HK1082745A1 - Single domain antibodies directed against tumour necrosis factor alpha and uses therefor - Google Patents

Single domain antibodies directed against tumour necrosis factor alpha and uses therefor

Info

Publication number
HK1082745A1
HK1082745A1 HK05111896.7A HK05111896A HK1082745A1 HK 1082745 A1 HK1082745 A1 HK 1082745A1 HK 05111896 A HK05111896 A HK 05111896A HK 1082745 A1 HK1082745 A1 HK 1082745A1
Authority
HK
Hong Kong
Prior art keywords
directed against
necrosis factor
antibodies directed
single domain
domain antibodies
Prior art date
Application number
HK05111896.7A
Other languages
English (en)
Chinese (zh)
Inventor
Karen Silence
Marc Lauwereys
Haard Hans De
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of HK1082745A1 publication Critical patent/HK1082745A1/xx

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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HK05111896.7A 2002-11-08 2005-12-22 Single domain antibodies directed against tumour necrosis factor alpha and uses therefor HK1082745A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42506302P 2002-11-08 2002-11-08
US42507302P 2002-11-08 2002-11-08
EP03447005 2003-01-10
EPPCT/EP03/06581 2003-06-23
EPPCT/EP03/07313 2003-07-08
PCT/BE2003/000192 WO2004041862A2 (en) 2002-11-08 2003-11-07 Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor

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HK1082745A1 true HK1082745A1 (en) 2006-06-16

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US (7) US20060115470A1 (xx)
EP (8) EP2258392A1 (xx)
JP (5) JP2006520584A (xx)
AU (1) AU2010226938B2 (xx)
CA (3) CA2505325C (xx)
HK (1) HK1082745A1 (xx)
IL (1) IL168357A (xx)
MX (1) MXPA05004955A (xx)
NZ (4) NZ563471A (xx)
RU (1) RU2704232C2 (xx)
WO (3) WO2004041865A2 (xx)

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US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
ATE328906T1 (de) 2002-06-28 2006-06-15 Domantis Ltd Dual-specifische liganden mit erhöhter halbwertszeit
US20060002935A1 (en) * 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
AU2003251238A1 (en) 2002-08-07 2004-02-25 Umc Utrecht Holding B.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004041865A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
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