KR920000754A - 환식아미드 유도체 - Google Patents
환식아미드 유도체 Download PDFInfo
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- KR920000754A KR920000754A KR1019910009534A KR910009534A KR920000754A KR 920000754 A KR920000754 A KR 920000754A KR 1019910009534 A KR1019910009534 A KR 1019910009534A KR 910009534 A KR910009534 A KR 910009534A KR 920000754 A KR920000754 A KR 920000754A
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- cyclic amide
- dione
- dihydro
- pharmacologically acceptable
- ethyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 식(Ⅰ) : R1-(CH2)n-Z의 환식 아미드 유도체 또는 그것의 약리학적 허용염. 상기식에서 R1은 치환 또는 비치환 환식 아미드화합물로부터 유도된 기이고 n은 0 또는 1 내지 10의 정수이고 Z는,이고 여기서 R2는 아릴, 치환아릴, 시클로알킬 또는 복소환기이고 m은 1 내지 6의 정수이고, R3은 수소원자 또는 저급알킬이고 R4는 아릴 또는 치환아릴, 시클로알킬 또는 복소환식기이고 p는 1 내지 6의 정수이고 단 환식아미드 화합물을 퀴나졸린-온 또는 퀴나졸린-디온이고 R2와 R4는 아릴 또는 치환아릴 어느것도 아니다.
- 제1항에 있어서, Z가 (1)인 것을 특징으로 하는 환식 아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항에 있어서, Z가 (1)이고 R2가 페닐, 피리딜, 시클로펜틸 및 1,3-디옥산-2-일로 구성되는 군으로부터 선택되고 n이 1 또는 2이고 m이 1 또는 2인 것을 특징으로 하는 환식아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항에 있어서, Z가 (1)이고 R2가 페닐, 피리딜, 시클로펜틸 및 1,3-디옥산-2-일로 구성되는 군으로부터 선택되고 n이 1 또는 2이고 m이 1또는 2이고 R1에 대한 환식아미드 유도체가 2H-3,4-디히드로-1,3-벤즈옥사진-2-온, 2H-3,4-디히드로-1,3-벤즈옥사진-2,4-디온, 1,2,3,4-테트라하드로-퀴나졸린-2,4-디온, 1,2,3,4-테트라하드로-퀴나졸린-2-온, 1,2,3,4-테트라하드로-피리도(3,2-d)피리미딘-2,4-디온, 1,2,3,4-테트라하드로-프레리딘-2,4-디온 및 1,2,3,4-테트라하드로-피리도(3,2-d)피리미딘-2-온으로 구성되는 군으로 부터 선택되는 것을 특징으로 하는 환식 아미드유도체 또는 그것의 약리학적 허용염.
- 제4항에 있어서, R1이 저급알킬 또는 저급 알콕시기로 치환되는 것을 특징으로 하는 환식 아미드유도체 또는 그것의 약리학적 허용염.
- 제4항에 있어서, R1이 메톡시로 치환되는 것을 특징으로 하는 환식아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항에 있어서, Z가 (2)인 것을 특징으로 하는 환식아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항에 있어서, Z가 (2)이고 R3가 저급알킬이고 R4가 페닐, 피리딜, 시클로펜틸 및 1,3-디옥산-2-일로부터 선택되는 것을 특징으로 하는 환식 아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항에 있어서, 유도체가 3-(2-(1-벤질-4-피레리딜)에틸)5-메톡시-2H-3,4-디히드로-1,3-벤즈옥사딘-2-온, 3-(2-(1-(4-피리딜메틸)-4-피레리딜)에틸)-2H-3,4-디히드로-1,3-벤즈옥사딘-2-온, 3-(2-(1,3-디옥소란-2-일-메틸)-4-피레리딘)에틸)-6-메톡시-2H-3,4-디히드로-1,3-벤즈옥사딘-2-온, 3-(2-(시클로펜틸메틸-4-피레리딜)에틸-2H-3,4-디히드로-1,3-벤즈옥사딘-2,4-디온, 3-(2-(1,3-디옥소란-2-일-메틸)-4-피레리딘)에틸)-2H-3,4-디히드로-1,3-벤즈옥사딘-2,4-디온, 3-(2-(1-(1,3-디옥소란-2-일-메틸)-4-피레리딘)에틸)-5-메톡시-1,2,3,4-테트라히드로-퀴나졸린-2,4-디온, 3-(2-(1-벤질-4-피레리딜)에틸)-6-메톡시-2H-3,4-디히드로-1,3-벤즈옥사진-2-온 및 3-(2-(1-벤질-4-피레리딜)에틸)-6-메톡시-2H-3,4-디히드로-1,3-벤즈옥사진-2,4-디온, 으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 환식아미드 유도체 또는 그것의 약리학적 허용염.
- 제1항의 환식 아미드 유도체의 약리학적 유효량 및 약리학적 허용담체를 함유하는 것을 특징으로 하는 약학적 조성물.
- 제1항의 유도체의 약리학적 유효량을 환자에 투여하는 것으로 이루어지는 것을 특징으로 하는 중추 콜린 기능의 불완전에 기인한 질병의 치료 및 예방방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15713490 | 1990-06-15 | ||
JP2-157134 | 1990-06-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920000754A true KR920000754A (ko) | 1992-01-29 |
KR940004391B1 KR940004391B1 (en) | 1994-05-25 |
Family
ID=15642948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR91009534A KR940004391B1 (en) | 1990-06-15 | 1991-06-10 | Cyclic amide derivatives |
Country Status (17)
Country | Link |
---|---|
US (6) | US5292735A (ko) |
EP (3) | EP0742216B1 (ko) |
JP (2) | JP2807577B2 (ko) |
KR (1) | KR940004391B1 (ko) |
CN (1) | CN1045206C (ko) |
AT (3) | ATE164156T1 (ko) |
AU (2) | AU653938B2 (ko) |
CA (2) | CA2044515C (ko) |
DE (3) | DE69130120T2 (ko) |
DK (2) | DK0468187T3 (ko) |
ES (2) | ES2113355T3 (ko) |
FI (1) | FI114797B (ko) |
HU (2) | HU216188B (ko) |
NO (1) | NO180540B1 (ko) |
NZ (2) | NZ238534A (ko) |
PT (1) | PT97993B (ko) |
ZA (1) | ZA914423B (ko) |
Families Citing this family (47)
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CA2167198C (en) * | 1993-07-15 | 1999-03-16 | Kunio Satake | Benzylaminoquinuclidines |
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FR2750991A1 (fr) * | 1996-07-12 | 1998-01-16 | Pf Medicament | Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament |
FR2752732B1 (fr) | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
DE19708846A1 (de) * | 1997-03-05 | 1998-09-17 | Gruenenthal Gmbh | Neue Benzoxazindionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
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CN108658887B (zh) * | 2018-06-20 | 2022-04-05 | 中南大学 | 苯并[d][1,3]噁嗪-2,4(1H)-二酮衍生物及其合成方法和用途 |
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1991
- 1991-05-22 JP JP3117420A patent/JP2807577B2/ja not_active Expired - Lifetime
- 1991-06-03 AU AU78136/91A patent/AU653938B2/en not_active Expired
- 1991-06-10 KR KR91009534A patent/KR940004391B1/ko not_active IP Right Cessation
- 1991-06-10 ZA ZA914423A patent/ZA914423B/xx unknown
- 1991-06-12 NO NO19912252A patent/NO180540B1/no not_active IP Right Cessation
- 1991-06-13 ES ES91109708T patent/ES2113355T3/es not_active Expired - Lifetime
- 1991-06-13 DK DK91109708T patent/DK0468187T3/da active
- 1991-06-13 NZ NZ238534A patent/NZ238534A/en not_active IP Right Cessation
- 1991-06-13 DE DE69130120T patent/DE69130120T2/de not_active Expired - Lifetime
- 1991-06-13 CA CA002044515A patent/CA2044515C/en not_active Expired - Lifetime
- 1991-06-13 EP EP96109320A patent/EP0742216B1/en not_active Expired - Lifetime
- 1991-06-13 FI FI912851A patent/FI114797B/fi not_active IP Right Cessation
- 1991-06-13 CA CA002175502A patent/CA2175502C/en not_active Expired - Lifetime
- 1991-06-13 EP EP95108191A patent/EP0677516B1/en not_active Expired - Lifetime
- 1991-06-13 DE DE69129090T patent/DE69129090T2/de not_active Expired - Lifetime
- 1991-06-13 NZ NZ272015A patent/NZ272015A/xx not_active IP Right Cessation
- 1991-06-13 AT AT91109708T patent/ATE164156T1/de not_active IP Right Cessation
- 1991-06-13 ES ES95108191T patent/ES2123858T3/es not_active Expired - Lifetime
- 1991-06-13 DK DK95108191T patent/DK0677516T3/da active
- 1991-06-13 DE DE69132827T patent/DE69132827T2/de not_active Expired - Lifetime
- 1991-06-13 AT AT96109320T patent/ATE209198T1/de not_active IP Right Cessation
- 1991-06-13 AT AT95108191T patent/ATE170517T1/de not_active IP Right Cessation
- 1991-06-13 EP EP91109708A patent/EP0468187B1/en not_active Expired - Lifetime
- 1991-06-14 PT PT97993A patent/PT97993B/pt not_active IP Right Cessation
- 1991-06-14 US US07/715,754 patent/US5292735A/en not_active Expired - Lifetime
- 1991-06-14 HU HU911986A patent/HU216188B/hu unknown
- 1991-06-15 CN CN91104087A patent/CN1045206C/zh not_active Expired - Lifetime
-
1993
- 1993-12-13 US US08/165,490 patent/US5504088A/en not_active Expired - Lifetime
-
1995
- 1995-01-18 AU AU10246/95A patent/AU680704B2/en not_active Expired
- 1995-05-25 US US08/451,068 patent/US5919778A/en not_active Expired - Lifetime
- 1995-05-25 US US08/449,739 patent/US5620976A/en not_active Expired - Lifetime
- 1995-05-25 US US08/449,738 patent/US5654308A/en not_active Expired - Lifetime
- 1995-05-25 US US08/449,749 patent/US5521182A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00611P patent/HU211895A9/hu unknown
- 1995-09-11 JP JP23238195A patent/JP3224187B2/ja not_active Expired - Lifetime
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