JPH0564982B2 - - Google Patents

Info

Publication number: JPH0564982B2
Authority: JP; Japan
Prior art keywords: polymer; organic solvent; present; porous; sucrose
Prior art date: 1987-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP62262310A

Other languages

English (en)

Japanese (ja)

Other versions

JPH01104635A (ja

Inventor

Takao Okada

Hironobu Fukuzaki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taki Chemical Co Ltd

Original Assignee

Taki Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-16

Filing date

1987-10-16

Publication date

1993-09-16

1987-10-16 Application filed by Taki Chemical Co Ltd filed Critical Taki Chemical Co Ltd

1987-10-16 Priority to JP62262310A priority Critical patent/JPH01104635A/ja

1989-04-21 Publication of JPH01104635A publication Critical patent/JPH01104635A/ja

1993-09-16 Publication of JPH0564982B2 publication Critical patent/JPH0564982B2/ja

Status Granted legal-status Critical Current

Links

229920000642 polymer Polymers 0.000 claims description 24
239000000463 material Substances 0.000 claims description 23
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 22
239000003960 organic solvent Substances 0.000 claims description 22
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
239000004310 lactic acid Substances 0.000 claims description 11
235000014655 lactic acid Nutrition 0.000 claims description 11
238000004519 manufacturing process Methods 0.000 claims description 7
239000000945 filler Substances 0.000 claims description 6
229920001577 copolymer Polymers 0.000 claims description 5
239000000126 substance Substances 0.000 claims 1
239000011148 porous material Substances 0.000 description 27
239000000654 additive Substances 0.000 description 18
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 17
229930006000 Sucrose Natural products 0.000 description 17
239000005720 sucrose Substances 0.000 description 17
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
230000000996 additive effect Effects 0.000 description 8
238000000034 method Methods 0.000 description 8
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 7
230000000052 comparative effect Effects 0.000 description 7
239000002245 particle Substances 0.000 description 7
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
230000005484 gravity Effects 0.000 description 6
238000001035 drying Methods 0.000 description 5
238000000605 extraction Methods 0.000 description 5
238000007710 freezing Methods 0.000 description 5
230000008014 freezing Effects 0.000 description 5
239000000203 mixture Substances 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 4
238000010828 elution Methods 0.000 description 4
238000010438 heat treatment Methods 0.000 description 4
239000007788 liquid Substances 0.000 description 4
108010010803 Gelatin Proteins 0.000 description 3
239000004372 Polyvinyl alcohol Substances 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
238000001816 cooling Methods 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
229920000747 poly(lactic acid) Polymers 0.000 description 3
239000004626 polylactic acid Substances 0.000 description 3
229920002451 polyvinyl alcohol Polymers 0.000 description 3
239000001103 potassium chloride Substances 0.000 description 3
235000011164 potassium chloride Nutrition 0.000 description 3
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 2
JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
229920000954 Polyglycolide Polymers 0.000 description 2
241000700159 Rattus Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000012620 biological material Substances 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
210000002449 bone cell Anatomy 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000004737 colorimetric analysis Methods 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
238000001493 electron microscopy Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
239000004633 polyglycolic acid Substances 0.000 description 2
235000002639 sodium chloride Nutrition 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
239000002904 solvent Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000000560 biocompatible material Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000007398 colorimetric assay Methods 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
239000007943 implant Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000004745 nonwoven fabric Substances 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229920003170 water-soluble synthetic polymer Polymers 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Landscapes

Materials For Medical Uses (AREA)
Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)

JP62262310A 1987-10-16 1987-10-16 多孔質体の製造方法 Granted JPH01104635A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP62262310A JPH01104635A (ja)	1987-10-16	1987-10-16	多孔質体の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP62262310A JPH01104635A (ja)	1987-10-16	1987-10-16	多孔質体の製造方法

Publications (2)

Publication Number	Publication Date
JPH01104635A JPH01104635A (ja)	1989-04-21
JPH0564982B2 true JPH0564982B2 (nl)	1993-09-16

Family

ID=17374006

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62262310A Granted JPH01104635A (ja)	1987-10-16	1987-10-16	多孔質体の製造方法

Country Status (1)

Country	Link
JP (1)	JPH01104635A (nl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5223546A (en) *	1991-04-24	1993-06-29	Mitsui Toatsu Chemicals, Inc.	High polymer network
US5502092A (en) *	1994-02-18	1996-03-26	Minnesota Mining And Manufacturing Company	Biocompatible porous matrix of bioabsorbable material
JP2001081229A (ja) *	1999-09-16	2001-03-27	Toyo Cloth Co Ltd	生分解性多孔質膜及びその製造方法
JP2002020530A (ja) *	2000-07-05	2002-01-23	Toyo Cloth Co Ltd	生分解性多孔質膜及び構造体、及びその製造方法
JP4344216B2 (ja) *	2003-10-30	2009-10-14	ハナキゴム株式会社	連続気泡を有する高分子化合物多孔体の製造方法
JP4904256B2 (ja) *	2004-03-22	2012-03-28	エージェンシーフォーサイエンス，テクノロジーアンドリサーチ	組織および骨用の足場において傾斜細孔構造を得るための方法、ならびに、組織および骨用の傾斜細孔構造を有する足場
JP6533104B2 (ja) *	2015-06-18	2019-06-19	株式会社ジーシー	細胞工学用支持体の製造方法

1987
- 1987-10-16 JP JP62262310A patent/JPH01104635A/ja active Granted

Also Published As

Publication number	Publication date
JPH01104635A (ja)	1989-04-21

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