ES2297727T3 - Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. - Google Patents

Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Download PDF

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Publication number
ES2297727T3
ES2297727T3 ES05754708T ES05754708T ES2297727T3 ES 2297727 T3 ES2297727 T3 ES 2297727T3 ES 05754708 T ES05754708 T ES 05754708T ES 05754708 T ES05754708 T ES 05754708T ES 2297727 T3 ES2297727 T3 ES 2297727T3
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Spain
Prior art keywords
group
octahidropirrolo
antivirical
pirrol
employment
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ES05754708T
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English (en)
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Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de la fórmula I, en la que: X1 se elige entre el grupo formado por -C(=O)R3, -S(=O)2R3 y -C(=O)OR3; X2 se elige entre el grupo formado por -C(=O)R4, -S(=O)2R4, bencilo y -CH2(piridin-3-ilo), dicho bencilo está opcionalmente sustituido por halógeno o alquilo C1-3; uno de R1 y R2 es: (i) fenilo opcionalmente sustituido de una a cuatro veces por sustituyentes elegidos con independencia de su aparición entre el grupo formado por halógeno, alquilo C1-6 y alcoxi C1-6; (ii) heteroarilo elegido entre el grupo formado por piridinilo, N-óxido de piridinilo, pirimidinilo y tiazolilo, dicho heteroarilo está opcionalmente sustituido de una a tres veces por sustituyentes elegidos con independencia entre sí entre el grupo formado por halógeno, alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; y el otro de R1 y R2 es hidrógeno.
ES05754708T 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. Active ES2297727T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
US578759P 2004-06-09

Publications (1)

Publication Number Publication Date
ES2297727T3 true ES2297727T3 (es) 2008-05-01

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05754708T Active ES2297727T3 (es) 2004-06-09 2005-06-01 Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos.

Country Status (21)

Country Link
US (2) US7164019B2 (es)
EP (1) EP1761542B1 (es)
JP (1) JP2008501743A (es)
CN (1) CN101001860A (es)
AR (1) AR049209A1 (es)
AT (1) ATE382623T1 (es)
AU (1) AU2005251891A1 (es)
BR (1) BRPI0511982A (es)
CA (1) CA2569910A1 (es)
DE (1) DE602005004144T2 (es)
DK (1) DK1761542T3 (es)
ES (1) ES2297727T3 (es)
IL (1) IL179534A0 (es)
MX (1) MXPA06014404A (es)
NO (1) NO20070137L (es)
PL (1) PL1761542T3 (es)
PT (1) PT1761542E (es)
RU (1) RU2006146608A (es)
TW (1) TW200701981A (es)
WO (1) WO2005121145A2 (es)
ZA (1) ZA200609837B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101291905A (zh) 2005-10-19 2008-10-22 弗·哈夫曼-拉罗切有限公司 苯乙酰胺nnrt抑制剂
KR20080102387A (ko) * 2006-02-15 2008-11-25 에프. 호프만-라 로슈 아게 헤테로-바이사이클릭 항바이러스 화합물
BRPI0707923A2 (pt) * 2006-02-15 2011-05-17 Hoffmann La Roche compostos heterocìclicos antivirais
DE602007013573D1 (de) 2006-08-16 2011-05-12 Hoffmann La Roche Nicht-nukleosidische reverse-transkriptase-hemmer
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
CA2662835A1 (en) * 2006-09-18 2008-03-27 Remy Lemoine Octahydropyrrolo [3, 4-c] pyrrole derivatives and their use as antiviral agents
TWI405763B (zh) * 2006-11-02 2013-08-21 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
EP2089384B1 (en) 2006-12-13 2015-08-05 F. Hoffmann-La Roche AG 2-(piperidin-4-yl)-4-phenoxy-or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
US8464207B2 (en) * 2007-10-12 2013-06-11 Novell Intellectual Property Holdings, Inc. System and method for tracking software changes
GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
DK2477983T3 (en) 2009-09-16 2015-06-29 Univ Edinburgh (4-phenyl-piperidin-1-yl) - [5-1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONFORBINDELSER AND THEIR USE
ES2534516T3 (es) 2010-01-07 2015-04-23 E.I. Du Pont De Nemours And Company Compuestos heterocíclicos fungicidas
MX344142B (es) 2010-04-29 2016-12-07 The Univ Of Edinburgh (8-aza-biciclico[3.2.1]oct-8-il)-[5-(1h-pirazol-4-il)-tiofen-3-il ]-metanonas 3, 3-disubstituidas como inhibidores de 1(beta)-hsd1.
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
PT2861566T (pt) 2012-06-13 2017-02-08 Hoffmann La Roche Novos diazaspirocicloalcanos e azaspirocicloalcanos
AR092645A1 (es) * 2012-09-25 2015-04-29 Hoffmann La Roche Derivados biciclicos inhibidores de autotaxina (atx)
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
ES2707739T3 (es) 2013-09-26 2019-04-04 Cadent Therapeutics Inc Moduladores negativos de octahidro-ciclopenta[c]pirrol selectivo de NR2B
DK3074400T3 (en) 2013-11-26 2018-01-15 Hoffmann La Roche Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
CN104744451A (zh) * 2013-12-30 2015-07-01 中国科学院上海药物研究所 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途
CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
LT3122750T (lt) 2014-03-26 2019-11-11 Hoffmann La Roche Biciklinių junginių, tokių kaip autotaksino (atx) ir lizofosfatidinės rūgšties (lpa), gamybos inhibitoriai
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
UA123362C2 (uk) 2015-09-04 2021-03-24 Ф. Хоффманн-Ля Рош Аг Феноксиметильні похідні
BR112018006034A2 (pt) 2015-09-24 2018-10-09 Hoffmann La Roche compostos bicíclicos como inibidores de atx
CA2983782A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
RU2724899C2 (ru) 2015-09-24 2020-06-26 Ф. Хоффманн-Ля Рош Аг Новые бициклические соединения в качестве дуальных ингибиторов atx/ca
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
MA45656A (fr) 2016-07-14 2021-03-24 Pfizer Nouveaux pyrimidine carboxamides utilisées comme inhibiteurs de l'enzyme vanin-1
MX2019010772A (es) 2017-03-16 2019-12-16 Hoffmann La Roche Compuestos heterociclicos utiles como inhibidores dobles de autotaxina (atx)/anhidrasa carbonica (ca).
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2021250197A1 (en) * 2020-06-10 2021-12-16 Cyxone Ab Method for preparing a crystalline form of rabeximod
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930266A1 (de) 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
DK0728758T3 (da) * 1995-02-27 2004-02-23 Hoffmann La Roche Dioxopyrrolo-pyrrolderivater
GB9519563D0 (en) 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
CN1084751C (zh) 1996-08-13 2002-05-15 麦克公司 钯催化的吲哚化反应
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
WO2000055143A1 (en) * 1999-03-17 2000-09-21 F. Hoffmann-La Roche Ag Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators
SK286968B6 (sk) 1999-05-04 2009-08-06 Schering Corporation Piperidín-piperidinyl ako CCR5 antagonista, farmaceutický prostriedok s jeho obsahom a jeho použitie
SK286641B6 (sk) 1999-05-04 2009-03-05 Schering Corporation Piperazínové deriváty užitočné ako CCR5 antagonisty, farmaceutické prípravky s ich obsahom a ich použitie
WO2001040227A1 (fr) * 1999-12-03 2001-06-07 Ono Pharmaceutical Co., Ltd. Derives triazaspiro[5.5]undecane et medicaments contenant ces derives en tant que principe actif
US6815438B2 (en) 1999-12-14 2004-11-09 Neurosearch A/S Heteroaryl-diazabicycloalkanes
DE60023100T2 (de) 2000-01-05 2006-07-06 Pfizer Inc. Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten
KR100523501B1 (ko) 2000-05-26 2005-10-25 화이자 인코포레이티드 Ｃｃｒ5 조절제로서의 트리아졸릴 트로판 유도체
ES2253409T3 (es) 2000-07-21 2006-06-01 Ak Food Technology, Inc Procedimiento, aparato y producto de infusion liquida y ablandamiento.
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
CA2440803A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
GB0211418D0 (en) * 2002-05-17 2002-06-26 Glaxo Group Ltd Compounds
AR042628A1 (es) 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5

Also Published As

Publication number Publication date
ATE382623T1 (de) 2008-01-15
EP1761542A2 (en) 2007-03-14
RU2006146608A (ru) 2008-07-20
US20070117859A1 (en) 2007-05-24
DE602005004144D1 (de) 2008-02-14
PL1761542T3 (pl) 2008-06-30
ZA200609837B (en) 2008-09-25
CN101001860A (zh) 2007-07-18
WO2005121145A3 (en) 2006-03-02
DK1761542T3 (da) 2008-04-28
TW200701981A (en) 2007-01-16
DE602005004144T2 (de) 2009-01-29
WO2005121145A2 (en) 2005-12-22
JP2008501743A (ja) 2008-01-24
CA2569910A1 (en) 2005-12-22
IL179534A0 (en) 2007-05-15
NO20070137L (no) 2007-03-06
MXPA06014404A (es) 2007-02-19
AR049209A1 (es) 2006-07-05
AU2005251891A1 (en) 2005-12-22
US7164019B2 (en) 2007-01-16
BRPI0511982A (pt) 2008-01-22
US20060014767A1 (en) 2006-01-19
EP1761542B1 (en) 2008-01-02
US7714018B2 (en) 2010-05-11
PT1761542E (pt) 2008-03-26

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