JPS57200361A - "indomethacin(r)" pharmaceutical with low irritant action - Google Patents

"indomethacin(r)" pharmaceutical with low irritant action

Info

Publication number
JPS57200361A
JPS57200361A JP8591781A JP8591781A JPS57200361A JP S57200361 A JPS57200361 A JP S57200361A JP 8591781 A JP8591781 A JP 8591781A JP 8591781 A JP8591781 A JP 8591781A JP S57200361 A JPS57200361 A JP S57200361A
Authority
JP
Japan
Prior art keywords
indomethacin
pharmaceutical
irritant action
cyclodextrin
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8591781A
Other languages
Japanese (ja)
Inventor
Yoshinari Yamahira
Takaharu Fujioka
Tetsuo Noguchi
Shigeji Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP8591781A priority Critical patent/JPS57200361A/en
Publication of JPS57200361A publication Critical patent/JPS57200361A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: An "Indomethacin " pharmaceutical with low irritant action, prepared by adding β-cyclodextrin to an "Indomethacin " pharmaceutical containing L- arginine, having reduced irritant action, and useful as an eye drop or injection.
CONSTITUTION: An "Indomethacin " pharmaceutical with low irritant action containing (A) "Indomethacin " expressed by the formula, (B) L-arginine and (C) β-cyclodextrin at a molar ratio between (A) and (B) of about 1:1 and (A) and (C) of preferably 1:≥0.5, particularly (1:1)W(1:2). The pharmaceutical is obtained by simply adding the β-cyclodextrin to an aqueous solution of the "Indomethacin " and the L-arginine; however, the composition is preferably freeze-dried from the standpoint of the stability for a long term. The pharmaceutical can be administered as an eye drop or injection, and various additives, e.g. a pharmacologically acceptable excipient or protective agent, can be mixed if necessary.
COPYRIGHT: (C)1982,JPO&Japio
JP8591781A 1981-06-03 1981-06-03 "indomethacin(r)" pharmaceutical with low irritant action Pending JPS57200361A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8591781A JPS57200361A (en) 1981-06-03 1981-06-03 "indomethacin(r)" pharmaceutical with low irritant action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8591781A JPS57200361A (en) 1981-06-03 1981-06-03 "indomethacin(r)" pharmaceutical with low irritant action

Publications (1)

Publication Number Publication Date
JPS57200361A true JPS57200361A (en) 1982-12-08

Family

ID=13872142

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8591781A Pending JPS57200361A (en) 1981-06-03 1981-06-03 "indomethacin(r)" pharmaceutical with low irritant action

Country Status (1)

Country Link
JP (1) JPS57200361A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62123116A (en) * 1985-08-19 1987-06-04 Takeda Chem Ind Ltd Aqueous solution agent
US4870060A (en) * 1985-03-15 1989-09-26 Janssen Pharmaceutica Derivatives of γ-cylodextrin
EP0435682A2 (en) * 1989-12-28 1991-07-03 Allergan, Inc. The use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension
GB2240041B (en) * 1989-12-22 1993-09-01 Scras Agents for blocking endothelin derived relaxing factor
FR2738149A1 (en) * 1995-09-06 1997-03-07 Chauvin Lab Sa COLLYRE BASED ON INDOMETACIN READY TO USE
US5744154A (en) * 1995-09-06 1998-04-28 Laboratoire Chauvin S.A. Ready-to-use indomethacin-based eye lotion
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870060A (en) * 1985-03-15 1989-09-26 Janssen Pharmaceutica Derivatives of γ-cylodextrin
JPS62123116A (en) * 1985-08-19 1987-06-04 Takeda Chem Ind Ltd Aqueous solution agent
JPH0478614B2 (en) * 1985-08-19 1992-12-11 Takeda Yakuhin Kogyo Kk
GB2240041B (en) * 1989-12-22 1993-09-01 Scras Agents for blocking endothelin derived relaxing factor
EP0435682A2 (en) * 1989-12-28 1991-07-03 Allergan, Inc. The use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension
FR2738149A1 (en) * 1995-09-06 1997-03-07 Chauvin Lab Sa COLLYRE BASED ON INDOMETACIN READY TO USE
EP0761217A1 (en) * 1995-09-06 1997-03-12 Laboratoire Chauvin S.A. Ready-to-use eye lotion containing indomethacin
US5744154A (en) * 1995-09-06 1998-04-28 Laboratoire Chauvin S.A. Ready-to-use indomethacin-based eye lotion
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same

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