ES2529691T3 - Derivados de 3-amino-imidazo [1,2-A] piridina como inhibidores de SGLT - Google Patents
Derivados de 3-amino-imidazo [1,2-A] piridina como inhibidores de SGLT Download PDFInfo
- Publication number
- ES2529691T3 ES2529691T3 ES07725570T ES07725570T ES2529691T3 ES 2529691 T3 ES2529691 T3 ES 2529691T3 ES 07725570 T ES07725570 T ES 07725570T ES 07725570 T ES07725570 T ES 07725570T ES 2529691 T3 ES2529691 T3 ES 2529691T3
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- Spain
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- mnr4r4
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- respectively independently
- cooa
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Compuestos de la fórmula I en donde R, R', respectivamente de forma independiente el uno del otro, representan A, OA, Hal, NO2 o COOA, R1, R1', respectivamente de forma independiente el uno del otro, representan H, A, F, Cl, NH2, OH, CN o COOA, R1" representa H o NH2, R2, R2', respectivamente de forma independiente el uno del otro, representan H, Hal, A, OH, OA, CN, NO2, NR4R4', CH2NR4R4', O(CH2)mNR4R4',O(CH2)mOR4, NH(CH2)mNR4R4', O(C>=O)(CH2)mNR4R4', NH(C>=O)(CH2)mNR4R4', CH2O(CH2)mNR4R4', CH2OR4, (CH2)mCOOR4, OSO2A, OHet, O(CH2)mCONR4R4', O(CH2)mAr, O(CH2)mCH(OH)(CH2)mOH o OSO2NR4R4', R2 y R2' representan de forma conjunta también -CH>=CH-CH>=CH-, R2" representa H, A, Hal, OH u OA, R3, R3', respectivamente de forma independiente el uno del otro, representan A, OA, Hal, NO2 o COOA, R4, R4', respectivamente de forma independiente el uno del otro, representan H o A, A representa alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 ó 6 átomos de C, en donde 1-5 átomos de H pueden ser reemplazados por F, Het representa tetrahidrofuranilo, tetrahidropiranilo, dioxolanilo, pirrolidinilo, piperidinilo, morfolinilo o piperazinilo, los cuales también pueden ser mono-sustituidos por >=O (oxígeno de carbonilo), Ar representa fenilo, Hal representa F, Cl, Br o I, m representa 1, 2 ó 3, n representa 0, 1 ó 2, así como sus sales, solvatos y estereoisómeros que pueden utilizarse farmacéuticamente, incluyendo las mezclas de los mismos en cualquier proporción.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006028862A DE102006028862A1 (de) | 2006-06-23 | 2006-06-23 | 3-Amino-imidazo[1,2-a]pyridinderivate |
DE102006028862 | 2006-06-23 | ||
PCT/EP2007/004674 WO2007147478A1 (de) | 2006-06-23 | 2007-05-25 | 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2529691T3 true ES2529691T3 (es) | 2015-02-24 |
Family
ID=38335700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07725570T Active ES2529691T3 (es) | 2006-06-23 | 2007-05-25 | Derivados de 3-amino-imidazo [1,2-A] piridina como inhibidores de SGLT |
Country Status (11)
Country | Link |
---|---|
US (1) | US8258151B2 (es) |
EP (1) | EP2032571B1 (es) |
JP (1) | JP5324436B2 (es) |
AR (1) | AR061574A1 (es) |
AU (1) | AU2007263391B2 (es) |
CA (1) | CA2655780C (es) |
DE (1) | DE102006028862A1 (es) |
ES (1) | ES2529691T3 (es) |
IL (1) | IL195915A (es) |
TW (1) | TW200808792A (es) |
WO (1) | WO2007147478A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534243A (en) * | 1994-09-26 | 1996-07-09 | The Procter & Gamble Company | Aqueous oral compositions |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
BRPI0918841B8 (pt) | 2008-08-28 | 2021-05-25 | Pfizer | derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos |
EP2334675B1 (en) * | 2008-09-16 | 2014-03-26 | Csir | Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors |
SI2496583T1 (sl) | 2009-11-02 | 2015-02-27 | Pfizer Inc. | Derivati dioksa-biciklo(3.2.1)oktan-2,3,4-triola |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
RU2656593C2 (ru) | 2013-01-31 | 2018-06-06 | Неомед Инститьют | Соединения имидазопиридина, полезные при лечении состояния, связанного с активностью p2x3 и/или p2x2/3 |
EP3670502A4 (en) * | 2017-10-11 | 2021-01-20 | Daikin Industries, Ltd. | PROCESS FOR THE PRODUCTION OF CYCLIC CARBONATE WITH AN UNSATURATED GROUP, AND NEW CYCLIC CARBONATE |
US11778392B2 (en) | 2019-11-14 | 2023-10-03 | Starkey Laboratories, Inc. | Ear-worn electronic device configured to compensate for hunched or stooped posture |
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-
2006
- 2006-06-23 DE DE102006028862A patent/DE102006028862A1/de not_active Withdrawn
-
2007
- 2007-05-25 AU AU2007263391A patent/AU2007263391B2/en not_active Ceased
- 2007-05-25 ES ES07725570T patent/ES2529691T3/es active Active
- 2007-05-25 JP JP2009516925A patent/JP5324436B2/ja not_active Expired - Fee Related
- 2007-05-25 US US12/305,744 patent/US8258151B2/en not_active Expired - Fee Related
- 2007-05-25 EP EP07725570.1A patent/EP2032571B1/de not_active Not-in-force
- 2007-05-25 CA CA2655780A patent/CA2655780C/en not_active Expired - Fee Related
- 2007-05-25 WO PCT/EP2007/004674 patent/WO2007147478A1/de active Application Filing
- 2007-06-21 TW TW096122293A patent/TW200808792A/zh unknown
- 2007-06-22 AR ARP070102746A patent/AR061574A1/es unknown
-
2008
- 2008-12-14 IL IL195915A patent/IL195915A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2032571A1 (de) | 2009-03-11 |
AU2007263391A1 (en) | 2007-12-27 |
AU2007263391B2 (en) | 2012-05-17 |
JP2009541376A (ja) | 2009-11-26 |
CA2655780C (en) | 2015-11-24 |
TW200808792A (en) | 2008-02-16 |
CA2655780A1 (en) | 2007-12-27 |
DE102006028862A1 (de) | 2007-12-27 |
US8258151B2 (en) | 2012-09-04 |
IL195915A0 (en) | 2009-09-01 |
IL195915A (en) | 2014-01-30 |
US20110195991A1 (en) | 2011-08-11 |
EP2032571B1 (de) | 2014-12-03 |
JP5324436B2 (ja) | 2013-10-23 |
WO2007147478A1 (de) | 2007-12-27 |
AR061574A1 (es) | 2008-09-03 |
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