CY2019009I1 - Αναστολεις πρωτεϊνικων κινασων - Google Patents

Αναστολεις πρωτεϊνικων κινασων

Info

Publication number
CY2019009I1
CY2019009I1 CY2019009C CY2019009C CY2019009I1 CY 2019009 I1 CY2019009 I1 CY 2019009I1 CY 2019009 C CY2019009 C CY 2019009C CY 2019009 C CY2019009 C CY 2019009C CY 2019009 I1 CY2019009 I1 CY 2019009I1
Authority
CY
Cyprus
Prior art keywords
protein kinase
kinase inhibitors
inhibitors
protein
kinase
Prior art date
Application number
CY2019009C
Other languages
English (en)
Other versions
CY2019009I2 (el
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42267022&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2019009(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY2019009I1 publication Critical patent/CY2019009I1/el
Publication of CY2019009I2 publication Critical patent/CY2019009I2/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
CY2019009C 2008-12-22 2019-02-19 Αναστολεις πρωτεϊνικων κινασων CY2019009I2 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08380343 2008-12-22
US15495409P 2009-02-24 2009-02-24
EP09775477.4A EP2379528B1 (en) 2008-12-22 2009-12-15 Protein kinase inhibitors
PCT/US2009/068030 WO2010075074A1 (en) 2008-12-22 2009-12-15 Protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CY2019009I1 true CY2019009I1 (el) 2019-11-27
CY2019009I2 CY2019009I2 (el) 2019-11-27

Family

ID=42267022

Family Applications (1)

Application Number Title Priority Date Filing Date
CY2019009C CY2019009I2 (el) 2008-12-22 2019-02-19 Αναστολεις πρωτεϊνικων κινασων

Country Status (41)

Country Link
US (1) US7855211B2 (el)
EP (1) EP2379528B1 (el)
JP (1) JP5417453B2 (el)
KR (1) KR101297497B1 (el)
CN (1) CN102264725B (el)
AR (1) AR074575A1 (el)
AU (1) AU2009330365B2 (el)
BR (1) BRPI0924183B8 (el)
CA (1) CA2747055C (el)
CO (1) CO6382125A2 (el)
CR (1) CR20110343A (el)
CY (1) CY2019009I2 (el)
DK (1) DK2379528T3 (el)
DO (1) DOP2011000204A (el)
EA (1) EA018808B1 (el)
EC (1) ECSP11011157A (el)
ES (1) ES2435798T3 (el)
FI (1) FIC20190008I1 (el)
GT (1) GT201100181A (el)
HK (1) HK1159630A1 (el)
HN (1) HN2011001701A (el)
HR (1) HRP20131051T1 (el)
HU (1) HUS000509I2 (el)
IL (1) IL213350A (el)
JO (1) JO2885B1 (el)
MA (1) MA32903B1 (el)
MX (1) MX2011006757A (el)
MY (1) MY150547A (el)
NZ (1) NZ593114A (el)
PA (1) PA8852901A1 (el)
PE (1) PE20120107A1 (el)
PL (1) PL2379528T3 (el)
PT (1) PT2379528E (el)
RS (1) RS53061B (el)
SG (1) SG172331A1 (el)
SI (1) SI2379528T1 (el)
TN (1) TN2011000293A1 (el)
TW (1) TWI429635B (el)
UA (1) UA104603C2 (el)
WO (1) WO2010075074A1 (el)
ZA (1) ZA201104505B (el)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1879573B1 (en) 2005-05-10 2012-12-19 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
HUE036813T2 (hu) 2008-07-08 2018-07-30 Incyte Holdings Corp 1,2,5-Oxadiazolok mint indolamin-2,3-dioxigenáz inhibitorok
EP3822273B1 (en) 2012-06-13 2024-04-10 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
EP2880448B1 (en) 2012-08-03 2022-06-29 Foundation Medicine, Inc. Human papilloma virus as predictor of cancer prognosis
CN105143463A (zh) * 2013-02-25 2015-12-09 诺华股份有限公司 新的雄激素受体突变
CN105407723A (zh) 2013-03-15 2016-03-16 G1治疗公司 高效的抗赘生剂和抗增生剂
PT2968290T (pt) 2013-03-15 2019-11-27 G1 Therapeutics Inc Protecção transitória de células normais durante a quimioterapia
SG10201708520YA (en) 2013-04-19 2017-12-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
AU2014375500B2 (en) * 2013-12-31 2017-03-16 Xuanzhu Biopharmaceutical Co., Ltd. Kinase inhibitor and use thereof
US9949976B2 (en) 2013-12-31 2018-04-24 Xuanzhu Pharma Co., Ltd. Kinase inhibitor and use thereof
TWI558399B (zh) * 2014-02-26 2016-11-21 美國禮來大藥廠 癌症之組合療法
CN104910137B (zh) * 2014-03-10 2017-04-19 山东轩竹医药科技有限公司 Cdk激酶抑制剂
US10555931B2 (en) 2014-05-28 2020-02-11 Piramal Enterprises Limited Pharmaceutical combination for the treatment of cancer
MY187555A (en) * 2014-07-24 2021-09-29 Beta Pharma Inc 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof
CN105294655B (zh) * 2014-07-26 2019-03-15 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
EP3191098A4 (en) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
PT3218005T (pt) 2014-11-12 2023-04-11 Seagen Inc Compostos que interagem com glicano e métodos de uso
TWI704151B (zh) * 2014-12-22 2020-09-11 美商美國禮來大藥廠 Erk抑制劑
CN105732615B (zh) * 2014-12-31 2018-05-01 山东轩竹医药科技有限公司 Cdk激酶抑制剂
CN104529904B (zh) 2015-01-09 2016-08-31 苏州明锐医药科技有限公司 玻玛西尼的制备方法
MX2017010673A (es) 2015-02-20 2018-03-21 Incyte Corp Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr).
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN111333627A (zh) * 2015-03-11 2020-06-26 正大天晴药业集团股份有限公司 作为抗癌药物的取代的2-氢-吡唑衍生物
TWI609687B (zh) 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
TWI696617B (zh) * 2015-04-28 2020-06-21 大陸商上海復尚慧創醫藥研究有限公司 特定蛋白質激酶抑制劑
CN107614499B (zh) 2015-05-29 2020-09-18 帝人制药株式会社 吡啶并[3,4-d]嘧啶衍生物及其药学上可允许的盐
CN104892580B (zh) * 2015-06-17 2018-01-26 镇江圣安医药有限公司 一种新型苯并咪唑‑嘧啶胺衍生物、及其应用
CN106316935B (zh) * 2015-06-30 2019-03-26 正大天晴药业集团股份有限公司 一种Abemaciclib中间体的制备方法
CN105111191B (zh) * 2015-07-21 2018-06-08 上海皓元生物医药科技有限公司 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途
CN106467517B (zh) * 2015-08-14 2019-09-06 正大天晴药业集团股份有限公司 氘修饰的Abemaciclib衍生物
CN105153119B (zh) * 2015-09-11 2019-01-01 广州必贝特医药技术有限公司 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用
CN106608879A (zh) * 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
IL302822A (en) 2015-11-12 2023-07-01 Seagen Inc Compounds interacting with glycans and methods of use
CN106810536A (zh) * 2015-11-30 2017-06-09 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017108781A1 (en) * 2015-12-22 2017-06-29 Ratiopharm Gmbh Abemaciclib form iv
CN106928216A (zh) * 2015-12-31 2017-07-07 中国科学院上海药物研究所 具有erk激酶抑制活性的化合物、其制备方法和用途
JP6663021B2 (ja) * 2015-12-31 2020-03-11 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド 窒素含有縮合複素環化合物、製造方法、中間体、組成物および使用
CN108602799B (zh) * 2016-02-06 2021-08-03 上海复尚慧创医药研究有限公司 一类激酶抑制剂
WO2017160568A1 (en) 2016-03-16 2017-09-21 Eli Lilly And Company Combination therapy comprising the cdk4/6 inhibitor necitumumab and the egfr inhibitor abemaciclib for use in treating cancer
WO2017161253A1 (en) 2016-03-18 2017-09-21 Tufts Medical Center Compositions and methods for treating and preventing metabolic disorders
CN107266421B (zh) * 2016-04-08 2020-12-04 正大天晴药业集团股份有限公司 取代的苯并咪唑类衍生物
CN107286134B (zh) * 2016-04-11 2019-04-12 上海勋和医药科技有限公司 2,4-二取代嘧啶衍生物作为cdk抑制剂及其应用
EP3442529B1 (en) 2016-04-12 2021-05-26 Eli Lilly and Company Combination therapy with notch and cdk4/6 inhibitors for the treatment of lung cancer
KR102418766B1 (ko) 2016-04-12 2022-07-08 일라이 릴리 앤드 캄파니 암 치료에 사용하기 위한 Notch 및 PI3K/mTOR 억제제의 조합 요법
WO2017180461A1 (en) 2016-04-15 2017-10-19 Eli Lilly And Company Combination therapy of ramucirumab and abemaciclib for use in treatment of mantle cell lymphoma
EP3445765A4 (en) * 2016-04-22 2019-09-18 Dana Farber Cancer Institute, Inc. DEGRADATION OF CYCLINE-DEPENDENT KINASE 4/6 (CDK4 / 6) BY CONJUGATION OF CDK4 / 6 INHIBITORS WITH E3 LIGASE-LIKE LIGAND AND METHODS OF USE
PL3622953T3 (pl) 2016-05-17 2021-08-16 Scandion Oncology A/S Leczenie skojarzone nowotworu
ES2904880T3 (es) 2016-05-20 2022-04-06 Lilly Co Eli Terapia combinada con inhibidores de Notch y de PD-1 o PD-L1
WO2017205213A1 (en) 2016-05-23 2017-11-30 Eli Lilly And Company Combination therapy of abemaciclib and immune checkpoint modulators for use in the treatment of cancer
CN109152838A (zh) * 2016-05-23 2019-01-04 伊莱利利公司 用于治疗癌症的派姆单抗和玻玛西尼的组合
CN109384768A (zh) * 2016-06-07 2019-02-26 上海宣创生物科技有限公司 玻玛西尼a晶型、b晶型、c晶型及其制备方法
WO2018017410A1 (en) 2016-07-22 2018-01-25 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of breast cancer
BR112019003722A2 (pt) 2016-08-23 2019-05-28 Eisai R&D Man Co Ltd terapias de combinação para o tratamento de carcinoma hepatocelular
CN112225724B (zh) * 2016-09-07 2022-04-29 江苏豪森药业集团有限公司 苯并咪唑类化合物激酶抑制剂及其制备方法和应用
CN107793399A (zh) * 2016-09-07 2018-03-13 上海翰森生物医药科技有限公司 Cdk4/6抑制剂及其制备方法和应用
EP3502103B1 (en) * 2016-09-09 2022-04-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
CN107868082A (zh) * 2016-09-22 2018-04-03 上海宣创生物科技有限公司 玻玛西尼甲磺酸盐a晶型及其制备方法
WO2018063873A1 (en) 2016-09-27 2018-04-05 Eli Lilly And Company Combination therapy of abemaciclib and a pi3 kinase/mtor dual inhibitor for use in the treatment of pancreatic cancer
CA3039405A1 (en) 2016-10-12 2018-04-19 Eli Lilly And Company Targeted treatment of mature t-cell lymphoma
KR20190071763A (ko) 2016-10-20 2019-06-24 화이자 인코포레이티드 폐 동맥 고혈압을 치료하기 위한 항증식제
WO2018081204A1 (en) * 2016-10-26 2018-05-03 Li George Y DEUTERATED N-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL) PYRIDIN-2-YL)-5-FLUORO-4-(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[d]IMIDAZOL-6-YL)PYRIMIDIN-2-AMINE
CN106588884B (zh) * 2016-11-10 2019-04-09 浙江大学 2-多取代芳环-嘧啶类衍生物及制备和医药用途
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
MY196497A (en) 2016-11-28 2023-04-17 Teijin Pharma Ltd Pyrido[3, 4-D]Pyrimidine Derivative And Pharmaceutically Acceptable Salt Thereof
WO2018108167A1 (zh) 2016-12-16 2018-06-21 基石药业 Cdk4/6抑制剂
US11053238B2 (en) 2016-12-22 2021-07-06 Betta Pharmaceuticals Co., Ltd. Benzimidazole derivatives, preparation methods and uses thereof
CN108264512B (zh) * 2016-12-30 2022-05-03 上海医药集团股份有限公司 含氮稠杂环化合物、其制备方法、中间体、组合物和应用
CN117357638A (zh) 2017-02-17 2024-01-09 弗雷德哈钦森癌症中心 用于治疗bcma相关癌症和自身免疫性失调的联合疗法
GB201702947D0 (en) * 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
US10729692B2 (en) * 2017-02-26 2020-08-04 Institute For Cancer Research Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death
JP2020510671A (ja) 2017-03-03 2020-04-09 シアトル ジェネティックス, インコーポレイテッド グリカン相互作用化合物および使用の方法
WO2018170447A1 (en) 2017-03-16 2018-09-20 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of breast cancer
CN110545803A (zh) * 2017-05-02 2019-12-06 伊莱利利公司 用于***阳性、早期、激素受体阳性、人表皮生长因子受体2阴性乳腺癌的辅助治疗的内分泌疗法和abemaciclib组合
CN108794452B (zh) * 2017-05-05 2021-05-28 上海时莱生物技术有限公司 具有激酶抑制活性的化合物、其制备方法和用途
CN108929312A (zh) * 2017-05-22 2018-12-04 南开大学 具有cdk或hdac抑制活性的新型苯并杂环联嘧啶抑制剂
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN110799191B (zh) 2017-06-16 2023-05-26 贝塔制药有限公司 N-(2-(2-(二甲氨基)乙氧基)-4-甲氧基-5-((4-(1-甲基-1h-吲哚-3-基)嘧啶-2-基)氨基)苯基)丙烯酰胺及其盐的药物制剂
CN109503573A (zh) * 2017-09-14 2019-03-22 昆明圣加南生物科技有限公司 2-取代苯胺基嘧啶衍生物及其用途
CN107827875B (zh) * 2017-09-25 2021-07-09 文韬创新药物研究(北京)有限责任公司 一种苯并咪唑类衍生物作为周期蛋白依赖性激酶4/6抑制剂的应用
CN109761959B (zh) * 2017-11-09 2020-09-08 杭州科巢生物科技有限公司 一种Abemaciclib甲磺酸盐的合成方法
WO2019102492A1 (en) 2017-11-23 2019-05-31 Mylan Laboratories Limited Crystalline polymorphs of abemaciclib
WO2019126731A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
WO2019133864A1 (en) 2017-12-29 2019-07-04 Accutar Biotechnology DUAL INHIBITORS OF PARP1 and CDK
SG11202005937QA (en) 2018-01-08 2020-07-29 G1 Therapeutics Inc G1t38 superior dosage regimes
SG11202006748RA (en) 2018-01-29 2020-08-28 Beta Pharma Inc 2h-indazole derivatives as cdk4 and cdk6 inhibitors and therapeutic uses thereof
CN110117272B (zh) * 2018-02-05 2021-12-10 上海翰森生物医药科技有限公司 细胞周期蛋白依赖性激酶抑制剂的盐及其晶型
EP3752491A4 (en) 2018-02-15 2021-12-01 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS USED AS KINASE INHIBITORS
TW202400599A (zh) 2018-02-27 2024-01-01 美商英塞特公司 作為a2a / a2b抑制劑之咪唑并嘧啶及***并嘧啶
CN108191747A (zh) * 2018-03-14 2018-06-22 盐城师范学院 一种Abemaciclib中间体的制备方法
BR112020017807A2 (pt) 2018-04-05 2020-12-22 Johnson Matthey Public Limited Company Composto, e, processos para a preparação da forma i em estado sólido de solvato de abc em metanol variável, para a preparação da forma iii de hidrato e abemaciclib em estado sólido e para a preparação da forma ii de abemaciclib anidro em estado sólido
CN111801323A (zh) * 2018-04-16 2020-10-20 杭州领业医药科技有限公司 玻玛西尼甲磺酸盐晶型及其制备方法和药物组合物
MA52360A (fr) 2018-04-26 2021-03-03 Pfizer Dérivés de 2-amino-pyridine ou de 2-amino-pyrimidine utilisés en tant qu'inhibiteurs de kinases dépendantes des cyclines
CN112867716A (zh) 2018-05-04 2021-05-28 因赛特公司 Fgfr抑制剂的固体形式和其制备方法
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
KR20210005714A (ko) * 2018-05-06 2021-01-14 아얄라 파마큐티컬즈 아이엔씨. 비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조합 조성물 및 이의 사용 방법
CA3100731A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
TW202402759A (zh) 2018-07-05 2024-01-16 美商英塞特公司 作為a2a/a2b抑制劑之稠合吡嗪衍生物
AU2019310595B2 (en) * 2018-07-27 2022-11-24 1200 Pharma Llc CDK inhibitors and uses thereof
CN109232541B (zh) * 2018-09-30 2020-04-24 中国医学科学院放射医学研究所 脯氨酰羟化酶与组蛋白去乙酰化酶双重抑制剂及其制备方法和应用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN109180589A (zh) * 2018-10-16 2019-01-11 武汉工程大学 玻玛西尼中间体的制备方法
US20220041577A1 (en) * 2018-11-30 2022-02-10 Hangzhou Innogate Pharma Co., Ltd. Heterocyclic Compound as CDK-HDAC Double-Channel Inhibitor
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A KINASE INHIBITOR
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶
EP3917532A4 (en) * 2019-01-29 2022-09-28 Beta Pharma, Inc. 2H-INDAZOLE DERIVATIVES USED AS THERAPEUTIC AGENTS AGAINST BRAIN CANCERS AND BRAIN METASTASIS
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
JP2022519772A (ja) 2019-02-15 2022-03-24 インサイト・コーポレイション サイクリン依存性キナーゼ2バイオマーカー及びその使用
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
CN114364675A (zh) * 2019-05-05 2022-04-15 上海齐鲁锐格医药研发有限公司 Cdk抑制剂
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3148776A1 (en) 2019-08-01 2021-02-04 Incyte Corporation A dosing regimen for an ido inhibitor
WO2021030843A1 (en) 2019-08-13 2021-02-18 Johnson Matthey Public Limited Company Solid-state forms of abemaciclib, their use and preparation
JP2023509260A (ja) 2019-08-14 2023-03-08 インサイト・コーポレイション Cdk2阻害剤としてのイミダゾリルピリミジニルアミン化合物
AR120184A1 (es) 2019-10-11 2022-02-02 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
AU2020366006A1 (en) 2019-10-14 2022-04-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN110540535B (zh) * 2019-10-23 2020-07-31 上海再启生物技术有限公司 适合放大制备4-(6-氨基吡啶-3-基)取代哌啶的工艺方法
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021133886A1 (en) 2019-12-23 2021-07-01 Accutar Biotechnology Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
EP4114401A1 (en) 2020-03-06 2023-01-11 Incyte Corporation Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
EP4126244A4 (en) * 2020-03-27 2024-03-27 Jiangsu Alphamab Biopharmaceuticals Co Ltd COMBINATION OF ANTI-HER2 ANTIBODIES AND CDK INHIBITORS FOR TUMOR TREATMENT
CA3179692A1 (en) 2020-04-16 2021-10-21 Incyte Corporation Fused tricyclic kras inhibitors
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
EP4159728A1 (en) * 2020-06-22 2023-04-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Preparation method for cdk4/6 inhibitor
CN113880814B (zh) * 2020-07-01 2024-01-05 杭州百诚医药科技股份有限公司 一种嘧啶胺类化合物及应用
CN113880809B (zh) * 2020-07-03 2022-10-18 盛世泰科生物医药技术(苏州)有限公司 一种嘧啶类衍生物及其制备方法和应用
US20220064188A1 (en) 2020-08-28 2022-03-03 Incyte Corporation Vinyl imidazole compounds as inhibitors of kras
WO2022042738A1 (zh) * 2020-08-31 2022-03-03 甘李药业股份有限公司 一种含cdk4/6抑制剂的药物组合物
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
CN114539225B (zh) * 2020-11-11 2024-02-20 上海拓界生物医药科技有限公司 2-氨基-嘧啶类化合物
CN112390793B (zh) * 2021-01-19 2021-04-27 中国药科大学 Cdk6/dyrk2双靶点抑制剂及其制备方法和应用
WO2022155941A1 (en) 2021-01-25 2022-07-28 Qilu Regor Therapeutics Inc. Cdk2 inhibitors
WO2022162122A1 (en) 2021-01-29 2022-08-04 Biotx.Ai Gmbh Genetically verified netosis inhibitor for use in the treatment of a sars-cov2 infection
US20240116925A1 (en) * 2021-02-10 2024-04-11 Shanghai Pharmaceuticals Holding Co., Ltd. Salt of nitrogen-containing fused heterocyclic compound or crystal form thereof, and preparation method therefor, pharmaceutical composition thereof, and use thereof
WO2022206888A1 (en) 2021-03-31 2022-10-06 Qilu Regor Therapeutics Inc. Cdk2 inhibitors and use thereof
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
WO2022218247A1 (zh) * 2021-04-12 2022-10-20 甘李药业股份有限公司 作为cdk4/6抑制剂的氘代化合物
AR126101A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
CN113248500B (zh) * 2021-06-10 2021-10-19 中国药科大学 氮杂吲哚嘧啶胺杂环化合物及其制备方法和应用
US20230056631A1 (en) 2021-07-07 2023-02-23 Incyte Corporation Tricyclic compounds as inhibitors of kras
CA3224841A1 (en) 2021-07-14 2023-01-19 Zhenwu Li Tricyclic compounds as inhibitors of kras
WO2023034290A1 (en) 2021-08-31 2023-03-09 Incyte Corporation Naphthyridine compounds as inhibitors of kras
WO2023040914A1 (zh) * 2021-09-14 2023-03-23 甘李药业股份有限公司 一种cdk4/6抑制剂的医药用途
WO2023049697A1 (en) 2021-09-21 2023-03-30 Incyte Corporation Hetero-tricyclic compounds as inhibitors of kras
US20230143938A1 (en) 2021-10-01 2023-05-11 Incyte Corporation Pyrazoloquinoline kras inhibitors
WO2023064857A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras
US20230226040A1 (en) 2021-11-22 2023-07-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a kras inhibitor
TW202329937A (zh) 2021-12-03 2023-08-01 美商英塞特公司 雙環胺ck12抑制劑
WO2023107428A1 (en) * 2021-12-07 2023-06-15 The Regents Of The University Of California Methods for treating traumatic brain injury
WO2023107525A1 (en) 2021-12-10 2023-06-15 Eli Lilly And Company Cdk4 and 6 inhibitor in combination with fulvestrant for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer in patients previously treated with a cdk4 and 6 inhibitor
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
US20230183251A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
WO2023114225A1 (en) 2021-12-14 2023-06-22 Board Of Regents, The University Of Texas System Pharmaceutical combination comprising abemaciclib and a pi3k and/or a mtor inhibitor for the treatment of mantle cell lymphoma
WO2023114264A1 (en) 2021-12-15 2023-06-22 Eli Lilly And Company Combination for treatment of high-risk metastatic hormone-sensitive prostate cancer
WO2023109875A1 (en) * 2021-12-16 2023-06-22 Edigene Therapeutics (Beijing) Inc. Biomarkers for colorectal cancer treatment
AR128043A1 (es) 2021-12-22 2024-03-20 Incyte Corp Sales y formas sólidas de un inhibidor de fgfr y procesos para su preparación
WO2023168686A1 (en) 2022-03-11 2023-09-14 Qilu Regor Therapeutics Inc. Substituted cyclopentanes as cdk2 inhibitors
TW202341982A (zh) 2021-12-24 2023-11-01 大陸商上海齊魯銳格醫藥研發有限公司 Cdk2抑制劑及其用途
WO2023172921A1 (en) 2022-03-07 2023-09-14 Incyte Corporation Solid forms, salts, and processes of preparation of a cdk2 inhibitor
CN115057845B (zh) * 2022-06-14 2024-05-03 山东罗欣药业集团恒欣药业有限公司 一种阿贝西利的制备方法
WO2023250430A1 (en) 2022-06-22 2023-12-28 Incyte Corporation Bicyclic amine cdk12 inhibitors
US20240101557A1 (en) 2022-07-11 2024-03-28 Incyte Corporation Fused tricyclic compounds as inhibitors of kras g12v mutants
WO2024032751A1 (zh) * 2022-08-12 2024-02-15 正大天晴药业集团股份有限公司 一种取代的2-氢-吡唑衍生物的晶型及其制备方法
WO2024049926A1 (en) 2022-08-31 2024-03-07 Arvinas Operations, Inc. Dosage regimens of estrogen receptor degraders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619284D0 (en) 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
AU2001237041B9 (en) 2000-02-17 2005-07-28 Amgen Inc. Kinase inhibitors
KR20060111716A (ko) 2002-01-22 2006-10-27 워너-램버트 캄파니 엘엘씨 2-(피리딘-2-일아미노)-피리도[2,3-d]피리미딘-7-온
PT1648889E (pt) * 2003-07-11 2008-12-10 Warner Lambert Co Sal isetionato de um inibidor selectivo da cdk4
CA2545384A1 (en) 2003-11-10 2005-05-26 Merck Sharp & Dohme Limited Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain
US20080242681A1 (en) 2004-01-22 2008-10-02 Altana Pharma Ag N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors
US20070117818A1 (en) 2004-02-04 2007-05-24 Masaichi Hasegawa Pyrimidinone compounds useful as kinase inhibitors
JP4866723B2 (ja) 2004-02-26 2012-02-01 協和発酵キリン株式会社 好中球性炎症疾患の予防及び/または治療剤
WO2006053109A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Heteroaryl compounds
BRPI0706747A2 (pt) 2006-01-30 2011-04-05 Exelixis Inc 4-aril-2-amino-pirimidinas ou 4-aril-2-aminoalquil-pirimidinas como moduladores jak-2 e composições farmacêuticas que os contenham
US8293747B2 (en) 2007-07-19 2012-10-23 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors

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