KR102173433B1 - 키나아제 억제제로써의 피리미딘 유도체 - Google Patents

키나아제 억제제로써의 피리미딘 유도체 Download PDF

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KR102173433B1
KR102173433B1 KR1020167002970A KR20167002970A KR102173433B1 KR 102173433 B1 KR102173433 B1 KR 102173433B1 KR 1020167002970 A KR1020167002970 A KR 1020167002970A KR 20167002970 A KR20167002970 A KR 20167002970A KR 102173433 B1 KR102173433 B1 KR 102173433B1
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alkyl
halo
substituted
optionally substituted
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KR1020167002970A
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KR20160037929A (ko
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시아오 수
시아오보 왕
롱 마오
리 자오
비아오 시
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에이시아 바이오사이언시스 인코포레이티드.
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/04—Ortho-condensed systems
KR1020167002970A 2013-07-11 2014-07-11 키나아제 억제제로써의 피리미딘 유도체 KR102173433B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361845342P 2013-07-11 2013-07-11
US61/845,342 2013-07-11
US201461923179P 2014-01-02 2014-01-02
US61/923,179 2014-01-02
PCT/US2014/046442 WO2015006754A2 (en) 2013-07-11 2014-07-11 Heterocyclic compounds and uses thereof

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KR20160037929A KR20160037929A (ko) 2016-04-06
KR102173433B1 true KR102173433B1 (ko) 2020-11-04

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US (1) US10562918B2 (zh)
EP (1) EP3019496B1 (zh)
JP (1) JP6564771B2 (zh)
KR (1) KR102173433B1 (zh)
CN (3) CN105916851A (zh)
AU (1) AU2014287016B2 (zh)
BR (1) BR112016000195A8 (zh)
CA (1) CA2917364C (zh)
DK (1) DK3019496T3 (zh)
ES (1) ES2761572T3 (zh)
HK (1) HK1223351A1 (zh)
IL (1) IL243420A0 (zh)
MX (1) MX368491B (zh)
NZ (1) NZ715687A (zh)
RU (1) RU2677653C2 (zh)
SG (1) SG11201600062RA (zh)
WO (1) WO2015006754A2 (zh)

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