HRP20000511A2 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives - Google Patents
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives Download PDFInfo
- Publication number
- HRP20000511A2 HRP20000511A2 HR20000511A HRP20000511A HRP20000511A2 HR P20000511 A2 HRP20000511 A2 HR P20000511A2 HR 20000511 A HR20000511 A HR 20000511A HR P20000511 A HRP20000511 A HR P20000511A HR P20000511 A2 HRP20000511 A2 HR P20000511A2
- Authority
- HR
- Croatia
- Prior art keywords
- ethyl
- ethylamino
- isoxazol
- purin
- furan
- Prior art date
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- YQUJSBYIKMQCIT-UHFFFAOYSA-N 2-purin-9-yloxolane-3,4-diol Chemical class OC1C(O)COC1N1C2=NC=NC=C2N=C1 YQUJSBYIKMQCIT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 254
- 239000000203 mixture Substances 0.000 claims description 108
- -1 cyclopropenylmethyl Chemical group 0.000 claims description 68
- 239000002904 solvent Substances 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 27
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 19
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 11
- 125000002757 morpholinyl group Chemical group 0.000 claims description 11
- 125000003386 piperidinyl group Chemical group 0.000 claims description 11
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 125000004076 pyridyl group Chemical group 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000002785 azepinyl group Chemical group 0.000 claims description 6
- 125000002393 azetidinyl group Chemical group 0.000 claims description 6
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims description 6
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 6
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
- 208000006673 asthma Diseases 0.000 claims description 5
- 125000004193 piperazinyl group Chemical group 0.000 claims description 5
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 3
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 3
- 229910005965 SO 2 Inorganic materials 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 3
- NNPKMJTZHWAPAC-RBOWJBJUSA-N (2r,3r,4s,5s)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[6-(2-phenylethylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](N2C3=NC(NCCN4CCCCC4)=NC(NCCC=4C=CC=CC=4)=C3N=C2)O1 NNPKMJTZHWAPAC-RBOWJBJUSA-N 0.000 claims description 2
- SHAGTVNCZUBUCI-IMNMKIORSA-N (2r,3r,4s,5s)-2-[6-(2,2-diphenylethylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NCC(C=4C=CC=CC=4)C=4C=CC=CC=4)=C3N=C2)O1 SHAGTVNCZUBUCI-IMNMKIORSA-N 0.000 claims description 2
- WSZKIEGTRVUDQA-IYXIZZNPSA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[6-(pentan-3-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(CC)C=3)O)C=NC=2C(NC(CC)CC)=NC=1NCCN1CCCCC1 WSZKIEGTRVUDQA-IYXIZZNPSA-N 0.000 claims description 2
- FQBKNNBFHAYPCZ-OLWIJOGUSA-N (2s,3s,4r,5r)-2-[3-(1-hydroxyethyl)-1,2-oxazol-5-yl]-5-[6-(pentan-3-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(C=3)C(C)O)O)C=NC=2C(NC(CC)CC)=NC=1NCCN1CCCCC1 FQBKNNBFHAYPCZ-OLWIJOGUSA-N 0.000 claims description 2
- YKOWBJJOJNGCAD-SHYZEUOFSA-N [(2r,3s,5r)-3-hydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl dihydrogen phosphate Chemical compound O=C1N=C(NO)C=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 YKOWBJJOJNGCAD-SHYZEUOFSA-N 0.000 claims description 2
- 125000000298 cyclopropenyl group Chemical group [H]C1=C([H])C1([H])* 0.000 claims description 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 238000010511 deprotection reaction Methods 0.000 claims description 2
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims description 2
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 2
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical group C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- AXQZJJVCWCQUBA-KXEAFHOWSA-N (2r,3r,4s,5s)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[2-(2-pyridin-2-ylethylamino)-6-(thian-4-ylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](N2C3=NC(NCCC=4N=CC=CC=4)=NC(NC4CCSCC4)=C3N=C2)O1 AXQZJJVCWCQUBA-KXEAFHOWSA-N 0.000 claims 1
- BXDLHXBCFBMFTQ-JZJXAQOMSA-N (2r,3r,4s,5s)-2-[2-(ethylamino)-6-[(3-iodophenyl)methylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound C=12N=CN([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(CC)C=3)O)C2=NC(NCC)=NC=1NCC1=CC=CC(I)=C1 BXDLHXBCFBMFTQ-JZJXAQOMSA-N 0.000 claims 1
- HZOHMZGMBDIMIM-CFNUTJGKSA-N (2r,3r,4s,5s)-2-[6-(2,2-diphenylethylamino)-2-(2-morpholin-4-ylethylamino)purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCOCC4)=NC(NCC(C=4C=CC=CC=4)C=4C=CC=CC=4)=C3N=C2)O1 HZOHMZGMBDIMIM-CFNUTJGKSA-N 0.000 claims 1
- NUVIXGRCGGLAAS-IMNMKIORSA-N (2r,3r,4s,5s)-2-[6-(2,2-diphenylethylamino)-2-[2-(pyridin-2-ylamino)ethylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCNC=4N=CC=CC=4)=NC(NCC(C=4C=CC=CC=4)C=4C=CC=CC=4)=C3N=C2)O1 NUVIXGRCGGLAAS-IMNMKIORSA-N 0.000 claims 1
- BYZVGFPGQNGQMM-ZOJNDGCKSA-N (2r,3r,4s,5s)-2-[6-(2-cyclohexylethylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCC=4N=CN(C)C=4)=NC(NCCC4CCCCC4)=C3N=C2)O1 BYZVGFPGQNGQMM-ZOJNDGCKSA-N 0.000 claims 1
- AOPUCSGJQSGPKA-FBHSLPMESA-N (2r,3r,4s,5s)-2-[6-(3,3-dimethylbutylamino)-2-(2-morpholin-4-ylethylamino)purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCOCC4)=NC(NCCC(C)(C)C)=C3N=C2)O1 AOPUCSGJQSGPKA-FBHSLPMESA-N 0.000 claims 1
- PNENCUZRNOQNGK-IYXIZZNPSA-N (2r,3r,4s,5s)-2-[6-(3,3-dimethylbutylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NCCC(C)(C)C)=C3N=C2)O1 PNENCUZRNOQNGK-IYXIZZNPSA-N 0.000 claims 1
- VLMXBVLPRDNRNB-FBHSLPMESA-N (2r,3r,4s,5s)-2-[6-(3,3-dimethylbutylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCC=4N=CN(C)C=4)=NC(NCCC(C)(C)C)=C3N=C2)O1 VLMXBVLPRDNRNB-FBHSLPMESA-N 0.000 claims 1
- XDXRJEQHCDBRSK-NZCWTCFWSA-N (2r,3r,4s,5s)-2-[6-(benzylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(3-ethyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCC=4N=CN(C)C=4)=NC(NCC=4C=CC=CC=4)=C3N=C2)O1 XDXRJEQHCDBRSK-NZCWTCFWSA-N 0.000 claims 1
- GQCMVUPPLDWAQE-NZCWTCFWSA-N (2r,3r,4s,5s)-2-[6-(pentan-3-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]-5-(3-propyl-1,2-oxazol-5-yl)oxolane-3,4-diol Chemical compound O1N=C(CCC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NC(CC)CC)=C3N=C2)O1 GQCMVUPPLDWAQE-NZCWTCFWSA-N 0.000 claims 1
- YGQUWYZDAZAHOF-IYXIZZNPSA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[2-(2-piperidin-1-ylethylamino)-6-(thian-4-ylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NC4CCSCC4)=C3N=C2)O1 YGQUWYZDAZAHOF-IYXIZZNPSA-N 0.000 claims 1
- PSDBBIQJWFUXEZ-DZCCDHAISA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[2-(oxan-4-ylamino)-6-(pentan-3-ylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(CC)C=3)O)C=NC=2C(NC(CC)CC)=NC=1NC1CCOCC1 PSDBBIQJWFUXEZ-DZCCDHAISA-N 0.000 claims 1
- NZSQLZFWQKBZMV-NZCWTCFWSA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[6-(3-fluoro-4-hydroxyanilino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NC=4C=C(F)C(O)=CC=4)=C3N=C2)O1 NZSQLZFWQKBZMV-NZCWTCFWSA-N 0.000 claims 1
- WKLLTMXJLCOJEF-IYXIZZNPSA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[6-(oxan-4-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCN4CCCCC4)=NC(NC4CCOCC4)=C3N=C2)O1 WKLLTMXJLCOJEF-IYXIZZNPSA-N 0.000 claims 1
- NYCQFLPZVKNGHH-IYXIZZNPSA-N (2s,3s,4r,5r)-2-(3-ethyl-1,2-oxazol-5-yl)-5-[6-(oxan-4-ylamino)-2-(2-pyridin-2-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound O1N=C(CC)C=C1[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC(NCCC=4N=CC=CC=4)=NC(NC4CCOCC4)=C3N=C2)O1 NYCQFLPZVKNGHH-IYXIZZNPSA-N 0.000 claims 1
- SJSHNUZYLVMPBM-FBHSLPMESA-N (2s,3s,4r,5r)-2-(3-methyl-1,2-oxazol-5-yl)-5-[6-(pentan-3-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(C)C=3)O)C=NC=2C(NC(CC)CC)=NC=1NCCN1CCCCC1 SJSHNUZYLVMPBM-FBHSLPMESA-N 0.000 claims 1
- OYJCZWPBQRKWGQ-DZCCDHAISA-N (2s,3s,4r,5r)-2-[3-(hydroxymethyl)-1,2-oxazol-5-yl]-5-[2-[2-(1-methylimidazol-4-yl)ethylamino]-6-(pentan-3-ylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(CO)C=3)O)C=NC=2C(NC(CC)CC)=NC=1NCCC1=CN(C)C=N1 OYJCZWPBQRKWGQ-DZCCDHAISA-N 0.000 claims 1
- DVHGNGSVBRBDEK-FBHSLPMESA-N (2s,3s,4r,5r)-2-[3-(hydroxymethyl)-1,2-oxazol-5-yl]-5-[6-(pentan-3-ylamino)-2-(2-piperidin-1-ylethylamino)purin-9-yl]oxolane-3,4-diol Chemical compound N=1C=2N([C@H]3[C@@H]([C@H](O)[C@H](O3)C=3ON=C(CO)C=3)O)C=NC=2C(NC(CC)CC)=NC=1NCCN1CCCCC1 DVHGNGSVBRBDEK-FBHSLPMESA-N 0.000 claims 1
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- 239000003085 diluting agent Substances 0.000 claims 1
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- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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- CSRZQMIRAZTJOY-UHFFFAOYSA-N trimethylsilyl iodide Chemical class C[Si](C)(C)I CSRZQMIRAZTJOY-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9802066.2A GB9802066D0 (en) | 1998-01-31 | 1998-01-31 | Chemical compounds |
GBGB9813528.8A GB9813528D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
PCT/EP1999/000503 WO1999038877A2 (en) | 1998-01-31 | 1999-01-29 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
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HRP20000511A2 true HRP20000511A2 (en) | 2000-12-31 |
Family
ID=26313042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20000511A HRP20000511A2 (en) | 1998-01-31 | 2000-07-28 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
Country Status (39)
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US (1) | US6762170B1 (es) |
EP (1) | EP1051425B1 (es) |
JP (1) | JP2002501928A (es) |
KR (1) | KR20010034473A (es) |
CN (1) | CN1289338A (es) |
AP (1) | AP2000001875A0 (es) |
AR (1) | AR014508A1 (es) |
AT (1) | ATE226957T1 (es) |
AU (1) | AU757183B2 (es) |
BG (1) | BG63783B1 (es) |
BR (1) | BR9907270A (es) |
CA (1) | CA2318278A1 (es) |
CO (1) | CO4980872A1 (es) |
DE (1) | DE69903708T2 (es) |
DK (1) | DK1051425T3 (es) |
EA (1) | EA003194B1 (es) |
EE (1) | EE200000441A (es) |
ES (1) | ES2186330T3 (es) |
GE (1) | GEP20022839B (es) |
HK (1) | HK1030611A1 (es) |
HR (1) | HRP20000511A2 (es) |
HU (1) | HUP0101305A3 (es) |
ID (1) | ID26326A (es) |
IL (1) | IL137042A0 (es) |
IS (1) | IS5550A (es) |
MA (1) | MA26601A1 (es) |
NO (1) | NO20003867D0 (es) |
NZ (1) | NZ505452A (es) |
OA (1) | OA11447A (es) |
PE (1) | PE20000280A1 (es) |
PL (1) | PL342670A1 (es) |
PT (1) | PT1051425E (es) |
SI (1) | SI1051425T1 (es) |
SK (1) | SK11192000A3 (es) |
SV (1) | SV1999000009A (es) |
TR (1) | TR200002218T2 (es) |
TW (1) | TW434250B (es) |
WO (1) | WO1999038877A2 (es) |
YU (1) | YU44900A (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9813554D0 (en) | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
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