SG10201902924RA - Antibodies that bind ebola glycoprotein and uses thereof - Google Patents
Antibodies that bind ebola glycoprotein and uses thereofInfo
- Publication number
- SG10201902924RA SG10201902924RA SG10201902924RA SG10201902924RA SG10201902924RA SG 10201902924R A SG10201902924R A SG 10201902924RA SG 10201902924R A SG10201902924R A SG 10201902924RA SG 10201902924R A SG10201902924R A SG 10201902924RA SG 10201902924R A SG10201902924R A SG 10201902924RA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- bind
- ebola glycoprotein
- glycoprotein
- bind ebola
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 3
- 108090000288 Glycoproteins Proteins 0.000 title abstract 3
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 title abstract 2
- 241001115402 Ebolavirus Species 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
ANTmODIES THAT BIND EBOLA GLYCOPROTEIN AND USES THEREOF Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody- based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies. Figure for publication: None
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462059746P | 2014-10-03 | 2014-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201902924RA true SG10201902924RA (en) | 2019-05-30 |
Family
ID=54291751
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201902924RA SG10201902924RA (en) | 2014-10-03 | 2015-10-02 | Antibodies that bind ebola glycoprotein and uses thereof |
SG11201702606TA SG11201702606TA (en) | 2014-10-03 | 2015-10-02 | Antibodies that bind ebola glycoprotein and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201702606TA SG11201702606TA (en) | 2014-10-03 | 2015-10-02 | Antibodies that bind ebola glycoprotein and uses thereof |
Country Status (8)
Country | Link |
---|---|
US (2) | US10894818B2 (en) |
EP (1) | EP3201226A2 (en) |
JP (2) | JP2017531642A (en) |
CN (1) | CN106999566B (en) |
AU (2) | AU2015327819B2 (en) |
CA (1) | CA2963470A1 (en) |
SG (2) | SG10201902924RA (en) |
WO (1) | WO2016054598A2 (en) |
Families Citing this family (18)
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US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
TWI710573B (en) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | Human antibodies to ebola virus glycoprotein |
CN108135994B (en) | 2015-05-13 | 2022-01-25 | 宾夕法尼亚州大学信托人 | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
EP3302563A1 (en) * | 2015-05-29 | 2018-04-11 | H. Hoffnabb-La Roche Ag | Humanized anti-ebola virus glycoprotein antibodies and methods of use |
CA2984711C (en) | 2015-07-15 | 2023-08-29 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as metabotropic glutamate receptor modulators |
US20190240328A1 (en) * | 2016-09-24 | 2019-08-08 | The Trustees Of The University Of Pennsylvania | Novel humanized anti-ebola antibodies useful in preventing ebola infections |
CA3053305A1 (en) | 2017-02-17 | 2018-08-23 | Mapp Biopharmaceutical, Inc. | Monoclonal antibodies and cocktails for treatment of ebola infections |
TW201837170A (en) | 2017-02-28 | 2018-10-16 | 賓州大學委員會 | Novel AAV mediated influenza vaccines |
JOP20190200A1 (en) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | Compositions useful in treatment of spinal muscular atrophy |
FI3589730T3 (en) | 2017-02-28 | 2024-02-22 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
CN113512111B (en) * | 2017-03-10 | 2023-08-15 | 北京天广实生物技术股份有限公司 | anti-Ebola virus monoclonal antibody, preparation method and application thereof |
CN106868025B (en) * | 2017-03-13 | 2020-01-21 | 中国人民解放军军事医学科学院生物工程研究所 | Method for preparing tripolymer Ebola virus glycoprotein mutant by using yeast |
US20200216519A1 (en) * | 2017-09-15 | 2020-07-09 | The Wistar Institute Of Anatomy And Biology | Dna antibody constructs for use against ebola virus |
CN108299559B (en) * | 2017-12-29 | 2021-11-26 | 上海科技大学 | Zaire type Ebola virus detection antibody and preparation method and application thereof |
TW202016125A (en) * | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | Systems and methods for quantifying and modifying protein viscosity |
WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
EP4192879A2 (en) * | 2020-08-06 | 2023-06-14 | Abpro Corporation | Anti-claudin 18.2 multi-specific antibodies and uses thereof |
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-
2015
- 2015-10-02 AU AU2015327819A patent/AU2015327819B2/en not_active Ceased
- 2015-10-02 CN CN201580064291.3A patent/CN106999566B/en not_active Expired - Fee Related
- 2015-10-02 US US15/515,746 patent/US10894818B2/en active Active
- 2015-10-02 JP JP2017517793A patent/JP2017531642A/en active Pending
- 2015-10-02 CA CA2963470A patent/CA2963470A1/en not_active Abandoned
- 2015-10-02 WO PCT/US2015/053871 patent/WO2016054598A2/en active Application Filing
- 2015-10-02 SG SG10201902924RA patent/SG10201902924RA/en unknown
- 2015-10-02 EP EP15778588.2A patent/EP3201226A2/en not_active Withdrawn
- 2015-10-02 SG SG11201702606TA patent/SG11201702606TA/en unknown
-
2020
- 2020-10-05 JP JP2020168479A patent/JP2021001226A/en active Pending
- 2020-12-04 US US17/112,581 patent/US20210095007A1/en not_active Abandoned
-
2021
- 2021-05-17 AU AU2021203156A patent/AU2021203156A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170298120A1 (en) | 2017-10-19 |
EP3201226A2 (en) | 2017-08-09 |
CA2963470A1 (en) | 2016-04-07 |
SG11201702606TA (en) | 2017-04-27 |
JP2017531642A (en) | 2017-10-26 |
US10894818B2 (en) | 2021-01-19 |
US20210095007A1 (en) | 2021-04-01 |
WO2016054598A2 (en) | 2016-04-07 |
AU2021203156A1 (en) | 2021-06-10 |
CN106999566A (en) | 2017-08-01 |
CN106999566B (en) | 2022-01-28 |
JP2021001226A (en) | 2021-01-07 |
AU2015327819B2 (en) | 2021-07-01 |
WO2016054598A3 (en) | 2016-05-19 |
AU2015327819A1 (en) | 2017-04-27 |
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