FR2115060A1 - Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin - Google Patents
Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirinInfo
- Publication number
- FR2115060A1 FR2115060A1 FR7042536A FR7042536A FR2115060A1 FR 2115060 A1 FR2115060 A1 FR 2115060A1 FR 7042536 A FR7042536 A FR 7042536A FR 7042536 A FR7042536 A FR 7042536A FR 2115060 A1 FR2115060 A1 FR 2115060A1
- Authority
- FR
- France
- Prior art keywords
- aspirin
- derivs
- arginine
- lysine
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/90—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title cpds. are soluble derivs. of aspirin which are more easily prepd. than by earlier crystallisation processes. Prepd. by gradual addn. of aspirin to a stirred soln. of lysine or arginine, e.g. in water, filtering and freeze-drying, e.g. in vials.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7042536A FR2115060A1 (en) | 1970-11-26 | 1970-11-26 | Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7042536A FR2115060A1 (en) | 1970-11-26 | 1970-11-26 | Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2115060A1 true FR2115060A1 (en) | 1972-07-07 |
FR2115060B1 FR2115060B1 (en) | 1974-08-30 |
Family
ID=9064778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7042536A Granted FR2115060A1 (en) | 1970-11-26 | 1970-11-26 | Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2115060A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2210389A1 (en) * | 1972-12-15 | 1974-07-12 | Synthelabo | Diacetoxy benzoic acid salts with amino acids - inhibitors of thrombocyte aggregation, free from undesirable side effects |
EP0324402A1 (en) * | 1988-01-13 | 1989-07-19 | EURORESEARCH S.r.L. | Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process |
EP0425362A2 (en) * | 1989-10-24 | 1991-05-02 | Roussel-Uclaf | Furosemide salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them |
GB2240041B (en) * | 1989-12-22 | 1993-09-01 | Scras | Agents for blocking endothelin derived relaxing factor |
FR2714292A1 (en) * | 1993-12-23 | 1995-06-30 | Synthelabo | Medicaments contg. lysine acetyl-salicylate and vitamin E |
EP0736301A1 (en) * | 1995-04-07 | 1996-10-09 | Synthelabo | Pharmaceutical composition containing lysine acetylsalicylate and vitamin E |
WO2002005782A2 (en) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Stable salts of o-acetylsalicyclic with basic amino acids |
AU2004218728B2 (en) * | 2000-07-18 | 2006-11-09 | Bayer Healthcare Ag | Stable salts of O-acetylsalicyclic acid with basic amino acids |
FR2950625A1 (en) * | 2009-09-30 | 2011-04-01 | Holis Technologies | Making O-acetylsalicylic acid salt of basic amino acid comprises collecting aqueous solution of basic amino acid, O-acetylsalicylic acid solution in organic solvent, reacting to obtain desired salt, adding acetone to medium and isolating |
WO2011039432A1 (en) * | 2009-09-30 | 2011-04-07 | Holis Technologies | Method for preparing a salt of o-acetylsalicylic acid and a basic amino acid, and resulting composition |
CN114795988A (en) * | 2022-03-07 | 2022-07-29 | 山东滨州智源生物科技有限公司 | Water-soluble salicylic acid and preparation method and application thereof |
-
1970
- 1970-11-26 FR FR7042536A patent/FR2115060A1/en active Granted
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2210389A1 (en) * | 1972-12-15 | 1974-07-12 | Synthelabo | Diacetoxy benzoic acid salts with amino acids - inhibitors of thrombocyte aggregation, free from undesirable side effects |
EP0324402A1 (en) * | 1988-01-13 | 1989-07-19 | EURORESEARCH S.r.L. | Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process |
EP0425362A2 (en) * | 1989-10-24 | 1991-05-02 | Roussel-Uclaf | Furosemide salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them |
EP0425362A3 (en) * | 1989-10-24 | 1991-11-21 | Roussel-Uclaf | Furosemide salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them |
GB2240041B (en) * | 1989-12-22 | 1993-09-01 | Scras | Agents for blocking endothelin derived relaxing factor |
FR2714292A1 (en) * | 1993-12-23 | 1995-06-30 | Synthelabo | Medicaments contg. lysine acetyl-salicylate and vitamin E |
EP0736301A1 (en) * | 1995-04-07 | 1996-10-09 | Synthelabo | Pharmaceutical composition containing lysine acetylsalicylate and vitamin E |
WO2002005782A2 (en) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Stable salts of o-acetylsalicyclic with basic amino acids |
WO2002005782A3 (en) * | 2000-07-18 | 2003-10-02 | Bayer Ag | Stable salts of o-acetylsalicyclic with basic amino acids |
AU2001278471B2 (en) * | 2000-07-18 | 2004-07-22 | Bayer Schering Pharma Aktiengesellschaft | Stable salts of o-acetylsalicyclic with basic amino acids |
AU2004218728B2 (en) * | 2000-07-18 | 2006-11-09 | Bayer Healthcare Ag | Stable salts of O-acetylsalicyclic acid with basic amino acids |
AU2004218728B8 (en) * | 2000-07-18 | 2006-12-07 | Bayer Healthcare Ag | Stable salts of O-acetylsalicyclic acid with basic amino acids |
US7449198B2 (en) | 2000-07-18 | 2008-11-11 | Bayer Healthcare Ag | Stable salts of O-acetylsalicylic acid with basic amino acids |
CZ300337B6 (en) * | 2000-07-18 | 2009-04-22 | Bayer Healthcare Ag | Stable salts of o-acetylsalicylic acid with basic amino acids |
FR2950625A1 (en) * | 2009-09-30 | 2011-04-01 | Holis Technologies | Making O-acetylsalicylic acid salt of basic amino acid comprises collecting aqueous solution of basic amino acid, O-acetylsalicylic acid solution in organic solvent, reacting to obtain desired salt, adding acetone to medium and isolating |
WO2011039432A1 (en) * | 2009-09-30 | 2011-04-07 | Holis Technologies | Method for preparing a salt of o-acetylsalicylic acid and a basic amino acid, and resulting composition |
FR2965261A1 (en) * | 2009-09-30 | 2012-03-30 | Holis Technologies | PROCESS FOR THE PREPARATION OF AN O-ACETYLSALICYLIC ACID SALT OF A BASIC AMINO ACID AND COMPOSITION OBTAINED THEREBY |
CN114795988A (en) * | 2022-03-07 | 2022-07-29 | 山东滨州智源生物科技有限公司 | Water-soluble salicylic acid and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
FR2115060B1 (en) | 1974-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property |