | ↑ | A88P | 0.5 | ↑ |
G55D | 1 | ↓ | V93I | 1 | ↓ |
E57S | 1.5 | ↓ |
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CN201410461126.9A CN104311662B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
CN201410461635.1A CN104292330B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
CN201310075262.XA CN103204933B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN201310075262.XA CN103204933B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN201410461126.9A Division CN104311662B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
CN201410461635.1A Division CN104292330B (zh) | 2013-03-08 | 2013-03-08 | 一种稳定性高的人源抗vegf抗体及其应用 |
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CN103204933A CN103204933A (zh) | 2013-07-17 |
CN103204933B true CN103204933B (zh) | 2014-11-05 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2017053807A2 (en) * | 2015-09-23 | 2017-03-30 | Genentech, Inc. | Optimized variants of anti-vegf antibodies |
BR112019025105A2 (pt) * | 2017-06-30 | 2020-10-20 | Zymeworks Inc. | fabs quiméricos estabilizados |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102167740A (zh) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | 一种全人源抗vegf单克隆抗体、其制备方法及用途 |
CN103012589A (zh) * | 2012-12-11 | 2013-04-03 | 上海赛伦生物技术有限公司 | 人源抗人血管内皮细胞生长因子抗体及其应用 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102167740A (zh) * | 2010-02-25 | 2011-08-31 | 百迈博药业有限公司 | 一种全人源抗vegf单克隆抗体、其制备方法及用途 |
CN103012589A (zh) * | 2012-12-11 | 2013-04-03 | 上海赛伦生物技术有限公司 | 人源抗人血管内皮细胞生长因子抗体及其应用 |
Non-Patent Citations (4)
Title |
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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer;N Ferrara et al.;《Nature Reviews》;20040531;第3卷(第5期);第391-400页 * |
NFerraraetal..Discoveryanddevelopmentofbevacizumab an anti-VEGF antibody for treating cancer.《Nature Reviews》.2004 * |
血管内皮生长因子与肺癌的关系;陈公琰;《中华肿瘤杂志》;20050830;第27卷(第8期);第449-451页 * |
陈公琰.血管内皮生长因子与肺癌的关系.《中华肿瘤杂志》.2005,第27卷(第8期),第449-451页. * |
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