AR082825A2 - Inhibidores heterociclicos nitrogenados de mek, composiciones farmaceuticas que los contienen, metodos para prepararlos y uso de los mismos para el tratamiento de trastornos hiperproliferativos o inflamatorios - Google Patents

Inhibidores heterociclicos nitrogenados de mek, composiciones farmaceuticas que los contienen, metodos para prepararlos y uso de los mismos para el tratamiento de trastornos hiperproliferativos o inflamatorios

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Publication number
AR082825A2
AR082825A2 ARP110103181A ARP110103181A AR082825A2 AR 082825 A2 AR082825 A2 AR 082825A2 AR P110103181 A ARP110103181 A AR P110103181A AR P110103181 A ARP110103181 A AR P110103181A AR 082825 A2 AR082825 A2 AR 082825A2
Authority
AR
Argentina
Prior art keywords
hiterociclic
nitrogenated
hyperproliferative
mek
inhibitors
Prior art date
Application number
ARP110103181A
Other languages
English (en)
Inventor
Jeongbeob Seo
Joseph P Lyssikatos
James Blake
Allison L Marlow
Eli M Wallace
Hong Woon Yang
Mark Richard Fielding
Richard Anthony Storey
Rebecca Jane Booth
John David Pittam
John Leonard
Original Assignee
Array Biopharma Inc
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37943261&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR082825(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Astrazeneca Ab filed Critical Array Biopharma Inc
Publication of AR082825A2 publication Critical patent/AR082825A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Un compuesto que tiene la fórmula (1) o una sal farmacéuticamente aceptable de él, en donde: R3 es HOCH2CH2O o (S)-MeCH(OH)CH2O; y R9 es H, CH3, F o Cl, y Me es CH3; siempre que cuando R9 es Cl, entonces R3 no puede ser HOCH2CH2O.
ARP110103181A 2005-05-18 2011-08-31 Inhibidores heterociclicos nitrogenados de mek, composiciones farmaceuticas que los contienen, metodos para prepararlos y uso de los mismos para el tratamiento de trastornos hiperproliferativos o inflamatorios AR082825A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68233505P 2005-05-18 2005-05-18

Publications (1)

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AR082825A2 true AR082825A2 (es) 2013-01-09

Family

ID=37943261

Family Applications (3)

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ARP060101994A AR055057A1 (es) 2005-05-18 2006-05-17 Inhibidores heterociclicos de mek, formas cristalinas de los mismos, procesos para su preparacion y metodos de uso de los mismos en composiciones farmaceuticas y medicamentos para el tratamiento de un trastorno hiperproliferativo o de una condicion inflamatoria.
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