ES2509820T3 - Derivados de indazol como inhibidores de la cinasa para el tratamiento del cáncer - Google Patents
Derivados de indazol como inhibidores de la cinasa para el tratamiento del cáncer Download PDFInfo
- Publication number
- ES2509820T3 ES2509820T3 ES07857632.9T ES07857632T ES2509820T3 ES 2509820 T3 ES2509820 T3 ES 2509820T3 ES 07857632 T ES07857632 T ES 07857632T ES 2509820 T3 ES2509820 T3 ES 2509820T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- heterocyclyl
- branched
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000000623 heterocyclic group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (I): en el que: Ar es arilo opcionalmente sustituido con uno o mas sustituyentes elegidos independientemente entre halOgeno, alquenilo, alquinilo, ciano, nitro, NHCOR4, COR4, NR5R6, NR5COR4, 0R7, SR7, SOR10, SO2R10, NHSOR10, NHSO2R10, R8R9N-alquilo C1-C6, R80-alquilo C1-C6, un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo y arilo, en los que: R4 es hidrOgeno, alquenilo, alquinilo, NR5R6, 0R7, SR7, R8R9N-alquilo Ci-C6, R80-alquilo C1-C6, un alquilo Ci-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo; R5 y R6 son independientemente hidrógeno, alquenilo, alquinilo, R8R9N-alquilo C2-C6, R80-alquilo C2-C6, un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo, o R5 y R6, tomados junto con el atomo de nitrógeno al que estan unidos pueden formar un grupo heterociclilo opcionalmente sustituido; R7 es hidrogeno, alquenilo, alquinilo, COR4, SOR10, SO2R10, R8R9N-alquilo C2-C6, R80-alquilo C2-C6, un alquilo Ci-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo, donde R4 es como se ha definido anteriormente; R8 y R9 son independientemente hidr6geno, alquenilo, alquinilo, COR4, un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo, o R8 y R9, tomados junto con el atomo de nitrogeno al que estan unidos, pueden formar un grupo heterociclilo opcionalmente sustituido, donde R4 es como se ha definido anteriormente; R10 es hidrOgeno, alquenilo, alquinilo, NR5R6, 0R7, R8R9N-alquilo Ci-C6, R80-alquilo Ci-C6, un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo, donde R5, R6, R7, R8 y R9 son como se han definido anteriormente; R es un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, cicloalquilo C3-C6, heterociclilo o arilo; R1, R2 y R3 son independientemente hidrógeno, halogeno, nitro, un alquilo C1-C6 lineal o ramificado opcionalmente sustituido adicionalmente, NR5R6 u 0R7, donde R5, R6 y R7 son corm se han definido anteriormente; y una de sus sales farmaceuticamente aceptable.
Description
Claims (1)
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imagen1 imagen2 imagen3 imagen4 imagen5 imagen6
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06126701 | 2006-12-20 | ||
EP06126701 | 2006-12-20 | ||
PCT/EP2007/063998 WO2008074749A1 (en) | 2006-12-20 | 2007-12-14 | Indazole derivatives as kinase inhibitors for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2509820T3 true ES2509820T3 (es) | 2014-10-20 |
Family
ID=39245139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07857632.9T Active ES2509820T3 (es) | 2006-12-20 | 2007-12-14 | Derivados de indazol como inhibidores de la cinasa para el tratamiento del cáncer |
Country Status (15)
Country | Link |
---|---|
US (1) | US8114865B2 (es) |
EP (1) | EP2120932B1 (es) |
JP (1) | JP5302896B2 (es) |
CN (1) | CN101594862B (es) |
AU (1) | AU2007336335B8 (es) |
BR (1) | BRPI0720589A2 (es) |
CA (1) | CA2673095C (es) |
DK (1) | DK2120932T3 (es) |
EA (1) | EA017852B1 (es) |
ES (1) | ES2509820T3 (es) |
MX (1) | MX2009006401A (es) |
PL (1) | PL2120932T3 (es) |
PT (1) | PT2120932E (es) |
SI (1) | SI2120932T1 (es) |
WO (1) | WO2008074749A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
CN101754962B (zh) * | 2007-07-19 | 2013-12-25 | 赛马拜制药公司 | 作为rup3或gpr119受体的激动剂治疗糖尿病和代谢性病症的n-氮杂环状经取代吡咯、吡唑、咪唑、***和四唑衍生物 |
PL2176231T3 (pl) | 2007-07-20 | 2017-04-28 | Nerviano Medical Sciences S.R.L. | Podstawione pochodne indazolu aktywne jako inhibitory kinazy |
EP2373626B1 (en) * | 2008-12-18 | 2016-08-24 | Nerviano Medical Sciences S.r.l. | Substituted indazole derivatives active as kinase inhibitors |
AR078411A1 (es) | 2009-05-07 | 2011-11-09 | Lilly Co Eli | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende |
CN102666553B (zh) | 2009-10-01 | 2015-05-06 | 赛马拜制药公司 | 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 |
EP2519517B1 (en) | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
EA201290919A1 (ru) * | 2010-03-16 | 2013-03-29 | Дана-Фарбер Кэнсер Инститьют, Инк. | Индазольные соединения и их применение |
WO2012075318A2 (en) * | 2010-12-01 | 2012-06-07 | Cell Signaling Technology, Inc. | Fn1 and alk gene translocations in cancer and alk kinase expression in ovarian cancer |
FR2970967B1 (fr) | 2011-01-27 | 2013-02-15 | Pf Medicament | Derives de type azaindazole ou diazaindazole comme medicament |
US9408850B2 (en) * | 2011-05-12 | 2016-08-09 | Nerviano Medical Sciences S.R.L. | Substituted indazole derivatives active as kinase inhibitors |
US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
JP6106685B2 (ja) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | C−jun−n−末端キナーゼ(jnk)の阻害剤 |
CN104220442B (zh) * | 2012-04-05 | 2016-11-23 | 内尔维阿诺医学科学有限公司 | 烷化剂 |
ES2771100T3 (es) * | 2012-05-23 | 2020-07-06 | Nerviano Medical Sciences Srl | Proceso para la preparación de n-[5-(3,5-difluoro-bencil)-1h-indazol-3-il]-4-(4-metil-piperazin-1-il)-2-(tetrahidro-piran-4-ilamino)-benzamida |
KR101936851B1 (ko) * | 2012-07-16 | 2019-01-11 | 한국과학기술연구원 | 단백질 키나아제 저해제인 신규 피라졸로피리딘 유도체 또는 인다졸 유도체 |
EP2689778A1 (en) | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindoles or diazaindoles for treating pain |
EP2689779A1 (en) | 2012-07-27 | 2014-01-29 | Pierre Fabre Medicament | Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk |
DK2888010T3 (da) | 2012-08-22 | 2021-06-28 | Univ Cornell | Fremgangsmåder til at hæmme fascin |
EP2909194A1 (en) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2015058126A1 (en) | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
WO2015110467A1 (en) * | 2014-01-23 | 2015-07-30 | Nerviano Medical Sciences S.R.L. | Process for the preparation of substituted n-(5-benzenesulfonyl-1h-indazol-3-yl)-benzamides |
TWI672141B (zh) * | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ros1突變癌細胞之分子 |
JP6691869B2 (ja) * | 2014-02-20 | 2020-05-13 | コーネル ユニヴァーシティー | ファシンを阻害するための化合物及び方法 |
US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
KR102595599B1 (ko) * | 2014-12-02 | 2023-11-02 | 이그니타, 인코포레이티드 | 신경모세포종의 치료를 위한 병용 |
EP3233840B1 (en) | 2014-12-16 | 2018-11-21 | Eudendron S.r.l. | Heterocyclic derivatives modulating activity of certain protein kinases |
AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
CN104530045A (zh) * | 2015-01-14 | 2015-04-22 | 中国药科大学 | 吡唑并[4,3-c]四氢吡啶类c-Met激酶抑制剂及其制备方法和用途 |
WO2016123629A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US10550121B2 (en) | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2996978A1 (en) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
AU2016370846B2 (en) | 2015-12-18 | 2022-08-25 | Ignyta, Inc. | Combinations for the treatment of cancer |
US10292983B2 (en) | 2016-08-03 | 2019-05-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
WO2019018570A1 (en) | 2017-07-19 | 2019-01-24 | Ignyta, Inc. | PHARMACEUTICAL COMPOSITIONS CONTAINING ENTRECTINIB |
CN111225913B (zh) | 2017-08-16 | 2024-05-31 | 范德比尔特大学 | 作为mglur4变构增强剂的吲唑化合物、组合物和治疗神经功能障碍的方法 |
JP7311498B2 (ja) | 2017-10-17 | 2023-07-19 | イグナイタ インコーポレイテッド | 薬学的組成物および剤形 |
CN110452176A (zh) * | 2018-05-07 | 2019-11-15 | 四川大学 | 吲唑类衍生物及其制备方法和用途 |
EP3725777A1 (en) * | 2019-04-17 | 2020-10-21 | Rottapharm Biotech S.r.l. | Benzo- and pyrido-pyrazoles as protein kinase inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1432416B1 (en) * | 2001-09-26 | 2011-01-19 | Pfizer Italia S.r.l. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
FR2836915B1 (fr) * | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
TW200501960A (en) * | 2002-10-02 | 2005-01-16 | Bristol Myers Squibb Co | Synergistic kits and compositions for treating cancer |
WO2004078116A2 (en) * | 2003-03-03 | 2004-09-16 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
FR2871158A1 (fr) * | 2004-06-04 | 2005-12-09 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
EP1853590A1 (en) * | 2005-03-03 | 2007-11-14 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
CL2009001158A1 (es) * | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer. |
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2007
- 2007-12-14 CA CA2673095A patent/CA2673095C/en not_active Expired - Fee Related
- 2007-12-14 US US12/520,387 patent/US8114865B2/en active Active
- 2007-12-14 WO PCT/EP2007/063998 patent/WO2008074749A1/en active Application Filing
- 2007-12-14 PT PT78576329T patent/PT2120932E/pt unknown
- 2007-12-14 MX MX2009006401A patent/MX2009006401A/es active IP Right Grant
- 2007-12-14 BR BRPI0720589-9A patent/BRPI0720589A2/pt active Search and Examination
- 2007-12-14 DK DK07857632.9T patent/DK2120932T3/da active
- 2007-12-14 EP EP07857632.9A patent/EP2120932B1/en active Active
- 2007-12-14 JP JP2009542015A patent/JP5302896B2/ja active Active
- 2007-12-14 ES ES07857632.9T patent/ES2509820T3/es active Active
- 2007-12-14 SI SI200731506T patent/SI2120932T1/sl unknown
- 2007-12-14 CN CN200780049818.0A patent/CN101594862B/zh active Active
- 2007-12-14 AU AU2007336335A patent/AU2007336335B8/en not_active Ceased
- 2007-12-14 PL PL07857632T patent/PL2120932T3/pl unknown
- 2007-12-14 EA EA200970595A patent/EA017852B1/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SI2120932T1 (sl) | 2014-09-30 |
AU2007336335B8 (en) | 2014-07-24 |
EA200970595A1 (ru) | 2010-02-26 |
AU2007336335A1 (en) | 2008-06-26 |
MX2009006401A (es) | 2009-06-23 |
US8114865B2 (en) | 2012-02-14 |
AU2007336335A8 (en) | 2014-07-24 |
PT2120932E (pt) | 2014-10-10 |
DK2120932T3 (da) | 2014-10-13 |
AU2007336335A2 (en) | 2009-08-06 |
JP5302896B2 (ja) | 2013-10-02 |
EP2120932B1 (en) | 2014-07-09 |
BRPI0720589A2 (pt) | 2014-02-25 |
CN101594862B (zh) | 2015-11-25 |
EA017852B1 (ru) | 2013-03-29 |
US20100197665A1 (en) | 2010-08-05 |
AU2007336335B2 (en) | 2013-05-30 |
EP2120932A1 (en) | 2009-11-25 |
JP2010530840A (ja) | 2010-09-16 |
CA2673095C (en) | 2016-03-15 |
CN101594862A (zh) | 2009-12-02 |
WO2008074749A9 (en) | 2009-05-07 |
WO2008074749A1 (en) | 2008-06-26 |
PL2120932T3 (pl) | 2015-02-27 |
CA2673095A1 (en) | 2008-06-26 |
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