MX2015012401A - Composiciones y metodos de alterar niveles de colesterol. - Google Patents

Composiciones y metodos de alterar niveles de colesterol.

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Publication number
MX2015012401A
MX2015012401A MX2015012401A MX2015012401A MX2015012401A MX 2015012401 A MX2015012401 A MX 2015012401A MX 2015012401 A MX2015012401 A MX 2015012401A MX 2015012401 A MX2015012401 A MX 2015012401A MX 2015012401 A MX2015012401 A MX 2015012401A
Authority
MX
Mexico
Prior art keywords
compositions
methods
cholesterol levels
altering cholesterol
altering
Prior art date
Application number
MX2015012401A
Other languages
English (en)
Inventor
Stephen G Hoge
Eric Yi-Chun Huang
Joseph Beene Bolen
Justin Guild
Antonin De Fougerolles
Jeff Lynn Ellsworth
Original Assignee
Moderna Therapeutics Inc
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Filing date
Publication date
Application filed by Moderna Therapeutics Inc filed Critical Moderna Therapeutics Inc
Publication of MX2015012401A publication Critical patent/MX2015012401A/es

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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13017Cholesterol 7-alpha-monooxygenase (1.14.13.17)

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  • Gastroenterology & Hepatology (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con composiciones, métodos y equipos que usan polinucleótidos, transcritos primarios y moléculas de ARNmm. La presente invención también se relaciona con composiciones y métodos para alterar niveles de colesterol usando polinucleótidos, transcritos primarios y moléculas de ARNmm.
MX2015012401A 2013-03-15 2014-03-14 Composiciones y metodos de alterar niveles de colesterol. MX2015012401A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361786737P 2013-03-15 2013-03-15
US201361828214P 2013-05-29 2013-05-29
US201361839488P 2013-06-26 2013-06-26
US201361903474P 2013-11-13 2013-11-13
US14/135,887 US8980864B2 (en) 2013-03-15 2013-12-20 Compositions and methods of altering cholesterol levels
PCT/US2014/027453 WO2014152540A1 (en) 2013-03-15 2014-03-14 Compositions and methods of altering cholesterol levels

Publications (1)

Publication Number Publication Date
MX2015012401A true MX2015012401A (es) 2016-04-15

Family

ID=51530005

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012401A MX2015012401A (es) 2013-03-15 2014-03-14 Composiciones y metodos de alterar niveles de colesterol.

Country Status (13)

Country Link
US (4) US8980864B2 (es)
EP (1) EP2970987B1 (es)
JP (1) JP6396415B2 (es)
KR (1) KR20160008521A (es)
CN (1) CN105308183A (es)
AU (1) AU2014239589A1 (es)
BR (1) BR112015023386A8 (es)
CA (1) CA2906092A1 (es)
HK (1) HK1220489A1 (es)
MX (1) MX2015012401A (es)
RU (1) RU2015143930A (es)
SG (1) SG11201507511SA (es)
WO (1) WO2014152540A1 (es)

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KR20160008521A (ko) 2016-01-22
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CA2906092A1 (en) 2014-09-25
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