HK134693A - Agents for blocking endothelin derived relaxing factor - Google Patents

Agents for blocking endothelin derived relaxing factor

Info

Publication number: HK134693A
Authority: HK; Hong Kong
Prior art keywords: agents; relaxing factor; derived relaxing; endothelin; blocking
Prior art date: 1989-12-22

Application number

HK1346/93A

Other languages

English (en)

Inventor

Pierre Braquet

Pierre-Etienne Cha Lassauniere

Jean-Michel Guillon

Michel Auguet

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-22

Filing date

1993-12-09

Publication date

1993-12-17

1993-12-09 Application filed by Scras filed Critical Scras

1993-12-17 Publication of HK134693A publication Critical patent/HK134693A/xx

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
230000000903 blocking effect Effects 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
230000002040 relaxant effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polyurethanes Or Polyureas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK1346/93A 1989-12-22 1993-12-09 Agents for blocking endothelin derived relaxing factor HK134693A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898929076A GB8929076D0 (en)	1989-12-22	1989-12-22	Treatment of shock by blocking agents of edrf effect or formation

Publications (1)

Publication Number	Publication Date
HK134693A true HK134693A (en)	1993-12-17

Family

ID=10668428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK1346/93A HK134693A (en)	1989-12-22	1993-12-09	Agents for blocking endothelin derived relaxing factor

Country Status (21)

Country	Link
US (1)	US5081148A (fr)
JP (1)	JP2706578B2 (fr)
KR (1)	KR950005866B1 (fr)
AT (1)	AT403122B (fr)
AU (1)	AU629777B2 (fr)
BE (1)	BE1005531A5 (fr)
CA (1)	CA2032904C (fr)
CH (1)	CH681692A5 (fr)
DE (1)	DE4041283C2 (fr)
DK (1)	DK176168B1 (fr)
FR (1)	FR2656220B1 (fr)
GB (2)	GB8929076D0 (fr)
HK (1)	HK134693A (fr)
IE (1)	IE64403B1 (fr)
IT (1)	IT1246511B (fr)
LU (1)	LU87867A1 (fr)
MY (1)	MY105328A (fr)
NL (1)	NL194717C (fr)
OA (1)	OA09337A (fr)
SE (1)	SE504922C2 (fr)
ZA (1)	ZA9010004B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468881B (sv) *	1991-01-09	1993-04-05	Kabi Pharmacia Ab	Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
GB9127376D0 (en) *	1991-12-24	1992-02-19	Wellcome Found	Amidino derivatives
GB9200114D0 (en) *	1992-01-04	1992-02-26	Scras	Dual inhibitors of no synthase and cyclooxygenase
US5385940A (en) *	1992-11-05	1995-01-31	The General Hospital Corporation	Treatment of stroke with nitric-oxide releasing compounds
US5585402A (en) *	1992-12-23	1996-12-17	Glaxo Wellcome Inc.	Nitric oxide synthase inhibitors
US5436270A (en) *	1993-04-07	1995-07-25	National Science Council	Method for protecting against endotoxin-induced shock
GB9312204D0 (en) *	1993-06-14	1993-07-28	Zeneca Ltd	Therapeutic composition
GB9312761D0 (en) *	1993-06-21	1993-08-04	Wellcome Found	Amino acid derivatives
US6297276B1 (en)	1993-10-04	2001-10-02	Glaxosmithkline	Substituted urea and isothiourea derivatives as no synthase inhibitors
US6090846A (en) *	1994-06-01	2000-07-18	Glaxo Wellcome Inc.	Substituted urea and isothiourea derivatives as no synthase inhibitors
US6225305B1 (en)	1993-10-04	2001-05-01	Glaxo Wellcome Inc.	Substituted urea and isothiorea derivatives as no synthase inhibitors
EP0724435B1 (fr) *	1993-10-21	2002-08-14	G.D. Searle & Co.	Derives amidino utiles comme inhibiteurs de l'oxyde nitrique-synthase
ATE177078T1 (de) *	1993-10-21	1999-03-15	Searle & Co	Amidino-derivate als no-synthetase inhibitoren
GB9404400D0 (en) *	1994-03-07	1994-04-20	Wood Pauline J	Potentiation of bioreductive agents
ES2151055T3 (es) *	1994-03-10	2000-12-16	Searle & Co	Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa.
US5684008A (en)	1994-11-09	1997-11-04	G. D. Searle & Co.	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
FR2727111B1 (fr) *	1994-11-21	1997-01-17	Hoechst Lab	Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
JPH10510540A (ja) *	1994-12-12	1998-10-13	オメロスメディカルシステムズ，インコーポレーテッド	灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
RU2180852C2 (ru) *	1994-12-12	2002-03-27	Омерос Медикл Системс, Инк.	Ингибирующий раствор и способ подавления боли, воспаления или спазма
KR100517210B1 (ko) *	1994-12-12	2006-06-07	오메로스 코포레이션	통증,염증및경련억제용관주용액
FR2730930B1 (fr)	1995-02-27	1997-04-04	Oreal	Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) *	1995-03-04	1995-04-26	Sod Conseils Rech Applic	Arginine derivatives
ATE246678T1 (de) *	1995-04-20	2003-08-15	Searle & Co	Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren
US5830917A (en) *	1995-09-11	1998-11-03	G. D. Searle & Co.	L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) *	1996-03-06	1999-11-09	G.D. Searle & Co.	Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) *	1996-03-06	1999-08-31	G.D. Searle & Co.	Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US6369272B1 (en)	1997-01-13	2002-04-09	Glaxosmithkline	Nitric oxide synthase inhibitors
US6620848B2 (en)	1997-01-13	2003-09-16	Smithkline Beecham Corporation	Nitric oxide synthase inhibitors
US5981556A (en) *	1997-07-22	1999-11-09	G.D. Searle & Co.	1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
GB9811599D0 (en)	1998-05-30	1998-07-29	Glaxo Group Ltd	Nitric oxide synthase inhibitors
JP2002517502A (ja)	1998-06-10	2002-06-18	ジー・ディー・サール・アンド・カンパニー	複素二環状及び三環状一酸化窒素シンターゼ阻害剤
US6344473B1 (en)	2000-08-07	2002-02-05	G.D. Searle & Co.	Imidazoles useful as nitric oxide synthase inhibitors
CA2552195C (fr)	2003-12-30	2012-01-24	Vasopharm Biotech Gmbh	4-amino-7,8-dihydropteridines, compositions pharmaceutiques les contenant, et leur utilisation pour traiter des maladies causees par une augmentation du niveau d'oxyde nitrique

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Publication number	Priority date	Publication date	Assignee	Title
GB931921A (en) *	1960-12-22	1963-07-24	Lab Roques	Therapeutic compositions intended for the treatment of any hepatic malfunctionings
DE1767212B1 (de) *	1967-04-13	1971-05-06	Sumitomo Chemical Co	Verfahren zur Herstellung injizierbarer Arzneimittel
FR2115060A1 (en) *	1970-11-26	1972-07-07	Metabio	Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
CA1029660A (fr) *	1973-06-01	1978-04-18	Kyowa Hakko Kogyo Co.	Prevention des lesions gastriques
FR2320759A1 (fr) *	1975-08-11	1977-03-11	Union Pharma Scient Appl	Solution d'acide acetylsalicylique extemporanee injectable
IT1127322B (it) *	1979-12-28	1986-05-21	Italfarmaco Spa	Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
IT1127321B (it) *	1979-12-28	1986-05-21	Italfarmaco Spa	Composizione farmaceutiche aventi specifiche proprieta' terapeutiche nei confronti dell'edema polmonare acuto,di alcuni stati di shock e dell'iperfibrinolisi
JPS5781409A (en) *	1980-11-10	1982-05-21	Toko Yakuhin Kogyo Kk	External plaster
JPS57197211A (en) *	1981-05-28	1982-12-03	Sumitomo Chem Co Ltd	Useful eye drop composition
JPS57200361A (en) *	1981-06-03	1982-12-08	Sumitomo Chem Co Ltd	"indomethacin(r)" pharmaceutical with low irritant action
JPS6239524A (ja) *	1985-08-13	1987-02-20	Toko Yakuhin Kogyo Kk	消炎鎮痛軟膏剤
JPH0236570B2 (ja) *	1985-05-30	1990-08-17	Toko Yakuhin Kogyo Kk	Shoenchintsunankozai
IT1201511B (it) *	1985-12-23	1989-02-02	Italfarmaco Spa	Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
AU1489688A (en) *	1987-02-20	1988-09-14	Shriners Hospitals For Crippled Children	Omega-3 fatty acids in traumatic injury treatment

1989
- 1989-12-22 GB GB898929076A patent/GB8929076D0/en active Pending
1990
- 1990-12-11 NL NL9002720A patent/NL194717C/nl not_active IP Right Cessation
- 1990-12-12 ZA ZA9010004A patent/ZA9010004B/xx unknown
- 1990-12-12 SE SE9003974A patent/SE504922C2/sv not_active IP Right Cessation
- 1990-12-14 BE BE9001200A patent/BE1005531A5/fr not_active Expired - Fee Related
- 1990-12-18 IT IT02241390A patent/IT1246511B/it active IP Right Grant
- 1990-12-19 US US07/630,273 patent/US5081148A/en not_active Expired - Lifetime
- 1990-12-19 IE IE459290A patent/IE64403B1/en not_active IP Right Cessation
- 1990-12-19 FR FR9015904A patent/FR2656220B1/fr not_active Expired - Fee Related
- 1990-12-19 CH CH4034/90A patent/CH681692A5/fr not_active IP Right Cessation
- 1990-12-20 AT AT0260690A patent/AT403122B/de not_active IP Right Cessation
- 1990-12-20 MY MYPI90002223A patent/MY105328A/en unknown
- 1990-12-21 OA OA59932A patent/OA09337A/fr unknown
- 1990-12-21 DK DK199003041A patent/DK176168B1/da not_active IP Right Cessation
- 1990-12-21 AU AU68376/90A patent/AU629777B2/en not_active Ceased
- 1990-12-21 LU LU87867A patent/LU87867A1/fr unknown
- 1990-12-21 KR KR1019900021355A patent/KR950005866B1/ko not_active IP Right Cessation
- 1990-12-21 DE DE4041283A patent/DE4041283C2/de not_active Expired - Fee Related
- 1990-12-21 CA CA002032904A patent/CA2032904C/fr not_active Expired - Lifetime
- 1990-12-24 GB GB9028013A patent/GB2240041B/en not_active Expired - Lifetime
- 1990-12-25 JP JP2419113A patent/JP2706578B2/ja not_active Expired - Lifetime
1993
- 1993-12-09 HK HK1346/93A patent/HK134693A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA9010004B (en)	1991-10-30
OA09337A (fr)	1992-09-15
AT403122B (de)	1997-11-25
FR2656220A1 (fr)	1991-06-28
SE9003974L (sv)	1991-06-23
GB8929076D0 (en)	1990-02-28
KR950005866B1 (ko)	1995-06-02
GB2240041A (en)	1991-07-24
DE4041283A1 (de)	1991-06-27
JPH04364124A (ja)	1992-12-16
SE504922C2 (sv)	1997-05-26
JP2706578B2 (ja)	1998-01-28
KR910011253A (ko)	1991-08-07
CA2032904C (fr)	1996-01-02
AU6837690A (en)	1991-06-27
MY105328A (en)	1994-09-30
SE9003974D0 (sv)	1990-12-12
US5081148A (en)	1992-01-14
NL194717C (nl)	2003-01-07
IE64403B1 (en)	1995-08-09
GB9028013D0 (en)	1991-02-13
DK304190D0 (da)	1990-12-21
DE4041283C2 (de)	2000-07-13
NL9002720A (nl)	1991-07-16
DK304190A (da)	1991-06-23
DK176168B1 (da)	2006-11-13
LU87867A1 (fr)	1991-05-07
GB2240041B (en)	1993-09-01
IT9022413A1 (it)	1991-06-23
IT1246511B (it)	1994-11-19
AU629777B2 (en)	1992-10-08
IT9022413A0 (it)	1990-12-18
NL194717B (nl)	2002-09-02
FR2656220B1 (fr)	1995-01-13
BE1005531A5 (fr)	1993-09-28
CH681692A5 (fr)	1993-05-14
ATA260690A (de)	1997-04-15
CA2032904A1 (fr)	1991-06-23
IE904592A1 (en)	1991-07-03

Legal Events

Date	Code	Title	Description
2004-12-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Publication	Publication Date	Title
GB2240041B (en)	1993-09-01	Agents for blocking endothelin derived relaxing factor
AR244967A1 (es)	1993-12-30	Silla.
GB2249721B (en)	1993-08-18	Seating
GB8905496D0 (en)	1989-04-19	Improved push chair
GB2231365B (en)	1992-08-26	Seat
ZA907392B (en)	1992-05-27	Spread
EP0420315A3 (en)	1991-05-08	Spread
GB8925248D0 (en)	1989-12-28	Spread
GB8900732D0 (en)	1989-03-08	Agents
SG138193G (en)	1994-03-31	Agents for blocking endothelin derived relaxing factor
GB2231787B (en)	1992-12-02	Chair
AU106904S (en)	1990-02-28	High chair
CA63474S (en)	1989-06-09	Chair
CA64039S (en)	1989-08-31	Chair
CA62286S (en)	1989-01-10	Chair
HU906978D0 (en)	1991-05-28	Blocking for tool-chuck
AU106833S (en)	1990-02-14	Chair component
AU106912S (en)	1990-02-28	Chair
AU108156S (en)	1990-07-05	Chair
AU110186S (en)	1991-02-05	Chair
AU106569S (en)	1990-01-31	Chair
AU108890S (en)	1990-09-05	Chair
AU106707S (en)	1990-02-06	Chair
AU108189S (en)	1990-07-06	Chair
AU106917S (en)	1990-02-28	Chair