MX2019010772A - Compuestos heterociclicos utiles como inhibidores dobles de autotaxina (atx)/anhidrasa carbonica (ca). - Google Patents
Compuestos heterociclicos utiles como inhibidores dobles de autotaxina (atx)/anhidrasa carbonica (ca).Info
- Publication number
- MX2019010772A MX2019010772A MX2019010772A MX2019010772A MX2019010772A MX 2019010772 A MX2019010772 A MX 2019010772A MX 2019010772 A MX2019010772 A MX 2019010772A MX 2019010772 A MX2019010772 A MX 2019010772A MX 2019010772 A MX2019010772 A MX 2019010772A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- heterocyclic compounds
- compounds useful
- compounds
- linking group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La invención proporciona nuevos compuestos que tienen la fórmula general (I) (ver Fórmula) en la que R1, R2, Y, X, W, m y n son como se definen en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17161249 | 2017-03-16 | ||
PCT/EP2018/056140 WO2018167001A1 (en) | 2017-03-16 | 2018-03-13 | Heterocyclic compounds useful as dual atx/ca inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010772A true MX2019010772A (es) | 2019-12-16 |
Family
ID=58347248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010772A MX2019010772A (es) | 2017-03-16 | 2018-03-13 | Compuestos heterociclicos utiles como inhibidores dobles de autotaxina (atx)/anhidrasa carbonica (ca). |
Country Status (20)
Country | Link |
---|---|
US (1) | US11059794B2 (es) |
JP (1) | JP7157755B2 (es) |
KR (1) | KR20190129924A (es) |
CN (1) | CN110392679B (es) |
AR (1) | AR111279A1 (es) |
AU (1) | AU2018233079B9 (es) |
BR (1) | BR112019019017A2 (es) |
CA (1) | CA3053329A1 (es) |
CL (1) | CL2019002609A1 (es) |
CO (1) | CO2019009373A2 (es) |
CR (1) | CR20190423A (es) |
IL (1) | IL269188B (es) |
MA (1) | MA49879A (es) |
MX (1) | MX2019010772A (es) |
PE (1) | PE20191757A1 (es) |
PH (1) | PH12019502118A1 (es) |
RU (1) | RU2019132254A (es) |
SG (1) | SG11201908560SA (es) |
TW (1) | TW201838982A (es) |
WO (1) | WO2018167001A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
PT2900669T (pt) | 2012-09-25 | 2019-10-29 | Hoffmann La Roche | Derivados de hexahidropirrolo[3,4−c]pirrol e compostos relacionados enquanto inibidores da autotaxina (atx) e enquanto inibidores da produção de ácido lisofosfatídico (lpa) para o tratamento de, por exemplo, doenças renais |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
WO2015078803A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL |
CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
SI3122750T1 (sl) | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
CN107922415B (zh) | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
MA42918A (fr) | 2015-09-24 | 2018-08-01 | Hoffmann La Roche | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx |
CA3053329A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
CN113412113A (zh) * | 2018-12-11 | 2021-09-17 | 豪夫迈·罗氏有限公司 | 氨基嗪酰胺 |
WO2020119896A1 (en) * | 2018-12-11 | 2020-06-18 | F. Hoffmann-La Roche Ag | Heterocyclic inhibitors of atx |
CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
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-
2018
- 2018-03-13 CA CA3053329A patent/CA3053329A1/en active Pending
- 2018-03-13 AU AU2018233079A patent/AU2018233079B9/en not_active Ceased
- 2018-03-13 MA MA049879A patent/MA49879A/fr unknown
- 2018-03-13 KR KR1020197030084A patent/KR20190129924A/ko not_active Application Discontinuation
- 2018-03-13 BR BR112019019017A patent/BR112019019017A2/pt not_active Application Discontinuation
- 2018-03-13 PE PE2019001583A patent/PE20191757A1/es unknown
- 2018-03-13 WO PCT/EP2018/056140 patent/WO2018167001A1/en unknown
- 2018-03-13 SG SG11201908560S patent/SG11201908560SA/en unknown
- 2018-03-13 RU RU2019132254A patent/RU2019132254A/ru not_active Application Discontinuation
- 2018-03-13 CN CN201880017056.4A patent/CN110392679B/zh active Active
- 2018-03-13 CR CR20190423A patent/CR20190423A/es unknown
- 2018-03-13 MX MX2019010772A patent/MX2019010772A/es unknown
- 2018-03-13 JP JP2019550561A patent/JP7157755B2/ja active Active
- 2018-03-15 TW TW107108748A patent/TW201838982A/zh unknown
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KR20190129924A (ko) | 2019-11-20 |
MA49879A (fr) | 2020-06-24 |
CO2019009373A2 (es) | 2019-09-09 |
SG11201908560SA (en) | 2019-10-30 |
PH12019502118A1 (en) | 2020-07-06 |
IL269188B (en) | 2021-12-01 |
CN110392679B (zh) | 2023-04-07 |
IL269188A (en) | 2019-11-28 |
US20200002297A1 (en) | 2020-01-02 |
WO2018167001A1 (en) | 2018-09-20 |
AU2018233079B9 (en) | 2021-07-22 |
PE20191757A1 (es) | 2019-12-12 |
CN110392679A (zh) | 2019-10-29 |
US11059794B2 (en) | 2021-07-13 |
JP7157755B2 (ja) | 2022-10-20 |
AU2018233079B2 (en) | 2021-06-24 |
CA3053329A1 (en) | 2018-09-20 |
BR112019019017A2 (pt) | 2020-04-14 |
AU2018233079A1 (en) | 2019-08-29 |
EP3596059A1 (en) | 2020-01-22 |
CR20190423A (es) | 2019-11-01 |
AR111279A1 (es) | 2019-06-26 |
TW201838982A (zh) | 2018-11-01 |
RU2019132254A (ru) | 2021-04-16 |
RU2019132254A3 (es) | 2021-06-04 |
JP2020514355A (ja) | 2020-05-21 |
CL2019002609A1 (es) | 2020-02-14 |
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