HRP20020475B1 - Novi derivati benzoimidazola korisni kao sredstvaprotiv proliferacije - Google Patents

Novi derivati benzoimidazola korisni kao sredstvaprotiv proliferacije

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HRP20020475B1
HRP20020475B1 HR20020475A HRP20020475A HRP20020475B1 HR P20020475 B1 HRP20020475 B1 HR P20020475B1 HR 20020475 A HR20020475 A HR 20020475A HR P20020475 A HRP20020475 A HR P20020475A HR P20020475 B1 HRP20020475 B1 HR P20020475B1
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cr4r5
aryl
groups
cycloalkyl
alkyl
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HR20020475A
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English (en)
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Ernest Barth Wayne
Joseph Luzzio Michael
Peter Lyssikatos Joseph
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Pfizer Products Inc.
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Publication of HRP20020475A2 publication Critical patent/HRP20020475A2/hr
Publication of HRP20020475B1 publication Critical patent/HRP20020475B1/hr

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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Spoj formule,ili njegova farmaceutski prihvatljiva sol, predlijek ili solvat, naznačen time štoX jeCH ili N; R1 se bira između -(CR4R5)tC(O)OR3, -(CR4R5)tC(O)NR3R4, -(CR4R5)tOR3, -(CR4R5)tC(O)(C3-C10 cikloalkil), -(CR4R5)tC(O)(C6-C10 aril), -(CR4R5)tC(O)(4- do 10- člani heterocikl), -(CR4R5)t(C3-C10 cikloalkil), -(CR4R5)t(C6-C10 aril) i -(CR4R5)t(4- do 10- člani heterocikl), gdje svaki t je, nezavisno, cijeli broj od 0 do 5; spomenuti cikloalkilni, arilni i heterociklički R1 ostaci izborno su spojeni sa benzenskim prstenom, C5-C8 cikloalkilnom skupinom, ili 4- do 10- članom heterocikličkom skupinom; -(CR4R5)t- ostaci prethodnih R1 skupina izborno obuhvaćaju dvostruku ili trostruku vezu ugljik-ugljik, gdje t je cijeli broj od 2 do 5; svakaod prethodnih R1 skupina je izborno supstituiranas 1 ili 2 skupine koje se nezavisno biraju između-NR3R4, -OR3, C1-C10 alkila, C2-C10 alkenila i C2-C10 alkinila, pri čemu su spomenute alkilne, alkenilne i alkinilne skupine supstituirane s 1 ili 2 skupine koje se nezavisno biraju između -NR3R4 i -OR3; i prethodne R1 skupine su izborno supstituirane s 1 do 3 R2 skupina; svaki R2 se, nezavisno, bira između H, C1-C10 alkila, C2-C10 alkenil, C2-C10alkinila, C3-C10 cikloalkila, okso, halogen, cijano, nitro, trifluormetila, difluormetoksi, trifluormetoksi, azido, -OR3, -C(O)R3, -C(O)OR3, ?NR4C(O)OR6, -OC(O)R3, -NR4SO2R6, -SO2NR3R4, -NR4C(O)R3, -C(O)NR3R4, -NR5C(O)NR3R4, -NR3R4, ?S(O)j(CR4R5)m(C6-C10 aril), -S(O)j(C1-C6 alkil), gdje j je cijelibroj od 0 do 2, -(CR4R5)m(C6-C10 aril), ?O(CR4R5)m(C6-C10 aril), -NR4(CR4R5)m(C6-C10 aril), -O(CR4R5)m(4- do 10- člani heterocikl), ?NR4(CR4R5)m(4- do 10- člani heterocikl), -(CR4R5)m(4- do 10- članiheterocikl) i -(CR4R5)m(C3-C10 cikloalkil), gdje svaki m je, nezavisno, cijeli broj od 0 do 4; spomenute alkilne, alkenilne i alkinilne skupine izborno sadrže 1 do 2 hetero ostatka koji se biraju između O, -S(O)j, gdje j je cijeli broj od 0 do 2, i -N(R3)-, pod uvjetom da dva atoma O, dva atoma S, ili O i S atomi nisu direktno vezani jedan za drugi, i pod uvjetom da svaki O atom, S atom ili N atom nije direktno vezan za trostruku vezu ili nearomatičnu dvostruku vezu; spomenute cikloalkilne, arilne i heterocikličke R2 skupine su izborno spojenesa C6-C10 arilnom skupinom, C5-C8 cikloalkilnom skupinom, ili sa 4- do 10- članom heterocikličkom skupinom; a spomenute alkilne, cikloalkilne, arilnei heterocikličke R2 skupine su izborno supstituirane s 1 do 5 supstituenata koji se nezavisno biraju između okso (=O), halogen, cijano, nitro, trifluormetila, difluormetoksi, trifluormetoksi, azido, -NR4SO2R6, -SO2NR3R4, -C(O)R3, -C(O)OR3, -OC(O)R3,-NR4C(O)OR6, -NR4C(O)R3, -C(O)NR3R4, ?NR3R4, -OR3, C1-C10 alkila, -(CR4R5)m(C6-C10 aril) i -(CR4R5)m(4- do 10- člani heterocikl), gdje svaki m je, nezavisno, cijeli broj od 0 do 4; svaki R3 se, nezavisno, bira između H, C1-C10 alkila, -(CR4R5)m(C6-C10 aril) i -(CR4R5)m(4- do 10- člani heterocikl), gdje svaki m je, nezavisno, cijeli broj od 0 do 4;spomenuta a
HR20020475A 1999-11-30 2002-05-29 Novi derivati benzoimidazola korisni kao sredstvaprotiv proliferacije HRP20020475B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16821799P 1999-11-30 1999-11-30
PCT/IB2000/001636 WO2001040217A1 (en) 1999-11-30 2000-11-10 Novel benzoimidazole derivatives useful as antiproliferative agents

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HRP20020475A2 HRP20020475A2 (en) 2005-10-31
HRP20020475B1 true HRP20020475B1 (hr) 2007-06-30

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US (1) US7019147B1 (hr)
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