DK0565377T3 - Terapeutiske midler til behandling af Parkinsons sygdom - Google Patents

Terapeutiske midler til behandling af Parkinsons sygdom

Info

Publication number
DK0565377T3
DK0565377T3 DK93302780.7T DK93302780T DK0565377T3 DK 0565377 T3 DK0565377 T3 DK 0565377T3 DK 93302780 T DK93302780 T DK 93302780T DK 0565377 T3 DK0565377 T3 DK 0565377T3
Authority
DK
Denmark
Prior art keywords
group
parkinson
disease
treatment
therapeutic agents
Prior art date
Application number
DK93302780.7T
Other languages
English (en)
Inventor
Akio Ishii
Fumio Suzuki
Shunji Ichikawa
Junichi Shimada
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of DK0565377T3 publication Critical patent/DK0565377T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
DK93302780.7T 1992-04-08 1993-04-08 Terapeutiske midler til behandling af Parkinsons sygdom DK0565377T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8711592 1992-04-08

Publications (1)

Publication Number Publication Date
DK0565377T3 true DK0565377T3 (da) 1998-03-16

Family

ID=13905960

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93302780.7T DK0565377T3 (da) 1992-04-08 1993-04-08 Terapeutiske midler til behandling af Parkinsons sygdom

Country Status (11)

Country Link
EP (1) EP0565377B1 (da)
JP (1) JP2613352B2 (da)
AT (1) ATE161723T1 (da)
BR (1) BR1100636A (da)
CA (1) CA2093403C (da)
DE (1) DE69316067T2 (da)
DK (1) DK0565377T3 (da)
ES (1) ES2112386T3 (da)
GR (1) GR3026233T3 (da)
HK (1) HK1001835A1 (da)
NO (1) NO303265B1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ211593A3 (en) * 1992-02-19 1994-03-16 Yukio Ishida Rice with high absorption of water, method of its preparation and use
US5543415A (en) * 1992-07-08 1996-08-06 Kyowa Hakko Kogyo Co., Ltd. Antidepressants
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
EP0711282B1 (en) * 1993-07-28 2002-06-05 Aventis Pharma Limited Compounds as pde iv and tnf inhibitors
ATE218139T1 (de) * 1994-02-23 2002-06-15 Kyowa Hakko Kogyo Kk Xanthin-derivate
ATE281835T1 (de) * 1996-08-07 2004-11-15 Kyowa Hakko Kogyo Kk Fettemulsion, die ein xanthinderivat enthält
EP1016407B1 (en) * 1997-09-05 2006-05-10 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for treating brain ischemia
US7241890B2 (en) 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
NZ543109A (en) 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
KR20060070572A (ko) 2003-09-18 2006-06-23 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물
JP4714024B2 (ja) 2004-01-28 2011-06-29 協和発酵キリン株式会社 片頭痛の治療剤
NZ561939A (en) 2005-03-30 2011-03-31 Conforma Therapeutics Corp Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
WO2006115690A2 (en) * 2005-04-22 2006-11-02 Novacardia, Inc. Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions
MX2009006346A (es) * 2006-12-22 2010-03-03 Sanol Arznei Schwarz Gmbh Derivados de 8-etinilxantina como antagonistas de receptores de a2a selectivos.
US7994357B2 (en) * 2009-04-03 2011-08-09 Naturewise Biotech & Medicals Corporation Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
WO2020125779A1 (en) * 2018-12-21 2020-06-25 Sunshine Lake Pharma Co., Ltd. 8-substituted styryl xanthine derivatives and uses thereof
WO2020216152A1 (en) * 2019-04-24 2020-10-29 Dongguan Hec New Drug R&D Co., Ltd. 8-substituted aryl vinyl xanthine derivatives and uses thereof
CN110041331B (zh) * 2019-05-17 2020-08-07 广东东阳光药业有限公司 苯乙烯基黄嘌呤衍生物及其用途
CN112409360B (zh) * 2019-08-22 2022-12-23 广东东阳光药业有限公司 杂芳基乙烯基黄嘌呤衍生物及其用途
US20230017597A1 (en) * 2019-11-11 2023-01-19 Sunshine Lake Pharma Co., Ltd. 8-substituted styryl xanthine derivatives and uses thereof
CN111072663B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111018856B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT297021B (de) * 1969-07-30 1972-03-10 Parke Davis & Co Verfahren zur Herstellung neuer Xanthinverbindungen
DE8817122U1 (da) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
GB8906792D0 (en) * 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
FR2665636B1 (fr) * 1990-08-10 1994-10-07 Adir Utilisation d'un derive de la trimethyl-1,3,7 xanthine pour le traitement des troubles de la memoire, des troubles intellectuels de la senescence et de la maladie d'alzheimer.
DE69130869T2 (de) * 1990-10-18 1999-06-10 Kyowa Hakko Kogyo Kk Xanthinderivate

Also Published As

Publication number Publication date
JPH0616559A (ja) 1994-01-25
BR1100636A (pt) 2000-04-18
NO303265B1 (no) 1998-06-22
NO931317D0 (no) 1993-04-06
CA2093403C (en) 1999-08-10
DE69316067D1 (de) 1998-02-12
HK1001835A1 (en) 1998-07-10
JP2613352B2 (ja) 1997-05-28
CA2093403A1 (en) 1993-10-09
ATE161723T1 (de) 1998-01-15
DE69316067T2 (de) 1998-07-02
EP0565377A1 (en) 1993-10-13
NO931317L (no) 1993-10-11
EP0565377B1 (en) 1998-01-07
GR3026233T3 (en) 1998-05-29
ES2112386T3 (es) 1998-04-01

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