ES2500068T3 - Inhibidores heterocíclicos de MEK y métodos de uso de los mismos - Google Patents

Inhibidores heterocíclicos de MEK y métodos de uso de los mismos Download PDF

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ES2500068T3
ES2500068T3 ES11003826.2T ES11003826T ES2500068T3 ES 2500068 T3 ES2500068 T3 ES 2500068T3 ES 11003826 T ES11003826 T ES 11003826T ES 2500068 T3 ES2500068 T3 ES 2500068T3
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mek
methods
hoch2ch20
cyclopropyl
ethyl
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Richard Anthony Storey
Rebecca Jane Booth
John David Pittam
Allison L. Marlow
Eli Wallace
Jeongbeob Seo
Joseph P. Lyssikatos
Hong Woon Yang
Jim Blake
John Leonard
Mark Richard Fielding
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AstraZeneca AB
Array Biopharma Inc
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AstraZeneca AB
Array Biopharma Inc
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Abstract

Composicion farmaceutica que comprende un compuesto que tiene la formula IV:**Fórmula** o una sal farmaceuticamente aceptable del mismo, en la que: R1 es Cl o F; R3 es H, Me, Et, OH, Me0-, Et0-, HOCH2CH20-, HOCH2C(Me)20-, (S)-MeCH(OH)CH20-, (R)- HOCH2CH(OH)CH20-, ciclopropil-CH20-, HOCH2CH2-, R7 es metilo o etilo, en el que dicho nnetilo y etilo estan opcionalmente sustituidos con uno o mas F; R8 es Br, I o SMe; y R9 es H, alquilo C1-C4, Cl o CN, en el que dicho alquilo esta opcionalmente sustituido con uno o mas grupos seleccionados independientemente de F o CN, siempre que cuando a) R1 es F, R8 es Br, R9 es H y R7 es o bien Me o bien Et, entonces R3 no puede ser HOCH2CH20; b) R1 es F, R8 es I, R9 es H y R3 es Me0, entonces R7 no puede ser Me; y c) R1 es F, R8 es Me, R9 es H y R3 es ciclopropil-CH20, entonces R7 no puede ser Me; en combinación con un agente antitumoral o un inhibidor de la transducción de senates

Description

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ES11003826.2T 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos Active ES2500068T3 (es)

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ES08004958T Active ES2333182T3 (es) 2005-05-18 2006-05-17 Derivados de 4-(fenilamino)-6-oxo-1,6-dihidropiridazina-3-carboxamida como inhibidores de mek para el tratamiento de enfermedades hiperproliferativas.
ES06836069T Active ES2378760T3 (es) 2005-05-18 2006-05-17 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
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