HK1127093A1 - Multiplexed analyses of test samples - Google Patents
Multiplexed analyses of test samplesInfo
- Publication number
- HK1127093A1 HK1127093A1 HK09106550.0A HK09106550A HK1127093A1 HK 1127093 A1 HK1127093 A1 HK 1127093A1 HK 09106550 A HK09106550 A HK 09106550A HK 1127093 A1 HK1127093 A1 HK 1127093A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- test samples
- multiplexed analyses
- multiplexed
- analyses
- samples
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/30—Characterised by physical treatment
- C12Q2523/313—Irradiation, e.g. UV irradiation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/101—Homogeneous assay format, e.g. one pot reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75967506P | 2006-01-17 | 2006-01-17 | |
PCT/US2007/060557 WO2007084886A2 (en) | 2006-01-17 | 2007-01-16 | Multiplexed analyses of test samples |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1127093A1 true HK1127093A1 (en) | 2009-09-18 |
Family
ID=38288365
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09106550.0A HK1127093A1 (en) | 2006-01-17 | 2009-07-17 | Multiplexed analyses of test samples |
HK16105620.9A HK1217540A1 (zh) | 2006-01-17 | 2016-05-16 | 包括適配體的試劑盒 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16105620.9A HK1217540A1 (zh) | 2006-01-17 | 2016-05-16 | 包括適配體的試劑盒 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20070166740A1 (es) |
EP (3) | EP2952894B1 (es) |
JP (3) | JP5680827B2 (es) |
KR (1) | KR101149688B1 (es) |
CN (1) | CN101374965B (es) |
AU (1) | AU2007205974A1 (es) |
CA (1) | CA2634987C (es) |
DK (1) | DK1994171T3 (es) |
ES (3) | ES2644499T3 (es) |
HK (2) | HK1127093A1 (es) |
HU (1) | HUE025489T2 (es) |
PL (1) | PL1994171T3 (es) |
PT (1) | PT1994171E (es) |
SI (1) | SI1994171T1 (es) |
TW (1) | TWI507528B (es) |
WO (1) | WO2007084886A2 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP2083269B1 (en) * | 2006-09-27 | 2013-09-04 | National University Corporation Tokyo University of Agriculture and Technology | Method of assaying target substance in sample, aptamer molecule and method of constructing the same |
US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
US9068216B2 (en) * | 2007-03-22 | 2015-06-30 | Bret T. Barnhizer | Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes |
AU2013203386B2 (en) * | 2007-07-17 | 2015-10-08 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
AU2015261546B2 (en) * | 2007-07-17 | 2017-09-28 | Somalogic Operating Co., Inc. | Multiplexed analyses of test samples |
US8409795B2 (en) * | 2007-07-17 | 2013-04-02 | Somalogic, Inc. | Selex and photoSELEX |
GB0719367D0 (en) | 2007-10-03 | 2007-11-14 | Procarta Biosystems Ltd | Transcription factor decoys, compositions and methods |
GB0906130D0 (en) * | 2008-10-03 | 2009-05-20 | Procrata Biosystems Ltd | Transcription factor decoys |
US8841429B2 (en) | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
GB201002413D0 (en) | 2010-02-12 | 2010-03-31 | Procarta Biosystems Ltd | Nucleic acid complexes |
EP2542266A4 (en) | 2010-03-03 | 2013-10-23 | Somalogic Inc | 4-1BB-BINDING APTAMERS AND USE THEREOF IN THE TREATMENT OF DISEASES AND DISORDERS |
SG184497A1 (en) | 2010-04-12 | 2012-11-29 | Somalogic Inc | 5-position modified pyrimidines and their use |
CN102608091A (zh) * | 2012-03-22 | 2012-07-25 | 中国科学院广州生物医药与健康研究院 | 一种快速免标记检测硫离子的方法 |
WO2013149086A1 (en) | 2012-03-28 | 2013-10-03 | Somalogic, Inc. | Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions |
SG11201407505XA (en) * | 2012-06-07 | 2014-12-30 | Somalogic Inc | Aptamer-based multiplexed assays |
JP6248633B2 (ja) * | 2012-08-31 | 2017-12-20 | 東レ株式会社 | 標的核酸の検出方法 |
CN112961860A (zh) | 2013-03-14 | 2021-06-15 | 私募蛋白质体公司 | 结合il-6的适体及其在治疗或诊断il-6介导的疾患中的用途 |
EP3693472A1 (en) | 2013-09-09 | 2020-08-12 | Somalogic, Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
KR102290214B1 (ko) | 2013-11-21 | 2021-08-18 | 소마로직, 인크. | 시티딘-5-카르복스아미드 변형된 뉴클레오티드 조성물 및 그와 관련된 방법들 |
CN103616423A (zh) * | 2013-12-02 | 2014-03-05 | 济南大学 | 一种检测土霉素的竞争型适配体传感器的制备方法及应用 |
KR101506147B1 (ko) * | 2013-12-13 | 2015-03-26 | 삼성전자 주식회사 | 시약 세트, 시료 검사방법, 미세유동장치 및 검사장치 |
EP3108045B1 (en) * | 2014-02-18 | 2018-10-31 | Somalogic, Inc. | Compositions and methods for detecting microorganisms |
CN106574925B (zh) * | 2014-05-23 | 2019-07-26 | 萤火虫生物股份有限公司 | 用于生物测定的底物介导的反应器 |
NO2718257T3 (es) * | 2014-05-30 | 2018-04-14 | ||
WO2016145362A2 (en) | 2015-03-12 | 2016-09-15 | The Regents Of The University Of Michigan | Inhibitors of dek protein and related methods |
JP7203613B2 (ja) | 2016-07-01 | 2023-01-13 | ソマロジック オペレーティング カンパニー インコーポレイテッド | 修飾ヌクレオシドを含むオリゴヌクレオチド |
EP3548621B1 (en) | 2016-12-01 | 2022-02-23 | Aptitude Medical Systems, Inc. | Methods and systems for identifying candidate nucleic acid agent |
JP7279633B2 (ja) * | 2017-03-29 | 2023-05-23 | 東洋紡株式会社 | 核酸の検出方法 |
US11639933B2 (en) * | 2017-09-27 | 2023-05-02 | Bio-Rad Laboratories, Inc. | Digital affinity linkage assay |
JP7217913B2 (ja) * | 2018-02-16 | 2023-02-06 | 株式会社日立ハイテクサイエンス | プラスチック標準物質の製造方法 |
SG11202009802WA (en) * | 2018-04-03 | 2020-11-27 | The Royal Institution For The Advancement Of Learning/Mcgill Univ | Colocalization-by-linkage sandwich assays |
CA3098722A1 (en) * | 2018-06-08 | 2019-12-12 | Ultivue, Inc. | Multiplexed catalyzed reporter deposition |
AU2019290130A1 (en) * | 2018-06-22 | 2021-01-28 | Somalogic Operating Co., Inc. | Improved proteomic multiplex assays |
JP7153494B2 (ja) * | 2018-07-27 | 2022-10-14 | シスメックス株式会社 | 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット |
KR102129937B1 (ko) * | 2018-07-31 | 2020-07-03 | 재단법인 아산사회복지재단 | 종이기반 핵산검출용 키트 및 pcr 증폭산물을 분석하기 위한 방법 |
CN110824168B (zh) * | 2018-08-10 | 2023-06-09 | 天津医科大学 | 一种多肽探针及其在翻译后修饰的结合蛋白鉴定中的应用 |
KR102526641B1 (ko) * | 2018-10-25 | 2023-04-26 | 티엘 제노믹스 인크. | 미세유로에 의한 혈구의 분급을 위한 혈액의 전처리 |
LU101073B1 (en) | 2018-12-21 | 2020-06-24 | Luxembourg Inst Science & Tech List | Dna aptamers specific of adenovirus types |
CN113624724A (zh) * | 2020-05-07 | 2021-11-09 | 廖世奇 | 一种适配体分子信标对靶分子的多元检测分析方法 |
CN111735869A (zh) * | 2020-05-29 | 2020-10-02 | 中山大学 | 一种蛋白质的检测试剂及检测方法 |
CN112180102B (zh) * | 2020-09-29 | 2022-06-14 | 郑州安图生物工程股份有限公司 | 花生过敏原特异性IgE定量检测试剂、试剂盒及其应用 |
MX2023012081A (es) | 2021-04-13 | 2023-10-25 | Somalogic Operating Co Inc | Nucleosidos modificados. |
CN113122544A (zh) * | 2021-04-25 | 2021-07-16 | 杭州广科安德生物科技有限公司 | 一种特异性结合timp1蛋白的核酸适配体及其应用 |
CN113720894B (zh) * | 2021-09-02 | 2022-07-08 | 清华大学 | 一种直接采样电离分析***及方法、应用 |
WO2024084470A1 (en) * | 2022-10-21 | 2024-04-25 | Standard Biotools Canada Inc. | Tissue imaging replicas |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599720A (en) * | 1982-08-27 | 1997-02-04 | Multilyte Limited | Measurement of analyte concentration |
GB8314523D0 (en) * | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
US4587044A (en) * | 1983-09-01 | 1986-05-06 | The Johns Hopkins University | Linkage of proteins to nucleic acids |
US4737453A (en) * | 1984-12-12 | 1988-04-12 | Immunomedics, Inc. | Sandwich immunoassay utilizing a separation specific binding substance |
US4752566A (en) * | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
US4978608A (en) * | 1987-09-04 | 1990-12-18 | Molecular Devices Corporation | DNA detection system |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5688935A (en) * | 1990-06-11 | 1997-11-18 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
US6344321B1 (en) * | 1990-06-11 | 2002-02-05 | Gilead Sciences, Inc. | Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met |
US5567588A (en) * | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
US5763177A (en) * | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US6001577A (en) | 1998-06-08 | 1999-12-14 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US5874218A (en) * | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Method for detecting a target compound in a substance using a nucleic acid ligand |
US5660985A (en) * | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
US6346611B1 (en) * | 1990-06-11 | 2002-02-12 | Gilead Sciences, Inc. | High affinity TGfβ nucleic acid ligands and inhibitors |
US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5861254A (en) * | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
US5654151A (en) * | 1990-06-11 | 1997-08-05 | Nexstar Pharmaceuticals, Inc. | High affinity HIV Nucleocapsid nucleic acid ligands |
US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
ES2259800T3 (es) * | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
IE920562A1 (en) * | 1991-02-21 | 1992-08-26 | Gilead Sciences | Aptamer specific for biomolecules and method of making |
US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US6007987A (en) * | 1993-08-23 | 1999-12-28 | The Trustees Of Boston University | Positional sequencing by hybridization |
US6458539B1 (en) * | 1993-09-17 | 2002-10-01 | Somalogic, Inc. | Photoselection of nucleic acid ligands |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5658738A (en) * | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
US5681702A (en) * | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5908745A (en) * | 1996-01-16 | 1999-06-01 | University Of Chicago | Use of continuous/contiguous stacking hybridization as a diagnostic tool |
US6140098A (en) * | 1996-08-30 | 2000-10-31 | Schering Corporation | Nucleic acids encoding mammalian proteinases; related reagents |
RU2233878C2 (ru) * | 1997-01-21 | 2004-08-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ отбора желательного белка и нуклеиновой кислоты, средства для его осуществления |
US6037137A (en) * | 1997-02-20 | 2000-03-14 | Oncoimmunin, Inc. | Fluorogenic peptides for the detection of protease activity |
JP4086325B2 (ja) * | 1997-04-23 | 2008-05-14 | プリュックテュン,アンドレアス | 標的分子と相互作用する(ポリ)ペプチドをコードする核酸分子の同定方法 |
US6242246B1 (en) * | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
EP0995798A1 (en) * | 1998-10-24 | 2000-04-26 | Novimmune Sa | Transcription factor of MHC class II genes, substances capable of inhibiting this new transcription factor and medical uses of these substances |
US7074586B1 (en) * | 1999-06-17 | 2006-07-11 | Source Precision Medicine, Inc. | Quantitative assay for low abundance molecules |
JP3463098B2 (ja) * | 1999-10-08 | 2003-11-05 | 独立行政法人産業技術総合研究所 | モジュレートアプタマー及びこれを用いた標的タンパク質の検出方法 |
SE516272C2 (sv) * | 2000-02-18 | 2001-12-10 | Ulf Landegren | Metoder och kit för analytdetektion mha proximitets-probning |
US6897015B2 (en) * | 2000-03-07 | 2005-05-24 | Bioforce Nanosciences, Inc. | Device and method of use for detection and characterization of pathogens and biological materials |
WO2001079562A1 (en) * | 2000-04-18 | 2001-10-25 | Gilead Sciences, Inc. | Aptamer based two-site binding assay |
US6376190B1 (en) | 2000-09-22 | 2002-04-23 | Somalogic, Inc. | Modified SELEX processes without purified protein |
JP2004537037A (ja) * | 2001-04-11 | 2004-12-09 | ピーティーシー セラピューティクス,インコーポレーテッド | 特異的rna構造モチーフと結合する小分子を同定する方法 |
US6942972B2 (en) * | 2001-10-24 | 2005-09-13 | Beckman Coulter, Inc. | Efficient synthesis of protein-oligonucleotide conjugates |
WO2003050276A1 (en) | 2001-12-05 | 2003-06-19 | Dow Global Technologies Inc. | Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications |
JP2005517456A (ja) * | 2002-02-15 | 2005-06-16 | ソマロジック・インコーポレーテッド | 核酸リガンドによる標的結合を検出する方法および試薬 |
CA2476764A1 (en) * | 2002-02-19 | 2003-08-28 | Syntherica Corporation | Compositions and methods for surrogate antibody modulation of an immune response and transport |
EP1478931B2 (en) * | 2002-02-28 | 2018-11-07 | Microsens Biophage Limited | Binding of pathological forms of prion proteins |
US20030219801A1 (en) | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
US20030228603A1 (en) * | 2002-04-05 | 2003-12-11 | Cload Sharon T. | Compositions selective for caffeine or aspartame and methods of using same |
JP2005526972A (ja) | 2002-05-02 | 2005-09-08 | シファーゲン バイオシステムズ, インコーポレイテッド | 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ |
US7045366B2 (en) | 2003-09-12 | 2006-05-16 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel blend surface coatings |
US20040216174A1 (en) * | 2003-03-14 | 2004-10-28 | Siegfried Hekimi | Screening assays for targets and drugs useful in treatment and prevention of lipid metabolism disorders |
US7229763B2 (en) * | 2003-04-07 | 2007-06-12 | Beckman Coulter, Inc. | Assay system using labeled oligonucleotides |
US7195875B2 (en) * | 2003-04-18 | 2007-03-27 | Beckman Coulter, Inc. | Oligonucleotide pairs for multiplexed binding assays |
JP4357284B2 (ja) | 2003-05-15 | 2009-11-04 | トヨタ自動車株式会社 | 内燃機関の制御装置 |
US7993872B2 (en) * | 2003-06-18 | 2011-08-09 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
WO2005024042A2 (en) * | 2003-09-04 | 2005-03-17 | The Regents Of The University Of California | Aptamers and methods for their in vitro selection and uses thereof |
US20050250147A1 (en) * | 2004-05-10 | 2005-11-10 | Macevicz Stephen C | Digital profiling of polynucleotide populations |
JP2006258458A (ja) | 2005-03-15 | 2006-09-28 | Sumitomo Bakelite Co Ltd | 医療材料用高分子化合物及び該高分子化合物を用いたバイオチップ用基板 |
-
2007
- 2007-01-16 SI SI200731656T patent/SI1994171T1/sl unknown
- 2007-01-16 ES ES15158380.4T patent/ES2644499T3/es active Active
- 2007-01-16 EP EP15158380.4A patent/EP2952894B1/en active Active
- 2007-01-16 ES ES07718147.7T patent/ES2538038T3/es active Active
- 2007-01-16 WO PCT/US2007/060557 patent/WO2007084886A2/en active Application Filing
- 2007-01-16 AU AU2007205974A patent/AU2007205974A1/en not_active Abandoned
- 2007-01-16 EP EP13158346.0A patent/EP2613147B1/en active Active
- 2007-01-16 JP JP2008550555A patent/JP5680827B2/ja active Active
- 2007-01-16 CA CA2634987A patent/CA2634987C/en active Active
- 2007-01-16 HU HUE07718147A patent/HUE025489T2/en unknown
- 2007-01-16 EP EP07718147.7A patent/EP1994171B1/en active Active
- 2007-01-16 KR KR1020087017428A patent/KR101149688B1/ko active IP Right Grant
- 2007-01-16 CN CN2007800032689A patent/CN101374965B/zh active Active
- 2007-01-16 TW TW096101613A patent/TWI507528B/zh active
- 2007-01-16 PT PT77181477T patent/PT1994171E/pt unknown
- 2007-01-16 PL PL07718147T patent/PL1994171T3/pl unknown
- 2007-01-16 ES ES13158346.0T patent/ES2538121T3/es active Active
- 2007-01-16 US US11/623,535 patent/US20070166740A1/en not_active Abandoned
- 2007-01-16 DK DK07718147.7T patent/DK1994171T3/en active
-
2009
- 2009-07-17 HK HK09106550.0A patent/HK1127093A1/xx unknown
-
2014
- 2014-09-01 JP JP2014176974A patent/JP6144654B2/ja active Active
-
2016
- 2016-05-16 HK HK16105620.9A patent/HK1217540A1/zh unknown
-
2017
- 2017-02-09 JP JP2017021895A patent/JP6768547B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1127093A1 (en) | Multiplexed analyses of test samples | |
EP2076613A4 (en) | MULTIPLEX ANALYSIS OF TEST SAMPLES | |
GB0625595D0 (en) | Sample analyser | |
ZA201000095B (en) | Multiple analysis of blood samples | |
EP2068701A4 (en) | INTEGRATED MEASURING DEVICE FOR THE ANALYSIS OF BIOLOGICAL SAMPLES | |
EP2035831A4 (en) | METHODS OF ANALYZING LIAISON INTERACTIONS | |
GB0715171D0 (en) | Sample processor | |
GB0714789D0 (en) | Reservoir sample chain-of-custody | |
EP2215450A4 (en) | METHOD AND COMPOSITIONS FOR ANALYZE DETECTION | |
GB2484429B (en) | Parallel mass analysis | |
GB2484361B (en) | Parallel mass analysis | |
IL200211A0 (en) | Sample analysis system | |
EP2017598A4 (en) | SAMPLE INTRODUCTION SYSTEM | |
GB2436623B (en) | Microtome | |
EP1995764A4 (en) | MASS ANALYZER | |
EP2088426A4 (en) | MASS SPECTROMETRY OF A BIOLOGICAL SAMPLE USING IMMUNE PRECIPITATION | |
GB0524782D0 (en) | Analysis of samples | |
GB0601538D0 (en) | Epigenetic analysis | |
HK1118608A1 (en) | Measuring range extension of chromatographic rapid tests | |
EP2067019A4 (en) | DEVICE WITH MULTIPLE CAPILLARES FOR SAMPLE PREPARATION | |
GB0707291D0 (en) | Microscope test sample | |
EP1896834A4 (en) | PROOF OF ILLEGAL SAMPLES | |
EP1995763A4 (en) | mass | |
GB0611114D0 (en) | Analysis technique | |
PL1918709T3 (pl) | Sposób analizowania płytek krwi |