HK1159630A1 - Protein kinase inhibitors - Google Patents

Protein kinase inhibitors

Info

Publication number
HK1159630A1
HK1159630A1 HK12100213.7A HK12100213A HK1159630A1 HK 1159630 A1 HK1159630 A1 HK 1159630A1 HK 12100213 A HK12100213 A HK 12100213A HK 1159630 A1 HK1159630 A1 HK 1159630A1
Authority
HK
Hong Kong
Prior art keywords
protein kinase
kinase inhibitors
inhibitors
protein
kinase
Prior art date
Application number
HK12100213.7A
Other languages
English (en)
Inventor
David Andrew Coates
Dios Magana Alfonso De
Prado Gonzales Ana De
Prado Catalina Miriam Filadelfa Del
Paredes Maria Cristina Garcia
Lawrence Mark Gelbert
John Monte Knobeloch
De La Nava Eva Maria Martin
Ortega Finger Maria Dolores Martin
Perez Jose Antonio Martinez
Herranz Ana Isabel Mateo
Martinez Carlos Perez
Martinez Concepcion Sanchez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42267022&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1159630(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1159630A1 publication Critical patent/HK1159630A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK12100213.7A 2008-12-22 2012-01-09 Protein kinase inhibitors HK1159630A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08380343 2008-12-22
US15495409P 2009-02-24 2009-02-24
PCT/US2009/068030 WO2010075074A1 (en) 2008-12-22 2009-12-15 Protein kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1159630A1 true HK1159630A1 (en) 2012-08-03

Family

ID=42267022

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12100213.7A HK1159630A1 (en) 2008-12-22 2012-01-09 Protein kinase inhibitors

Country Status (41)

Country Link
US (1) US7855211B2 (ru)
EP (1) EP2379528B1 (ru)
JP (1) JP5417453B2 (ru)
KR (1) KR101297497B1 (ru)
CN (1) CN102264725B (ru)
AR (1) AR074575A1 (ru)
AU (1) AU2009330365B2 (ru)
BR (1) BRPI0924183B8 (ru)
CA (1) CA2747055C (ru)
CO (1) CO6382125A2 (ru)
CR (1) CR20110343A (ru)
CY (1) CY2019009I2 (ru)
DK (1) DK2379528T3 (ru)
DO (1) DOP2011000204A (ru)
EA (1) EA018808B1 (ru)
EC (1) ECSP11011157A (ru)
ES (1) ES2435798T3 (ru)
FI (1) FIC20190008I1 (ru)
GT (1) GT201100181A (ru)
HK (1) HK1159630A1 (ru)
HN (1) HN2011001701A (ru)
HR (1) HRP20131051T1 (ru)
HU (1) HUS000509I2 (ru)
IL (1) IL213350A (ru)
JO (1) JO2885B1 (ru)
MA (1) MA32903B1 (ru)
MX (1) MX2011006757A (ru)
MY (1) MY150547A (ru)
NZ (1) NZ593114A (ru)
PA (1) PA8852901A1 (ru)
PE (1) PE20120107A1 (ru)
PL (1) PL2379528T3 (ru)
PT (1) PT2379528E (ru)
RS (1) RS53061B (ru)
SG (1) SG172331A1 (ru)
SI (1) SI2379528T1 (ru)
TN (1) TN2011000293A1 (ru)
TW (1) TWI429635B (ru)
UA (1) UA104603C2 (ru)
WO (1) WO2010075074A1 (ru)
ZA (1) ZA201104505B (ru)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101386494B1 (ko) 2005-05-10 2014-04-24 인사이트 코포레이션 인돌아민 2,3-디옥시게나제의 조절제 및 이의 사용방법
KR101649548B1 (ko) 2008-07-08 2016-08-19 인사이트 홀딩스 코포레이션 인돌아민 ２,３-디옥시게나아제의 억제제로서의 １,２,５-옥사디아졸
ME03300B (me) 2012-06-13 2019-07-20 Incyte Holdings Corp Supsтituisana triciklična jedinjenja као inhibiтori fgfr
CA2880764C (en) 2012-08-03 2022-08-30 Foundation Medicine, Inc. Human papilloma virus as predictor of cancer prognosis
EP3696276A1 (en) * 2013-02-25 2020-08-19 Novartis AG Novel androgen receptor mutation
US9527857B2 (en) 2013-03-15 2016-12-27 GI Therapeutics, Inc. HSPC-sparing treatments for RB-positive abnormal cellular proliferation
WO2014144740A2 (en) 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Highly active anti-neoplastic and anti-proliferative agents
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
RU2670762C2 (ru) * 2013-12-31 2018-10-25 Хуаньчжу Фарма Ко., Лтд. Производные 6-(пиримидиноаминопиридин)бензоимидазола, полезные для лечения рака
US9949976B2 (en) 2013-12-31 2018-04-24 Xuanzhu Pharma Co., Ltd. Kinase inhibitor and use thereof
TWI558399B (zh) * 2014-02-26 2016-11-21 美國禮來大藥廠 癌症之組合療法
CN104910137B (zh) * 2014-03-10 2017-04-19 山东轩竹医药科技有限公司 Cdk激酶抑制剂
ES2873959T3 (es) 2014-05-28 2021-11-04 Piramal Entpr Ltd Combinación farmacéutica que comprende un inhibidor de CDK y un inhibidor de tiorredoxina reductasa para el tratamiento del cáncer
SG10202004716RA (en) * 2014-07-24 2020-06-29 Beta Pharma Inc 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof
CN105294683B (zh) * 2014-07-26 2018-01-23 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
EP4183806A3 (en) 2014-11-12 2023-08-02 Seagen Inc. Glycan-interacting compounds and methods of use
TWI704151B (zh) * 2014-12-22 2020-09-11 美商美國禮來大藥廠 Ｅｒｋ抑制劑
CN105732615B (zh) * 2014-12-31 2018-05-01 山东轩竹医药科技有限公司 Cdk激酶抑制剂
CN104529904B (zh) 2015-01-09 2016-08-31 苏州明锐医药科技有限公司 玻玛西尼的制备方法
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EA038045B1 (ru) 2015-02-20 2021-06-28 Инсайт Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
US9969719B2 (en) * 2015-03-11 2018-05-15 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug
TWI609687B (zh) 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
TWI696617B (zh) * 2015-04-28 2020-06-21 大陸商上海復尚慧創醫藥研究有限公司 特定蛋白質激酶抑制劑
PL3305785T3 (pl) 2015-05-29 2021-12-27 Teijin Pharma Limited Pochodna pirydo[3,4-d]pirymidyny i jej farmaceutycznie dopuszczalna sól
CN104892580B (zh) * 2015-06-17 2018-01-26 镇江圣安医药有限公司 一种新型苯并咪唑‑嘧啶胺衍生物、及其应用
CN106316935B (zh) * 2015-06-30 2019-03-26 正大天晴药业集团股份有限公司 一种Abemaciclib中间体的制备方法
CN105111191B (zh) * 2015-07-21 2018-06-08 上海皓元生物医药科技有限公司 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途
CN106467517B (zh) * 2015-08-14 2019-09-06 正大天晴药业集团股份有限公司 氘修饰的Abemaciclib衍生物
CN105153119B (zh) * 2015-09-11 2019-01-01 广州必贝特医药技术有限公司 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用
CN106608879A (zh) 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
IL302822A (en) 2015-11-12 2023-07-01 Seagen Inc Compounds interacting with glycans and methods of use
CN106810536A (zh) 2015-11-30 2017-06-09 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017108781A1 (en) * 2015-12-22 2017-06-29 Ratiopharm Gmbh Abemaciclib form iv
CN106928216A (zh) * 2015-12-31 2017-07-07 中国科学院上海药物研究所 具有erk激酶抑制活性的化合物、其制备方法和用途
US10662186B2 (en) 2015-12-31 2020-05-26 Shanghai Pharmaceuticals Holding Co., Ltd. Substituted pyrimidines as cyclin-dependent kinase inhibitors
TWI736578B (zh) * 2016-02-06 2021-08-21 大陸商上海複尚慧創醫藥研究有限公司 6-5元稠合唑環衍生物及其藥物組合物，以及作為藥物的應用
WO2017160568A1 (en) 2016-03-16 2017-09-21 Eli Lilly And Company Combination therapy comprising the cdk4/6 inhibitor necitumumab and the egfr inhibitor abemaciclib for use in treating cancer
WO2017161253A1 (en) 2016-03-18 2017-09-21 Tufts Medical Center Compositions and methods for treating and preventing metabolic disorders
CN107266421B (zh) * 2016-04-08 2020-12-04 正大天晴药业集团股份有限公司 取代的苯并咪唑类衍生物
CN107286134B (zh) * 2016-04-11 2019-04-12 上海勋和医药科技有限公司 2，4-二取代嘧啶衍生物作为cdk抑制剂及其应用
WO2017180385A1 (en) 2016-04-12 2017-10-19 Eli Lilly And Company Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer
AU2017249078B2 (en) * 2016-04-12 2022-10-20 Eli Lilly And Company Combination therapy with notch and CDK4/6 inhibitors for the treatment of cancer
US20190125864A1 (en) 2016-04-15 2019-05-02 Eli Lilly And Company Combination therapy of ramucirumab and abemaciclib for use in treatment of mantle cell lymphoma
CN109071552B (zh) * 2016-04-22 2022-06-03 达纳－法伯癌症研究所公司 细胞周期蛋白依赖性激酶4/6(cdk4/6)通过cdk4/6抑制剂与e3连接酶配体的缀合的降解及使用方法
DK3622953T3 (da) 2016-05-17 2021-04-26 Scandion Oncology As Kombinationsbehandling af cancer
MA45025A (fr) 2016-05-20 2019-03-27 Lilly Co Eli Traitement d'association utilisant des inhibiteurs de notch et de pd-1 ou pd-l1
WO2017205213A1 (en) 2016-05-23 2017-11-30 Eli Lilly And Company Combination therapy of abemaciclib and immune checkpoint modulators for use in the treatment of cancer
CN109152838A (zh) * 2016-05-23 2019-01-04 伊莱利利公司 用于治疗癌症的派姆单抗和玻玛西尼的组合
CN109384768A (zh) * 2016-06-07 2019-02-26 上海宣创生物科技有限公司 玻玛西尼a晶型、b晶型、c晶型及其制备方法
WO2018017410A1 (en) 2016-07-22 2018-01-25 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of breast cancer
CN109803684B (zh) 2016-08-23 2022-08-23 卫材 R&D 管理有限公司 用于治疗肝细胞癌的组合疗法
CN107793399A (zh) * 2016-09-07 2018-03-13 上海翰森生物医药科技有限公司 Cdk4/6抑制剂及其制备方法和应用
WO2018045957A1 (zh) * 2016-09-07 2018-03-15 江苏豪森药业集团有限公司 一种cdk4/6抑制剂及其制备方法和应用
JP7100625B2 (ja) * 2016-09-09 2022-07-13 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 置換２－ｈ－ピラゾール誘導体の結晶形、塩型及びその製造方法
CN107868082A (zh) * 2016-09-22 2018-04-03 上海宣创生物科技有限公司 玻玛西尼甲磺酸盐a晶型及其制备方法
WO2018063873A1 (en) * 2016-09-27 2018-04-05 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of pancreatic cancer
EP3525796A1 (en) 2016-10-12 2019-08-21 Eli Lilly and Company Targeted treatment of mature t-cell lymphoma
EP3804724B1 (en) 2016-10-20 2022-12-07 Pfizer Inc. Cdk inhibitors for treating pah
WO2018081204A1 (en) * 2016-10-26 2018-05-03 Li George Y DEUTERATED N-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL) PYRIDIN-2-YL)-5-FLUORO-4-(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[d]IMIDAZOL-6-YL)PYRIMIDIN-2-AMINE
CN106588884B (zh) * 2016-11-10 2019-04-09 浙江大学 2-多取代芳环-嘧啶类衍生物及制备和医药用途
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
JP6785876B2 (ja) 2016-11-28 2020-11-18 帝人ファーマ株式会社 ピリド［３，４−ｄ］ピリミジン誘導体及びその薬学的に許容される塩
RU2747311C2 (ru) 2016-12-16 2021-05-04 СиСТОУН ФАРМАСЬЮТИКАЛС (СУЧЖОУ) КО., ЛТД. Ингибитор CDK4/6
TWI732083B (zh) * 2016-12-22 2021-07-01 大陸商貝達藥業股份有限公司 苯并咪唑衍生物、其藥物組合物及其應用
WO2018121766A1 (zh) * 2016-12-30 2018-07-05 上海医药集团股份有限公司 含氮稠杂环化合物、其制备方法、中间体、组合物和应用
ES2949364T3 (es) 2017-02-17 2023-09-28 Fred Hutchinson Cancer Center Terapias de combinación para el tratamiento de cánceres y trastornos autoinmunitarios relacionados con BCMA
GB201702947D0 (en) * 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
US10729692B2 (en) * 2017-02-26 2020-08-04 Institute For Cancer Research Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death
KR102653141B1 (ko) 2017-03-03 2024-04-01 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법
JP7219224B2 (ja) 2017-03-16 2023-02-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 乳癌の治療のための組合せ療法
EP3618820A1 (en) * 2017-05-02 2020-03-11 Eli Lilly and Company Endocrine therapy and abemaciclib combination for the adjuvant treatment of node-positive, early stage, hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer
CN108794452B (zh) * 2017-05-05 2021-05-28 上海时莱生物技术有限公司 具有激酶抑制活性的化合物、其制备方法和用途
CN108929312A (zh) * 2017-05-22 2018-12-04 南开大学 具有cdk或hdac抑制活性的新型苯并杂环联嘧啶抑制剂
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
MX2019015177A (es) 2017-06-16 2020-02-07 Beta Pharma Inc Formulaciones farmaceuticas de n-(2-(2-(dimetilamino)etoxi)-4-meto xi-5((4-(1-metil-1h-indol-3-il)pirimidin-2-il)amino)fenil)acrilam ida y las sales de ellas.
CN109503573A (zh) * 2017-09-14 2019-03-22 昆明圣加南生物科技有限公司 2-取代苯胺基嘧啶衍生物及其用途
CN107827875B (zh) * 2017-09-25 2021-07-09 文韬创新药物研究（北京）有限责任公司 一种苯并咪唑类衍生物作为周期蛋白依赖性激酶4/6抑制剂的应用
CN109761959B (zh) * 2017-11-09 2020-09-08 杭州科巢生物科技有限公司 一种Abemaciclib甲磺酸盐的合成方法
WO2019102492A1 (en) 2017-11-23 2019-05-31 Mylan Laboratories Limited Crystalline polymorphs of abemaciclib
CN112020500A (zh) 2017-12-22 2020-12-01 拉文纳制药公司 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物
US10519136B2 (en) 2017-12-29 2019-12-31 Accutar Biotechnology Dual inhibitors of PARP1 and CDK
RU2020123665A (ru) 2018-01-08 2022-02-10 Г1 Терапьютикс, Инк. Преимущественные режимы дозирования g1т38
BR112020015405A2 (pt) 2018-01-29 2020-12-08 Beta Pharma, Inc. Compostos de 2h-indazóis como inibidores cdk4 e cdk6, composições farmacêuticas que os compreendem, seus usos terapêuticos e métodos de preparação
CN110117272B (zh) * 2018-02-05 2021-12-10 上海翰森生物医药科技有限公司 细胞周期蛋白依赖性激酶抑制剂的盐及其晶型
JP2021514359A (ja) 2018-02-15 2021-06-10 ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． キナーゼ阻害剤としての複素環式化合物
CN112384515A (zh) 2018-02-27 2021-02-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶
CN108191747A (zh) * 2018-03-14 2018-06-22 盐城师范学院 一种Abemaciclib中间体的制备方法
CN112119073A (zh) 2018-04-05 2020-12-22 庄信万丰股份有限公司 阿贝西尼的固态形式、其用途和制备
WO2019200502A1 (zh) * 2018-04-16 2019-10-24 杭州领业医药科技有限公司 玻玛西尼甲磺酸盐晶型及其制备方法和药物组合物
CA3098283C (en) 2018-04-26 2023-05-23 Pfizer Inc. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
EA202092649A1 (ru) 2018-05-04 2021-06-21 Инсайт Корпорейшн Соли ингибитора fgfr
JP2021523169A (ja) * 2018-05-06 2021-09-02 アヤラ ファーマシューティカルズ インコーポレイテッド ビスフルオロアルキル−１，４−ベンゾジアゼピノン化合物を含む組み合わせ組成物およびその使用方法
MX2020012376A (es) 2018-05-18 2021-03-09 Incyte Corp Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
EP3818063A1 (en) 2018-07-05 2021-05-12 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
JP2021531349A (ja) * 2018-07-27 2021-11-18 カリフォルニア インスティチュート オブ テクノロジー Ｃｄｋインヒビター及びその使用
CN109232541B (zh) * 2018-09-30 2020-04-24 中国医学科学院放射医学研究所 脯氨酰羟化酶与组蛋白去乙酰化酶双重抑制剂及其制备方法和应用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN109180589A (zh) * 2018-10-16 2019-01-11 武汉工程大学 玻玛西尼中间体的制备方法
WO2020108661A1 (zh) * 2018-11-30 2020-06-04 杭州英创医药科技有限公司 作为cdk-hdac双通路抑制剂的杂环化合物
CN113195000A (zh) 2018-12-21 2021-07-30 第一三共株式会社 抗体-药物缀合物和激酶抑制剂的组合
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶
AU2020215684A1 (en) * 2019-01-29 2021-08-12 Beta Pharma, Inc. 2h-indazole derivatives as therapeutic agents for brain cancers and brain metastases
CA3130210A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Cyclin-dependent kinase 2 biomarkers and uses thereof
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
SG11202112229UA (en) * 2019-05-05 2021-12-30 Qilu Regor Therapeutics Inc Cdk inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3148776A1 (en) 2019-08-01 2021-02-04 Incyte Corporation A dosing regimen for an ido inhibitor
WO2021030843A1 (en) 2019-08-13 2021-02-18 Johnson Matthey Public Limited Company Solid-state forms of abemaciclib, their use and preparation
MX2022001940A (es) 2019-08-14 2022-05-10 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
PE20221905A1 (es) 2019-10-11 2022-12-23 Incyte Corp Aminas biciclicas como inhibidoras de la cdk2
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclyl heterocycles as fgr suppressors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN110540535B (zh) * 2019-10-23 2020-07-31 上海再启生物技术有限公司 适合放大制备4-(6-氨基吡啶-3-基)取代哌啶的工艺方法
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
CA3161892A1 (en) 2019-12-23 2021-07-01 Jie Fan Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
JP2023516441A (ja) 2020-03-06 2023-04-19 インサイト・コーポレイション Ａｘｌ／ｍｅｒ阻害剤及びｐｄ－１／ｐｄ－ｌ１阻害剤を含む併用療法
CN114245753A (zh) * 2020-03-27 2022-03-25 江苏康宁杰瑞生物制药有限公司 用于肿瘤治疗的抗her2抗体与cdk抑制剂的组合
IL297165A (en) 2020-04-16 2022-12-01 Incyte Corp Soysag tricyclic CRS inhibitors
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
EP4159728A1 (en) * 2020-06-22 2023-04-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Preparation method for cdk4/6 inhibitor
CN113880814B (zh) * 2020-07-01 2024-01-05 杭州百诚医药科技股份有限公司 一种嘧啶胺类化合物及应用
CN113880809B (zh) * 2020-07-03 2022-10-18 盛世泰科生物医药技术(苏州)有限公司 一种嘧啶类衍生物及其制备方法和应用
WO2022047093A1 (en) 2020-08-28 2022-03-03 Incyte Corporation Vinyl imidazole compounds as inhibitors of kras
WO2022042738A1 (zh) * 2020-08-31 2022-03-03 甘李药业股份有限公司 一种含cdk4/6抑制剂的药物组合物
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
CN114539225B (zh) * 2020-11-11 2024-02-20 上海拓界生物医药科技有限公司 2-氨基-嘧啶类化合物
CN112390793B (zh) * 2021-01-19 2021-04-27 中国药科大学 Cdk6/dyrk2双靶点抑制剂及其制备方法和应用
WO2022155941A1 (en) 2021-01-25 2022-07-28 Qilu Regor Therapeutics Inc. Cdk2 inhibitors
WO2022162122A1 (en) 2021-01-29 2022-08-04 Biotx.Ai Gmbh Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
EP4293021A1 (en) * 2021-02-10 2023-12-20 Shanghai Pharmaceuticals Holding Co., Ltd. Salt of nitrogen-containing fused heterocyclic compound or crystal form thereof, and preparation method therefor, pharmaceutical composition thereof, and use thereof
WO2022206888A1 (en) 2021-03-31 2022-10-06 Qilu Regor Therapeutics Inc. Cdk2 inhibitors and use thereof
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
CN117222636A (zh) * 2021-04-12 2023-12-12 甘李药业股份有限公司 作为cdk4/6抑制剂的氘代化合物
US20230002384A1 (en) 2021-06-09 2023-01-05 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
AR126102A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
CN113248500B (zh) * 2021-06-10 2021-10-19 中国药科大学 氮杂吲哚嘧啶胺杂环化合物及其制备方法和应用
KR20240032915A (ko) 2021-07-07 2024-03-12 인사이트 코포레이션 Kras의 저해제로서의 삼환식 화합물
CA3224841A1 (en) 2021-07-14 2023-01-19 Zhenwu Li Tricyclic compounds as inhibitors of kras
US20230174555A1 (en) 2021-08-31 2023-06-08 Incyte Corporation Naphthyridine compounds as inhibitors of kras
WO2023040914A1 (zh) * 2021-09-14 2023-03-23 甘李药业股份有限公司 一种cdk4/6抑制剂的医药用途
WO2023049697A1 (en) 2021-09-21 2023-03-30 Incyte Corporation Hetero-tricyclic compounds as inhibitors of kras
US20230143938A1 (en) 2021-10-01 2023-05-11 Incyte Corporation Pyrazoloquinoline kras inhibitors
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras
TW202320792A (zh) 2021-11-22 2023-06-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｋｒａｓ抑制劑之組合療法
TW202329937A (zh) 2021-12-03 2023-08-01 美商英塞特公司 雙環胺ｃｋ１２抑制劑
WO2023107428A1 (en) * 2021-12-07 2023-06-15 The Regents Of The University Of California Methods for treating traumatic brain injury
WO2023107525A1 (en) 2021-12-10 2023-06-15 Eli Lilly And Company Cdk4 and 6 inhibitor in combination with fulvestrant for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer in patients previously treated with a cdk4 and 6 inhibitor
US20230183251A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
WO2023114225A1 (en) 2021-12-14 2023-06-22 Board Of Regents, The University Of Texas System Pharmaceutical combination comprising abemaciclib and a pi3k and/or a mtor inhibitor for the treatment of mantle cell lymphoma
WO2023114264A1 (en) 2021-12-15 2023-06-22 Eli Lilly And Company Combination for treatment of high-risk metastatic hormone-sensitive prostate cancer
WO2023109875A1 (en) * 2021-12-16 2023-06-22 Edigene Therapeutics (Beijing) Inc. Biomarkers for colorectal cancer treatment
US20230192722A1 (en) 2021-12-22 2023-06-22 Incyte Corporation Salts and solid forms of an fgfr inhibitor and processes of preparing thereof
WO2023168686A1 (en) 2022-03-11 2023-09-14 Qilu Regor Therapeutics Inc. Substituted cyclopentanes as cdk2 inhibitors
TW202341982A (zh) 2021-12-24 2023-11-01 大陸商上海齊魯銳格醫藥研發有限公司 Ｃｄｋ２抑制劑及其用途
US20230279004A1 (en) 2022-03-07 2023-09-07 Incyte Corporation Solid forms, salts, and processes of preparation of a cdk2 inhibitor
CN115057845B (zh) * 2022-06-14 2024-05-03 山东罗欣药业集团恒欣药业有限公司 一种阿贝西利的制备方法
WO2023250430A1 (en) 2022-06-22 2023-12-28 Incyte Corporation Bicyclic amine cdk12 inhibitors
WO2024015731A1 (en) 2022-07-11 2024-01-18 Incyte Corporation Fused tricyclic compounds as inhibitors of kras g12v mutants
WO2024032751A1 (zh) * 2022-08-12 2024-02-15 正大天晴药业集团股份有限公司 一种取代的2-氢-吡唑衍生物的晶型及其制备方法
WO2024049926A1 (en) 2022-08-31 2024-03-07 Arvinas Operations, Inc. Dosage regimens of estrogen receptor degraders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619284D0 (en) 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
CN1429222A (zh) 2000-02-17 2003-07-09 安姆根有限公司 激酶抑制剂
ATE314370T1 (de) * 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
JP4053073B2 (ja) 2003-07-11 2008-02-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 選択的ｃｄｋ４阻害剤のイセチオン酸塩
EP1685124A1 (en) 2003-11-10 2006-08-02 MERCK SHARP & DOHME LTD. Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain
WO2005070900A1 (en) 2004-01-22 2005-08-04 Altana Pharma Ag N-4-(6- (heteo) aryl-pyrimidin-4-ylaminophenyl) -bezenesulfonamides as kinase inhibitors
EP1713793A4 (en) 2004-02-04 2009-09-02 Smithkline Beecham Corp PYRIMIDINONE COMPOUNDS SUITED AS KINASEINHIBITORS
WO2005082904A1 (ja) 2004-02-26 2005-09-09 Kyowa Hakko Kogyo Co., Ltd. 好中球性炎症疾患の予防及び／または治療剤
WO2006053109A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Heteroaryl compounds
BRPI0706747A2 (pt) 2006-01-30 2011-04-05 Exelixis Inc 4-aril-2-amino-pirimidinas ou 4-aril-2-aminoalquil-pirimidinas como moduladores jak-2 e composições farmacêuticas que os contenham
KR101552742B1 (ko) 2007-07-19 2015-09-11 머크 샤프 앤드 돔 코포레이션 단백질 키나제 억제제로서의 헤테로사이클릭 아미드 화합물

Also Published As

Publication number Publication date
CA2747055A1 (en) 2010-07-01
CN102264725A (zh) 2011-11-30
KR20110091551A (ko) 2011-08-11
BRPI0924183B1 (pt) 2019-12-17
US7855211B2 (en) 2010-12-21
PT2379528E (pt) 2013-11-25
SG172331A1 (en) 2011-07-28
HUS1900014I1 (hu) 2019-04-29
IL213350A0 (en) 2011-07-31
ECSP11011157A (es) 2011-07-29
GT201100181A (es) 2014-04-08
TW201031653A (en) 2010-09-01
PA8852901A1 (es) 2010-07-27
JP5417453B2 (ja) 2014-02-12
EP2379528A1 (en) 2011-10-26
RS53061B (en) 2014-04-30
MY150547A (en) 2014-01-30
KR101297497B1 (ko) 2013-08-20
BRPI0924183A2 (pt) 2016-07-05
CY2019009I1 (el) 2019-11-27
EP2379528B1 (en) 2013-09-18
EA201170872A1 (ru) 2011-12-30
PE20120107A1 (es) 2012-02-20
AR074575A1 (es) 2011-01-26
BRPI0924183B8 (pt) 2021-05-25
WO2010075074A1 (en) 2010-07-01
DK2379528T3 (da) 2013-10-14
ES2435798T3 (es) 2013-12-23
TWI429635B (zh) 2014-03-11
UA104603C2 (en) 2014-02-25
NZ593114A (en) 2012-11-30
AU2009330365B2 (en) 2012-07-12
CY2019009I2 (el) 2019-11-27
ZA201104505B (en) 2012-11-28
PL2379528T3 (pl) 2014-04-30
CR20110343A (es) 2011-09-14
US20100160340A1 (en) 2010-06-24
JP2012513396A (ja) 2012-06-14
MA32903B1 (fr) 2011-12-01
IL213350A (en) 2014-08-31
HRP20131051T1 (hr) 2013-12-06
TN2011000293A1 (en) 2012-12-17
HN2011001701A (es) 2013-07-22
EA018808B1 (ru) 2013-10-30
CN102264725B (zh) 2014-04-16
SI2379528T1 (sl) 2013-11-29
CO6382125A2 (es) 2012-02-15
JO2885B1 (en) 2015-03-15
FIC20190008I1 (fi) 2019-02-20
HUS000509I2 (hu) 2021-03-29
MX2011006757A (es) 2011-07-20
DOP2011000204A (es) 2011-09-30
AU2009330365A1 (en) 2010-07-01
CA2747055C (en) 2014-01-14

Similar Documents

Publication Publication Date Title
HUS1900014I1 (hu) Proteinkináz inhibitorok
IL210073A0 (en) Protein kinase inhibitors
IL206416A0 (en) Benzofuropyrimidinones as protein kinase inhibitors
IL210069A0 (en) Protein kinase inhibitors
EP2200436A4 (en) SUBSTITUTED PYRIMIDINYLAMINE AS PROTEIN KINASENHEMMER
PL2193133T3 (pl) Imidazolotiadiazole do stosowania jako inhibitory kinazy białkowej
ZA201004942B (en) Ptrrolopyrazine kinase inhibitors
BRPI0910668A2 (pt) inibidores de proteína quinases
HRP20130787T1 (en) Imidazopyridazinecarbonitriles useful as kinase inhibitors
HRP20130698T1 (en) Novel phenylpyrazinones as kinase inhibitors
EP2346508A4 (en) HETEROCYCLIC INHIBITORS OF KINASES
EP2387572A4 (en) PROTEIN KINASE C HEMMER AND ITS USE
EP2413938A4 (en) KINASEPROTEINBINDENDE HEMMER
IL207415A0 (en) Protein kinase inhibitors and use thereof
EP2136829A4 (en) INHIBITORS OF BINDING TO A PROTEIN KINASE
EP2231152A4 (en) THIENOPYRANONES AS KINASE INHIBITORS
EP2247185A4 (en) INHIBITORS OF TYROSINE KINASE
ZA200810573B (en) Substituted 3-cyanopyridines as protein kinase inhibitors
EP2254566A4 (en) INHIBITORS OF BINDING TO PROTEIN KINASE
LTC2379528I2 (lt) Baltymų kinazės slopikliai
GB0807642D0 (en) IKK- serine-threonine protein kinase inhibitors
GB0715470D0 (en) IKK- serine-threonine protein kinase inhibitors
GB0807908D0 (en) ikk-beta serine-theronine protein kinase inhibitors
EP2403494A4 (en) PROTEIN KINASE BINDING INHIBITORS
GB0621719D0 (en) Ikk- serine-threonine protein kinase inhibitors