JPS57200361A - "indomethacin(r)" pharmaceutical with low irritant action - Google Patents
"indomethacin(r)" pharmaceutical with low irritant actionInfo
- Publication number
- JPS57200361A JPS57200361A JP8591781A JP8591781A JPS57200361A JP S57200361 A JPS57200361 A JP S57200361A JP 8591781 A JP8591781 A JP 8591781A JP 8591781 A JP8591781 A JP 8591781A JP S57200361 A JPS57200361 A JP S57200361A
- Authority
- JP
- Japan
- Prior art keywords
- indomethacin
- pharmaceutical
- irritant action
- cyclodextrin
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: An "Indomethacin " pharmaceutical with low irritant action, prepared by adding β-cyclodextrin to an "Indomethacin " pharmaceutical containing L- arginine, having reduced irritant action, and useful as an eye drop or injection.
CONSTITUTION: An "Indomethacin " pharmaceutical with low irritant action containing (A) "Indomethacin " expressed by the formula, (B) L-arginine and (C) β-cyclodextrin at a molar ratio between (A) and (B) of about 1:1 and (A) and (C) of preferably 1:≥0.5, particularly (1:1)W(1:2). The pharmaceutical is obtained by simply adding the β-cyclodextrin to an aqueous solution of the "Indomethacin " and the L-arginine; however, the composition is preferably freeze-dried from the standpoint of the stability for a long term. The pharmaceutical can be administered as an eye drop or injection, and various additives, e.g. a pharmacologically acceptable excipient or protective agent, can be mixed if necessary.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8591781A JPS57200361A (en) | 1981-06-03 | 1981-06-03 | "indomethacin(r)" pharmaceutical with low irritant action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8591781A JPS57200361A (en) | 1981-06-03 | 1981-06-03 | "indomethacin(r)" pharmaceutical with low irritant action |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57200361A true JPS57200361A (en) | 1982-12-08 |
Family
ID=13872142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8591781A Pending JPS57200361A (en) | 1981-06-03 | 1981-06-03 | "indomethacin(r)" pharmaceutical with low irritant action |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57200361A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62123116A (en) * | 1985-08-19 | 1987-06-04 | Takeda Chem Ind Ltd | Aqueous solution agent |
US4870060A (en) * | 1985-03-15 | 1989-09-26 | Janssen Pharmaceutica | Derivatives of γ-cylodextrin |
EP0435682A2 (en) * | 1989-12-28 | 1991-07-03 | Allergan, Inc. | The use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension |
GB2240041B (en) * | 1989-12-22 | 1993-09-01 | Scras | Agents for blocking endothelin derived relaxing factor |
FR2738149A1 (en) * | 1995-09-06 | 1997-03-07 | Chauvin Lab Sa | COLLYRE BASED ON INDOMETACIN READY TO USE |
US5744154A (en) * | 1995-09-06 | 1998-04-28 | Laboratoire Chauvin S.A. | Ready-to-use indomethacin-based eye lotion |
US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
-
1981
- 1981-06-03 JP JP8591781A patent/JPS57200361A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870060A (en) * | 1985-03-15 | 1989-09-26 | Janssen Pharmaceutica | Derivatives of γ-cylodextrin |
JPS62123116A (en) * | 1985-08-19 | 1987-06-04 | Takeda Chem Ind Ltd | Aqueous solution agent |
JPH0478614B2 (en) * | 1985-08-19 | 1992-12-11 | Takeda Yakuhin Kogyo Kk | |
GB2240041B (en) * | 1989-12-22 | 1993-09-01 | Scras | Agents for blocking endothelin derived relaxing factor |
EP0435682A2 (en) * | 1989-12-28 | 1991-07-03 | Allergan, Inc. | The use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension |
FR2738149A1 (en) * | 1995-09-06 | 1997-03-07 | Chauvin Lab Sa | COLLYRE BASED ON INDOMETACIN READY TO USE |
EP0761217A1 (en) * | 1995-09-06 | 1997-03-12 | Laboratoire Chauvin S.A. | Ready-to-use eye lotion containing indomethacin |
US5744154A (en) * | 1995-09-06 | 1998-04-28 | Laboratoire Chauvin S.A. | Ready-to-use indomethacin-based eye lotion |
US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
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