ATE382623T1 - Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln - Google Patents

Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln

Info

Publication number
ATE382623T1
ATE382623T1 AT05754708T AT05754708T ATE382623T1 AT E382623 T1 ATE382623 T1 AT E382623T1 AT 05754708 T AT05754708 T AT 05754708T AT 05754708 T AT05754708 T AT 05754708T AT E382623 T1 ATE382623 T1 AT E382623T1
Authority
AT
Austria
Prior art keywords
octahydropyrrolo
antiviral agents
pyrrole derivatives
pyrrole
derivatives
Prior art date
Application number
AT05754708T
Other languages
English (en)
Inventor
Eun Lee
Chris Melville
David Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE382623T1 publication Critical patent/ATE382623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05754708T 2004-06-09 2005-06-01 Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln ATE382623T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09

Publications (1)

Publication Number Publication Date
ATE382623T1 true ATE382623T1 (de) 2008-01-15

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05754708T ATE382623T1 (de) 2004-06-09 2005-06-01 Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln

Country Status (21)

Country Link
US (2) US7164019B2 (de)
EP (1) EP1761542B1 (de)
JP (1) JP2008501743A (de)
CN (1) CN101001860A (de)
AR (1) AR049209A1 (de)
AT (1) ATE382623T1 (de)
AU (1) AU2005251891A1 (de)
BR (1) BRPI0511982A (de)
CA (1) CA2569910A1 (de)
DE (1) DE602005004144T2 (de)
DK (1) DK1761542T3 (de)
ES (1) ES2297727T3 (de)
IL (1) IL179534A0 (de)
MX (1) MXPA06014404A (de)
NO (1) NO20070137L (de)
PL (1) PL1761542T3 (de)
PT (1) PT1761542E (de)
RU (1) RU2006146608A (de)
TW (1) TW200701981A (de)
WO (1) WO2005121145A2 (de)
ZA (1) ZA200609837B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007045573A1 (en) 2005-10-19 2007-04-26 F. Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
WO2007093520A1 (en) * 2006-02-15 2007-08-23 F. Hoffmann-La Roche Ag Hetero-bycyclic antiviral compounds
RU2008136763A (ru) * 2006-02-15 2010-03-20 Ф.Хоффманн-Ля Рош Аг (Ch) Гетероциклические противовирусные соединения
AU2007286345B2 (en) 2006-08-16 2012-03-08 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
EP2066674B1 (de) * 2006-09-18 2010-06-30 F.Hoffmann-La Roche Ag Octahydropyrrolo[3,4-c]pyrrolderivate und ihre verwendung als antivirale mittel
TWI404532B (zh) * 2006-11-02 2013-08-11 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
AU2007332654B2 (en) 2006-12-13 2013-06-20 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
US8464207B2 (en) * 2007-10-12 2013-06-11 Novell Intellectual Property Holdings, Inc. System and method for tracking software changes
GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
US8642621B2 (en) 2009-09-16 2014-02-04 The University Of Edinburgh (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use
MX2012007935A (es) 2010-01-07 2012-08-15 Du Pont Compuestos heterociclicos fungicidas.
BR112012027640B1 (pt) 2010-04-29 2021-08-03 The University Of Edinburgh Composto, composição farmacêutica, e, métodos de preparar uma composição farmacêutica, de inibir a função da 11beta-hidroxiesteroide desidrogenase do tipo 1
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
SI2861566T1 (sl) 2012-06-13 2017-03-31 F. Hoffmann-La Roche Ag Novi diazaspirocikloalkan in azaspirocikloalkan
LT2900669T (lt) * 2012-09-25 2019-11-11 Hoffmann La Roche Heksahidropirol[3,4-c]pirolo dariniai ir susiję junginai kaip autotaksino (atx) inhibitoriai ir kaip lizofosfatidinės rūgšties (lpa) gamybos inhibitoriai, skirti gydyti pvz., inkstų ligas
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
ES2707739T3 (es) 2013-09-26 2019-04-04 Cadent Therapeutics Inc Moduladores negativos de octahidro-ciclopenta[c]pirrol selectivo de NR2B
DK3074400T3 (en) 2013-11-26 2018-01-15 Hoffmann La Roche Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
CN104744451A (zh) * 2013-12-30 2015-07-01 中国科学院上海药物研究所 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途
MX370659B (es) 2014-03-26 2019-12-19 Hoffmann La Roche Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa).
CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
RU2018112230A (ru) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов atx
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
WO2018011681A1 (en) 2016-07-14 2018-01-18 Pfizer Inc. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
SG11201908560SA (en) 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
CN115698010A (zh) * 2020-06-10 2023-02-03 赛克松公司 用于制备结晶形式的rabeximod的方法
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930266A1 (de) 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
EP0728758B1 (de) * 1995-02-27 2003-10-15 F. Hoffmann-La Roche Ag Dioxopyrrolo-pyrrolderivate
GB9519563D0 (en) 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
SK17899A3 (en) 1996-08-13 2000-02-14 Merck & Co Inc Palladium catalyzed indolization
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
AU3555200A (en) * 1999-03-17 2000-10-04 F. Hoffmann-La Roche Ag Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators
HUP0203528A3 (en) 1999-05-04 2003-11-28 Schering Corp Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use
BR0010304A (pt) 1999-05-04 2002-02-13 Schering Corp Derivados de piperazina úteis como antagonistas do ccr5
DE60016454T2 (de) 1999-12-03 2005-08-04 Ono Pharmaceutical Co. Ltd. Triazaspiro[5.5]undecanderivate und Drogen, die dasselbe als aktiven Inhaltsstoff enthalten
US6815438B2 (en) 1999-12-14 2004-11-09 Neurosearch A/S Heteroaryl-diazabicycloalkanes
ES2249237T3 (es) 2000-01-05 2006-04-01 Pfizer Inc. Compuestos de bencimidazol como antagonistas del receptor orl1.
DE60135685D1 (de) 2000-05-26 2008-10-16 Pfizer Triazolyltropanderivate als ccr5-modulatoren
EP1304926B1 (de) 2000-07-21 2005-12-21 AK Food Technology, Inc Vorrichtung und verfahren zum mürbemachen und zur marinierung von nahrungsmitteln und das hergestellte produkt
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
BR0207952A (pt) * 2001-03-07 2004-07-27 Pfizer Prod Inc Moduladores da atividade de receptores de quimiocina
GB0211418D0 (en) * 2002-05-17 2002-06-26 Glaxo Group Ltd Compounds
AR042628A1 (es) 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5

Also Published As

Publication number Publication date
WO2005121145A2 (en) 2005-12-22
IL179534A0 (en) 2007-05-15
US7714018B2 (en) 2010-05-11
DK1761542T3 (da) 2008-04-28
AR049209A1 (es) 2006-07-05
PL1761542T3 (pl) 2008-06-30
EP1761542B1 (de) 2008-01-02
US7164019B2 (en) 2007-01-16
ES2297727T3 (es) 2008-05-01
PT1761542E (pt) 2008-03-26
JP2008501743A (ja) 2008-01-24
EP1761542A2 (de) 2007-03-14
US20070117859A1 (en) 2007-05-24
CN101001860A (zh) 2007-07-18
DE602005004144D1 (de) 2008-02-14
RU2006146608A (ru) 2008-07-20
CA2569910A1 (en) 2005-12-22
US20060014767A1 (en) 2006-01-19
BRPI0511982A (pt) 2008-01-22
ZA200609837B (en) 2008-09-25
MXPA06014404A (es) 2007-02-19
NO20070137L (no) 2007-03-06
TW200701981A (en) 2007-01-16
AU2005251891A1 (en) 2005-12-22
DE602005004144T2 (de) 2009-01-29
WO2005121145A3 (en) 2006-03-02

Similar Documents

Publication Publication Date Title
ATE382623T1 (de) Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln
ATE384725T1 (de) Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung
DE60321043D1 (de) Biphenylderivate und deren verwendung als fungizide
DE502005007196D1 (de) 8-ä3-amino-piperidin-1-ylü-xanthine, deren herstellung und deren verwendung als dpp-iv hemmer
NO20053955D0 (no) Pyrazolo [1,5-A] pyrimidinderivater
ATE377591T1 (de) Pyrimidinderivate und deren verwendung als cb2- modulatoren
ATE466012T1 (de) Pyrazolo 3,4-b pyridinverbindungen und ihre verwendung als phosphodiesterase inhibitoren
DE502005006424D1 (de) Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel
DE602004027354D1 (de) SUBSTITUIERTE 8y-PYRIDINYLDIHYDROSPIROiCYCLOALKYL PYRIMIDOi1,2-A PYRIMIDIN-6-ON- UND 8y-PYRIMIDINYLDIHYDROSPIROiCYCLOALKYL PYRIMIDOi1,2-A PYRIMIDIN-6-ONDERIVATE UND DEREN VERWENDUNG BEI NEURODEGENERATIVEN KRANKHEITEN
ATE260917T1 (de) N-(5,7-dimethoxy(1,2,4)triazolo(1,5-a)pyrimidin 2-yl)arylsulfonamid verbindungen und deren verwendung als herbizide
DE602005019752D1 (de) Isoxazolinderivate und deren verwendung als herbizide
DE602005006815D1 (de) 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung
ATE360632T1 (de) Substituierte 8&#39;-pyri(mi)dinyl-dihydrospiro- (cycloalkylamin)-pyrimido(1,2a)pyrimidin-6- onderivate
ATE417045T1 (de) Substituierte diazaspiroä5.5üundecanderivate und deren verwendung als neurokininantagonisten
ATE487707T1 (de) (6-flu0r-benz0äl, 3üdioxolyl)-morpholin-4-yl- methanone und deren verwendung als cbl-liganden
UY29439A1 (es) Nuevos compuestos
DE602005022060D1 (de) Diaminoalkohole und deren verwendung als renininhibitoren
NL1030503A1 (nl) Octahydropyrrolo[3,4-c]-pyrroolderivaten.
ATE433977T1 (de) Substituierte 8-perfluoro-6,7,8,9- tetrahydropyrimido 1,2-a pyrimidin-4-on-derivate
ATE551329T1 (de) Chinazolinonderivate und deren verwendung als cb- agonisten
ATE512148T1 (de) Pyrazolo- und imidazopyrimidinderivate
ATE555097T1 (de) 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
DE60107603D1 (de) Pyrimidinverbindungen und deren verwendung als pestizide
DE602005007866D1 (de) 1-phenyl- und 1-pyridylpyrazolderivate und deren verwendung als pestizide
ATE353083T1 (de) Naphthyridin-derivate und ihre verwendung als fungizide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1761542

Country of ref document: EP

REN Ceased due to non-payment of the annual fee