PE20091005A1 - N-(2-(hetaril)aril)arilsulfonamidas y n-(2-(hetaril)hetaril)arilsulfonamidas - Google Patents

N-(2-(hetaril)aril)arilsulfonamidas y n-(2-(hetaril)hetaril)arilsulfonamidas

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Publication number
PE20091005A1
PE20091005A1 PE2008001064A PE2008001064A PE20091005A1 PE 20091005 A1 PE20091005 A1 PE 20091005A1 PE 2008001064 A PE2008001064 A PE 2008001064A PE 2008001064 A PE2008001064 A PE 2008001064A PE 20091005 A1 PE20091005 A1 PE 20091005A1
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PE
Peru
Prior art keywords
alkyl
hetaryl
arylsulfonamides
chloro
tert
Prior art date
Application number
PE2008001064A
Other languages
English (en)
Inventor
Trevor T Charvat
Cheng Hu
Anita Melikian
Aaron Novack
Andrew M K Pennell
Jay Powers
Sreenivas Punna
Edward J Sullivan
William D Thomas
Solomon Ungashe
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of PE20091005A1 publication Critical patent/PE20091005A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

REFERIDA A UN DERIVADO DE SULFONAMIDA DE FORMULA (I), DONDE Ar1 ES UN ARILO DE 6 CARBONOS O UN HETEROARILO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO C1-C6, ALQUENILO C2-C8, ENTRE OTROS; A ES N O CR4; EL GRUPO FORMADO POR X1, X2 Y X3 ES N-N=N, C=N-N(R5), N-C(R6)=N, ENTRE OTROS; R2, R3, R4 Y R6 SON H, ALQUILO C1-C8, HALOGENO, ENTRE OTROS; R5 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-TERT-BUTIL-N-(4-CLORO-2-(1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL)FENIL)BENCENSULFONAMIDAS, 4-TERT-BUTIL-N-(4-CLORO-2-(1-METIL-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL)FENIL)BENCENSULFONAMIDA, 4-TERT-BUTIL-N-(4-CLORO-2-(4-(METOXIMETIL)-1H-1,2,3-TRIAZOL-1-IL)FENIL)BENCENSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LAS QUIMIOQUINAS, EN PARTICULAR, DE CCR9, Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, CANCER, ENFERMEDADES CARDIOVASCULARES, ENTRE OTRAS
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KR20160035608A (ko) 2016-03-31
CA2691031C (en) 2014-12-09
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