MX2010002004A - Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa. - Google Patents

Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa.

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Publication number
MX2010002004A
MX2010002004A MX2010002004A MX2010002004A MX2010002004A MX 2010002004 A MX2010002004 A MX 2010002004A MX 2010002004 A MX2010002004 A MX 2010002004A MX 2010002004 A MX2010002004 A MX 2010002004A MX 2010002004 A MX2010002004 A MX 2010002004A
Authority
MX
Mexico
Prior art keywords
compounds
kinase inhibitors
haloalkoxy
pyrimidine
phenyl
Prior art date
Application number
MX2010002004A
Other languages
English (en)
Inventor
Juliet Nabakka
Shuli You
Xiaolin Li
Jon Loren
Xiaodong Liu
Donatella Chianelli
Valentina Molteni
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39929716&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010002004(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of MX2010002004A publication Critical patent/MX2010002004A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La invención proporciona compuestos de la fórmula (I): (ver fórmula I) y composiciones farmacéuticas de los mismos, los cuales son útiles como inhibidores de cinasa de proteína, así como métodos para utilizar tales compuestos con el fin de tratar, disminuir, o prevenir una condición asociada con una actividad de cinasa anormal o mal regulada. En algunas modalidades, la invención proporciona métodos para utilizar tales compuestos con el fin de tratar, disminuir, o prevenir enfermedades o trastornos que involucren una activación anormal de las cinasas c-kit, PDGFRa, PDGFRß, CSF1R, Abl, BCRAbl, CSK, JNK1, JNK2, p38, p70S6K, TGFß, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2ß, BRK, Fms, KDR, c-raf o b-raf.
MX2010002004A 2007-08-22 2008-08-19 Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa. MX2010002004A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95726007P 2007-08-22 2007-08-22
PCT/US2008/073573 WO2009026276A1 (en) 2007-08-22 2008-08-19 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2010002004A true MX2010002004A (es) 2010-03-11

Family

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MX2010002004A MX2010002004A (es) 2007-08-22 2008-08-19 Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa.

Country Status (24)

Country Link
US (1) US8293757B2 (es)
EP (1) EP2190825B1 (es)
JP (2) JP5599312B2 (es)
KR (2) KR101218926B1 (es)
CN (1) CN101784530A (es)
AR (1) AR068014A1 (es)
AU (1) AU2008289037B2 (es)
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